International Cancer Conference Journal最新文献_第3页

An autopsy case of sigmoid colon cancer with multiple cerebral infarctions associated with drug-induced interstitial lung disease: a case implicating local PAI-1 overexpression. 乙状结肠直肠癌伴多发脑梗死伴药物性间质性肺疾病的尸检病例：一例涉及局部PAI-1过表达的病例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-04-07 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00851-9

Kayu Kinouchi, Yasuhiro Mitsui, Hiroyuki Ueda, Naoya Murakami, Ryohei Nakao, Kengo Atsumi, Koichi Tsuneyama, Tetsuji Takayama

{"title":"An autopsy case of sigmoid colon cancer with multiple cerebral infarctions associated with drug-induced interstitial lung disease: a case implicating local PAI-1 overexpression.","authors":"Kayu Kinouchi, Yasuhiro Mitsui, Hiroyuki Ueda, Naoya Murakami, Ryohei Nakao, Kengo Atsumi, Koichi Tsuneyama, Tetsuji Takayama","doi":"10.1007/s13691-026-00851-9","DOIUrl":"10.1007/s13691-026-00851-9","url":null,"abstract":"A 68-year-old Japanese man receiving panitumumab-containing chemotherapy for metastatic sigmoid colon cancer presented with fever and visual field constriction. Laboratory tests revealed markedly elevated D-dimer, KL-6, and IL-6 levels. Chest computed tomography demonstrated serious diffuse interstitial infiltrates in both lungs, while brain magnetic resonance imaging revealed multiple cerebral infarctions, predominantly in the right occipital lobe. Bronchoscopy further revealed active bleeding within the airways. Despite intensive multidisciplinary treatment, including steroid pulse therapy and antibiotics, he died of respiratory failure on the 19th day of hospitalization. Autopsy findings revealed diffuse alveolar damage and multiple cerebral thrombotic infarctions. Notably, no evidence of rupture of atherosclerotic plaques in the cerebral arteries was observed, whereas multiple thromboembolic lesions were identified. Immunohistochemical analysis demonstrated positive staining for plasminogen activator inhibitor-1 (PAI-1) in alveolar macrophages as well as in macrophages within cerebral arterial thrombi. This case represents the first reported instance in which severe drug-induced interstitial lung (DI-ILD) disease led to profound coagulation-fibrinolysis abnormalities through local PAI-1 expression, resulting in multiple cerebral infarctions. In cases such as this, where anticoagulant therapy is difficult to administer due to DI-ILD associated coagulopathy, PAI-1 may represent a promising therapeutic target molecule.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"312-318"},"PeriodicalIF":0.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A giant testicular tumor requiring skin valvuloplasty. 需要皮肤瓣膜成形术的巨大睾丸肿瘤。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-04-07 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00846-6

Shigeaki Nakazawa, Shunki Nakagawa, Yu Ishizuya, Yoshiyuki Yamamoto, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Norio Nonomura

{"title":"A giant testicular tumor requiring skin valvuloplasty.","authors":"Shigeaki Nakazawa, Shunki Nakagawa, Yu Ishizuya, Yoshiyuki Yamamoto, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Norio Nonomura","doi":"10.1007/s13691-026-00846-6","DOIUrl":"10.1007/s13691-026-00846-6","url":null,"abstract":"Giant testicular tumors, typically defined as those with volumes exceeding ten times the normal testicular volume, are extremely rare in developed countries. However, a relatively high number of such cases have been reported in Japan. Social stigma and lack of awareness often contribute to delayed medical consultation, resulting in advanced disease requiring complex surgical interventions. Despite its aggressive presentation, testicular cancer is curable when diagnosed early, highlighting the importance of public education and awareness. A 45-year-old man presented with hemorrhagic shock due to bleeding from massively enlarged left scrotum. He first noticed painless scrotal swelling 3 years earlier, which rapidly progressed over the previous 6 months. Imaging revealed a 34-cm heterogeneous testicular mass with bilateral inguinal lymphadenopathy. Tumor marker levels were significantly elevated (alpha-fetoprotein: 689 ng/mL, lactate dehydrogenase: 6,566 IU/L). Emergency radical orchiectomy and bilateral inguinal lymph node dissection were performed. Due to extensive skin necrosis, vacuum-assisted closure therapy was initiated, followed by delayed skin valvuloplasty. Histopathological analysis confirmed nonseminomatous germ cell tumor (Stage IIIA), and adjuvant vincristine, ifosfamide, and cisplatin chemotherapy was administered. The patient remains recurrence-free 2 years postoperatively. Although rare, giant testicular tumors require prompt diagnosis and multidisciplinary management. Early detection is essential for preventing life-threatening complications and enabling curative treatment. Public awareness of testicular self-examination and high curability of testicular cancer can significantly reduce delays in seeking medical attention.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"301-305"},"PeriodicalIF":0.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative total kidney irradiation for acute kidney injury caused by bilateral renal infiltration of chemotherapy-resistant mantle cell lymphoma: a case report. 姑息性全肾照射治疗双侧肾浸润性化疗耐药套细胞淋巴瘤急性肾损伤1例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-27 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00863-5

