{"title":"An encyclopedic review on stereotactic hypofrac tionated radiotherapy, re-irradiation, and cancer genome research","authors":"Alireza Heidari, Victoria Peterson","doi":"10.14419/ijac.v8i1.30501","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30501","url":null,"abstract":"Cancer is a disease that humans have been involved with, and scientists have done great efforts to treat it. But they have not had much success, On the other hand Nano science as a new scientific in various branches of science have been made many changes. Hence can be used to treat cancer of Nano science. Currently, cancer treatment is such that drugs used are not selectivity. The cancer cells are not specifically identified, it destroys healthy tissue and cause harm to the human body. So if we can reduce drug dose of the drug to the targeted tissue must be, we have partially solved the problem. With earlier studies, researchers in the field of folate and gold nanoclusters have done, specified in the detection and destruction of cancer cells are highly effective and very promising future. The gold nanoclusters were used because it has unique properties such as adsorption of heat for the destruction of cancer cells and is also well connected to the folate. the 4-aminothiophenol (4Atp) is one of the best linker for binding folate and gold Nano clusters. In this study we used computational method for computing stability of complex (folate and Nano clusters) and geometrical and physicochemical properties. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86103306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A pervasive review on biomarker in cervical intraepithelial lesions and carcinoma","authors":"Alireza Heidari, Victoria Peterson","doi":"10.14419/ijac.v8i1.30502","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30502","url":null,"abstract":"Basically, medical diagnosis problems are the most effective component of treatment policies. Recently, significant advances have been formed in medical diagnosis fields using data mining techniques. Data mining or Knowledge Discovery is searching large databases to discover patterns and evaluate the probability of next occurrences. In this research, Bayesian Classifier is used as a Non-linear datamining tool to determine the seriousness of breast cancer. The recorded observations of the Fine Needle Aspiration (FNA) tests that are obtained at the University of Wisconsin are considered as experimental data set in this research. The Tabu search algorithm for structural learning of Bayesian classifier and Genie simulator for parametric learning of Bayesian classifier were used. Finally, the obtained results by the proposed model were compared with actual results. The comparison process indicates that seriousness of the disease in 86.18% of cases are guessed very close to the actual values by proposed model. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72844407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. P, Senthil Kumar G P, C. R., Vidya D N, Bhadresh D R, M. S
{"title":"Validated extractive analytical methods for the estimation of pregabalin in bulk and pharmaceutical dosage form","authors":"P. P, Senthil Kumar G P, C. R., Vidya D N, Bhadresh D R, M. S","doi":"10.14419/ijac.v8i1.30273","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30273","url":null,"abstract":"Two simple, rapid, sensitive and accurate spectrophotometric methods are described for the determination of Pregabalin (PRG) in bulk and pharmaceutical formulations. The methods are based on the reactions of the drug with bromocresol purple (BCP) and bromocresol green (BCG) in buffered hydrochloric acid solutions at pH 1.2 to give coloured ion-pair complexes extractable with chloroform. The coloured products are quantitated spectrophotometrically at 431 nm with BCP and 444.80 nm with BCG. Beer's law is obeyed in the concentration range 10-50 µg/ml with both reagents. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods are found to be simple, accurate and reproducible that was successfully applied for the analysis of capsule formulations. The developed methods are easy to use, accurate and highly cost-effective for routine studies relative to HPLC and other techniques. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74968493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Determination of fluorescence lifetimes of fluorescein from fluorescence quenching data","authors":"A. Ogunsipe, O. Opeolu","doi":"10.14419/ijac.v8i1.29995","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.29995","url":null,"abstract":"The fluorescence quenching of fluorescein by 1,4-benzoquinone (BQ) in five solvents – methanol, ethanol, phosphate buffer saline (PBS, pH 7.4), N,N'-dimethylformamide (DMF) and dimethylsulphoxide (DMSO) is hereby investigated. Fluorescein’s fluorescence was effectively quenched by BQ, and the quenching was dynamic (purely collisional) within the BQ’s concentration range (0.001 to 0.004 M) used in this work. Accordingly, the quenching data were in conformity with the Stern-Volmer’s model. Stern-Volmer’s constant (KSV) values range between 17.4 in DMSO and 43.4 in methanol. KSV values, together with the calculated bimolecular rate constants (kD) in the respective solvents, were used to semi-empirically estimate the fluorescence lifetimes (tF) of fluorescein in the individual solvents. Just as for KSV values, tF values are solvent-viscosity dependent, with the lowest values being obtained in methanol and the highest in DMSO, which are the least and most viscous solvents respectively. tF values obtained in this work are 3.55, 3.71, 3.78, 4.13 and 4.51 ns (in methanol, PBS 7.4, ethanol, DMF and DMSO, respectively). ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76045816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ait Sidi Mou, E. E. Ghanjaoui, M. Daoudi, B. El Gamany
{"title":"Study on qualitative analysis in cosmetic takaout plant by multivariate statistical","authors":"A. Ait Sidi Mou, E. E. Ghanjaoui, M. Daoudi, B. El Gamany","doi":"10.14419/ijac.v8i1.30133","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30133","url":null,"abstract":"This study examines the distributions and behavior of trace elements in five takaout plant samples. Multivariate statistical methods involving principal component analysis and hierarchical cluster analysis are applied. The measurements were performed using 21 elements (Al, B, Ba, Ca, Co, Cr, Cu, Er, Fe, K, La, Mg, Mn, Na, Ni, Sc, Sr, Ti, Y, Yb, Zn) at µg g-1 level determined by ICP-OES. The coefficients calculated for samples indicated a poorly negative correlation between the trace elements and Pr. A strong positive correlations among K, Na, Ca, Mg, Fe, Al, Sr, Ti, Er and Cr show a similarity in their change rules. Also, negative correlations between K and Na with Mn, Zn and Ba were showed, which indicates that these elements haven’t a similarity in their behaviors, the increase of one (K and Na) conducting of decrease of others (Mn, Zn and Ba). The correlation matrix shows that Cr has good consistency with the trace elements in the sample. In particular, the correlation coefficient with Mg followed by Sr, Ca, and Fe correlations. These strong correlations between these variables show the similarity of the phenomena at the origin in takaout plant. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83996322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed Atiga Elbagermi, Antisar Abdulmajid Bin Haleem, Khaled Muftah Elsherif
{"title":"Evaluation of essential and heavy metal levels in pasteurized and long-life cow milk","authors":"Mohamed Atiga Elbagermi, Antisar Abdulmajid Bin Haleem, Khaled Muftah Elsherif","doi":"10.14419/ijac.v8i1.30154","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30154","url":null,"abstract":"In the present investigation, 11 cow’s milk samples (pasteurized and long life) were collected from supermarkets in Misurata city, Libya. For the determination of metal contents, the milk samples were subjected to the optimized microwave digestion method using HNO3 and H2O2. The levels of Na, K, Mg, Ca, Fe, Cu, Cr, Mn, Co, Ni, Zn, Cd, and Pb were evaluated by Microwave Plasma - Atomic Emission Spectrophotometer (MP-AES 4100). It was found that potassium is the most concentrated essential metal while zinc is the highest detected heavy metal in all milk samples. The levels of Co and Cd were not detected in all milk samples under investigation (lower than instrumental detection limits). The mean concentrations of the detected metals were as follows: 828.05±0.82, 587.57±0.87, 512.38±0.30, 73.79±0.19, 2.014±0.19, 1.89±0.16, 0.178±0.03, 0.061±0.02, 0.074±0.01, 0.053±0.001, and 0.045±0.001 for: K, Ca, Na, Mg, Zn, Fe, Cu, Mn, Ni, Pb, and Cr ppm, respectively. There is no significant difference in the mean concentrations of Ni, Cr and Pb between the investigated milk samples. Though, the levels of essential and heavy metals observed were similar with other reported values in the literature. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91534184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A semi-empirical estimation of ground and excited state dipole moments of zinc phthalocyanine from solvatochromic shift data","authors":"A. Ogunsipe","doi":"10.14419/IJAC.V6I2.11019","DOIUrl":"https://doi.org/10.14419/IJAC.V6I2.11019","url":null,"abstract":"A semi-empirical determination of ground and excited state dipole moments of zinc phthalocyanine (ZnPc) from solvatochromic shifts is hereby presented. The ratio of the excited- and ground-state dipole moments of ZnPc ( ) was estimated by a combination of the Bakshiev and the Kawski-Chamma-Viallet’s equations, while the difference in the excited- and ground-state dipole moments (Dm) was estimated usingthe molecular-microscopic solvent polarity parameters ( ), alongside the Stokes’ shifts (Dῡ) in the various solvents. The dipole moment of ZnPc is significantly higher in the excited singlet state (me = 3.12 D) than in the ground state (mg = 1.50 D). Obviously charge separation is greater in the excited state of ZnPc than in its ground state. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"86 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91118257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vibrational biospectroscopic study and chemical structure analysis of unsaturated polyamides nanoparticles as anti–cancer polymeric nanomedicines using synchrotron radiation","authors":"A. Heidari","doi":"10.14419/IJAC.V6I2.12528","DOIUrl":"https://doi.org/10.14419/IJAC.V6I2.12528","url":null,"abstract":"Firstly, unsaturated polyamides nanoparticles were hardened by continuous synchrotron radiation and then, the induced changes in its chemical structure were studied by Attenuated Total Reflection–Fourier Transform Infrared (ATR–FTIR) spectroscopy. It was shown that applying synchrotron radiation for hardening not only leads to reduction of hardening time but also creates cross link in polymer by breaking Carbon–Carbon double bond, without any considerable change in its chemical structure. In addition, an unsaturated polyamide nanoparticle as anti–cancer polymeric nanomedicines is hardened by synchrotron radiation. Its chemical structure before and after hardening is studied using Raman and Attenuated Total Reflection–Fourier Transform Infrared (ATR–FTIR) spectroscopy. The results show that Raman spectroscopy is considerably better than Attenuated Total Reflection–Fourier Transform Infrared (ATR–FTIR) spectroscopy in detecting the changes happened in chemical structure. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83195627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non enzymatic NADH-dependent reduction of Cis-[Co(en)2(H2O)2]3+ in aqueous medium","authors":"B. Behera, J. Behera","doi":"10.14419/ijac.v6i2.13047","DOIUrl":"https://doi.org/10.14419/ijac.v6i2.13047","url":null,"abstract":"The kinetics of the electron transfer reaction of NADH with Cis-[Co(en)2(H2O)2]3+ has been studied over the range 1.0 ≤ 102 [NADH] ≤ 3.0 mol dm-3, 7.0 ≤ pH ≤ 8.0 and 200C ≤ t ≤ 350C in aqueous medium. The rate of electron transfer reaction was found to be first-order dependence each in [NADH]T and Cis-[Co(en)2(H2O)2]3+T. The products of the reaction were found to be NAD+ and Co(II). The corresponding activation parameters of the electron transfer reactions were found to be as ΔH#=27.55 kJ mol-1 and ΔS#= -189.35 JK-1mol-1. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90344114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of temperature on cadmium oxide (CdO) nanoparticles produced by synchrotron radiation in the human cancer cells, tissues and tumors","authors":"A. Heidari","doi":"10.14419/IJAC.V6I2.12521","DOIUrl":"https://doi.org/10.14419/IJAC.V6I2.12521","url":null,"abstract":"In this work, the effect of temperature of the ablation environment on the properties of Cadmium Oxide (CdO) nanoparticles produced by synchrotron radiation is investigated. To produce nanoparticles, synchrotron radiation pulse with 1064 (nm) wavelength is used to emit Cadmium in the human cancer cells, tissues and tumors. All test parameters were kept constant and human cancer cells, tissues and tumors temperature was changed to produce samples at 20°C and 65°C. Then, ATR–FTIR, XRD, TEM and UV–Visible spectroscopy analyses were performed to investigate their properties. The results show that the size of nanoparticles is increased by increase in temperature of ablation environment. In addition, in the current experimental research, Gold (Au)–Cadmium Oxide (CdO) alloy is created at the size of nano. In this regard, same volume of Gold and Cadmium Oxide (CdO) solutions were mixed together and emitted by the synchrotron radiation pulse with wavelength of 532 (nm). The Gold and Cadmium Oxide (CdO) solutions have been produced, separately, using synchrotron radiation ablation process. To produce them, synchrotron radiation pulse with wavelength of 1064 (nm) and pulse width of 7 (ns) and repeating frequency of 5 (Hz) was used. The results show that synchrotron radiation emission with wavelength of 532 (nm) is an appropriate method for producing Gold compounds in the size of nano. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"362 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76505953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}