International Cancer Conference Journal最新文献

{"title":"A case of liposarcoma derived from fatty tissue around the inferior mesenteric artery resected by combined aortic resection.","authors":"Ryo Nakajima, Takahisa Hirokawa, Motoki Futamata, Daiki Sakurai, Airi Kageyama, Tsuyoshi Saito, Junki Kato, Kohei Kitamura, Shuhei Ueno, Hirotaka Miyai, Minoru Yamamoto, Takayuki Saito, Kenji Kobayashi, Moritsugu Tanaka, Masahiro Kimura","doi":"10.1007/s13691-025-00803-9","DOIUrl":"10.1007/s13691-025-00803-9","url":null,"abstract":"<p><p>The prognosis of sarcoma is poor; only radical resection with a negative margin has curative potential. We report a case of liposarcoma with complete surgical resection including the abdominal aorta. A 70-year-old man visited his doctor with the chief complaint of left abdominal distention. A computed tomography scan showed a mass of 15 cm, and the patient was referred to our hospital. The inferior mesenteric artery ran through the center of the tumor. The tumor surrounded the abdominal aorta, in close to the inferior vena cava, left iliopsoas muscle, left kidney, duodenum, and marginal arteries of left colon. We diagnosed the tumor as a sarcoma originated from the mesentery membrane, with invading the retroperitoneum, but with no unresectable factors. Radical surgical resection combined with aortic resection was performed. The tumor was histopathologically diagnosed as dedifferentiated liposarcoma, and was in close to surgical margin but not exposed. The patient could be discharged without major complications. Combined resection including the abdominal aorta was considered an acceptable procedure. On the other hand, the patient had a recurrence at 10 months postoperatively and died at 12 months, and techniques to ensure surgical margin and perioperative treatment may need to be considered to improve outcomes.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"497-502"},"PeriodicalIF":0.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALK-positive anaplastic large cell lymphoma presenting as an endobronchial polyp in a pediatric patient.","authors":"Hema A Venkatappa, Ashwini Nargund, Geeta V Patil Okaly, Sanghamitra Mukherjee, Champaka Gopal","doi":"10.1007/s13691-025-00805-7","DOIUrl":"10.1007/s13691-025-00805-7","url":null,"abstract":"<p><p>Anaplastic large cell lymphoma (ALCL) accounts for 10-15% of pediatric and adolescent non-Hodgkin lymphoma cases, with lung involvement observed in 14% of cases. We present a case of primary isolated ALCL in the endobronchial region of a 14-year-old boy. He presented with fever, dyspnea on exertion, cough, and left chest pain. A chest X-ray revealed a complete cut-off of the left main bronchus, which was further evaluated by bronchoscopy, showing complete occlusion of the left main bronchus by an endoluminal mass. Bronchoscopy with electrocautery snaring was performed, and immunomorphological findings confirmed the diagnosis of primary ALCL of the left main bronchus. Clinical and radiological evaluation revealed no evidence of extra-thoracic disease. A standard chemotherapy protocol was initiated. ALCL is an uncommon neoplasm in the pediatric population and rarely presents as a primary lung tumor. However, when unusual pulmonary lesions are encountered, especially in children, ALCL should be part of the differential diagnosis.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"513-517"},"PeriodicalIF":0.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first case of <i>GOLGA5-RET</i> fusion-positive malignant spindle cell sarcoma of the head and neck responsive to selpercatinib.","authors":"Takehiro Nakao, Naoki Fukuda, Xiaofei Wang, Ryosuke Oki, Tetsuya Urasaki, Kenji Nakano, Makiko Ono, Junichi Tomomatsu, Ryo Ariyasu, Yukiko Sato, Ippei Fukada, Toru Sasaki, Kengo Takeuchi, Makoto Nishio, Yuji Miura, Shunji Takahashi","doi":"10.1007/s13691-025-00806-6","DOIUrl":"10.1007/s13691-025-00806-6","url":null,"abstract":"<p><p>Soft-tissue sarcoma (STS) is a rare malignancy that accounts for less than 1% of all cancers, and recent advances in molecular biology have led to its classification based on genomic