Innovare Journal of Ayurvedic Sciences最新文献

A REVIEW ON THE MEMORY POTENTIAL EFFECT OF “POLYGALA TENUIFOLIA, LYCII FRUCTUS AND CENTELLA ASIATICA” 关于 "远志、枸杞子和积雪草 "记忆潜能作用的综述

Innovare Journal of Ayurvedic Sciences Pub Date : 2024-04-01 DOI: 10.22159/ijas.2024v12.49983

Minakshi, AJEET PAL SINGH, AMAR PAL SINGH, Meenakshi Malhotra Singh

引用次数: 0

HYPOGLYCEMIC POTENTIAL OF HIBISCUS ROSA-SINENSIS AND MANGIFERA INDICA LEAVES BY IN VITRO METHODS 芙蓉和芒果叶的体外降糖潜能研究

Innovare Journal of Ayurvedic Sciences Pub Date : 2023-08-14 DOI: 10.22159/ijas.2023.v11i1.48737

Sireesha Kalva, Andhi Neha

{"title":"HYPOGLYCEMIC POTENTIAL OF HIBISCUS ROSA-SINENSIS AND MANGIFERA INDICA LEAVES BY IN VITRO METHODS","authors":"Sireesha Kalva, Andhi Neha","doi":"10.22159/ijas.2023.v11i1.48737","DOIUrl":"https://doi.org/10.22159/ijas.2023.v11i1.48737","url":null,"abstract":"Objective: The objective of the present study was to provide in vitro evidence for the potential inhibitory activity of extracts of Mangifera indica (MI) and Hibiscus rosa-sinensis on α-amylase and α-glucosidase enzymes.\u0000Methods: The plant extracts were prepared with methanol by maceration. Different concentrations (10, 20, 40, 80, and 100 μg/mL) of both the extracts were made using distilled water, and the extracts were subjected to α-amylase and α-glucosidase inhibitory assay. The absorbance was measured at 540 nm and 405 nm using spectrophotometer. Using this method, the percentage of α-amylase and α-glucosidase inhibitory activity and IC50 values of each extract were calculated.\u0000Results: The methanolic extracts of MI and H. rosa-sinensis exhibited significant α-amylase and α-glucosidase inhibitory activity. The inhibitory effect of α-amylase inhibitory assay was observed up to 89% and 90% at a concentration of 100 μg/mL in MI and H. rosa-sinensis, respectively. The inhibitory effect of α-glucosidase inhibitory assay was observed up to 89% and 91% at a concentration of 100 μg/mL in MI and H. rosa-sinensis, respectively, and is comparable to the standard acarbose (94% at 100 μg/mL). The IC50 values of α-amylase inhibitory assay of MI and H. rosa-sinensis are 35.33 and 30.97, respectively. The IC50 values of α-glucosidase inhibitory assay of MI and H. rosa-sinensis are 31.67 and 25.86, respectively. The IC50 value of acarbose is 6.94.\u0000Conclusion: The results obtained support that MI and H. rosa-sinensis extracts exhibit considerable α-amylase and α-glucosidase inhibitory activity which can be attributed to the phytochemical constituents present in them. Further, this study supports its usage in ethno medicines for the management of diabetes.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86297139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BACTERIOLOGICAL EVALUATION OF KWATA ABATTOIR WASTE WATER AWKA, NIGERIA 尼日利亚奥卡kwata屠宰场废水的细菌学评价

Innovare Journal of Ayurvedic Sciences Pub Date : 2023-07-12 DOI: 10.22159/ijs.2023.v11i1.48519

Ezeokoli Cm, Agu Kc, Nwosu Jc, Orji Mu, U. Li, Umeoduagu Nd, VICTOR-ADULOJU At, Ikenwa Bo

