Integrative zoology最新文献

{"title":"Melanocortin 1 Receptor Signaling Protects Against Tubular Epithelial Cell Injury and M1 Macrophage Polarization in Acute Kidney Injury.","authors":"Zhan Chen, Wenqing Chen, Yong Liu, Shaokang Pan, Jiayu Duan, Dongwei Liu, Jiancheng Dong, Zhangsuo Liu, Yingjin Qiao","doi":"10.1111/1749-4877.70113","DOIUrl":"https://doi.org/10.1111/1749-4877.70113","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is characterized by high incidence and mortality rates, and a lack of specific targeted therapies. Inflammatory responses mediated by immune cells and direct damage to renal tubular epithelial cells underlie AKI development. Melanocortin exerts renoprotective effects through systemic immune regulation; however, the renoprotective role of melanocortin 1 receptor (MC1R) remains unclear. MC1R-deficient (e/e) mice developed higher serum creatinine levels, more severe renal dysfunction, and greater histological damage than wild-type (WT) mice following folic acid-induced AKI. Treatment with MC1R agonist MS05 improved experimental nephritis in WT mice; however, this effect was less pronounced in e/e mice. The exacerbation of AKI in e/e mice was associated with damage to renal tubular epithelial cells and macrophage infiltration, where MC1R is highly expressed. MC1R alleviates tubular cell inflammation by inhibiting the nuclear factor-κB pathway and suppresses the polarization of M1 macrophages. Chimeric mice were generated through transplantation of bone marrow-derived macrophages after irradiation. Macrophages from e/e mice with MC1R dysfunction exacerbated kidney injury in WT mice, whereas those from WT mice mitigated kidney injury in e/e mice. Targeting MC1R in renal tubular epithelial cells and macrophages provides a novel treatment concept for AKI.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies.","authors":"Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun","doi":"10.1111/1749-4877.70110","DOIUrl":"https://doi.org/10.1111/1749-4877.70110","url":null,"abstract":"<p><p>Herbivorous insects are among the most ecologically successful animal groups. However, the adaptive mechanisms that allow them to exploit plant hosts, which are often nutrient-poor (low in simple sugars, high in structural carbohydrates) and defended by toxic secondary metabolites, are not fully resolved. Here, we investigated the evolutionary basis of herbivory in Lordiphosa clarofinis, a drosophilid species feeding on living plant tissues, using multi-omics approaches. Behavioral experiments revealed a strong oviposition preference for Galinsoga parviflora (a host rich in secondary metabolites), accompanied by elevated expression of chemosensory genes linked to host discrimination. Comparative genomic analyses revealed lineage-specific expansions of gene families associated with detoxification (e.g., cytochrome P450s) and carbohydrate metabolism, alongside positive selection on genes involved in fatty acid utilization and glycogen synthesis. Transcriptomic data showed differential expression of energy metabolism pathways in response to low-sugar plant diets, with upregulation of genes linked to lipid oxidation and gluconeogenesis. Metagenomic profiling of gut microbiota identified key taxa (e.g., Bacteroidetes) capable of degrading plant polysaccharides and synthesizing essential vitamins, potentially complementing host nutritional intake. Our results demonstrate that herbivory in L. clarofinis is associated with coordinated genomic, transcriptional, and microbial changes, rather than being attributable to a single adaptive mechanism. This study highlights how multi-level biological features covary with plant-based feeding and provides a framework for investigating the complex evolutionary and ecological correlates of herbivory in insects.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant and Fruit Traits Drive the Structure of Bird-Frugivore Networks in a Simplified Coastal Forest of Eastern China.","authors":"Ying Xu, Yimeng He, Yuanwen Pan, Ning Tang, Zheng Wang, Ning Li","doi":"10.1111/1749-4877.70109","DOIUrl":"https://doi.org/10.1111/1749-4877.70109","url":null,"abstract":"<p><p>Plant and fruit functional traits fundamentally structure mutualistic networks in forest ecosystems. However, it remains unclear how these traits affect the network structure in the coastal forests. Understanding the relationship between plant traits and network structure is crucial not only for fundamental ecology, but also for the effective conservation and management in the coastal forest ecosystems. Here, we examined avian-frugivory networks in the coastal forests of Dafeng, eastern China, by integrating key plant (height, canopy density, and fruit yield) and fruit traits (water content, crude fat, sugar, starch, and phenolics). The frugivory network exhibited a specialized and modular structure with significantly lower connectance and nestedness than null model expectations. Generalist species, particularly the light-vented bulbul (Pycnonotus sinensis), acted as the main forager in the network, interacting with all 12 plant species. The results of generalized additive models revealed complex nonlinear relationships between plant functional traits and network structure: fruit yield exhibited a threshold effect on species degree, while water content showed a unimodal effect. Crude fat and tannin content further influenced specialization through saturating and unimodal patterns, respectively. Overall, our study highlight that both structural and nutritional traits critically shape frugivory networks in coastal forests. Our findings also provide a trait-based framework for conservation of coastal forests, underscoring the need to preserve generalist frugivores and prioritize plant species with key functional traits to maintain ecosystem resilience.