information. Some <i>RET</i>-rearranged neoplasms have been reported to present pathological features similar to Neurotrophic Tyrosine Kinase Receptor-rearranged spindle cell neoplasms. Here, we report the first case of head and neck spindle cell sarcoma with a GOLGA5-RET fusion that demonstrated a sustained clinical response to selpercatinib, identified through targeted next-generation sequencing (NGS). The patient was a 43 year-old man with a tumor in the arytenoid region that was resected and diagnosed as a malignant spindle cell tumor. Despite initial treatment with surgical resection alone, local recurrence was confirmed, requiring salvage therapy with total laryngectomy and bilateral cervical dissection. Surgical specimen revealed a spindle tumor with a patternless pattern and collagenous stroma. Immunohistochemistry (IHC) with positivity for CD34, bcl-2 (focally), S100, and weak nuclear staining for STAT6, with absence of expression of CK AE1/3, desmin, c-kit, smooth muscle actin, myogenin, synaptophysin, and SOX10. Trk A/B/C were also negative on IHC. Following confirmation of multiple lung metastases, the patient was treated with doxorubicin monotherapy. Targeted NGS identified <i>GOLGA5-RET</i> rearrangement, <i>FGF14</i> amplification (equivocal), <i>CDKN2B</i> loss, and <i>CDKN2A</i> loss. <i>GOLGA5-RET</i> rearrangements were validated through fluorescence in situ hybridization. The patient subsequently was enrolled in a phase 1/2 trial for the selective <i>RET</i> inhibitor selpercatinib, resulting in a sustained partial response over 5 years. Although solitary fibrous tumor (SFT) was initially considered as a differential diagnosis based on immunohistochemical findings, the lack of strong and diffuse STAT6 expression made this diagnosis unlikely. Subsequent next-generation sequencing (NGS) revealed a RET fusion, leading to the diagnosis of an RET-rearranged spindle cell neoplasm. This case highlights the importance of genomic testing for certain spindle cell sarcomas and the potential benefit of <i>RET</i>-specific inhibitors against <i>RET</i>-altered sarcomas.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"352-357"},"PeriodicalIF":0.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion surgery following zolbetuximab-based chemotherapy for CLDN18.2-positive gastroesophageal junction cancer.","authors":"Yuki Ushimaru, Kazuyoshi Yamamoto, Yoshitomo Yanagimoto, Yasunori Masuike, Kei Yamamoto, Norihiro Matsuura, Takahito Sugase, Takashi Kanemura, Ryota Mori, Masatoshi Kitakaze, Masahiko Kubo, Yasunari Fukuda, Hisateru Komatsu, Masaaki Miyo, Toshinori Sueda, Yoshinori Kagawa, Kunihito Gotoh, Shogo Kobayashi, Hiroshi Miyata","doi":"10.1007/s13691-025-00804-8","DOIUrl":"10.1007/s13691-025-00804-8","url":null,"abstract":"<p><p>Gastric cancer remains a major cause of cancer-related mortality worldwide. Systemic chemotherapy is the primary treatment strategy for unresectable or metastatic gastric cancer, but long-term survival remains poor. Zolbetuximab, a monoclonal antibody targeting claudin-18 isoform 2 (CLDN18.2), has demonstrated efficacy in combination with chemotherapy for CLDN18.2-positive gastric and gastroesophageal junction (GEJ) adenocarcinomas. In select cases, systemic therapy can lead to a significant reduction in tumor burden, enabling conversion surgery, which has been associated with favorable outcomes. However, reports on zolbetuximab-based regimens facilitating conversion surgery remain scarce. A 27 year-old man presented with progressive dysphagia, nausea, and weight loss. Endoscopy revealed a type 3 GEJ adenocarcinoma (Siewert type II), and imaging confirmed liver and lymph-node metastases. Pathological analysis identified CLDN18.2 positivity, HER2 negativity (score 1 +), mismatch repair proficiency, and CPS 1 ≤ 5. The patient was treated with six cycles of zolbetuximab-CAPOX (zolbetuximab, capecitabine, and oxaliplatin), resulting in complete regression of liver metastases and significant tumor shrinkage. PET-CT showed no distant metastases, and endoscopic evaluation confirmed tumor regression with resolution of treatment-related