Yuki Mochizuki, Hiroyuki Inoo, Tomoaki Yano, Takamasa Mitsuyoshi, Itaru Ikeda, Akihiro Yoshimoto, Tadakazu Kondo, Masaki Kokubo

{"title":"Palliative total kidney irradiation for acute kidney injury caused by bilateral renal infiltration of chemotherapy-resistant mantle cell lymphoma: a case report.","authors":"Yuki Mochizuki, Hiroyuki Inoo, Tomoaki Yano, Takamasa Mitsuyoshi, Itaru Ikeda, Akihiro Yoshimoto, Tadakazu Kondo, Masaki Kokubo","doi":"10.1007/s13691-026-00863-5","DOIUrl":"10.1007/s13691-026-00863-5","url":null,"abstract":"Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma, and acute kidney injury (AKI) from direct renal infiltration is a rare but serious complication. The management of AKI secondary to renal infiltration is challenging in patients with relapsed/refractory (R/R) disease resistant to systemic chemotherapy. Herein, we report the case of a 74-year-old male with R/R MCL that was refractory to multiple lines of chemotherapy and Bruton's tyrosine kinase inhibitors. He developed AKI from bilateral lymphomatous renal infiltration and received palliative total kidney irradiation (15 Gy in five fractions). Since his renal function continued to worsen after initiating radiotherapy, hemodialysis was initiated. Following irradiation, his renal function rapidly improved, allowing discontinuation of hemodialysis. He was subsequently transitioned to best supportive care at home, with preserved renal function until death. This case highlights that palliative total kidney irradiation is an effective and feasible treatment option for restoring renal function in patients with AKI caused by chemorefractory MCL renal infiltration.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"349-353"},"PeriodicalIF":0.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintaining complete response to avelumab for lung metastases from native ureteral cancer after kidney transplantation: a case report. 肾移植后原生输尿管癌肺转移维持对avelumab的完全反应：一个病例报告。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-27 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00859-1

Yutaka Shiono, Masaomi Ikeda, Soichiro Shimura, Kohei Mori, Shuhei Hirano, Dai Koguchi, Haruko Takada, Hideyasu Tsumura, Daisuke Ishii, Kazumasa Matsumoto

{"title":"Maintaining complete response to avelumab for lung metastases from native ureteral cancer after kidney transplantation: a case report.","authors":"Yutaka Shiono, Masaomi Ikeda, Soichiro Shimura, Kohei Mori, Shuhei Hirano, Dai Koguchi, Haruko Takada, Hideyasu Tsumura, Daisuke Ishii, Kazumasa Matsumoto","doi":"10.1007/s13691-026-00859-1","DOIUrl":"10.1007/s13691-026-00859-1","url":null,"abstract":"We report the first case of metastatic urothelial carcinoma (mUC) in a kidney transplant recipient who was successfully treated with avelumab maintenance therapy. Twenty-three years after undergoing kidney transplantation, a 71-year-old woman was incidentally diagnosed with right lower native ureteral cancer during a follow-up evaluation for a pancreatic cyst. No evidence of distant metastasis or lymph node involvement (cT2N0M0) was found in staging investigations. Subsequently, the patient underwent robot-assisted radical nephroureterectomy the following month. Three months after the operation, a computed tomography (CT) scan detected multiple lung metastases. The patient received four cycles of gemcitabine and carboplatin therapy. Complete response was achieved, with the disappearance of all lung metastases on CT. Thus, avelumab maintenance therapy was initiated. 22 months after the initiation of avelumab maintenance therapy, no recurrence or adverse events were observed. In addition, the renal function of the transplanted kidney remained stable. Avelumab was effective in treating mUC in a kidney transplant recipient. However, careful management is required to prevent kidney transplant rejection.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"323-326"},"PeriodicalIF":0.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of successful combined intensity-modulated radiation therapy and hyperthermia for a large, drug-resistant chest wall recurrence of breast cancer. 一个成功的联合调强放射治疗和热疗的大，耐药胸壁复发乳腺癌的病例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-27 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00865-3

