{"title":"Atrial fibrillation and atrial flutter in China: trends and projections to 2050 from GBD 2023.","authors":"Rui Wu, Zijun Zhou, Boxuan Sun, Jiahui Li, Liming Yu, Huishan Wang","doi":"10.1007/s11739-026-04529-1","DOIUrl":"https://doi.org/10.1007/s11739-026-04529-1","url":null,"abstract":"<p><p>Atrial fibrillation and atrial flutter (AF/AFL) impose a mounting health burden worldwide, yet no comprehensive study has systematically evaluated their long‑term trajectories and future scenarios for China using the latest Global Burden of Disease (GBD) data. Using the GBD 2023 dataset, we extracted age- and sex-specific burden estimates of AF/AFL for China (1990-2023). Joinpoint regression, age-period-cohort modeling, decomposition analysis, frontier analysis, and autoregressive integrated moving average (ARIMA) forecasting were applied to characterize historical dynamics and future trajectories. In 2023, China had 12.39 million prevalent cases, 1.06 million incident cases, 65,008 deaths, and 1.75 million disability‑adjusted life years (DALYs). Males had higher age‑standardized prevalence rate (ASPR) (614.89 vs. 472.17) and age‑standardized incidence rate (ASIR) (49.22 vs. 43.00), while females had higher age‑standardized mortality rate (ASMR) (3.69 vs. 2.52) per 100,000. The age‑standardized DALY rate (ASDR) was slightly higher in males (79.24) than in females (77.34) per 100,000. The mortality rate, which fell substantially during 1998-2004 (annual percentage change [APC]: - 5.46; 95% confidence interval [CI]: - 6.28 to - 4.64), unexpectedly reversed to a sharp rise after 2020 (APC: 3.91; 95% CI: 2.23 to 5.62). Decomposition analysis identified population aging and demographic growth as the predominant drivers of the increasing burden. Frontier analysis revealed a persistent gap between observed burden and achievable benchmarks. ARIMA models project the burden will remain substantial through 2050, with sustained nonfatal morbidity. China's AF/AFL burden more than doubled from 1990 to 2023, driven by aging and population growth. The post-2020 mortality reversal and persistently high nonfatal burden highlight the urgent need for age- and sex-tailored prevention, early detection, and enhanced chronic care strategies.</p>","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah Gislon, Alessandra Fusco, Alice Marisa Ferrari, Chiara Marta, Giorgio Costantino
{"title":"Observed variability of oxygen administration between prehospital settings and the emergency department.","authors":"Hannah Gislon, Alessandra Fusco, Alice Marisa Ferrari, Chiara Marta, Giorgio Costantino","doi":"10.1007/s11739-026-04530-8","DOIUrl":"https://doi.org/10.1007/s11739-026-04530-8","url":null,"abstract":"","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre Odic, Olivier Nardi, Laura Foucault-Fruchard
{"title":"Oral semaglutide vs DPP-4 inhibitors in reducing risk of cognitive impairment in elderly patients with HFpEF and obesity: comment.","authors":"Pierre Odic, Olivier Nardi, Laura Foucault-Fruchard","doi":"10.1007/s11739-026-04533-5","DOIUrl":"https://doi.org/10.1007/s11739-026-04533-5","url":null,"abstract":"","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Òscar Miró, Natalia Miota, Pere Llorens, Víctor Gil, Javier Jacob, Pablo Herrero, Aitor Alquézar-Arbé, Mónica Villar Rodríguez, Cristina Antón, Naila Canadell, Blanca Coll-Vinent
{"title":"Correction: Influence of patient sex on clinical decision-making in acute heart failure: a risk-adjusted analysis using the MEESSI-AHF score.","authors":"Òscar Miró, Natalia Miota, Pere Llorens, Víctor Gil, Javier Jacob, Pablo Herrero, Aitor Alquézar-Arbé, Mónica Villar Rodríguez, Cristina Antón, Naila Canadell, Blanca Coll-Vinent","doi":"10.1007/s11739-026-04477-w","DOIUrl":"https://doi.org/10.1007/s11739-026-04477-w","url":null,"abstract":"","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The chick embryo chorioallantoic membrane as an in vivo assay to study the skin in melanoma and other skin pathological conditions.","authors":"Domenico Ribatti, Roberto