International Journal of Applied and Basic Medical Research最新文献

{"title":"A Rare Supraorbital Ridge Mass: The Chondroid Syringoma with Adipocytic Metaplasia.","authors":"Anil Prasad, Binod Kumar, Sameer Kumar Mehta, Minakshi Mishra","doi":"10.4103/ijabmr.ijabmr_363_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_363_24","url":null,"abstract":"<p><p>Chondroid syringoma (CS) is a rare benign skin adnexal neoplasm. Its incidence is very low among all primary skin tumors. Diagnosing it clinically can be difficult as it closely resembles other benign salivary or adnexal neoplasms. Until now, only a few cases have been reported from the periorbital region. Clinically, it can be mistaken for epidermal cysts, but ectopic salivary glands are a close differential diagnosis. To diagnose it, a complete removal is usually required, followed by a histopathological examination. We present a unique case of a 45-year-old female patient with a CS in her right supraorbital ridge and review the pertinent literature.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"60-62"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Withania somnifera</i> on Expression of Selected Genes in Hippocampus of Male Wistar Rats Subjected to Chronic Unpredictable Mild Stress.","authors":"Jinay Paresh Mehta, Urmila Anil Kagal, Prakash R Biradar","doi":"10.4103/ijabmr.ijabmr_330_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_330_24","url":null,"abstract":"<p><strong>Background: </strong>Depression affects millions globally, with existing treatments having many side effects. <i>Withania somnifera</i> (WS) shows potential as an antidepressant and neuroprotective agent, possibly by influencing brain-derived neurotrophic factor (BDNF)-related pathways.</p><p><strong>Aim: </strong>This study evaluated the effect of WS alone and in combination with fluoxetine on neuritin, NARP, and BDNF Exon-III gene expression in the hippocampus of male Wistar rats subjected to chronic unpredictable mild stress (CUMS).</p><p><strong>Materials and methods: </strong>Thirty male Wistar rats were divided into five groups (<i>n</i> = 6 each): normal group (NG), disease control (DC), standard treatment (ST), WS, and combination group of fluoxetine and WS (FW). Depression was induced using CUMS, except in the NG. The sucrose preference test confirmed depression at the end of 3^rd week and assessed treatment effects at the end of 7^th week. Gene expression in the hippocampus was analyzed through real-time PCR at the end of 7^th week.</p><p><strong>Results: </strong>After 7 weeks, the ST, WS, and FW groups showed a significant increase in sucrose preference compared to the DC group. The ST and FW groups showed significant upregulation of all three genes selected in the present study. Comparison between NG and FW groups showed no significant difference in gene expression.</p><p><strong>Conclusion: </strong>This study highlights the antidepressant effects of WS by demonstrating its effect on BDNF-associated gene expression. Fluoxetine combined with WS demonstrated additive effects which proves an adjuvant role of WS in the treatment of depression. Further studies involving human subjects are essential to validate the antidepressant effects of WS and its additive effects with fluoxetine.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"25-31"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confusion Surrounding the Mandatory Requirement of Thesis Submission: Review of the Postgraduate Medical Education Regulations of the National Medical Commission.","authors":"Rajiv Mahajan","doi":"10.4103/ijabmr.ijabmr_558_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_558_24","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"1-3"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kounis Syndrome after Oral Amoxicillin Clavulanate.","authors":"Sirsha Chatterjee, Saloni Paranjape, Gurbachan Singh","doi":"10.4103/ijabmr.ijabmr_461_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_461_24","url":null,"abstract":"<p><p>Kounis or allergic vasospastic angina has been described after exposure to several foods, drugs, and insect bites and stings. Mast cell degranulation during a hypersensitivity allergic or anaphylactic reaction leads to inflammatory mediators causing coronary spasm and thrombosis. A 44-year-old female with no comorbidities presented with sweating, dizziness, rashes, chest tightness, and epigastric discomfort 1 h after oral amoxicillin clavulanate. Electrocardiogram (ECG) showed ST segment changes along with elevated troponin I. Suspecting Kounis syndrome, she was administered pheniramine maleate, hydrocortisone, and oral antiplatelets along with intravenous fluids. Chest tightness was better, and ECG improved in 60 min. Since systemic adrenaline was to be avoided for fear of coronary vasospasm, for airway edema, nebulized adrenaline was administered. She recovered completely and was discharged after 48 h. This case highlights coronary vasospasm during an ongoing allergic reaction and its management with antihistamines, steroids, and antiplatelet drugs. Nebulized adrenaline was safely given with ECG monitoring for airway edema.