Eiichiro So, Norihito Ishida, Akihiko Chida, Sara Horie, Shotaro Kishimoto, Kai Tsugaru, Hideyuki Hayashi, Yuya Koda, Masahiro Ozaki, Hajime Okita, Takanori Kanai, Kenro Hirata
{"title":"一例罕见的alk阳性组织细胞增多症伴神经系统病变，患者为70岁，经部分切除和alectinib治疗成功。","authors":"Eiichiro So, Norihito Ishida, Akihiko Chida, Sara Horie, Shotaro Kishimoto, Kai Tsugaru, Hideyuki Hayashi, Yuya Koda, Masahiro Ozaki, Hajime Okita, Takanori Kanai, Kenro Hirata","doi":"10.1007/s13691-025-00776-9","DOIUrl":null,"url":null,"abstract":"<p><p>Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a recently classified rare subtype of histiocytic neoplasm, characterized by ALK immunoreactivity due to <i>ALK</i> gene rearrangement. Most reported cases have developed in infants and middle-aged individuals, with effective ALK inhibition. The clinicopathological spectrum remains uncharacterized because of few reported cases. Herein, we report a case of a 70-year-old woman diagnosed with ALK-positive histiocytosis involving the nervous system, successfully treated with partial surgical resection and alectinib administration. To the best of our knowledge, this is the oldest patient reported with this condition with nervous system involvement, expanding our understanding of its clinicopathological spectrum.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 3","pages":"327-334"},"PeriodicalIF":0.5000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229379/pdf/","citationCount":"0","resultStr":"{\"title\":\"A rare case of ALK-positive histiocytosis with neurological involvement in a 70-year-old woman successfully managed with partial resection and alectinib.\",\"authors\":\"Eiichiro So, Norihito Ishida, Akihiko Chida, Sara Horie, Shotaro Kishimoto, Kai Tsugaru, Hideyuki Hayashi, Yuya Koda, Masahiro Ozaki, Hajime Okita, Takanori Kanai, Kenro Hirata\",\"doi\":\"10.1007/s13691-025-00776-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a recently classified rare subtype of histiocytic neoplasm, characterized by ALK immunoreactivity due to <i>ALK</i> gene rearrangement. Most reported cases have developed in infants and middle-aged individuals, with effective ALK inhibition. The clinicopathological spectrum remains uncharacterized because of few reported cases. Herein, we report a case of a 70-year-old woman diagnosed with ALK-positive histiocytosis involving the nervous system, successfully treated with partial surgical resection and alectinib administration. To the best of our knowledge, this is the oldest patient reported with this condition with nervous system involvement, expanding our understanding of its clinicopathological spectrum.</p>\",\"PeriodicalId\":13703,\"journal\":{\"name\":\"International Cancer Conference Journal\",\"volume\":\"14 3\",\"pages\":\"327-334\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229379/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Cancer Conference Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13691-025-00776-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Cancer Conference Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13691-025-00776-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
A rare case of ALK-positive histiocytosis with neurological involvement in a 70-year-old woman successfully managed with partial resection and alectinib.
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a recently classified rare subtype of histiocytic neoplasm, characterized by ALK immunoreactivity due to ALK gene rearrangement. Most reported cases have developed in infants and middle-aged individuals, with effective ALK inhibition. The clinicopathological spectrum remains uncharacterized because of few reported cases. Herein, we report a case of a 70-year-old woman diagnosed with ALK-positive histiocytosis involving the nervous system, successfully treated with partial surgical resection and alectinib administration. To the best of our knowledge, this is the oldest patient reported with this condition with nervous system involvement, expanding our understanding of its clinicopathological spectrum.
期刊介绍：
This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO).
- Presents an online-only collection of original case reports on all types of cancer
- In particular, welcomes molecularly analyzed cancer cases
- The Official Publication of the Japan Society of Clinical Oncology (JSCO)
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