International Cancer Conference Journal最新文献

Thymic carcinoma, initially unresectable, converted to complete resection with pathological complete response following chemotherapy alone. 胸腺癌，最初不可切除，转化为完全切除，病理完全缓解化疗后单独。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-07-06 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00882-2

Kyojiro Nakamura, Fumihiko Kinoshita, Kentaro Tanaka, Mikiko Hashisako, Masakazu Matsuda, Naoya Iwamoto, Taichi Matsubara, Kazuki Takada, Yoshinao Oda, Tomoyoshi Takenaka, Tomoharu Yoshizumi

{"title":"Thymic carcinoma, initially unresectable, converted to complete resection with pathological complete response following chemotherapy alone.","authors":"Kyojiro Nakamura, Fumihiko Kinoshita, Kentaro Tanaka, Mikiko Hashisako, Masakazu Matsuda, Naoya Iwamoto, Taichi Matsubara, Kazuki Takada, Yoshinao Oda, Tomoyoshi Takenaka, Tomoharu Yoshizumi","doi":"10.1007/s13691-026-00882-2","DOIUrl":"10.1007/s13691-026-00882-2","url":null,"abstract":"Thymic carcinomas frequently invade adjacent structures, rendering complete surgical resection difficult. Although multimodal treatment strategies, including chemotherapy, radiotherapy, and surgery, are employed, the prognosis of thymic carcinoma remains poor. Furthermore, it is exceedingly rare to achieve a pathological complete response following chemotherapy alone or in combination with radiotherapy. A 69-year-old man presented with an anterior mediastinal tumor. Surgical resection of the tumor was planned for diagnostic and therapeutic purposes. However, chest computed tomography (CT) performed approximately 1 month after the initial CT scan revealed rapid tumor growth from 38 to 52 mm, with suspected invasion into the left upper lobe and left main pulmonary artery. We performed a surgical biopsy for diagnosis, and pathological examination confirmed thymic carcinoma. Since radiation therapy was not feasible because of interstitial pneumonia, the patient received chemotherapy with carboplatin plus paclitaxel. Post-chemotherapy CT revealed tumor shrinkage to 15 mm and a clear border with the left main pulmonary artery. Radical surgery was subsequently performed, and the tumor was resected along with the left upper lobe, mediastinal fat tissue, and pericardium. The resected specimen did not contain any residual tumor cells, indicating a complete pathological response. The patient has remained free of recurrence for two years after surgery. This patient, who initially had an unresectable thymic carcinoma, achieved complete resection in response to chemotherapy with carboplatin and paclitaxel, resulting in a complete pathological response.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"466-471"},"PeriodicalIF":0.4,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Large Cell Neuroendocrine Carcinoma (LCNEC) treated with tarlatamab. 塔拉他单抗治疗大细胞神经内分泌癌1例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-07-01 DOI: 10.1007/s13691-026-00877-z

Reimi Mizushima, Makiko Yomota, Satoko Togashi, Terufumi Kato, Yukio Hosomi

{"title":"A case of Large Cell Neuroendocrine Carcinoma (LCNEC) treated with tarlatamab.","authors":"Reimi Mizushima, Makiko Yomota, Satoko Togashi, Terufumi Kato, Yukio Hosomi","doi":"10.1007/s13691-026-00877-z","DOIUrl":"10.1007/s13691-026-00877-z","url":null,"abstract":"Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare, high-grade, neuroendocrine carcinoma with an aggressive clinical course, and there are few treatment options for relapsed and refractory cases. Tarlatamab, a first-in-class, bispecific T-cell engager targeting delta-like ligand 3 (DLL3) and CD3, holds promise as a therapeutic option for previously treated cases of small-cell lung cancer, but clinical data on LCNEC are exiguous. We report herein a 69-year-old, male patient. He underwent a left upper lobe partial resection for stage pT1bN0M0 LCNEC. Three years later, a recurrence with left pleural thickening, multiple liver metastases, and a marked elevation of pro-gastrin-releasing peptide developed. The patient had received five lines of systemic therapy over 2.5 years. Comprehensive genomic profiling revealed a high tumor mutational burden but no actionable targets. With approval from the institutional ethics committee, tarlatamab therapy was begun as sixth-line therapy. The patient experienced manageable grade 1 cytokine release syndrome. After two cycles, computed tomography demonstrated a partial response with a 40% reduction in the sum of target lesion diameters (130 mm to 78 mm), and the pro-gastrin-releasing peptide level decreased from 1610 ng/mL to 49.7 ng/mL. The patient has received nine cycles of tarlatamab over eight months, and the response has persisted during this period without any serious adverse events. The findings of the present case suggest that tarlatamab has the potential to induce a meaningful and durable response in pretreated LCNEC and support further clinical evaluation of DLL3-targeted, T-cell-engaging therapy for this disease.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"439-442"},"PeriodicalIF":0.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of advanced esophageal cancer with esophagorespiratory fistula complicated by lung abscess. 晚期食管癌合并食管呼吸瘘并发肺脓肿1例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-29 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00876-0