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Genetic Diversity in Climate Change Refugia Threatens the Endangered Himalayan Red Panda Ailurus fulgens.","authors":"Arjun Thapa, Tianxiao Ma, Fuwen Wei, Yibo Hu","doi":"10.1111/1749-4877.70103","DOIUrl":"https://doi.org/10.1111/1749-4877.70103","url":null,"abstract":"<p><p>Accelerated global warming in the Himalayas poses a significant threat to its unique ecosystem and endemic species, particularly the endangered Himalayan red panda (Ailurus fulgens). It faces severe threats from climate change, habitat fragmentation, and anthropogenic pressures. To assess its conservation status, we evaluated genetic diversity, population structure, and habitat suitability under past, current, and future climate. Using ensemble distribution modeling and landscape genetics approaches, we examined mitochondrial DNA control regions and 12 microsatellite loci, identifying 35 genetically distinct individuals from 196 samples. Two genetic clusters were observed, which included a western population with low genetic diversity (h = 0.200) and high inbreeding (F_IS = 0.178) and a central-eastern population with moderate diversity. Three climate change refugia, persisting since the Last Glacial Maximum, were identified, which covered 52% of the current habitat, but with low genetic diversity. Habitat suitability is projected to decrease by 47.37% (2050) and 51.28% (2070) under the SSP 585 scenario. Approximately 52.76% of the habitat lies within the refugia, with 12 potential linkages between the core habitats, although the western region exhibited high resistance to movement. Urgent actions are needed to protect refugia, enhance connectivity, and promote gene flow to ensure the resilience of this species against climate change and human threats.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Noise on the Juvenile Life Stage of Crustaceans: Behavioral, Cellular, and Molecular Responses in Procambarus clarkii.","authors":"Maria Ceraulo, Giuseppa Buscaino, Clarissa De Vita, Aiti Vizzini, Mirella Vazzana, Elena Papale, Francesco Longo, Francesco Paolo Faraone, Manuela Mauro","doi":"10.1111/1749-4877.70093","DOIUrl":"https://doi.org/10.1111/1749-4877.70093","url":null,"abstract":"<p><p>Underwater noise from human activities is an increasing concern due to its potential ecological impacts. While knowledge on its effects on aquatic species is growing, responses of juvenile invertebrates remain poorly understood. This study investigated behavioral, cellular, and molecular responses to noise (1-20 kHz linear sweep) in juvenile Procambarus clarkii (Girard, 1852). Behavioral parameters (including movement, interactions, feeding, and tail flips) were recorded using overhead video and analyzed with BORIS software. Cellular assays measured esterase, alkaline phosphatase, glucose, total protein (TP), peroxidase, superoxide dismutase (SOD), and cytotoxicity. Additionally, gene expression of crustin, prophenoloxidase (proPO), Heat shock protein 70 (HSP70), Heat shock protein 90 (HSP90), caspase, SOD and catalase (CAT) was assessed via real-time PCR. Specimens exposed to underwater noise exhibited increased interactions and feeding, but no significant changes in movement were observed. Results of cellular analysis revealed elevated protein content, hydrolase, and antioxidant activity, while glucose and cytotoxicity levels decreased. Molecular analyses showed upregulation of immune and stress-related genes (crustin, proPO, HSP70, HSP90, and caspase) and downregulation of SOD and CAT, indicating potential oxidative stress. These findings suggest that even early life stages of invertebrates are sensitive to underwater noise disturbance, affecting the specimens at multiple interconnected levels.