Internal and Emergency Medicine最新文献_第2页

Beyond wall thickness: a call for a new paradigm in the diagnostic gray zone of gallbladder cancer. 超越壁厚：对胆囊癌灰色地带诊断新范式的呼唤。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-07-03 DOI: 10.1007/s11739-025-04036-9

Xiaolin Wang, Qian Zhang

引用次数: 0

Short and long-term outcomes of COVID-19-associated venous thromboembolism: a propensity score-matched cohort study. covid -19相关静脉血栓栓塞的短期和长期结局：一项倾向评分匹配的队列研究

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-07-03 DOI: 10.1007/s11739-025-04042-x

Rubén Alonso-Beato, Pablo Demelo-Rodríguez, Lucía Ordieres-Ortega, Marina López-Rubio, Marta-Olimpia Lago-Rodríguez, Crhistian-Mario Oblitas, Luis Antonio Alvarez-Sala Walther, Francisco Galeano-Valle

{"title":"Short and long-term outcomes of COVID-19-associated venous thromboembolism: a propensity score-matched cohort study.","authors":"Rubén Alonso-Beato, Pablo Demelo-Rodríguez, Lucía Ordieres-Ortega, Marina López-Rubio, Marta-Olimpia Lago-Rodríguez, Crhistian-Mario Oblitas, Luis Antonio Alvarez-Sala Walther, Francisco Galeano-Valle","doi":"10.1007/s11739-025-04042-x","DOIUrl":"https://doi.org/10.1007/s11739-025-04042-x","url":null,"abstract":"Venous thromboembolism (VTE) is a recognized complication of SARS-CoV-2 infection, but its clinical features and both sort- and long-term outcomes remain incompletely characterized. We aimed to compare the clinical profile and outcomes of patients with VTE with and without recent COVID-19. We conducted a prospective cohort study including 2012 patients with objectively confirmed VTE. COVID-19-associated VTE was defined as VTE diagnosed within 30 days of a microbiologically confirmed SARS-CoV-2 infection. Clinical characteristics, treatment, and outcomes were compared between groups. Propensity score matching (1:1) and competing risk models were used to adjust for confounding. The primary outcomes-assessed at both 30 days and 365 days-included all-cause mortality, major bleeding, and VTE recurrence. A total of 272 patients (13.5%) had COVID-19-associated VTE. Compared with non-COVID cases, these patients more often had pulmonary embolism, higher D-dimer levels, and greater use of unfractionated heparin. At 30 days, COVID-19 was associated with increased mortality (HR 2.29; 95% CI 1.19-4.40) and major bleeding (HR 2.11; 95% CI 1.06-4.21). At one year, the bleeding risk remained higher (HR 1.54; 95% CI 1.02-2.33), while VTE recurrence was lower (HR 0.34; 95% CI 0.13-0.94). These results were consistent after propensity score matching. COVID-19-associated VTE is linked to worse short-term outcomes, including early mortality and bleeding, and to a persistently elevated bleeding risk at one year. Lower recurrence rates support the consideration of COVID-19 as a transient provoking factor.","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CA125 as a prognostic biomarker in acute heart failure; comment. CA125作为急性心力衰竭的预后生物标志物发表评论。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-07-03 DOI: 10.1007/s11739-025-04031-0

Milad Habibi, Nima Masoudi

引用次数: 0

Inaccurate and misleading meta-analysis of E-cigarettes and population-based diseases: comment. 电子烟与人群疾病的不准确和误导性荟萃分析：评论。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-07-02 DOI: 10.1007/s11739-025-04035-w

Venkata Dileep Kumar Veldi, Rachana Mehta, Ranjana Sah

引用次数: 0

What do patients do during a familial Mediterranean fever attack? Their strategies and associated factors. 家族性地中海热发作时，患者会怎么做？他们的策略和相关因素。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-07-01 DOI: 10.1007/s11739-025-04039-6

Özlem Kılıç, Seda Çolak, Emre Tekgöz, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz

{"title":"What do patients do during a familial Mediterranean fever attack? Their strategies and associated factors.","authors":"Özlem Kılıç, Seda Çolak, Emre Tekgöz, Mehmet Nur Kaya, Muhammet Çınar, Sedat Yılmaz","doi":"10.1007/s11739-025-04039-6","DOIUrl":"https://doi.org/10.1007/s11739-025-04039-6","url":null,"abstract":"Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterised by recurrent fever and serositis. Despite colchicine's proven efficacy, attacks may persist, necessitating the implementation of various mitigation strategies by patients. To identify attack mitigation strategies and associated factors in FMF patients. A cross-sectional study at a tertiary rheumatology clinic included adults (≥ 18 years) meeting Tel-Hashomer criteria, on colchicine for ≥ 6 months, with ≥ 1 attack in the past six months. Patients were asked about their attack mitigation strategies, including colchicine dose increase, emergency department (ED) admission, resting, abdominal hot pack, dietary changes, on-demand anakinra, herbs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroid use. Among 258 patients (98 men, 160 women; median age 35 years, disease duration 18 years), 93% used mitigation strategies. The most common first choice was ED admission (19.8%), followed by colchicine dose increase (18.2%), resting (14.3%), dietary changes (4.3%), NSAIDs (7%), paracetamol (6.6%), on-demand anakinra (6.2%), herbs (6.2%), and corticosteroids (5%). Normal C-reactive protein (CRP) levels, shorter last attack duration, lower international Severity Score for FMF (ISSF), non-working and non-M694V mutations were linked with colchicine dose increase (p < 0.05). M694V positivity, working, persistent CRP elevation, dominant serositis and musculoskeletal attacks, education level ≤ 8 years, longer last attack duration, higher ISSF, current colchicine resistance and non-adherence were linked with ED admission (p < 0.05). Most FMF patients used strategies to mitigate attacks, mainly ED admission and colchicine dose increase. These were influenced by genetic mutations, attack type, working status, education, and CRP levels.","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The space between us: navigating relational boundaries in times of care. 我们之间的空间：在关心的时候导航关系边界。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-06-30 DOI: 10.1007/s11739-025-04022-1

Benedetta Colaiacovo, Chiara Corvino, Marta Mocarelli, Fabrizio Elia, Marta Piria

引用次数: 0

The color of therapeutic adherence: a near miss in a dyslipidemic patient. 治疗依从性的颜色：血脂异常患者的近乎失败。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-06-28 DOI: 10.1007/s11739-025-04037-8

Beatrice Dal Pino, Francesco Sbrana

引用次数: 0

Patterns of heated tobacco product use and biochemically verified smoking status among customers of dedicated heated tobacco product stores. 加热烟草制品专卖店顾客的加热烟草制品使用模式和经生化验证的吸烟状况

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-06-27 DOI: 10.1007/s11739-025-04029-8

Konstantinos Farsalinos, Eleni Diamantopoulou, Theoni Agapitou, Giannis Trikilis, Anastasia Barbouni

