肛门直肠区同时发生恶性周围神经鞘瘤和恶性黑色素瘤。

IF 0.5 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2025-04-04 eCollection Date: 2025-07-01 DOI:10.1007/s13691-025-00760-3

Nobuto Yamazaki, Yoshinori Kikuchi, Kimihiko Yoshida, Yasuyuki Miura, Takamaru Koda, Yasuo Nagashima, Takayuki Suzuki, Satoru Kagami, Tomoaki Kaneko, Hiroyuki Shiokawa, Nanako Inoue, Naoki Onda, Mitsunori Ushigome, Akiharu Kurihara, Yasuko Kurose, Naobumi Tochigi, Kimihiko Funahashi

{"title":"肛门直肠区同时发生恶性周围神经鞘瘤和恶性黑色素瘤。","authors":"Nobuto Yamazaki, Yoshinori Kikuchi, Kimihiko Yoshida, Yasuyuki Miura, Takamaru Koda, Yasuo Nagashima, Takayuki Suzuki, Satoru Kagami, Tomoaki Kaneko, Hiroyuki Shiokawa, Nanako Inoue, Naoki Onda, Mitsunori Ushigome, Akiharu Kurihara, Yasuko Kurose, Naobumi Tochigi, Kimihiko Funahashi","doi":"10.1007/s13691-025-00760-3","DOIUrl":null,"url":null,"abstract":"A 69-year-old male presented to our clinic with bloody faecal matter. Examination revealed a 60-mm type 1 tumour on the posterior rectal wall and a 15-mm type Is tumour on the anterior rectal wall. R0 resection was performed via laparoscopic perineal rectal resection (extraperitoneal colectomy). Immunohistochemical staining led to the diagnosis of anorectal malignant peripheral nerve sheath tumour on the posterior rectal wall and anorectal malignant melanoma on the anterior rectal wall. Peritoneal dissemination occurred 10 months after resection, with the appearance of liver tumours. The liver was biopsied and pathological examination revealed metastasis due to malignant peripheral nerve sheath tumours. Primary treatment with doxorubicin plus ifosfamide and secondary treatment with etoposide plus carboplatin were ineffective.","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"14 3","pages":"246-253"},"PeriodicalIF":0.5000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229405/pdf/","citationCount":"0","resultStr":"{\"title\":\"Simultaneous malignant peripheral nerve sheath tumour and malignant melanoma of the anorectal region.\",\"authors\":\"Nobuto Yamazaki, Yoshinori Kikuchi, Kimihiko Yoshida, Yasuyuki Miura, Takamaru Koda, Yasuo Nagashima, Takayuki Suzuki, Satoru Kagami, Tomoaki Kaneko, Hiroyuki Shiokawa, Nanako Inoue, Naoki Onda, Mitsunori Ushigome, Akiharu Kurihara, Yasuko Kurose, Naobumi Tochigi, Kimihiko Funahashi\",\"doi\":\"10.1007/s13691-025-00760-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 69-year-old male presented to our clinic with bloody faecal matter. Examination revealed a 60-mm type 1 tumour on the posterior rectal wall and a 15-mm type Is tumour on the anterior rectal wall. R0 resection was performed via laparoscopic perineal rectal resection (extraperitoneal colectomy). Immunohistochemical staining led to the diagnosis of anorectal malignant peripheral nerve sheath tumour on the posterior rectal wall and anorectal malignant melanoma on the anterior rectal wall. Peritoneal dissemination occurred 10 months after resection, with the appearance of liver tumours. The liver was biopsied and pathological examination revealed metastasis due to malignant peripheral nerve sheath tumours. Primary treatment with doxorubicin plus ifosfamide and secondary treatment with etoposide plus carboplatin were ineffective.\",\"PeriodicalId\":13703,\"journal\":{\"name\":\"International Cancer Conference Journal\",\"volume\":\"14 3\",\"pages\":\"246-253\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229405/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Cancer Conference Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13691-025-00760-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Cancer Conference Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13691-025-00760-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

一名69岁男性因带血粪便前来就诊。检查发现直肠后壁有一个60毫米的1型肿瘤，直肠前壁有一个15毫米的Is型肿瘤。R0切除术通过腹腔镜会阴直肠切除术（腹腔外结肠切除术）进行。免疫组化染色诊断为直肠后壁肛门直肠恶性周围神经鞘瘤和直肠前壁肛门直肠恶性黑色素瘤。术后10个月出现腹膜播散，出现肝肿瘤。肝脏活检和病理检查显示恶性周围神经鞘肿瘤转移。阿霉素加异环磷酰胺一级治疗和依托泊苷加卡铂二级治疗均无效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Simultaneous malignant peripheral nerve sheath tumour and malignant melanoma of the anorectal region.

A 69-year-old male presented to our clinic with bloody faecal matter. Examination revealed a 60-mm type 1 tumour on the posterior rectal wall and a 15-mm type Is tumour on the anterior rectal wall. R0 resection was performed via laparoscopic perineal rectal resection (extraperitoneal colectomy). Immunohistochemical staining led to the diagnosis of anorectal malignant peripheral nerve sheath tumour on the posterior rectal wall and anorectal malignant melanoma on the anterior rectal wall. Peritoneal dissemination occurred 10 months after resection, with the appearance of liver tumours. The liver was biopsied and pathological examination revealed metastasis due to malignant peripheral nerve sheath tumours. Primary treatment with doxorubicin plus ifosfamide and secondary treatment with etoposide plus carboplatin were ineffective.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)