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota of Gray Snub-Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis.","authors":"Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li","doi":"10.1111/1749-4877.70092","DOIUrl":"https://doi.org/10.1111/1749-4877.70092","url":null,"abstract":"<p><p>As an extremely endangered species, the gray snub-nosed monkey (Rhinopithecus brelichi) relies on its gut microbiota for adaptation to environmental changes, particularly in coping with fluctuations in energy and nutrient availability. In this study, we employed metagenomic, metatranscriptomic, and widely targeted metabolomic analyses to characterize the gut microbiota of gray snub-nosed monkeys. Based on metagenome-assembled genomes (MAGs), we recovered 1229 non-redundant MAGs. Among them, a total of 103 MAGs exhibited significant seasonal variation, primarily belonging to the phyla Bacillota_A, Bacteroidota, and Bacillota_I. During winter, metagenomic results indicated that the gut microbiota exhibited an enhanced capacity to produce energy substrates such as amino acids, short-chain fatty acids, pyruvate, and acetyl-CoA, with increased conversion of these substrates. Metatranscriptomic analysis further confirmed that key carbon cycle-related genes and metabolic pathways were significantly upregulated in winter. Additionally, metabolite analysis indicated significantly lower levels of amino acids in winter fecal samples, suggesting that gray snub-nosed monkeys efficiently absorb and utilize metabolites, with the gut microbiota likely contributing to energy compensation. Notably, the gut microbiota may also synergistically support the host's non-shivering thermogenesis, helping maintain physiological functions in extreme cold conditions. This study elucidates the cooperative role of the gut microbiota in helping gray snub-nosed monkeys adapt to seasonal environmental fluctuations, providing new insights into how gut microbiota optimize winter energy utilization-an understanding with important implications for the conservation of endangered wildlife.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urbanization Modifies Birds' Acoustic Circadian Timing and Characteristics.","authors":"Wenyu Xu, Jiaxin Li, Yongshan Xu, Zheng Han, Wanlin Huang, Haitao Wang","doi":"10.1111/1749-4877.70089","DOIUrl":"https://doi.org/10.1111/1749-4877.70089","url":null,"abstract":"<p><p>Urban-dwelling organisms face significant challenges, and understanding how species adapt to novel urban environments is critical for conservation planning. In this study, we collected avian vocalization data from 220 sites across varying urbanization gradients in China using autonomous recording units SM4 to investigate how urbanization affects the circadian timing and characteristics of bird vocalizations. We found that all 60 bird species in highly urbanized areas advanced their dawn singing by an average of 23.89 min. Although not statistically significant, the dusk singing time was delayed by an average of 6.56 min. Urban-adapted species showed greater shifts compared to urban-sensitive taxa like woodpeckers. Additionally, by analyzing the acoustic characteristics of 3371 vocalizations from three widely distributed bird species, we investigated how avian acoustic traits vary along urbanization gradients. We found that the Asian tit (Parus cinereus) reduced its maximum frequency in highly urbanized areas. In contrast, the light-vented bulbul (Pycnonotus sinensis) and Eurasian tree sparrow (Passer montanus) adapted to the novel urban environment by increasing their minimum frequency and adjusting song structure. While such adjustments in singing timing and acoustic features may improve signal transmission efficiency, the ecological consequences-particularly in terms of immediate and ultimate fitness-remain largely unknown.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Costs of Biological Invasions in Marine Systems.","authors":"Liyi Yu, Chi Zhang, Shan Li, Aibin Zhan, Stelios Katsanevakis, Phillip J Haubrock, Pierre Courtois, Melina Kourantidou, Ali Serhan Tarkan, David Renault, Ellen J Dolan, Hongkun Huang, Yibo Zhang, Ross N Cuthbert, Chunlong Liu","doi":"10.1111/1749-4877.70099","DOIUrl":"10.1111/1749-4877.70099","url":null,"abstract":"<p><p>Marine systems worldwide are suffering escalating impacts from biological invasions, with increasing threats projected for the future. Despite substantial financial investments in managing marine invasive species, knowledge of their impacts remains patchy across regions and organismal groups. A global assessment of economic costs is urgently needed to assess invasion risk, guide management, and identify knowledge gaps. We analyzed the total economic costs of marine biological invasions worldwide from 1975 to 2021, examining the distributions of costs across time, regions, and organismal groups. Over this period, marine invasive species have cost at least US$4.3 billion, with the majority (US$3.0 billion) resulting from resource damages rather than management investments. These costs revealed substantial geographic and organismal biases. While most entries (56.8%) were associated with invasive plants, most of the costs (76.7%) were linked to invasive invertebrates. Moreover, the majority of costs were driven by a single species within each organismal group. Economic costs were available for only 26 out of 146 coastal countries, with sporadic data from Africa and South America. Economic costs were positively associated with national GDP but unrelated to the number of invaders. Compared to terrestrial (US$2 trillion) and freshwater (US$104.8 billion) systems, marine systems had both lower numbers and magnitudes of economic costs, with all values referring to total costs between 1975 and 2021. These findings highlight the need for improved management and cost-reporting systems to better address the impacts of marine invasions. In particular, management efforts should prioritize high-risk species and highly vulnerable regions, with the development of species-specific management strategies to enhance effectiveness. Moreover, proactive measures, such as strengthened regulations and pathway management, are crucial for reducing future risks and conserving marine biodiversity.