gastritis. Given the disappearance of non-curative factors, conversion surgery was performed. The patient underwent robot-assisted proximal gastrectomy with lower esophagectomy, D2 lymphadenectomy, and esophagogastrostomy with Delta anastomosis. Histopathological examination revealed a moderately differentiated adenocarcinoma (tub2 > por2) with residual tumor cells, classified as ypT3N1. Significant fibrosis and necrosis were observed within the tumor, with a histological response grade of 2a, indicating viable tumor cells with extensive treatment-induced changes. Surgical margins were negative, and no lymphovascular invasion was detected. The patient recovered uneventfully and was able to resume chemotherapy early, on postoperative day 20. This case demonstrates the potential of zolbetuximab-based chemotherapy in facilitating conversion surgery for CLDN18.2-positive GEJ adenocarcinoma. While clinical trials suggest reduced efficacy of zolbetuximab in GEJ cancer compared to gastric cancer, our case highlights the possibility of exceptional responses in select patients. Additionally, transient treatment-related gastritis observed during therapy raises questions about the effects of CLDN18.2 inhibition on gastric mucosal integrity. Further research is warranted to refine patient selection for CLDN18.2-targeted therapy and investigate its broader physiological effects.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"503-512"},"PeriodicalIF":0.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant radiotherapy for papillary tumor of the pineal region: a case report with a narrative review of the literature.","authors":"Francesco Cuccia, Gianluca Mortellaro, Marco Messina, Giovanni Tringali, Giuseppe Craparo, Giuseppina Iacoviello, Livio Blasi, Giuseppe Carruba, Giuseppe Ferrera","doi":"10.1007/s13691-025-00801-x","DOIUrl":"10.1007/s13691-025-00801-x","url":null,"abstract":"<p><p>Papillary tumors of the pineal region (PTPR) are rare neoplasms arising from pineal gland and occurring in less than 1% of adult patients. Surgery is reported as the main treatment option, although the role of radiotherapy, especially in the adjuvant setting, remains controversial. A young adult woman of 24 years received adjuvant radiotherapy after a subtotal resection of a PTPR. The patient was treated with helical tomotherapy for a total dose of 59.4 Gy delivered in 33 fractions with no concurrent chemotherapy. After initial follow-up MRI exams documented stable disease, later imaging reported a slight decrease in size of the treated lesion. After 2 years of follow-up the patient is in good general conditions, with no evidence of recurrence, and no major side effects from the treatment. This descriptive case highlights the role of adjuvant radiotherapy as a safe and effective treatment option to reduce the risk of local recurrence. Modern radiotherapy techniques may easily allow the delivery of higher doses to the target to reduce the incidence of disease relapse.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"479-485"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of multiple gastric adenocarcinoma of fundic gland type accidentally found by additional gastrectomy following endoscopic submucosal dissection.","authors":"Hiroshi Takeno, Hirohisa Okabe, Hidetoshi Nitta, Masahiro Tomita, Asuka Ono, Daisuke Kuroda, Hideyuki Kuroki, Katsuki Haraoka, Toshiro Masuda, Taizo Hibi, Masaaki Iwatsuki, Hiroki Sugita","doi":"10.1007/s13691-025-00781-y","DOIUrl":"10.1007/s13691-025-00781-y","url":null,"abstract":"<p><p>An octogenarian male underwent upper gastrointestinal (UGI) endoscopy for an annual surveillance program, which identified a 12 mm type 0-IIa lesion on the posterior wall of the gastric fornix. An endoscopic biopsy was performed, raising suspicion for malignancy. Subsequent endoscopic submucosal dissection (ESD) was conducted, and the final histopathological diagnosis confirmed fundic gland-type gastric adenocarcinoma. The tumor exhibited submucosal invasion to a depth of 1000 μm. No evidence of vascular invasion or residual malignant cells at the resection margins was observed. The patient decided to undergo additional proximal gastrectomy to rule out lymph node metastasis. Laparoscopic proximal gastrectomy was performed, and histopathological evaluation revealed no residual carcinoma at the ESD scar and no evidence of lymph node involvement. However, ten additional lesions of fundic gland-type gastric adenocarcinoma were identified, two of which demonstrated submucosal invasion. Biannual follow-up with endoscopy and contrast-enhanced computed tomography has been performed postoperatively. The patient has remained free of recurrence for three years.