{"title":"BACTERIOLOGICAL EVALUATION OF KWATA ABATTOIR WASTE WATER AWKA, NIGERIA","authors":"Ezeokoli Cm, Agu Kc, Nwosu Jc, Orji Mu, U. Li, Umeoduagu Nd, VICTOR-ADULOJU At, Ikenwa Bo","doi":"10.22159/ijs.2023.v11i1.48519","DOIUrl":"https://doi.org/10.22159/ijs.2023.v11i1.48519","url":null,"abstract":"Abattoir wastes can have a detrimental effect on the environment, public health, animal health, and economy of a country if they are not effectively managed and controlled. The bacteriological evaluation of waste water from Kwata abattoir was carried out to determine the bacterial load present and if the waste water generated is suitable for direct discharge into the environment. A total of two samples were aseptically collected, in which the physicochemical analysis of the waste water showed objectionable color and odor, pH of 7.3 and 6.5, and temperature of 30.2°C and 25.3°C for samples A and B, respectively, of which the pH and temperature were within acceptable limits by WHO. The membrane filter method was used to determine the total coliform and thermotolerant coliform counts present per 100 mL of the samples using MacConkey agar and Eosin Methylene Blue Agar, respectively. The total viable count was obtained for both samples: 5.1×105 CFU/mL for sample A and 1.4×106 CFU/mL for sample B. Phenotypic and biochemical tests were carried out for four isolates, which include Escherichia coli, Salmonella spp., Bacillus spp., and Bacillus cereus. Thus, it can be concluded from the above study that untreated abattoir waste water contains a high level of pollutants, which supports the growth of the microbial population, as evidenced in the microbial study. Therefore, waste water has to be treated before discharge into the environment to protect public health and promote the safety of the environment.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"38 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82827275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IN SILICO ANALYSIS AND DOCKING STUDY OF THE ACTIVE PHYTO COMPOUNDS OF MORINGA OLEIFERA AGAINST MARBURG VIRUS VP35 PROTEIN 辣木抗马尔堡病毒vp35蛋白活性植物化合物的硅分析与对接研究

Innovare Journal of Ayurvedic Sciences Pub Date : 2022-09-30 DOI: 10.22159/ijs.2022.v10i1.46218

S. Chavan, Shubham Wanarase, Sameer Sharma

{"title":"IN SILICO ANALYSIS AND DOCKING STUDY OF THE ACTIVE PHYTO COMPOUNDS OF MORINGA OLEIFERA AGAINST MARBURG VIRUS VP35 PROTEIN","authors":"S. Chavan, Shubham Wanarase, Sameer Sharma","doi":"10.22159/ijs.2022.v10i1.46218","DOIUrl":"https://doi.org/10.22159/ijs.2022.v10i1.46218","url":null,"abstract":"Objective: Marburg is a transmissible disease of the Filoviridae family. It infected a million people worldwide. Hence, an attempt was made to identify natural compounds from Moringa oleifera, having multiple medicinal values in Indian Ayurveda, to prevent the disease, using molecular docking, drug likeness prediction, absorption, distribution, metabolism, and excretion (ADME) analysis, and toxicity prediction.\u0000Methods: Marburg main protein was retrieved from the protein data bank database. The ligands with poor binding and molecules that can affect docking were removed and docking is done with the PyRx tool. ADME and drug-likeness analysis were done using Swiss-ADME and absorption, distribution, metabolism, excretion, and toxicity (ADMET) lab web server.\u0000Results: Ramachandran plot analysis shows the statistical distribution of the combinations of the backbone dihedral angles ϕ and ψ of the protein. Molecular docking studies show three compounds from M. oleifera have potential binding affinity to resist the main protein VP35 by preventing proteolytic cleavage, translation, and replication of the virus. ADMET profile and drug likeness and toxicity prediction showed that all three compounds Melanin, Diclazuril, and Tifentai were safe and possess drug-like properties.\u0000Conclusion: The present study suggests that Melanin, Diclazuril, and Tifentai have significant binding affinity and they could inhibit the main protein VP35 and also helps to manage the therapeutic strategies against Marburg Virus.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85682049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CLINICAL STUDY TO EVALUATE THE EFFICACY OF VIPAREETA MALLA TAILA IN DUSTA VRANA 临床研究评价小儿鼻窦炎治疗的疗效

Innovare Journal of Ayurvedic Sciences Pub Date : 2022-07-05 DOI: 10.22159/ijas.2022.v10i2.43258