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Availability of a Keystone Plant Resource Reduces Niche Overlap and Drives Distinct Species-Specific Changes in Niche Breadth Among Small Rodents.","authors":"Adriana A Perini, Emerson M Vieira","doi":"10.1111/1749-4877.70105","DOIUrl":"https://doi.org/10.1111/1749-4877.70105","url":null,"abstract":"<p><p>The araucaria pine (Araucaria angustifolia) is a putative keystone species in the Araucaria Forest of southern South America. Its large seeds (pinhões) constitute an important food resource for small rodents, whose abundance and trophic dynamics may vary with seed availability. We investigated the dietary importance of Araucaria angustifolia seeds for three native omnivorous sigmodontine rodents-Akodon paranaensis, Oligoryzomys flavescens, and Oligoryzomys nigripes-and evaluated whether their responses to seed availability support a single functional-group assumption. If rodents act as a single functional group, increased pinhão consumption should reduce niche breadth, increase interspecific niche overlap, and raise rodent abundance during seed production. We assessed rodent abundance through trapping over ten months spanning seed production and non-production periods and analyzed stomach contents to characterize diet composition. Food items were grouped into five categories, with arthropods, pinhões, and other seeds or fruits accounting for more than ninety-five percent of all recorded items. Arthropods were consumed more frequently during the non-production period, particularly by Akodon paranaensis. In contrast, Oligoryzomys species consumed more pinhões and reached peak abundance during the production period. Trophic niche overlap was greater than expected by chance only during the non-production period. During seed production, Oligoryzomys species reduced their niche breadth, whereas Akodon paranaensis broadened its diet, being less dependent on Araucaria angustifolia seeds. Overall, species exhibited distinct responses to pinhão availability, with Oligoryzomys spp.-especially O. nigripes-showing stronger functional and numerical responses, underscoring their key role in Araucaria seed-rodent interactions.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147672890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive Evolution of FOXO Family Regulating Lifespan Extension and Cancer Resistance in Long-Lived Species.","authors":"Linxia Sun, Xinrui Chen, Huijie Zhang, Zhikang Xu, Guang Yang, Shixia Xu","doi":"10.1111/1749-4877.70087","DOIUrl":"https://doi.org/10.1111/1749-4877.70087","url":null,"abstract":"<p><p>The extension of lifespan has evolved independently multiple times in mammals. Long-lived species exhibit markedly lower cancer mortality rates, indicating that they may have evolved enhanced cancer resistance to accommodate their prolonged lifespan. The FOXO protein family is considered to play key roles in modulating lifespan and cancer resistance in model organisms. However, the underlying molecular mechanisms of the FOXO protein family regulating lifespan extension and cancer resistance in long-lived species remain poorly understood. Here, evolutionary analysis of four FOXO genes across 137 mammalian species revealed all the four genes were under overall purifying selection. Nonetheless, we detected modestly elevated ω values in long-lived lineages relative to background groups, and 18 positively selected sites were identified in the four FOXO genes in long-lived mammals. To further test whether these FOXO genes have occurred functional changes, we selected FOXO3 and FOXO4 to perform functional validation. Cell experiments demonstrated that bowhead whale FOXO3 and FOXO4 significantly inhibited HeLa cell proliferation, migration, and invasion. Subcellular localization assays showed that mouse FOXO3 and FOXO4 were mostly distributed in the cytosolic cytoplasm, whereas bowhead whale FOXO3 and FOXO4 were predominantly localized in the nucleus, which may increase transcriptional activity and inhibit tumorigenesis in cetaceans. In particular, bowhead whale FOXO3 was found to upregulate the tumor suppressors PTEN and FASL while downregulating the oncogene BCL6, suggesting that this FOXO3-driven expression pattern may underlie cancer resistance in long-lived mammals. Overall, our findings provide novel insights into the molecular mechanisms underlying the cancer resistance in mammals.</p>","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}