天然产物淀粉样蛋白抑制剂

S. S, Suseem Sr
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引用次数: 0

摘要

像阿尔茨海默氏症这样的神经退行性疾病与鼠疫形成的淀粉样蛋白聚集体有关。许多天然产物,如类黄酮、酚酸、异黄酮和多不饱和脂肪酸,在降解、减缓和修复淀粉样蛋白(淀粉样蛋白抑制剂)的治疗能力中起主要作用。这些从植物中提取的化合物在体外和体内研究中都显示出相应的潜力。omega - 3脂肪酸对于大脑的营养生长至关重要,而ß-胡萝卜素在大脑的认知障碍和氧化应激中起着不可或缺的作用。介绍了以亚麻籽为原料,采用油压法提取欧米伽- 3脂肪酸,以胡萝卜为原料,采用物理化学法合成ß-胡萝卜素。本课题的主要目的是为抑制淀粉样蛋白抑制剂在大脑中的生长提供更有效的方法。我们观察到,与单独服用omega 3胶囊和脑室注射链脲佐菌素相比,含有omega 3和ß-胡萝卜素的产品更有效地减缓了蛋白质的聚集。这可以通过乙酰胆碱酯酶的硅活性来确定。分析表明,抑制剂和淀粉样蛋白之间存在广泛的相互作用。omega - 3与ß-胡萝卜素一起服用可以更有效地降低淀粉样蛋白的聚集。因此,建议该产品可用于治疗神经退行性疾病,如阿尔茨海默氏症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NATURAL PRODUCT-BASED AMYLOID PROTEIN INHIBITORS
Neurodegenerative disorders like Alzheimer’s are associated by plague formation of protein aggregates called amyloid proteins. Many natural-based products such as flavonoids, phenolic acids, iso-flavones, and polyunsaturated fatty acids play major role in therapeutic ability to degrade, slow down, and recondition the amyloid protein (amyloid protein inhibitors). These compounds extracted from plants have shown consequential potential in in vitro studies as well as in vivo studies. For requisite for brain nutritive growth, omega 3 fatty acids are important, whereas ß-carotene plays indispensable role in cognitive impairment and oxidative stress in the brain. It is described that omega 3 fatty acids are extracted from the source (flaxseed) by oil press method and ß-carotene is synthesized by physiochemical process from carrot. The main objective of this particular research topic is to provide more effectiveness in detaining the growth of amyloid protein inhibitors in brain. It is observed that the product with omega 3 and ß-carotene slow down the protein aggregation more efficiently than omega 3 capsules alone and intra-cerebroventricular injected streptozotocin. This can be determined by in silico activity of acetylcholinesterase. The analyses show extensive reciprocity between inhibitors and amyloid proteins. The administration of omega 3 with ß-carotene depreciates the amyloid protein aggregates more efficiently. Hence, it is suggested that the product can be used as treatment for neurodegenerative diseases like Alzheimer’s.
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