International Cancer Conference Journal最新文献

{"title":"Unique pattern of endometrial invasion in gastric-type adenocarcinoma of the uterine cervix: a report of two cases.","authors":"Kyosuke Kamijo, Tsutomu Miyamoto, Hirofumi Ando, Hisanori Kobara, Yayoi Satoh, Yaeko Kobayashi, Tanri Shiozawa","doi":"10.1007/s13691-026-00858-2","DOIUrl":"https://doi.org/10.1007/s13691-026-00858-2","url":null,"abstract":"<p><p>Gastric-type cervical adenocarcinoma (GAS), the most prevalent subtype of human papillomavirus (HPV)-independent cervical adenocarcinoma, is an aggressive malignancy with a poor prognosis. We herein present two cases of GAS with a unique endometrial infiltration pattern. Both cases were 37-year-old nulligravid women presenting with advanced GAS. A pathological examination revealed HPV-independent GAS that was positive for claudin 18 and negative for p16, with extensive invasion, including the myometrium and endometrium. Endometrial infiltration was characterized by a distinctive \"symbiotic\" pattern of invasion. In these areas, GAS glands intermingled with normal endometrial glands without disrupting the native architecture, and there was no distinct tumor border or stromal reaction. An immunohistochemical analysis revealed fewer CD8-positive tumor-infiltrating lymphocytes (TILs) around invasive GAS glands in the endometrium than in the normal endometrium and both the tumor center and invasive margin of the primary cervical lesion. These results are consistent with relative T-cell exclusion at the tumor-endometrium interface. This \"symbiotic\" invasion pattern differs from typical cervical adenocarcinoma, which forms distinct boundaries with desmoplastic stromal reactions. The observed pattern may contribute to the unexpectedly extensive spread of GAS frequently discovered only after surgical resection. The reduction in CD8-positive TILs density around invasive GAS glands indicates an immunologically \"cold\" tumor microenvironment that may contribute to treatment resistance. The present results provide novel insights into the pathology of GAS that may inform more effective diagnostic approaches and therapeutic strategies for this aggressive malignancy.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"284-294"},"PeriodicalIF":0.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy after fertility preservation and multimodal therapy including intensity-modulated radiotherapy for recurrent vulvar cancer: A case report.","authors":"Kosuke Murakami, Kiko Yamamoto, Takuya Uehara, Yukinori Matsuo, Noriomi Matsumura","doi":"10.1007/s13691-026-00855-5","DOIUrl":"https://doi.org/10.1007/s13691-026-00855-5","url":null,"abstract":"<p><p>Advanced or recurrent vulvar cancer in women of reproductive age is extremely rare, and the effects of radiotherapy (RT) on uterine and ovarian function in such cases remain poorly understood. Here, we report the case of a 36-year-old woman with recurrent vulvar cancer after initial surgery. She strongly desired fertility preservation, so before undergoing resection of the recurrent lesion and inguinal lymphadenectomy, she underwent ovarian stimulation using a random-start progestin-primed ovarian stimulation (PPOS) protocol, and embryos were cryopreserved. Because of the high risk of recurrence, the patient underwent adjuvant intensity-modulated radiotherapy (IMRT) postoperatively. Three months after irradiation, ovarian function was lost; however, endometrial regrowth and withdrawal bleeding were observed with oral administration of norgestrel and ethinylestradiol. Despite significant vaginal and cervical atrophy, frozen-thawed embryo transfer was successfully performed in a hormone replacement cycle. Pregnancy was achieved with the second blastocyst transfer. Unfortunately, the patient subsequently developed acute myeloid leukemia, and continuation of the pregnancy was no longer feasible. This case suggests that IMRT may minimize scatter radiation to the uterine cavity, allowing for partial preservation of uterine function. Even in cases of advanced or recurrent vulvar cancer, fertility preservation strategies should be considered when appropriate.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"278-283"},"PeriodicalIF":0.5,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcomatoid carcinoma of the common bile duct: A case report and review of the literature.","authors":"Sedat Alp Pinar, Mari-Claire McGuigan, Fraser Duthie, Abinaya Ezhil, David Holroyd, Nigel B Jamieson","doi":"10.1007/s13691-026-00852-8","DOIUrl":"https://doi.org/10.1007/s13691-026-00852-8","url":null,"abstract":"<p><p>Sarcomatoid carcinoma of the common bile duct is an exceptionally rare malignancy, with only eight cases previously reported in the English literature. We present the case of a 72-year-old Caucasian male who presented with obstructive jaundice and abnormal liver function tests, but without elevated tumour markers CA19-9 and CEA. Imaging with CT and MRCP revealed a polypoid mass in the common bile duct, and two ERCP attempts were unsuccessful. The patient underwent a pancreaticoduodenectomy without adjuvant chemotherapy and has remained recurrence-free for 16 months. Histopathology revealed sarcomatoid spindle cells negative for the expression of sarcomatous markers but positive for epithelial markers CAM5.2 and AE1/3, as well as MNF focally, along with chronic cholecystitis. Sarcomatoid carcinoma is a rare and challenging diagnosis that requires tissue confirmation and immunohistochemical staining for accurate identification. Despite its rarity, it is important to consider sarcomatoid carcinoma in the differential diagnosis of polypoid masses of the common bile duct, especially in the absence of elevated tumour markers. There is inconclusive evidence regarding the clinical outcomes for sarcomatoid carcinoma of the common bile duct and the effectiveness of various treatment strategies. Current literature indicates the widespread use of pancreaticoduodenectomy; while the role of chemotherapy remains unclear.