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"66-68"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression of Cyp7a1 in Liver Tissue of Type 2 Diabetic Rats Treated with Fenugreek and/or Metformin.","authors":"Saloni Garg, Urmila Kagal","doi":"10.4103/ijabmr.ijabmr_165_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_165_24","url":null,"abstract":"<p><strong>Background and aim: </strong>In the liver, glucose appears to affect gene transcription. High blood sugar boosts bile acid (BA) synthesis and mRNA expression of the cholesterol-7α-hydroxylase (Cyp7a1) gene, a key BA regulator. Fenugreek, also known as <i>Trigonella foenum-graecum</i> (TFG), is one of the few recognized powerful herbs to have anti-diabetic properties. However, whether it has an interaction when given along with metformin (MET) is unclear.</p><p><strong>Methodology: </strong>In the present study, we evaluated the effect of TFG alone and in combination with MET on random blood sugar (RBS) and Cyp7a1 gene expression in high fat diet and Streptozotocin (STZ; 30 mg/kg, i.p.)-induced diabetic male Wistar rats.</p><p><strong>Results: </strong>The MET, TFG, and combination of MET + TFG (CBN) significantly lowered the RBS levels (<i>P</i> < 0.0001, <i>P</i> < 0.009, and <i>P</i> < 0.002) of diabetic rats. All groups upregulated Cyp7a1 expression. MET upregulated it by 4.8-fold, whereas the TFG and CBN groups upregulated it by a substantial amount of 50.2-fold and 50.4-fold, respectively.</p><p><strong>Conclusion: </strong>This study has found that the administration of MET and TFG in combination may have an undesirable pharmacological interaction on blood glucose levels and BA synthesis. This information becomes critical for people who wish to take MET with TFG for ostensible better glucose management. It is advisable to avoid combining them. Moreover, the current investigation has proven Cyp7a1 to be an essential therapeutic target for both MET and TFG due to its involvement in both, BA synthesis and anti-diabetic effect.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"11-17"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Well-being and Quality of Life for Patients with Stable Spinal Cord Injury: A Cross-sectional Study.","authors":"Vidur Makkar, Aditya Pandurangi, Vidushi Makkar, Ume Hani, Mahesh Mahadevaiah, Swapna Pandurangi","doi":"10.4103/ijabmr.ijabmr_428_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_428_24","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) results in severe physical impairments and significant lifestyle disruptions, including paralysis, increased dependence on caregivers, and a tendency toward social isolation. These challenges deeply affect the psychological health and overall quality of life (QOL) of those impacted, especially in younger patients. Investigating the psychological and QOL outcomes in individuals with stable SCIs is crucial for developing tailored rehabilitation strategies.</p><p><strong>Aim: </strong>The study aimed to investigate the psychological health and QOL in patients with stable SCIs.</p><p><strong>Materials and methods: </strong>This observational cross-sectional study involved patients with stable traumatic SCIs recruited through WhatsApp support groups from two major centers in India. Eligible participants were adults who were at least 1-year postinjury. Those with severe head injuries or nontraumatic spinal injuries were excluded. Participants provided sociodemographic information and injury history and completed assessments evaluating psychological health and QOL. Data were analyzed using IBM SPSS software, and statistical significance was determined through Chi-square tests.</p><p><strong>Results: </strong>Psychological distress was identified in 26.2% of the participants. Younger participants exhibited significantly poorer QOL in the psychological domain (<i>P</i> = 0.02). Employment status showed a significant association with the physical domain (<i>P</i> = 0.037) and overall QOL scores (<i>P</i> = 0.046). Socioeconomic status was significantly correlated with both the psychological (<i>P</i> = 0.004) and social domains (<i>P</i> = 0.009).</p><p><strong>Conclusions: </strong>The study underscores the considerable impact of SCI on psychological health and overall QOL, with younger individuals disproportionately affected. Healthcare providers should prioritize the integration of psychological support and counseling in SCI rehabilitation programs.