{"title":"Patterns of heated tobacco product use and biochemically verified smoking status among customers of dedicated heated tobacco product stores.","authors":"Konstantinos Farsalinos, Eleni Diamantopoulou, Theoni Agapitou, Giannis Trikilis, Anastasia Barbouni","doi":"10.1007/s11739-025-04029-8","DOIUrl":"https://doi.org/10.1007/s11739-025-04029-8","url":null,"abstract":"To understand the population impact of heated tobacco products (HTPs), examining the profile of their users is crucial. This study aimed to assess characteristics, patterns of HTP use, and biochemically verified smoking status of customers visiting specialized HTP stores in Greece. Two specialized stores selling IQOS HTPs were randomly selected in Athens. Researchers recruited consecutive adult customers purchasing products for personal use during store visits. Current smoking status was determined by measuring exhaled carbon monoxide (eCO), with ≥ 7 ppm classifying participants as current smokers. A questionnaire explored demographics, past and current smoking history, HTP use patterns, and dependence indicators. A total of 373 HTP users participated. The vast majority (98.1%) had a smoking history prior to HTP initiation. Former smokers represented 67.8% of the study sample, defined based on self-report and having eCO < 7 ppm, with 90.1% of them reporting they had quit with the use of HTPs. Current smokers represented 30.3% of the sample and reported a 50% median reduction in daily cigarette consumption post-HTP use initiation. Never-smokers represented 1.9% of the sample, all of whom had eCO ≤ 3 ppm. Daily HTP use was the predominant pattern of use in both groups, but was more prevalent among former smokers. Most participants perceived HTPs as less harmful than cigarettes. From logistic regression analysis, factors associated with being a former smoker were HTP use duration (OR: 1.06, 95% CI 1.02-1.09) and daily HTP use (OR: 6.93, 95% CI 1.93-24.92). Customers of specialized HTP stores in Greece were predominantly individuals with a history of smoking. A substantial proportion was biochemically verified former smokers and reported they had quit with the help of HTPs. Use by never-smokers was rare in this retail setting, and did not lead to subsequent smoking.","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous coronary artery dissection-related STEMI as a primary manifestation of fibromuscular dysplasia. 自发性冠状动脉夹层相关STEMI是纤维肌肉发育不良的主要表现。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-06-26 DOI: 10.1007/s11739-025-04028-9

Ana Luísa Silva, Tatiana Pereira Dos Santos, Ana Sofia Martinho, Sílvia Monteiro, Francisco Gonçalves

引用次数: 0

Impact of intraoperative goal-directed therapy on perioperative outcomes in kidney transplantation: a multicenter randomized controlled trial. 术中目标导向治疗对肾移植围手术期预后的影响：一项多中心随机对照试验。

IF 3.2 3区医学

Internal and Emergency Medicine Pub Date : 2025-06-25 DOI: 10.1007/s11739-025-04021-2

Laici Cristiana, Gamberini Lorenzo, Vitale Giovanni, Guizzardi Chiara, Ravaioli Matteo, La Manna Gaetano, Comai Giorgia, Skurzak Stefano, Cerutti Elisabetta, Di Blasi Salvatore, Cerchiara Paolo, Gobbi Fabio, Cimatti Mirella, Ramahi Linda, Siniscalchi Antonio

{"title":"Impact of intraoperative goal-directed therapy on perioperative outcomes in kidney transplantation: a multicenter randomized controlled trial.","authors":"Laici Cristiana, Gamberini Lorenzo, Vitale Giovanni, Guizzardi Chiara, Ravaioli Matteo, La Manna Gaetano, Comai Giorgia, Skurzak Stefano, Cerutti Elisabetta, Di Blasi Salvatore, Cerchiara Paolo, Gobbi Fabio, Cimatti Mirella, Ramahi Linda, Siniscalchi Antonio","doi":"10.1007/s11739-025-04021-2","DOIUrl":"https://doi.org/10.1007/s11739-025-04021-2","url":null,"abstract":"Appropriate fluid management is crucial in anesthesiologic management during kidney transplantation (KT). Traditional parameters such as blood pressure and central venous pressure are unreliable and weakly supported by guidelines. Goal-directed fluid therapy (GDT) has emerged as a technique for administering fluids and vasoactive drugs based on algorithms to ensure adequate tissue perfusion. Current data suggest GDT may reduce tissue edema and respiratory complications in KT recipients. This multicenter, single-blind randomized controlled trial compared conventional fluid management strategies with a GDT algorithm using non-invasive pulse pressure contour analysis monitoring (ClearSight®) in KT patients. The primary outcome was the hospital length of stay. Secondary outcomes included postoperative complications, delayed graft function, 90-day graft loss, and intensive care unit (ICU) length of stay. Patients and postoperative care physicians were blinded to group assignments. The study enrolled 181 KT recipients over 32 months. The hospital length of stay did not significantly differ between the groups, with a difference of 0.5 days (95% CI: -2.5 to 5 days). No significant differences were found in surgical and medical complications, delayed graft function, graft loss, or ICU length of stay. In KT recipients, using a GDT algorithm did not result in clinically meaningful differences in hospital stay, complications, or graft dysfunction/loss.","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0