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"381-386"},"PeriodicalIF":0.4,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of successfully completed robot-assisted distal pancreatectomy for pancreatic tail cancer in a patient with prior colostomy: case report.","authors":"Taro Sakurai, Kazuto Shibuya, Mina Fukasawa, Katsuhisa Hirano, Toru Watanabe, Isaya Hashimoto, Isaku Yoshioka, Noriko Okuno, Kenichi Hirabayashi, Tsutomu Fujii","doi":"10.1007/s13691-025-00798-3","DOIUrl":"10.1007/s13691-025-00798-3","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreatic cancer may invade the colon, resulting in bowel obstruction and requiring the patient to undergo colostomy. Open surgery is often the treatment of choice for patients with colostomy, but we successfully and safely performed a robot-assisted distal pancreatectomy.</p><p><strong>Case presentation: </strong>The patient was a 55-year-old woman diagnosed with pancreatic tail cancer invading the left kidney and transverse colon. She underwent a transverse colostomy because of a colonic obstruction associated with colon invasion. She then received gemcitabine plus nab-paclitaxel, followed by modified FOLFIRINOX. After imaging confirmed tumour shrinkage, a robot-assisted distal pancreatectomy, transverse colon resection, and colostomy closure were planned. A partial colon resection, including colostomy, was performed first. As a result, robot-assisted surgery was possible with the usual field of view and port placement. During this procedure, the pancreatic tail, spleen, transverse colon (including invasive pancreatic cancer lesion), left adrenal gland, and part of the left kidney were resected en bloc. Finally, reconstruction of the colon was performed. The patient recovered well postoperatively and was discharged on postoperative day 9 with no complications. The patient has been recurrence-free for 2 months after surgery.</p><p><strong>Conclusion: </strong>This case demonstrates that robot-assisted distal pancreatectomy is feasible in selected patients with pancreatic cancer and prior colostomy.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"464-471"},"PeriodicalIF":0.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiomyopathy temporally associated with prior palbociclib treatment successfully treated with quadruple therapy for heart failure: a case report.","authors":"Iñaki Rodriguez, Alberto Vera, Carolina Tiraplegui, Teresa Rubio, Virginia Álvarez","doi":"10.1007/s13691-025-00802-w","DOIUrl":"10.1007/s13691-025-00802-w","url":null,"abstract":"<p><p>Palbociclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor that has demonstrated in combination with fulvestrant longer progression-free survival in the setting of advanced breast cancer. Although palbociclib has a relatively favorable toxicity profile, several cardiovascular events have been described including cardiomyopathy. However, adequate management of cardiotoxicity in this setting remains unclear. A 55-year-old female patient with metastatic breast cancer was admitted due to heart failure after finishing chemotherapy with palbociclib. Transthoracic echocardiography (TTE) showed a left ventricular ejection fraction (LVEF) of 30% and severe mitral regurgitation (MR). Under the suspicion of cardiomyopathy temporally associated with prior palbociclib treatment, quadruple therapy with angiotensin receptor-neprilysin inhibitor (ARNI), betablockers, mineralocorticoid receptor antagonist (MRA), and sodium-glucose cotransporter 2 inhibitor (iSLGT2) was initiated. Three months after medical therapy, the patient recovered LVEF up to 56%, and there was not MR on control TTE. This case illustrates that quadruple therapy for heart failure may be a viable option to achieve complete LVEF recovery in a case of cardiomyopathy occurring after palbociclib exposure.