Tamma","doi":"10.1007/s11739-026-04525-5","DOIUrl":"https://doi.org/10.1007/s11739-026-04525-5","url":null,"abstract":"<p><p>The chick chorioallantoic membrane (CAM) is a well-established model for studying angiogenesis, tumor growth, tissue grafting, and therapeutic responses; however, conventional in ovo approaches are limited by a short experimental window, immune-related constraints, and restricted imaging accessibility. Being naturally immunodeficient, the chick embryo accepts transplantation from various tissues and species. This article analyzes the literature data concerning the use of the CAM model to study melanoma and other skin pathological conditions, due to the lack of literature data summarizing this topic.</p>","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The liver of Polyphemus: a pre-Hippocratic antecedent of hepatic palpation in Homer's Odyssey?","authors":"Michele Augusto Riva, Mattia Montalbano","doi":"10.1007/s11739-026-04526-4","DOIUrl":"https://doi.org/10.1007/s11739-026-04526-4","url":null,"abstract":"","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comments on the \"Prevalence of opioid‑induced constipation in the emergency department\".","authors":"Umema Nadeem, Areesha Naz, Muhammad Hamza Saqib","doi":"10.1007/s11739-026-04524-6","DOIUrl":"https://doi.org/10.1007/s11739-026-04524-6","url":null,"abstract":"","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oscillometric ındices in obstructive sleep apnoea are more closely related to obesity than to disease severity.","authors":"Alperen Aksakal, Ayşenur Sağ, Buğra Kerget, Elif Yılmazel Uçar, Metin Akgün","doi":"10.1007/s11739-026-04523-7","DOIUrl":"https://doi.org/10.1007/s11739-026-04523-7","url":null,"abstract":"<p><p>Impulse oscillometry (IOS) abnormalities have been described in obstructive sleep apnoea syndrome (OSAS), but it remains unclear whether they reflect OSAS itself or the accompanying obesity. Using a body mass index (BMI)-comparable design, we examined the relative associations of obesity and OSAS severity with peripheral oscillometric indices. In this cross-sectional study, 124 adults (86 with OSAS and 38 BMI-comparable non-OSAS participants) underwent overnight polysomnography and daytime IOS. The full panel of oscillometric parameters was examined in relation to BMI and to OSAS diagnosis and severity, using Spearman' correlation and multivariable regression adjusted for age, sex, BMI and smoking status. Analyses were also stratified by obesity status and repeated using the oxygen desaturation index (ODI). No oscillometric parameter differed between the OSAS and BMI-comparable non-OSAS groups. BMI was strongly associated with the resistive and impedance indices (R5, R5-R20, R20 and Z5; Spearman ρ 0.35-0.62, all p < 0.001), and multivariable models explained approximately one quarter of their variance, whereas OSAS diagnosis and AHI-defined severity were not consistently associated after adjustment for BMI. Although AX, X5 and Z5 showed univariate trends with severity, none remained significant after adjustment, and none discriminated severe OSAS individually or in combination (AUC range, 0.60-0.66; DeLong p ≥ 0.31). Findings were unchanged in both obesity strata and with ODI. Peripheral oscillometric indices in OSAS appear to be more closely related to obesity than to OSAS severity. These findings do not support the use of IOS as a standalone tool for screening or grading OSAS and suggest that IOS is better interpreted as an obesity-related rather than an OSAS-specific signal.</p>","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bo Li, Xiaomin Huang, Yiyi Zhu, Hui Chen, Alexei Verkhratsky, Chenju Yi
{"title":"Ventricular fibrillation in a conscious patient with a left ventricular assist device: a case report.","authors":"Bo Li, Xiaomin Huang, Yiyi Zhu, Hui Chen, Alexei Verkhratsky, Chenju Yi","doi":"10.1007/s11739-026-04440-9","DOIUrl":"https://doi.org/10.1007/s11739-026-04440-9","url":null,"abstract":"","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}