Bhopinder Singh, Rajiv Dole, Manpreet Singh

{"title":"A CLINICAL STUDY TO EVALUATE THE EFFICACY OF VIPAREETA MALLA TAILA IN DUSTA VRANA","authors":"Bhopinder Singh, Rajiv Dole, Manpreet Singh","doi":"10.22159/ijas.2022.v10i2.43258","DOIUrl":"https://doi.org/10.22159/ijas.2022.v10i2.43258","url":null,"abstract":"Dusta vrana management is a common problem, encountered by medical practitioners all over the globe, that is, non-healing chronic ulcer. Without early and optimal intervention, the wound can rapidly deteriorate and leading to amputation of the affected limb. Studies reveal that it is difficult to achieve the complete aim of wound management with a single drug. In the present study, Vipareeta Malla Taila is selected from Bhaishajaya Ratnavali and Yogaratnakar. It consists of Sindoor, Kushta, Hingu, Rason, Chitrka Root, Langali, Hartal, Sharpunka, Shudh Tutha, Shudh Samundrafena, etc. These drugs having properties of Vrana Shodhana (cleansing), Ropana (healing), Vedanashamana (analgesic), Shothaharana (anti-inflammatory and reducing swelling) and bactericidal. It is a single-blind clinically study where 20 patients were selected. The patient would were treated with Vipareeta Malla Taila. Vipareeta Malla Taila mentioned by Acharya Yogratnakar in the context of Vrana chapter is found efficacious in wound healing. The drug initially acts as a debriding agent removing slough and necrotic tissues and subsequently paves way for smooth and uninterrupted healing of the ulcer. Topical application of Vipareeta Malla Taila reduces pain, burning sensation, and itching. It also decreases discharge, edema, and also helps in gradual improvement in floor and granulation tissue. The semi-occlusive dressing of Vipareeta Malla Taila provides moist environment which enhances epithelialization, prevents scab formation, and can be easily removed from wound surface without causing pain or damage to the new growing epithelium. Hence, from the present clinical study, it can be speculated that Vipareeta Malla Taila possesses sufficient efficacy in Vrana Shodana and Vrana Ropana without producing any adverse effects.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79023071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NATURAL PRODUCT-BASED AMYLOID PROTEIN INHIBITORS 天然产物淀粉样蛋白抑制剂

Innovare Journal of Ayurvedic Sciences Pub Date : 2022-06-27 DOI: 10.22159/ijs.2022.v10i1.41079

S. S, Suseem Sr

{"title":"NATURAL PRODUCT-BASED AMYLOID PROTEIN INHIBITORS","authors":"S. S, Suseem Sr","doi":"10.22159/ijs.2022.v10i1.41079","DOIUrl":"https://doi.org/10.22159/ijs.2022.v10i1.41079","url":null,"abstract":"Neurodegenerative disorders like Alzheimer’s are associated by plague formation of protein aggregates called amyloid proteins. Many natural-based products such as flavonoids, phenolic acids, iso-flavones, and polyunsaturated fatty acids play major role in therapeutic ability to degrade, slow down, and recondition the amyloid protein (amyloid protein inhibitors). These compounds extracted from plants have shown consequential potential in in vitro studies as well as in vivo studies. For requisite for brain nutritive growth, omega 3 fatty acids are important, whereas ß-carotene plays indispensable role in cognitive impairment and oxidative stress in the brain. It is described that omega 3 fatty acids are extracted from the source (flaxseed) by oil press method and ß-carotene is synthesized by physiochemical process from carrot. The main objective of this particular research topic is to provide more effectiveness in detaining the growth of amyloid protein inhibitors in brain. It is observed that the product with omega 3 and ß-carotene slow down the protein aggregation more efficiently than omega 3 capsules alone and intra-cerebroventricular injected streptozotocin. This can be determined by in silico activity of acetylcholinesterase. The analyses show extensive reciprocity between inhibitors and amyloid proteins. The administration of omega 3 with ß-carotene depreciates the amyloid protein aggregates more efficiently. Hence, it is suggested that the product can be used as treatment for neurodegenerative diseases like Alzheimer’s.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83351190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND EVALUATION OF LIPSTICK USING IXORA COCCINEA FLOWER EXTRACT AS A NATURAL COLORING AGENT 红唇花提取物作为天然着色剂的配方及评价

Innovare Journal of Ayurvedic Sciences Pub Date : 2022-02-16 DOI: 10.22159/ijas.2021.v10i1.44175

Vijayanand Pujari, R. Sawant, Neha Shivathaya, Rashmi Surve, Nandini Sunagar, V. Sawant, Sandip D. Patil