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"493-496"},"PeriodicalIF":0.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curative approach for solitary liver metastasis presenting as a rare pattern of organ spread in testicular cancer: a case report.","authors":"Sho Kiyota, Takashi Yoshida, Takahiro Nakamoto, Chisato Ohe, Yumiko Kono, Akiyo Kita, Yuki Masuo, Hidefumi Kinoshita","doi":"10.1007/s13691-025-00800-y","DOIUrl":"10.1007/s13691-025-00800-y","url":null,"abstract":"<p><p>Solitary liver metastasis is an uncommon presentation of metastatic testicular cancer. This report details the case of a 16-year-old boy who presented with high fever and slight enlargement of the left testicle. Imaging revealed para-aortic regional lymph node swelling and a large liver mass occupying most of the left lobe. Left radical inguinal orchiectomy was performed, followed by liver biopsy to distinguish between a primary tumor and distant metastasis. Histopathological analysis confirmed a mixed non-seminomatous germ cell tumor with liver metastasis. The patient underwent four cycles of combination chemotherapy with bleomycin, etoposide, and cisplatin, followed by two additional cycles of etoposide, ifosfamide, and cisplatin, until tumor marker negativity was confirmed. Despite chemotherapy, clinically significant residual masses remained in the regional lymph nodes and liver. Detailed imaging evaluation suggested that liver metastasis had occurred through mesenteric vein infiltration by para-aortic lymph node metastasis. Retroperitoneal lymph node dissection was performed, revealing no evidence of malignancy, followed by liver metastasectomy. The patient achieved complete remission and has remained recurrence-free for 4 years since multimodal therapy. Even in the cases of liver metastases associated with poor prognosis, a comprehensive therapeutic approach that considers the metastatic pathway can achieve curative outcomes.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"486-492"},"PeriodicalIF":0.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemostasis and life-saving by arterial embolization for a rupture of hepatic metastasis from choriocarcinoma after initiation of EMA/CO therapy: a case report and literature review.","authors":"Megumi Mizushima, Masakazu Abe, Yusuke Todo, Toshiya Itoh, Megumi Narumi, Madoka Matsuya, Toshiaki Shibata, Hirotake Murakami, Hiroaki Itoh","doi":"10.1007/s13691-025-00789-4","DOIUrl":"10.1007/s13691-025-00789-4","url":null,"abstract":"<p><p>Choriocarcinoma occurs in the uterus and various other organs, including liver, lungs, and brain. Depending on the site of onset, early identification is difficult due to non-specific or an asymptomatic presentation. Moreover, choriocarcinoma may be detected when the tumor grows considerably or ruptures. We encountered a case in which hepatic metastasis ruptured, leading to hemorrhagic shock. The rupture occurred after the initiation of etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine (EMA/CO) therapy for choriocarcinoma of unknown primary origin with multiple metastases in the liver, lungs, and peritoneal cavity. Hemostasis was achieved by hepatic artery embolization. EMA/CO therapy was resumed 10 days after the embolization. The patient was deemed to be in remission after 28 cycles, and the treatment was completed after 33 cycles. It may be necessary to consider emergency responses through multidisciplinary/inter-professional collaboration and appropriate length of hospitalization for patient observation. Furthermore, the possibility of lesion rupture due to tumor necrosis should be taken into account for large tumors and high serum human chorionic gonadotropin.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 4","pages":"446-452"},"PeriodicalIF":0.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}