International Journal of Advanced Chemistry最新文献_第7页

Development and validation of valganciclovir hydrochloride in bulk and pharmaceutical dosage form by HPTLC method 高效液相色谱法研究盐酸缬更昔洛韦原料药和药剂剂的研制与验证

International Journal of Advanced Chemistry Pub Date : 2020-09-19 DOI: 10.14419/ijac.v8i2.30926

K. K, J. Gnana Babu C., Sowmya H.G

{"title":"Development and validation of valganciclovir hydrochloride in bulk and pharmaceutical dosage form by HPTLC method","authors":"K. K, J. Gnana Babu C., Sowmya H.G","doi":"10.14419/ijac.v8i2.30926","DOIUrl":"https://doi.org/10.14419/ijac.v8i2.30926","url":null,"abstract":"A simple, rapid and accurate High performance thin layer chromatography is described for the Development and validation of HPTLC method for Valganciclovir Hydrochloride in bulk and Pharmaceutical dosage form. The separation is carried out on Merck TLC aluminum sheets of silica gel 60 F254 using Chloroform: Methanol: Ammonia (6.5:3.4:0.1v/v) mobile phase. Quantification was done by Densitometric scanning at 254nm. The linearity was found to be the range of 100-500ng/spot for Valganciclovir hydrochloride with the correlation coefficient of 0.9993. The regression equation was found to be Y=10.168x-94.8. The Rf value of Valganciclovir hydrochloride was found to be 0.74. The LOD and LOQ were found to 9.19 and 27.87 respectively. Average recovery was found to be 99.66% which show that the method was free from interference from excipients present in the formulation. Simultaneously the Percentage relative standard deviation was well within the range of 2%. The above method was validated according to the ICH guidelines. The established method enabled accurate, precise and applied to the analysis of Valganciclovir hydrochloride in bulk and Pharmaceutical dosage form. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83685287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular interaction on imidazolium based ionic liquids and serum albumin: A spectroscopy approach 咪唑类离子液体与血清白蛋白的分子相互作用:光谱学方法

International Journal of Advanced Chemistry Pub Date : 2020-09-19 DOI: 10.14419/ijac.v8i2.30994

Manoj Kumar Banjare, Ramesh Kumar Banjare, Kallol Kumar Ghosh

引用次数: 4

Optimization of groundnut shell fast pyrolysis for the production and characterization of bio-oil using fabricated fixed bed reactor 花生壳快速热解制备生物油的工艺优化及固定式反应器表征

International Journal of Advanced Chemistry Pub Date : 2020-09-19 DOI: 10.14419/ijac.v8i2.31050

Ige Ayodeji Rapheal, Elinge Cosmos Moki, A. Muhammad, G. Muhammed, Lawal Gusau Hassan

{"title":"Optimization of groundnut shell fast pyrolysis for the production and characterization of bio-oil using fabricated fixed bed reactor","authors":"Ige Ayodeji Rapheal, Elinge Cosmos Moki, A. Muhammad, G. Muhammed, Lawal Gusau Hassan","doi":"10.14419/ijac.v8i2.31050","DOIUrl":"https://doi.org/10.14419/ijac.v8i2.31050","url":null,"abstract":"Renewable plant materials are regarded as one of the most affirmative option for the production of fuels and chemicals. With the concept of pyrolysis process, there is every possibility to produce alternative sources of energy and fuels from renewable biomass. The study depicts the production, optimization and characterization of bio-oil from pyrolyzed groundnut shell using fabricated reactor. The pyrolysis process was produced with bio-oil response, bio-char response and non condensable gases response as products. The effect of pyrolysis variables were observed by the production of the bio-oil as the response. Sixty runs of pyrolysis experiments were suggested by box Benkhen design indicated optimum pyrolysis condition at particle size of 1.15mm mesh, reaction time of 83 mins and temperature of 650oC. The maximum bio-oil yield was obtained with 33.91% at optimum condition. The bio-oil samples had better performance which met the specifications for the measured properties and compares well with the ASTM standard. Therefore, using groundnut shell for bio-oil production via pyrolysis process can serve as an approach of providing a sustainable alternative source of fuel and friendly environment. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89673601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development and validation of HPTLC method for the estimation of cefadroxil in bulk and tablet dosage form 高效液相色谱法测定头孢地洛西原料药和片剂含量的建立与验证