Tatsuya Wakizono, Toshihiro Nakata, Subaru Tani, Takayuki Ohguri

{"title":"A case of successful combined intensity-modulated radiation therapy and hyperthermia for a large, drug-resistant chest wall recurrence of breast cancer.","authors":"Tatsuya Wakizono, Toshihiro Nakata, Subaru Tani, Takayuki Ohguri","doi":"10.1007/s13691-026-00865-3","DOIUrl":"10.1007/s13691-026-00865-3","url":null,"abstract":"Chest wall recurrence (CWR) of breast cancer that is large and resistant to multiple systemic therapies requires rapid and effective local control. We report a case of a 70-year-old woman with a 10-cm, ulcerated, drug-resistant CWR unresponsive to anthracyclines, taxanes, and trastuzumab. After initial hemostatic electron irradiation, intensity-modulated radiation therapy (IMRT) was delivered with concurrent weekly hyperthermia (HT) for six sessions. Intratumoral temperatures were successfully maintained at ≥ 43 °C. The tumor demonstrated rapid and marked shrinkage, followed by spontaneous sloughing during treatment. A near-complete clinical response was achieved at the end of therapy, with only Grade 2 radiation dermatitis and no severe toxicities. This case suggests that the integration of IMRT, which allows for precise dose distribution over large, irregular areas, with concurrent HT represents a potentially effective strategy for achieving marked local tumor control in drug-resistant, large-volume recurrences.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"362-367"},"PeriodicalIF":0.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of advanced esophagogastric junction cancer in which comprehensive genomic profiling by liquid biopsy led to the diagnosis of a second primary hepatocellular carcinoma. 晚期食管胃结癌的病例中，通过液体活检的全面基因组分析导致了第二原发性肝细胞癌的诊断。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-26 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00860-8

Akane Hirotani, Makoto Sugimori, Sho Sato, Haruo Miwa, Tsutomu Sato, Makoto Kudo, Manabu Morimoto, Chikara Kunisaki, Shin Maeda

{"title":"A case of advanced esophagogastric junction cancer in which comprehensive genomic profiling by liquid biopsy led to the diagnosis of a second primary hepatocellular carcinoma.","authors":"Akane Hirotani, Makoto Sugimori, Sho Sato, Haruo Miwa, Tsutomu Sato, Makoto Kudo, Manabu Morimoto, Chikara Kunisaki, Shin Maeda","doi":"10.1007/s13691-026-00860-8","DOIUrl":"10.1007/s13691-026-00860-8","url":null,"abstract":"The primary objective of comprehensive genomic profiling (CGP) is to identify actionable genomic alterations. We report a case in which CGP performed by liquid biopsy (LB) led to the diagnosis of multiple primary cancers. A 66-year-old man was diagnosed with unresectable esophagogastric junction cancer and received systemic chemotherapy. Initially, all distant metastases disappeared; however, a new liver tumor-first suspected to be a metastasis-appeared and gradually enlarged, while the other lesions remained controlled. CGP by LB, performed after initiation of fifth-line chemotherapy, detected genomic alterations suggestive of hepatocellular carcinoma (HCC). Subsequent liver biopsy confirmed the liver tumor, initially thought to be a metastasis, as a second primary HCC. This case suggests that CGP by LB may provide an opportunity to detect multiple primary cancers. When genomic alterations that are inconsistent with the clinical diagnosis are identified, the possibility of multiple primary cancers should be considered.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"327-333"},"PeriodicalIF":0.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly progressive synchronous multifocal gastrointestinal stenoses in bladder cancer: diagnostic challenges and clinical implications. 膀胱癌的快速进展同步多灶性胃肠道狭窄：诊断挑战和临床意义。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-25 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00862-6