Ayako Shimada, Hajime Higuchi, Takashi Oyama, Yuki Hirano, Yutaka Sugawara, Eri Mannoji, Momoko Kobayashi, Hironobu Wada, Shigetoshi Yoshida, Masahiro Shinoda, Osamu Itano

{"title":"A case of advanced esophageal cancer with esophagorespiratory fistula complicated by lung abscess.","authors":"Ayako Shimada, Hajime Higuchi, Takashi Oyama, Yuki Hirano, Yutaka Sugawara, Eri Mannoji, Momoko Kobayashi, Hironobu Wada, Shigetoshi Yoshida, Masahiro Shinoda, Osamu Itano","doi":"10.1007/s13691-026-00876-0","DOIUrl":"10.1007/s13691-026-00876-0","url":null,"abstract":"Esophagorespiratory fistula is associated with a poor prognosis in patients with esophageal cancer, which may cause lung abscess and respiratory deterioration. Here, we report our experience when facing challenges in managing a case of advanced esophageal cancer with esophagorespiratory fistula complicated by a large lung abscess. A woman in her 60s visited a nearby clinic complaining of fever and cough. She was initially diagnosed with lung abscess and treated with oral antibiotics. However, because of a poor clinical response, she was referred to our hospital for further examination and treatment. Computed tomography (CT) revealed an esophageal tumor with multiple mediastinal lymphadenopathies and mediastinal emphysema. She was suspected of having esophageal cancer, and upper gastrointestinal endoscopy and esophagography revealed a circumferential Type 3 tumor lesion extending 28-38 cm from the incisors, with fistula formation in the lung abscess. We inserted a double-elemental diet tube for drainage and enteral feeding, followed by CT-guided drainage of the lung abscess and placement of an esophageal stent. The inflammatory marker levels improved, and she was able to resume oral intake and was discharged. Subsequently, chemoimmunotherapy with 5-fluorouracil, cisplatin, and pembrolizumab was initiated. However, before starting the second chemotherapy course, the elevation of inflammatory markers was remarkable, and CT revealed reoccurrence of fistulas. The fistula was likely caused by shrinkage of the primary lesion. Despite intensive treatment, the patient's general condition deteriorated because of airway obstruction caused by progressive lymphadenopathy, and she died 4 months after the initial presentation.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"433-438"},"PeriodicalIF":0.4,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical implications of immune checkpoint inhibitor in chemotherapy-resistant advanced endometrial cancer with a pathogenic POLE mutation: a case report. 免疫检查点抑制剂在化疗耐药晚期子宫内膜癌伴致病性极点突变的临床意义：1例报告。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-29 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00879-x

Mina Oi, Akitoshi Yamamura, Tetsuya Ishibashi, Teruki Yoshida, Sayuri Takahashi, Shota Kanbayashi, Hirohiko Tani, Kenzo Kosaka, Masayo Ukita