International Journal of Advanced Chemistry Pub Date : 2020-09-02 DOI: 10.14419/ijac.v8i2.30963

Kirankumar S V, J. Gnana Babu C., S. H G

引用次数: 0

Development and validatation of HPTLC method for estimation of irbesartan in bulk and tablet dosage form 厄贝沙坦片剂和散装剂型hplc法的建立与验证

International Journal of Advanced Chemistry Pub Date : 2020-08-04 DOI: 10.14419/ijac.v8i1.30800

Yogeesh C S, S. H G, J. Gnana Babu C.

引用次数: 0

Hydride generation atomic fluorescence spectrometry (HG-AFS) determination of total arsenic in lipstick 氢化物发生原子荧光光谱法测定口红中总砷

International Journal of Advanced Chemistry Pub Date : 2020-07-25 DOI: 10.14419/ijac.v8i1.30889

M. E. Ghanjaoui, I. Adraoui, A. Gammoun, L. Cervera, M. El Rhazi, M. de la Guardia

引用次数: 0

The nutritional potentials and the fatty acid profile of the seed and seed oil of Caesalpinia bonducella 山葵种子及籽油的营养潜力及脂肪酸谱

International Journal of Advanced Chemistry Pub Date : 2020-07-25 DOI: 10.14419/ijac.v8i1.26278

A. Adeniyi, Sulaiman Wasiu Kayode, Akinyode Olakunle Abayomi

{"title":"The nutritional potentials and the fatty acid profile of the seed and seed oil of Caesalpinia bonducella","authors":"A. Adeniyi, Sulaiman Wasiu Kayode, Akinyode Olakunle Abayomi","doi":"10.14419/ijac.v8i1.26278","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.26278","url":null,"abstract":"The physicochemical properties of the seed and fatty acid profile of the seed oil of Caesalpinia bonducella were analyzed in this study, using standard methods of the Association of Official Analytical Chemists (AOAC). The proximate composition was found as follows: Moisture (3.24%), crude fat (41.76%), crude protein (28.63%), crude fibre (4.35%), ash content (2.94%) and carbohydrate (19.08%). The total unsaturated fatty acids (57.36%) was more abundant than the total saturated ones (42.68%). The seed oil had a high level of linoleic acid (28.15%), followed by oleic (18.41%), stearic (13.83%) and palmitic (13.56%). Other fatty acids had less than 10% each. There was a high level of unsaturation (57.36%) with oleic and linoleic acids dominating all other fatty acids with a total of 46.56%. The percentage of essential fatty acids (linoleic & linolenic acids) (32.96%) was also high at about ⅓ of the total oil content. The total poly-unsaturated fatty acids (36.99%) was higher than those of mono-unsaturated (20.37%). The high level of poly-unsaturated fatty acids in the oil sample is an advantage as these are essential components of the diet of man. The good total unsaturated/saturated (or P/S) ratio of the oil, (i.e.1.344), makes it to be very nutritionally useful if adopted for domestic purposes. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85215391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum chemical analysis of harmful dye 3-[ (4-anilinophenyl) diazenyl] benzenesulfonate, metanil yellow 有害染料3-[(4-苯胺苯基)二氮基]苯磺酸甲胺黄的量子化学分析

International Journal of Advanced Chemistry Pub Date : 2020-07-25 DOI: 10.14419/ijac.v8i1.30753