Keiichiro Yasuda, Masaki Tsujino, Hajime Yamasaki, Yutaka Kurahashi, Masahiro Nakagawa, Hidefumi Kishikawa, Takahiro Yoshida

{"title":"Rapidly progressive synchronous multifocal gastrointestinal stenoses in bladder cancer: diagnostic challenges and clinical implications.","authors":"Keiichiro Yasuda, Masaki Tsujino, Hajime Yamasaki, Yutaka Kurahashi, Masahiro Nakagawa, Hidefumi Kishikawa, Takahiro Yoshida","doi":"10.1007/s13691-026-00862-6","DOIUrl":"10.1007/s13691-026-00862-6","url":null,"abstract":"Gastrointestinal involvement by bladder cancer is rare and typically presents as localized invasion. We report an exceptional case of primary bladder urothelial carcinoma presenting with synchronous, multifocal stenoses of the duodenum, transverse colon, descending colon, and rectum due to retroperitoneal/peritoneal dissemination with or without intramural infiltration. A 71-year-old male, initially staged as T2N0M0, experienced rapid deterioration with bilateral ureteral strictures and multiple intestinal obstructions. Despite radiologic and endoscopic evidence of circumferential narrowing, multiple mucosal biopsies were negative for malignancy. A definitive diagnosis was achieved via transrectal ultrasound-guided needle biopsy, which revealed a discohesive, \"Indian-file\" infiltration pattern of urothelial carcinoma cells within the muscularis propria. This case underscores the risk of profound understaging and highlights the necessity for high clinical suspicion of dissemination despite unremarkable radiological findings when an atypical discohesive growth pattern is observed.Supplementary information: The online version contains supplementary material available at 10.1007/s13691-026-00862-6.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"342-348"},"PeriodicalIF":0.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ewing sarcoma of the frontal sinus in an elderly patient: a case report and review. 老年额窦尤文氏肉瘤1例报告及复习。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-21 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00849-3

Risako Hagiwara, Yosuke Ariizumi, Yumiko Tateishi, Susumu Kirimura, Takahiro Asakage

{"title":"Ewing sarcoma of the frontal sinus in an elderly patient: a case report and review.","authors":"Risako Hagiwara, Yosuke Ariizumi, Yumiko Tateishi, Susumu Kirimura, Takahiro Asakage","doi":"10.1007/s13691-026-00849-3","DOIUrl":"10.1007/s13691-026-00849-3","url":null,"abstract":"Ewing sarcoma is a malignant small round cell tumor with an aggressive clinical course that typically arises in the extremities or trunk of adolescents and young adults. Sinonasal Ewing sarcoma in elderly patients is extremely rare, and its diagnosis can be challenging owing to overlapping histopathological features with other malignancies. A 71-year-old woman with a sinonasal tumor was referred to our hospital. The initial pathological diagnosis based on an outpatient biopsy was olfactory neuroblastoma (ONB). However, the absence of tumor in the olfactory cleft suggested other histological types. A surgical biopsy was performed, and Ewing sarcoma was confirmed by immunostaining and fluorescence in situ hybridization. One month after surgical biopsy, rapid tumor growth with intracranial extension was observed. Chemotherapy and extensive skull-base surgery were declined. Although carbon-ion radiotherapy was effective for the primary tumor, bone metastases developed shortly after treatment, and the patient died 7 months after the initial visit. This case highlights the diagnostic pitfalls of sinonasal malignancies and the importance of endoscopic and radiologic findings as potential diagnostic clues. In frontal sinus Ewing sarcoma, local treatment alone is unlikely to achieve cure without chemotherapy. However, the standard regimen for Ewing sarcoma is often too toxic for elderly patients, underscoring the need for more tolerable treatment options. To our knowledge, this is the first reported case of frontal sinus Ewing sarcoma in a patient over 60 years old.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"306-311"},"PeriodicalIF":0.4,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of re-irradiation and bevacizumab for recurrent adult histological pineoblastoma: a case report. 再照射联合贝伐单抗治疗复发性成人组织学松果体母细胞瘤1例。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-21 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00861-7

Takahiro Tsuchiya, Makoto Ohno, Shohei Fujita, Yasuji Miyakita, Hirokazu Sugino, Hiroshi Igaki, Akihiko Yoshida, Masamichi Takahashi, Shunsuke Yanagisawa, Sho Osawa, Takuma Nakashima, Hiromichi Suzuki, Koichi Ichimura, Yoshitaka Narita