{"title":"Clinical implications of immune checkpoint inhibitor in chemotherapy-resistant advanced endometrial cancer with a pathogenic POLE mutation: a case report.","authors":"Mina Oi, Akitoshi Yamamura, Tetsuya Ishibashi, Teruki Yoshida, Sayuri Takahashi, Shota Kanbayashi, Hirohiko Tani, Kenzo Kosaka, Masayo Ukita","doi":"10.1007/s13691-026-00879-x","DOIUrl":"10.1007/s13691-026-00879-x","url":null,"abstract":"The POLE-ultramutated subtype of endometrial cancer is associated with a favorable prognosis and is most frequently presents at an early stage. Even in advanced disease, which is uncommon, available data suggest favorable outcomes and a potentially limited incremental benefit of immunotherapy. We report a case of chemotherapy-resistant, POLE-mutated advanced endometrial cancer that showed a remarkable and durable response to immunotherapy. A 54-year-old woman was diagnosed with stage IVB endometrial cancer (endometrioid carcinoma, grade 3). Despite first-line therapy consisting of paclitaxel plus carboplatin and cytoreductive surgery, the disease progressed. Subsequent doxorubicin plus cisplatin chemotherapy also failed to achieve an objective response. Comprehensive genomic profiling revealed a pathogenic POLE mutation (p.V411L) with a markedly elevated tumor mutational burden of 174 mutations/Mb, while the tumor was microsatellite stable. Pembrolizumab was initiated, resulting in substantial regression of peritoneal metastases and multiple lymph node metastases. Although treatment was interrupted because of immune-related adverse events, disease has remained controlled for more than 2 years after discontinuation. This clinical course suggests that timely comprehensive genomic profiling may provide clinically actionable molecular information to guide treatment modification, even in advanced POLE-mutated endometrial cancer showing chemotherapy resistance. It also highlights that immunotherapy may play an important role in achieving durable disease control in this molecularly defined subset.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"451-459"},"PeriodicalIF":0.4,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted axillary dissection using CT-Lymphography and the tattooing technique after neoadjuvant chemotherapy for node-positive breast cancer. 淋巴结阳性乳腺癌新辅助化疗后的ct淋巴造影和刺青技术靶向腋窝清扫。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-25 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00878-y

Takeshi Hashimoto, Shintaro Takao

{"title":"Targeted axillary dissection using CT-Lymphography and the tattooing technique after neoadjuvant chemotherapy for node-positive breast cancer.","authors":"Takeshi Hashimoto, Shintaro Takao","doi":"10.1007/s13691-026-00878-y","DOIUrl":"10.1007/s13691-026-00878-y","url":null,"abstract":"Targeted axillary dissection (TAD) has been introduced to improve axillary staging accuracy after neoadjuvant chemotherapy (NAC) in patients with node-positive breast cancer; however, reliable localization of the clipped lymph node (clipLN) remains technically challenging, particularly in cases with discordance between sentinel lymph node (SLN) and clipLN. We retrospectively reviewed a single-institution case series of patients with node-positive breast cancer who underwent TAD after NAC. CT-lymphography (CT-LG) was used for preoperative assessment of lymphatic anatomy, and the tattooing technique was applied for intraoperative localization of the clipLN. A total of 12 patients were included. SLN-clipLN discordance was frequently observed on CT-LG, including among ypN0 cases. ClipLN retrieval was successful in all patients who underwent the tattooing-assisted procedure. The combination of CT-LG and the tattooing technique facilitated intraoperative identification of clipLN, even in anatomically discordant cases. In this single-institution experience, TAD using CT-LG and the tattooing technique was technically feasible for clipLN localization after NAC. CT-LG aided preoperative recognition of anatomical discordance, while tattooing contributed to reproducible intraoperative localization. This experience reflects an initial implementation phase of TAD, and further studies are warranted to define optimal localization strategies for axillary management after NAC.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"443-450"},"PeriodicalIF":0.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plantar synovial sarcoma mimicking a vascular malformation in a child: a clinicopathologic case report. 模拟儿童血管畸形的足底滑膜肉瘤：一个临床病理病例报告。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-25 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00883-1