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13691-026-00852-8.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"258-266"},"PeriodicalIF":0.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of poorly differentiated thyroid carcinoma harboring an <i>SMARCB1</i> mutation.","authors":"Rika Sasaki, Haruhiko Yamazaki, Eita Kumagai, Aya Saito","doi":"10.1007/s13691-026-00854-6","DOIUrl":"https://doi.org/10.1007/s13691-026-00854-6","url":null,"abstract":"<p><p>SWItch/sucrose non-fermentable (SWI/SNF) chromatin-remodeling complexes regulate nucleosome positioning. Its involvement has been suggested in anaplastic thyroid carcinoma and poorly differentiated thyroid carcinoma. We herein report an extremely rare case of poorly differentiated thyroid carcinoma harboring a mutation in <i>SMARCB1</i>, a subunit of the SWI/SNF complex. The patient was a 75‑year‑old woman with bilateral thyroid nodules who had been followed up for 27 years, with cytology classified as Bethesda II. The nodule enlarged rapidly to 7 cm, and computed tomography suggested airway invasion and multiple pulmonary nodules. An open biopsy of the thyroid mass was performed, and the lesion was diagnosed as poorly differentiated thyroid carcinoma. Lenvatinib therapy was initiated at the previous hospital, resulting in tumor shrinkage, and total thyroidectomy was performed 62 days after the initiation of treatment. Five months later, the patient was referred to our hospital for surgical management of pulmonary lesions. Left basal segmentectomy was performed, and histopathological examination confirmed metastasis from poorly differentiated thyroid carcinoma. Lung metastatic tissue was submitted to GenMineTOP, and an <i>SMARCB1</i> mutation was detected. At the time of this report, 2 years and 7 months had passed since the initial surgery. Lenvatinib therapy was continued, and the disease remained stable. We report a case of poorly differentiated thyroid carcinoma with an <i>SMARCB1</i> mutation. The accumulation of similar cases and additional immunohistochemical evaluations of past specimens may contribute to the development of targeted therapeutic strategies.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"273-277"},"PeriodicalIF":0.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durable tumor control with stereotactic radiotherapy and doxorubucin-ifosfamide chemotherapy in primary intracranial sarcoma, <i>DICER1</i>-mutant: a case report.","authors":"Shohei Fujita, Makoto Ohno, Hirokazu Sugino, Akihiko Yoshida, Hiroshi Igaki, Asuka Kawachi, Masamichi Takahashi, Naokazu Hayashi, Chie Inomoto, Sumihito Nobusawa, Shunsuke Yanagisawa, Sho Osawa, Takahiro Tsuchiya, Yoshitaka Narita","doi":"10.1007/s13691-026-00856-4","DOIUrl":"https://doi.org/10.1007/s13691-026-00856-4","url":null,"abstract":"<p><p>Primary intracranial sarcoma, <i>DICER1</i>-mutant (PIS-DICER1), is an extremely rare and aggressive central nervous system tumor newly classified in the 2021 WHO classification of central nervous system tumors. It typically affects children and young adults and frequently recurs despite multimodal treatment, with no established standard therapy owing to limited clinical data. Herein, we report the case of a 28-year-old woman who developed a persistent headache and nausea shortly after giving birth. Imaging revealed a right cerebellar mass with obstructive hydrocephalus, for which gross total resection was performed. Histopathological and genomic analyses confirmed the diagnosis of PIS-DICER1. Six months later, the tumor recurred, necessitating a second resection. However, rapid regrowth was observed within two weeks. The patient subsequently underwent stereotactic radiotherapy (35 Gy in five fractions) targeting the recurrent lesion and surgical cavity, followed by six cycles of doxorubicin-ifosfamide chemotherapy. The combined approach achieved a complete response. Twelve months after treatment completion, a third surgery was performed for suspected recurrence; however, histopathological examination revealed radiation necrosis without a viable tumor. The patient remained in complete remission 40 months after the completion of chemoradiotherapy and 51 months after the initial surgery. This case demonstrates that stereotactic radiotherapy combined with doxorubicin-ifosfamide chemotherapy can achieve durable tumor control in PIS-DICER1, suggesting a potential therapeutic option for this highly aggressive tumor.