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"43-48"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Profiles of ROS1 Tyrosine Kinase: A Structural Analysis of G2032R and D2033N Mutations.","authors":"Syed Ikramul Hasan","doi":"10.4103/ijabmr.ijabmr_43_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_43_24","url":null,"abstract":"<p><strong>Background: </strong>ROS1, a proto-oncogene, drives cancer through chromosomal fusions. The G2032R and D2033N mutations, common in ROS1-rearranged non-small cell lung cancer, hinder crizotinib treatment. We investigate these mutations' impact on ROS1 structure through molecular dynamics (MD) simulations, revealing destabilization. Our findings shed light on how these mutations contribute to cancer development.</p><p><strong>Materials and methods: </strong>The crystal structure of human ROS1 (PDB ID: 7z5x) served as the template for homology modeling and further mutation insertion of G2032R and D2033N substitutions introduced using Swiss-PdbViewer. The MD simulations were conducted on the wild-type (WT) and mutant ROS1 kinase domains to explore the structural changes and interactions.</p><p><strong>Results: </strong>The initial model of the human ROS1 crystal structure was constructed, incorporating missing loop residues and then utilized for the MD simulation studies. The examination of conformational changes in WT, G2032R, and D2033N mutant ROS1 proteins involved observing alterations in the C-alpha protein. We observed that the mutations resulted in deviations in the MD trajectory over the 500 ns period. Consequently, the MD simulations unveiled significant conformational changes induced by the G2032R and D2033N mutations, affecting protein stability and dynamics, particularly in regions such as the ATP binding and active sites.</p><p><strong>Conclusion: </strong>Our study constructed an initial model of the human ROS1 and used it for MD simulation studies to examine the conformational changes in ROS1 mutants. Notably, our observations revealed that the mutations caused deviations in the MD trajectory. The G2032R and D2033N mutations significantly alter ROS1 structure, affecting its stability and dynamics, offering key insights into their role in cancer disease development.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"4-10"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ARL15</i> Gene Variant rs255758 Provides Susceptibility to Rheumatoid Arthritis in Northwest Indian Population.","authors":"Inder Mohan Singh Sandhu, Hemender Singh, Simranpreet Kaur, Ekta Rai, Anupama Mahajan, Gurinder Mohan, Swarkar Sharma","doi":"10.4103/ijabmr.ijabmr_156_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_156_24","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory autoimmune disease with a strong genetic component. <i>ARL15</i> gene variant rs255758 has been reported as a candidate for RA susceptibility. A replication study was performed on this variant by taking 188 RA cases and 310 healthy non-RA controls from northwest India in a case-control association study design.</p><p><strong>Materials and methods: </strong>DNA isolated from collected blood samples was analyzed by genotyping of the variant on real-time polymerase chain reaction using TaqMan Allele Discrimination Assay and statistically analyzed.</p><p><strong>Results: </strong>The variant was found to follow Hardy-Weinberg Equilibrium (<i>P</i> = 0.079) in the control group. The variant was significantly associated with RA susceptibility in the present studied population cohort (<i>P</i> = 0.024) with <i>C</i> as a risk allele and increased risk in the recessive model (<i>CC</i> vs. <i>CA</i> + <i>AA</i>; <i>P</i> = 0.004).</p><p><strong>Conclusion: </strong>The present study corroborates the earlier findings on the role of <i>ARL15</i> gene variant rs255758 in RA and further contributes to its genetic etiology.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"38-42"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-portfolio in Learning and Assessment of Community Medicine for Medical Undergraduate Students.","authors":"Medha Mathur, Sangeetha Samuel, Navgeet Mathur, Manjinder Kaur, Dinesh K Badyal","doi":"10.4103/ijabmr.ijabmr_334_24","DOIUrl":"10.4103/ijabmr.ijabmr_334_24","url":null,"abstract":"<p><strong>Background: </strong>A portfolio is a specific collection of student work and achievements in various areas. E-portfolio is an electronic collection that serves the purpose of storage and showcase with the ease of access for both students and evaluators. The knowledge and skills regarding immunization in medical students are of utmost importance for the successful implementation and conduction of the Universal Immunization Program in the country. Hence, this study proposed to use e-portfolio for learning and assessment of immunization in medical undergraduates.