Isabella Andrea Bolaños Bermúdez, María José Gutiérrez Sierra, Laura Nataly Panqueva Giraldo, David Fernando Torres Cortés, Oscar Mauricio Rivero Rapalino, Pablo Arbeláez Echeverri, Mauricio Alfonso Palau Lázaro

{"title":"Plantar synovial sarcoma mimicking a vascular malformation in a child: a clinicopathologic case report.","authors":"Isabella Andrea Bolaños Bermúdez, María José Gutiérrez Sierra, Laura Nataly Panqueva Giraldo, David Fernando Torres Cortés, Oscar Mauricio Rivero Rapalino, Pablo Arbeláez Echeverri, Mauricio Alfonso Palau Lázaro","doi":"10.1007/s13691-026-00883-1","DOIUrl":"10.1007/s13691-026-00883-1","url":null,"abstract":"Hypervascular plantar soft-tissue lesions in children may be misinterpreted as benign vascular abnormalities, particularly when Doppler ultrasound shows marked internal vascularity. We report a 12-year-old boy with a painful plantar foot mass initially considered a hemangioma or low-flow vascular malformation on ultrasound and MRI. Although imaging demonstrated prominent vascularity and enhancement, the lesion was predominantly solid, showed irregular enhancement and partially ill-defined margins, and lacked typical serpiginous morphology or definite flow voids. Image-guided biopsy revealed a malignant spindle-cell neoplasm. Histology showed an infiltrative monophasic spindle-cell tumor involving adjacent soft tissues, and immunohistochemistry demonstrated focal cytokeratin AE1/AE3 expression, multifocal EMA positivity, and strong diffuse nuclear SS18 staining, supporting synovial sarcoma. The patient underwent limb-sparing resection after multidisciplinary evaluation. This case emphasizes the importance of pathologic confirmation before vascular-directed intervention.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"472-476"},"PeriodicalIF":0.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Good local control acquired by chemoradiation for inoperable adenocarcinoma of the anal canal with pagetoid spread: a report of two cases. 纠正：不能手术的肛管腺癌伴页状扩散的放化疗获得良好的局部控制：附2例报告。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-24 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00881-3

Yukako Kida, Itaru Ikeda, Masahiro Yamada, Tomoyuki Goto, Junpei Yonemaru, Shuang Zhang, Yoshiyuki Watanabe, Chikako Yamauchi

引用次数: 0

Complete response after enfortumab vedotin plus pembrolizumab for a contralateral ureteral tumor in a solitary kidney after nephroureterectomy. 对肾输尿管切除术后孤立肾对侧输尿管肿瘤，采用安替妥单抗加派姆单抗治疗后完全缓解。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-23 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00880-4

Masataka Kubo, Fumihiko Urabe, Kosuke Iwatani, Tatsuya Shimomura, Takahiro Kimura

{"title":"Complete response after enfortumab vedotin plus pembrolizumab for a contralateral ureteral tumor in a solitary kidney after nephroureterectomy.","authors":"Masataka Kubo, Fumihiko Urabe, Kosuke Iwatani, Tatsuya Shimomura, Takahiro Kimura","doi":"10.1007/s13691-026-00880-4","DOIUrl":"10.1007/s13691-026-00880-4","url":null,"abstract":"Upper tract urothelial carcinoma (UTUC) is a relatively uncommon malignancy, and radical nephroureterectomy (RNU) is the standard treatment for high-risk disease. However, management becomes challenging in patients with a solitary kidney, as radical surgery may result in dialysis dependence. Recently, enfortumab vedotin combined with pembrolizumab has shown promising efficacy in advanced urothelial carcinoma. A 74-year-old man with a history of right radical nephroureterectomy for UTUC developed a tumor in the contralateral ureter accompanied by progressive renal dysfunction. Ureteroscopic biopsy demonstrated low-grade non-invasive urothelial carcinoma, however, imaging and endoscopic findings raised suspicion of clinically invasive disease (suspected cT2N0M0). Because radical surgery would likely have resulted in dialysis dependence, treatment selection was challenging. A ureteral stent was placed to relieve obstruction, and systemic therapy with enfortumab vedotin plus pembrolizumab was initiated after multidisciplinary discussion and detailed informed consent. After ten cycles of therapy, radiologic and endoscopic findings demonstrated marked tumor regression, and ureteroscopic biopsy revealed no definite residual malignancy. The ureteral stent was subsequently removed, and renal function remained stable. The patient has since remained free of disease progression without additional treatment during follow-up. We report a clinically challenging case of contralateral ureteral tumor in a solitary kidney that showed a favorable clinical course following treatment with enfortumab vedotin plus pembrolizumab. This case highlights the importance of individualized multidisciplinary decision-making in complex clinical situations.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"460-465"},"PeriodicalIF":0.4,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary mediastinal germ cell tumor in an 88-year-old man managed with carboplatin monotherapy and radiotherapy. 原发性纵隔生殖细胞瘤，88岁男性，卡铂单药治疗和放疗。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-06-19 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00866-2