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"267-272"},"PeriodicalIF":0.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term follow up of malignant transformation of epidermoid cyst at the cerebellopontine angle based on serial imaging findings; A case report and literature review.","authors":"Koji Saito, Akihiko Teshigawara, Miku Maeda, Nei Fukasawa, Yasuharu Akasaki, Yuzuru Hasegawa, Masayuki Shimoda, Yuichi Murayama, Toshihide Tanaka","doi":"10.1007/s13691-026-00853-7","DOIUrl":"https://doi.org/10.1007/s13691-026-00853-7","url":null,"abstract":"<p><p>We report a case of malignant transformation of epidermoid cysts during long-term follow up more than 10 years with literature review. Epidermoid cysts are benign congenital tumors, accounting for 0.2-1.8% of intracranial tumors. Malignant transformation is extremely rare, with limited reports describing the imaging features and prognosis. A 69-year-old woman had presented with a tumor exhibiting hyperintensity on diffusion-weighted imaging at the left cerebellopontine angle and had been followed-up for the past decade. After 10 years, she developed left facial paralysis and hearing impairment. Contrast-enhanced lesions appeared within the tumor, accompanied by edema. Intraoperative findings revealed a tumor with two distinct components of pearly tumor and hematoma invading the cranial nerves. The pathological diagnosis was squamous cell carcinoma without primary malignancies, suggesting malignant transformation of epidermoid cyst. Although the residual tumor initially seemed dormant after postoperative radiotherapy, the patient developed carcinomatous meningitis. The literature was searched for squamous cell carcinoma without primary cancers showing neuroradiological changes in signal intensity on diffusion- and T2-weighted imaging, revealing 103 cases with a mean interval of 106.1 months from initial diagnosis to malignant transformation of epidermoid cyst. Although postoperative radiotherapy or chemotherapy has been attempted, no standard has been established for adjuvant treatment. The clinical benefits of postoperative adjuvant therapy need to be confirmed in further studies. As neuroradiological alterations on diffusion-weighted imaging or Gd-enhanced T1-weighted imaging during follow-up of epidermoid cyst might indicate malignant transformation of epidermoid cyst, postoperative radiotherapy might be an option worth exploring.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"245-257"},"PeriodicalIF":0.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted nephroureterectomy for urothelial carcinoma in a horseshoe kidney: efficacy of isthmectomy using indocyanine green fluorescence imaging.","authors":"Shun Satake, Takuto Hara, Naoto Wakita, Kotaro Suzuki, Tomoaki Terakawa, Koji Chiba, Hideaki Miyake","doi":"10.1007/s13691-026-00850-w","DOIUrl":"https://doi.org/10.1007/s13691-026-00850-w","url":null,"abstract":"<p><p>We report a rare case of urothelial carcinoma arising in a horseshoe kidney, successfully treated with robot-assisted nephroureterectomy (RANU) using indocyanine green (ICG) fluorescence imaging to facilitate safe isthmectomy. A 76-year-old male with a left renal pelvic tumor was diagnosed with high-grade urothelial carcinoma (cT1N0M0). Preoperative imaging and three-dimensional reconstruction revealed complex vascular supply from the renal artery, an artery arising near the inferior mesenteric artery, and multiple branches from the common iliac artery, as well as bilateral ureters coursing close to the isthmus. After vascular control of the upper and mid poles, ICG was administered to visualize perfusion, which clearly delineated the ischemic boundary at the planned isthmus transection site. The demarcation line was pre-marked under Firefly mode, enabling precise transection with an endoscopic stapler. The procedure was completed without blood loss, and pathology confirmed pT1 urothelial carcinoma with negative margins. To the best of our knowledge, this is the first report demonstrating the efficacy of ICG in guiding perfusion-based isthmectomy during RANU for a horseshoe kidney, and the first to provide intraoperative video documentation of contralateral renal perfusion and resection line marking. The combined use of ICG fluorescence and stapler transection enabled a safe, bloodless, and oncologically complete procedure, although further cases will be required to validate the generalizability of this technique.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13691-026-00850-w.