Shreyas Parbat

{"title":"Quantum chemical analysis of harmful dye 3-[ (4-anilinophenyl) diazenyl] benzenesulfonate, metanil yellow","authors":"Shreyas Parbat","doi":"10.14419/ijac.v8i1.30753","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30753","url":null,"abstract":"In the present work, quantum chemical study of the harmful dye, metanil yellow is conducted. The optimized molecular geometry and harmonic vibrational frequencies of metanil yellow were calculated by DFT-B3LYP method with LANL2DZ basis set. The vibrational assignments were performed on the basis of the potential energy distribution (PED) of the vibrational modes. Infrared spectra and Bulk Raman spectra were also obtained and characteristic peaks for the title compound were studied. The nonlinear optical properties of the title compound were calculated and discussed. Dipole moment, polarizability and first-order hyperpolarizability of the title compound were reported in order to study nonlinear optical properties (NLO). HOMO-LUMO energy levels were also computed in order to get the bandgap energy. Global reactivity descriptors were calculated using the HOMO and LUMO to predict compound reactivity. UV–Vis spectrum of the title compound was calculated using TD–DFT method. The molecular orbital contributions were studied by density of states (DOSs). Mulliken atomic charges and atomic polar tensors (APT) on each atom were tabulated. A discussion of the vibrational energy of each mode is also presented in this article. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89684634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation of Paint using Natural Pigment from Lawsonia Inermis Leaves 用槐叶天然色素制备涂料的研究

International Journal of Advanced Chemistry Pub Date : 2020-06-14 DOI: 10.14419/ijac.v8i1.30712

Z. Y. Abba, S. M.Gumel, A. A.Idris, M. A.Ibrahim

引用次数: 1

Adsorption of Methyl Orange Dye onto Raw Maize Cob and Maize Cob Activated Carbon: Isotherms and Thermodynamic Studies 甲基橙染料在玉米芯和玉米芯活性炭上的吸附:等温线和热力学研究

International Journal of Advanced Chemistry Pub Date : 2020-06-14 DOI: 10.14419/ijac.v8i1.30676

Safiyya Ibrahim Abubakar, Muhammad Adamu Ibrahim, Muhammad Bashir Ibrahim

{"title":"Adsorption of Methyl Orange Dye onto Raw Maize Cob and Maize Cob Activated Carbon: Isotherms and Thermodynamic Studies","authors":"Safiyya Ibrahim Abubakar, Muhammad Adamu Ibrahim, Muhammad Bashir Ibrahim","doi":"10.14419/ijac.v8i1.30676","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30676","url":null,"abstract":"This study was aimed to evaluate the adsorption of Methyl orange (MO) onto raw maize cob (RMC) and maize cob activated carbon (MCAC) from aqueous solution using batch adsorption studies. The produced adsorbents were characterized by Scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR). The influence of contact time, dosage, concentration, temperature, and pH were investigated as well as Isotherm and Thermodynamic studies. Effect of contact time showed that Methyl orange adsorption were found to reach equilibrium within 125 and 110 minutes with optimum percentage removal of about 86.98% and 94.57% for raw maize cob and maize cob activated carbon respectively. The dye removal efficiency was found to increase with increasing initial dye concentration from 10 mg/L to 100 mg/L, and adsorption efficiency was found to be high at lower pH. However, increase in the dosage of the adsorbents lead to the increase in the adsorption process. The equilibrium adsorption data were analyzed using four adsorption models: Langmuir, Freundlich, Temkin, and D-R. The results revealed that MO with raw maize cob and maize cob activated carbon fit well to Freundlich with R2 value 0.977 and Temkin with R2 value 0.990 respectively and mean adsorption energy calculated from D-R shows it is physical adsorption and also values of enthalpy and Gibbs free energy proves that. Values of activation parameters such as free energy changes (∆G), enthalpy change (∆H) and entropy change (∆S) were calculated using Van't Hoff equation. All ∆G values were negative indicating that the adsorption was feasible and spontaneous. The result indicated that RMC and MCAC can be used for removal of MO from aqueous solution. The maize cob waste which is discarded as waste material was found to be effective adsorbent for the removal of Methyl orange dye from aqueous solution. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75053060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1