Hiroki Kodani, Shigeaki Nakazawa, Yu Ishizuya, Yoshiyuki Yamamoto, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Norio Nonomura

{"title":"Primary mediastinal germ cell tumor in an 88-year-old man managed with carboplatin monotherapy and radiotherapy.","authors":"Hiroki Kodani, Shigeaki Nakazawa, Yu Ishizuya, Yoshiyuki Yamamoto, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Norio Nonomura","doi":"10.1007/s13691-026-00866-2","DOIUrl":"10.1007/s13691-026-00866-2","url":null,"abstract":"Mediastinal seminoma is a rare extragonadal germ cell tumor that predominantly affects young adults. Cisplatin-based chemotherapy is the standard treatment; however, its use in elderly patients is often limited by age-related factors and organ dysfunction. We report the case of an 88-year-old man with a rapidly enlarging mediastinal seminoma who was managed with carboplatin monotherapy followed by radiotherapy. Three cycles of carboplatin (first cycle AUC 5.6; subsequent cycles up to AUC 7) were administered, resulting in initial tumor regression, followed by disease progression after the third cycle. Salvage radiotherapy achieved marked tumor shrinkage with normalization of lactate dehydrogenase levels and durable disease control. At 19 months after treatment initiation, the patient remains alive with stable disease. This case suggests that carboplatin-based chemotherapy followed by radiotherapy may represent a pragmatic treatment option for elderly patients with mediastinal seminoma who are unsuitable for cisplatin-based regimens.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"368-374"},"PeriodicalIF":0.4,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of undifferentiated carcinoma arising from adenomyosis. 起源于子宫腺肌症的未分化癌1例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-05-23 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00874-2

Yoko Aoyagi, Kaei Nasu, Haruto Nishida, Saki Aso, Mitsutake Yano, Eiji Kobayashi

{"title":"A case of undifferentiated carcinoma arising from adenomyosis.","authors":"Yoko Aoyagi, Kaei Nasu, Haruto Nishida, Saki Aso, Mitsutake Yano, Eiji Kobayashi","doi":"10.1007/s13691-026-00874-2","DOIUrl":"10.1007/s13691-026-00874-2","url":null,"abstract":"Malignant transformation of adenomyosis is rare, with endometrioid carcinoma being the most common histological type. Herein, we report the first extremely aggressive case of undifferentiated carcinoma arising from adenomyosis. A 59-year-old Japanese woman was referred to our hospital with complaints of general fatigue, abdominal fullness, and loss of appetite. Contrast-enhanced computed tomography (CT) and integrated whole-body positron emission tomography/CT using 18F-fluorodeoxyglucose revealed multiple para-aortic and pelvic lymph node swellings. Contrast-enhanced magnetic resonance imaging revealed a 3-cm degenerated intramural uterine tumor. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, para-aortic and pelvic lymphadenectomy, and partial omentectomy for the treatment. Pathologically, the patient was diagnosed with undifferentiated carcinoma arising from adenomyosis. Despite adjuvant chemotherapy, the patient died of the disease 7 months after the initial surgery. Further investigation of similar cases may reveal the clinical features of this disease.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"422-426"},"PeriodicalIF":0.4,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0