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"241-244"},"PeriodicalIF":0.5,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pembrolizumab plus chemotherapy following lack of response to nivolumab-based therapy in MSI-High/dMMR advanced gastric cancer: a case report.","authors":"Ryohei Kawabata, Hisashi Hara, Tomohira Takeoka, Yumiko Yasuhara, Terukazu Yoshihara, Akihiro Kitagawa, Takashi Takeda, Hideo Tomihara, Atsushi Naito, Masahiro Murakami, Shingo Noura, Atsushi Miyamoto","doi":"10.1007/s13691-026-00847-5","DOIUrl":"https://doi.org/10.1007/s13691-026-00847-5","url":null,"abstract":"<p><p>Microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR) gastric cancer is generally sensitive to immune checkpoint inhibitors (ICIs); however, the clinical role of re-administration of ICI plus chemotherapy after an initial lack of response remains unclear. We report a 76-year-old man with HER2-negative advanced gastric adenocarcinoma who exhibited no clear radiologic response and worsening gastric outlet obstruction after two cycles of first-line SOX (S-1 plus oxaliplatin) with nivolumab, necessitating gastrojejunostomy. He subsequently received ramucirumab-based therapy, paclitaxel, and irinotecan. Genomic profiling revealed MSI-H/dMMR with loss of MLH1 and PMS2 expression. Pembrolizumab combined with capecitabine and oxaliplatin (CAPOX) was initiated as fifth-line therapy, resulting in notable regression of hepatic and nodal metastases. This case underscores the clinical importance of early MSI/MMR and genomic testing and suggests that re-administration of ICI plus chemotherapy may be a therapeutic option for selected patients with advanced gastric cancer who initially show limited response to ICI-based therapy.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"234-240"},"PeriodicalIF":0.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexrazoxane reduces antithrombin activity: a case series.","authors":"Tomohiro Nagano, Kaho Makiuchi, Akifumi Matsumura, Daigo Niiya, Soichiro Fujii, Makoto Takeuchi","doi":"10.1007/s13691-026-00848-4","DOIUrl":"https://doi.org/10.1007/s13691-026-00848-4","url":null,"abstract":"<p><p>Dexrazoxane prevents anthracycline-induced cardiotoxicity and treats anthracycline extravasation. Although thrombosis is not a commonly observed adverse effect of dexrazoxane, a potential association has been suggested. We present three patients (four episodes) who experienced decreased antithrombin activity after dexrazoxane administration. All patients were prescribed dexrazoxane to protect soft tissues from anthracycline extravasation during chemotherapy for hematological malignancies. This led to a reduction in antithrombin activity after a median of 4 days from the first dexrazoxane injection. The activity levels recovered several days later, and one patient developed deep-vein thrombosis. There was no apparent explanation other than dexrazoxane use, raising the possibility that dexrazoxane may be associated with decreased antithrombin activity. We hypothesize that this decrease in antithrombin activity may contribute to thrombosis after dexrazoxane injection. Based on these cases and a review of previous reports on dexrazoxane and thrombosis, it is recommended that clinicians monitor antithrombin decline and thrombosis development in patients undergoing dexrazoxane treatment.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13691-026-00848-4.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"229-233"},"PeriodicalIF":0.5,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lattice radiotherapy for palliation in a case of metastatic adrenocortical carcinoma.","authors":"N P Jayashree, C Shambhavi, Sumeet Suresh Malapure, Ananth Pai, Naveen Salins, Shirley Lewis","doi":"10.1007/s13691-026-00845-7","DOIUrl":"https://doi.org/10.1007/s13691-026-00845-7","url":null,"abstract":"<p><p>Adrenocortical carcinoma (ACC) is rare, and metastatic ACC is associated with a poor prognosis. Palliative radiotherapy is valuable in patients with metastatic disease for symptom control. In large tumours, palliative radiotherapy entails large-volume irradiation with homogenous doses, where achieving a good response is uncertain. Lattice Radiotherapy (LRT) is a unique technique where high-dose regions can be achieved within the tumour, providing an edge over factors influencing radio resistance. A 30-year-old lady presented with a mass in the abdomen and was diagnosed with ACC with liver and lung metastases. She received chemotherapy with a palliative intent. Response assessment FDG-PET-CECT after six cycles showed disease progression. She had severe discomfort due to the distended abdomen with a 20 × 16 × 15 cm mass infiltrating the inferior surface of the liver. The patient was planned for palliative radiotherapy with the LRT technique. The entire tumour received 20 Gy in 5 fractions over one week, with high-dose vertices within the tumour receiving 35 Gy in 5 fractions. The treatment plan was generated with the volumetric modulated arc technique (VMAT), and the surrounding normal tissue dose constraints were achieved. At one month after radiotherapy, her symptoms of pain and mass effect were well controlled. The patient experienced grade 1 lower gastrointestinal toxicity that subsided with medication and sustained no grade 3 or 4 toxicity. Response assessment at three months post radiotherapy showed an interval decrease in size and uptake of the right suprarenal lesion, with a drop in standardised uptake value maximum from 11.61 to 3.41. Lattice radiotherapy is a valuable technique for palliation in voluminous tumours. It should be further explored for feasibility and safety to provide better local control and quality of life to patients with large tumours.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13691-026-00845-7.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 2","pages":"222-228"},"PeriodicalIF":0.5,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}