{"title":"Combination of re-irradiation and bevacizumab for recurrent adult histological pineoblastoma: a case report.","authors":"Takahiro Tsuchiya, Makoto Ohno, Shohei Fujita, Yasuji Miyakita, Hirokazu Sugino, Hiroshi Igaki, Akihiko Yoshida, Masamichi Takahashi, Shunsuke Yanagisawa, Sho Osawa, Takuma Nakashima, Hiromichi Suzuki, Koichi Ichimura, Yoshitaka Narita","doi":"10.1007/s13691-026-00861-7","DOIUrl":"10.1007/s13691-026-00861-7","url":null,"abstract":"Adult pineoblastoma is an uncommon malignant neoplasm. Relevant literature, particularly regarding its recurrence, is limited; to date, only eight cases of recurrent adult pineoblastoma with detailed treatment information have been reported. Therefore, the optimal treatment for recurrent adult pineoblastoma remains unclear. Here, we report the case of a 58-year-old man with a treatment history of pineal and disseminated pineoblastoma. The patient initially underwent an endoscopic biopsy and was histologically diagnosed with pineoblastoma. He then underwent adjuvant chemotherapy with ifosfamide, cisplatin, and etoposide, followed by radiotherapy, and remained relapse-free for four years. Subsequently, a recurrent spinal lesion was identified at the C2-3 level, and the patient was treated with eight cycles of ifosfamide, cisplatin, and etoposide. However, the lesion continued to grow, and the patient developed symptoms of gait instability. A second biopsy was performed and the patient was histologically diagnosed with pineoblastoma recurrence. The patient underwent local re-irradiation with bevacizumab, achieving a complete response with tumor regression. The patient remained recurrence-free at the 12-month follow-up visit after the second biopsy. These findings suggest that the combination of re-irradiation and bevacizumab may provide an effective therapeutic option for recurrent histological pineoblastoma in adults.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"334-341"},"PeriodicalIF":0.4,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe nail toxicity induced by FGFR inhibitor in FGFR2-rearranged cholangiocarcinoma. FGFR抑制剂在fgfr2重排胆管癌中诱导的严重指甲毒性。

IF 0.4

International Cancer Conference Journal Pub Date : 2026-03-14 eCollection Date: 2026-07-01 DOI: 10.1007/s13691-026-00857-3

Chiaki Kondo, Ayako Mitsuma, Yuichi Ando

{"title":"Severe nail toxicity induced by FGFR inhibitor in FGFR2-rearranged cholangiocarcinoma.","authors":"Chiaki Kondo, Ayako Mitsuma, Yuichi Ando","doi":"10.1007/s13691-026-00857-3","DOIUrl":"10.1007/s13691-026-00857-3","url":null,"abstract":"FGFR2 gene fusions are identified in approximately 10-16% of patients with intrahepatic cholangiocarcinoma and are targets of FGFR tyrosine kinase inhibitors (TKIs). While these agents are clinically effective, nail disorders are a documented class-effect toxicity, occurring in approximately 40%-50% of patients treated with various FGFR inhibitors, often impairing quality of life. We report a case of a 53-year-old man with locally advanced intrahepatic cholangiocarcinoma refractory to standard chemotherapy (cisplatin/gemcitabine, S-1) and proton beam therapy. Comprehensive genomic profiling revealed FGFR2::WAC and KCNH8::FGFR2 fusion genes. Treatment was initiated with pemigatinib (13.5 mg/day). One month later, painful nail deformities appeared, followed by thickening, black discoloration, and brittleness. Despite a dose reduction to 9 mg/day, the nail toxicity remained. Consequently, high-potency topical corticosteroids were administered, and symptoms subsided. After disease progression, the treatment was switched to futibatinib (16 mg daily), and during the three-month administration, the nail disorders did not worsen and tended to improve. In conclusion, we describe a case where severe nail toxicity induced by a reversible FGFR inhibitor was managed by switching to futibatinib and utilizing topical corticosteroids. Although effective treatments for nail-related events are limited, this case suggests the effectiveness of steroid ointments.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"15 3","pages":"319-322"},"PeriodicalIF":0.4,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0