</p><p><strong>Aim and objectives: </strong>The aims of this study were as follows: to develop an e-portfolio for learning and assessment in community medicine, to improve the knowledge of immunization schedules of undergraduates using e-portfolio, to improve the vaccination and counseling skills of undergraduates using e-portfolio, and to obtain feedback regarding the e-portfolio from students and faculty.</p><p><strong>Methodology: </strong>This interventional educational study was conducted at a tertiary care medical college including 48 students of Phase III MBBS after informed consent was signed. Prevalidated questionnaire and checklist were used for data collection. Students wrote reflections and uploaded their videos of immunization skills and counseling on the e-portfolio and 5 faculty members assessed the students and provided feedback to students. Feedback on the e-portfolio was taken at the end, and descriptive and qualitative analysis was done. Ethical approval for the study was obtained from the institutional ethics committee.</p><p><strong>Results: </strong>The e-portfolio was found to be effective in showcasing the progress and learning of the students. E-portfolio improved knowledge, skills, self-directed learning, and reflective writing. The competency of immunization improved after the use of e-portfolio (<i>P</i> < 0.001). Faculty and students had high satisfaction with the e-portfolio and found the e-portfolio to be innovative, convenient to use, and easily accessible.</p><p><strong>Conclusions: </strong>E-portfolio is user-friendly and effective in imparting and assessing immunization competency. The use of this intervention for other topics is recommended.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"14 4","pages":"266-272"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11691100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiential Learning of Active Learning Strategies in Mentor Learner Web-based Discussions: A Perceptions Study.","authors":"Archana Chauhan, Jarina Begum, K M Lavanya, Anju Gupta, Sujata Ghosh, Supriya Kulkarni","doi":"10.4103/ijabmr.ijabmr_277_24","DOIUrl":"10.4103/ijabmr.ijabmr_277_24","url":null,"abstract":"<p><strong>Background: </strong>Active learning strategies (ALSs) in medical education are valued for their effectiveness but face adoption challenges among educators, underscoring the need for a deeper understanding of their implementation and impact.</p><p><strong>Aim: </strong>The aim of the study was to investigate the perceptions of medical educators regarding the effectiveness and challenges of ALS through mentor-learner (ML) web-based discussions.</p><p><strong>Settings and design: </strong>The retrospective cross-sectional study analyzed data from 32 medical educators enrolled in the Foundation for Advancement of International Medical Education Research course at Christian Medical College, Ludhiana. It utilized a mixed-method approach, gathering both quantitative and qualitative data through ML web discussions.</p><p><strong>Materials and methods: </strong>The study used a \"dual-method\" approach, combining traditional online discussions with a \"role-reversal\" method on an ML web platform, promoting experiential learning. Participant responses on ALS implementation tasks were collected and analyzed within these discussions.</p><p><strong>Results: </strong>Participants shared various ALS for collaborative learning (20), classroom engagement (26), assessing prior knowledge (12), and note-taking during lectures (10). Further, among the 11 ALS examined, the ease of implementation varied significantly among participants (<i>P</i> < 0.0001). Challenges in ALS implementation included inadequate faculty training (91%), motivation (84%), resource constraints (81%), student (75%), and administrative resistance (69%). Four themes emerged as recommendations for effective ALS implementation: empowering educators, engaging students, streamlining support systems, and monitoring impact.</p><p><strong>Conclusion: </strong>The study highlights a mixed perspective of medical educators on ALS. Although ALS was perceived as effective in fostering critical thinking and developing collaborative learning among students, various challenges, such as a lack of skilled faculty and resources, necessitated robust faculty development initiatives.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"14 4","pages":"258-265"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11691109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}