一名转移性食管癌患者使用尼伐单抗后，卡培他滨和奥沙利铂诱发史蒂芬-约翰逊综合征。

IF 0.5 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2024-02-29 eCollection Date: 2024-04-01 DOI:10.1007/s13691-024-00660-y

Sumit Kumar, Anthialisha Nongkynrih, Biswajit Dey, Vikas Jagtap, Reena Lamba, Deiwakor Chyrmang

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引用次数: 0

摘要

史蒂文斯-约翰逊综合征（Stevens-Johnson Syndrome）表现为粘膜水疱和脱屑，其临床过程可能具有破坏性。虽然有报道称服用抗癌药物后会出现史蒂文斯-约翰逊综合征，但只有少数病例是在服用免疫检查点抑制剂后由细胞毒性抗癌药物诱发的。本报告描述了一例由卡培他滨和奥沙利铂（CAPEOX）联合化疗引起的史蒂文斯-约翰逊综合征，患者为食管鳞状细胞癌，之前曾接受过尼伐单抗治疗。

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Capecitabine and oxaliplatin induced Steven-Johnson syndrome following nivolumab in a patient of metastatic esophageal carcinoma.

Stevens-Johnson syndrome presents as mucocutaneous blistering and sloughing, which may follow a devastating clinical course. Although Stevens-Johnson syndrome has been reported following the administration of anticancer drugs, only a few cases induced by cytotoxic anticancer drugs, administered after immune checkpoint inhibitors, have been reported. The present report describes a case of Stevens-Johnson syndrome caused by capecitabine and oxaliplatin (CAPEOX) combination chemotherapy, in a patient with esophageal squamous cell carcinoma, who had been previously treated with nivolumab.

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)