{"title":"FORMULATION AND EVALUATION OF LIPSTICK USING IXORA COCCINEA FLOWER EXTRACT AS A NATURAL COLORING AGENT","authors":"Vijayanand Pujari, R. Sawant, Neha Shivathaya, Rashmi Surve, Nandini Sunagar, V. Sawant, Sandip D. Patil","doi":"10.22159/ijas.2021.v10i1.44175","DOIUrl":"https://doi.org/10.22159/ijas.2021.v10i1.44175","url":null,"abstract":"Objective: The objective of the present research work was to formulate and evaluate lipstick using fresh flowers of Ixora coccinea extract as a coloring agent.\u0000Methods: Fresh flowers of I. coccinea were collected, and coloring pigment was extracted by cold maceration technique using ethanol as solvent. Lipstick formulations (F1-F4) were prepared using beeswax, cocoa butter, carnauba wax, white petroleum jelly, coconut oil, and other excipients. The prepared formulations were evaluated for various evaluation parameters such as color, texture, pH, melting point, breaking point, hardness, spreadability, and aging stability.\u0000Results: The results of different evaluation parameters of prepared lipstick formulations were within the standard range. Formulation (F3) was good enough to meet the general characteristics for ideal lipstick as all the evaluation parameters met the standard values of lipsticks.\u0000Conclusion: The natural dye obtained from the petals of the I. coccinea flower plant was successfully used as a coloring agent in the formulation of lipstick in this study. Results of the study confirmed that this color pigment obtained from fresh flowers of I. coccinea may prove to be a useful choice in the formulation of lipstick. Natural coloring agents are safer options and are a better choice compared to their synthetic counterparts in cosmetic formulations.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80016661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AN AYURVEDIC REVIEW ON JANAPADODHWAMSA 关于janapaddhwamsa的阿育吠陀评论

Innovare Journal of Ayurvedic Sciences Pub Date : 2021-11-01 DOI: 10.22159/ijas.2021.v9i6.40524

S. Yadav, Ashutosh Yadav, T. Kushwaha

{"title":"AN AYURVEDIC REVIEW ON JANAPADODHWAMSA","authors":"S. Yadav, Ashutosh Yadav, T. Kushwaha","doi":"10.22159/ijas.2021.v9i6.40524","DOIUrl":"https://doi.org/10.22159/ijas.2021.v9i6.40524","url":null,"abstract":"Ayurveda the eternal life science from many centuries proved to be the most efficient tool in the health management system. It gives more weightage to the prevention than the cure. Janapadodhwamsa is one among the unique concept described in Ayurveda treatises which literally means demolition or annihilation of people or community. Acharya Charaka called it Janapadodhwamsa, Acharya Sushruta called it Maraka, and Acharya Bhela called it Janamaar. There are four factors that have been described which are common and essential for every living being, that is, Vayu (air), Jala (water), Desha (land), and Kaala (season). Among these four factors, Kaala is mainly main factor. Any abnormal alteration in these four factors can significantly influence individual or community or environment or all of them together. Vitiation of these four common factors is the cause for Janapadodhwamsa. Foremost reason for Janapadodhwamsa has been described as Adharma (immorality) and the root cause of Adharma is said to be Pragyaparadha (delinquency of wisdom). Considering the note worthiness of Janapadodhwamsa, a whole chapter has been depicted in CharakaSamhita illustrating its onset, causes, peculiar features, and management. Its causative agents, method of prevention has been clearly explained. To manage Janapadodhvamsa, it is advised to include the usage of Rasayana therapy, Panchkarama procedures, SadvritPaalan (code of right conducts), and Aachara Rasayana, that is, behavioral therapy.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"48 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79510655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF 2019 NOVEL CORONA VIRUS: A REVIEW 2019年新型冠状病毒流行病学与临床特征综述

Innovare Journal of Ayurvedic Sciences Pub Date : 2021-10-07 DOI: 10.22159/ijs.2021.v9i6.40448

T. S. L. Srikala, T. Kumar

引用次数: 0

RATIONALE BEHIND THE COMPARISON OF KABA SURAM AND OTHER SURAMS WITH CORONAVIRUS DISEASE AND OTHER VIRAL FEVERS – A LITERATURE REVIEW 卡巴苏拉姆和其他苏拉姆与冠状病毒病和其他病毒性发烧的比较背后的基本原理-文献综述

Innovare Journal of Ayurvedic Sciences Pub Date : 2021-09-08 DOI: 10.22159/ijas.2021.v9i5.42835

Manickavasagam Rengaraju, Kanakavalli Kadarkarai

引用次数: 1