Integrative zoology最新文献

Future Climate Change Will Severely Threaten the Current Habitat of Ichthyophis kohtaoensis in China. 未来气候变化将严重威胁中国科陶鱼的生存环境。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-05-08 DOI: 10.1111/1749-4877.70116

Ziyi Zhou, Jieling Lai, Xingzhi Han, Guifen Li, Tingrui Zhang, Zhiling Wu, Baojun Sun, Yongjian Bei

{"title":"Future Climate Change Will Severely Threaten the Current Habitat of Ichthyophis kohtaoensis in China.","authors":"Ziyi Zhou, Jieling Lai, Xingzhi Han, Guifen Li, Tingrui Zhang, Zhiling Wu, Baojun Sun, Yongjian Bei","doi":"10.1111/1749-4877.70116","DOIUrl":"https://doi.org/10.1111/1749-4877.70116","url":null,"abstract":"In the context of climate change, species extinction and biodiversity loss of amphibians have become widespread concerns. Assessing the impacts of climate change on amphibians is a basis for understanding their survival and developing effective conservation strategies. However, some fundamental information, such as the distribution area and determinants of a rare caecilian species (Ichthyophis kohtaoensis), remains largely scarce. To address this gap, we conducted a systematic and integrative investigation by extensive field survey and literature collection to outline the geographic range of this species. With the distribution database, we employed species distribution models to assess the impacts of climate change and human activities on its distribution under current and two future climate scenarios with different shared socioeconomic pathways (SSP1-2.6 and SSP5-8.5). The results indicate that the current distribution of I. kohtaoensis is approximately 186 420 km2, and climate variables are the dominant factor in determining its distribution. Moreover, its current potential habitat area may decrease by more than 42.5%, facing a risk of extinction under climate change. In addition, habitat loss is more severe under the high-emission scenario (SSP5-8.5) than under the low-emission scenario (SSP1-2.6), reflecting the species' sensitivity to climate change. This study also provides fundamental information to guide future population-rediscovery efforts for I. kohtaoensis and to inform the development of conservation strategies and implementation.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadal Development-Related Genes and a Male-Specific Genetic Marker Identified in the Endangered Sichuan Taimen (Hucho bleekeri). 濒危四川台门（Hucho bleekeri）性腺发育相关基因和雄性特异性遗传标记的鉴定。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-29 DOI: 10.1111/1749-4877.70115

Qinyao Wei, Hua Li, Yeyu Chen, Huanchao Yang, Jun Du, Zhaobin Song

{"title":"Gonadal Development-Related Genes and a Male-Specific Genetic Marker Identified in the Endangered Sichuan Taimen (Hucho bleekeri).","authors":"Qinyao Wei, Hua Li, Yeyu Chen, Huanchao Yang, Jun Du, Zhaobin Song","doi":"10.1111/1749-4877.70115","DOIUrl":"https://doi.org/10.1111/1749-4877.70115","url":null,"abstract":"Sex determination and differentiation represent fundamental topics in reproductive biology. Sichuan taimen (Hucho bleekeri), a first-class national protected fish species in China, lacks obvious secondary sexual characteristics, making it challenging to distinguish sex without resorting to invasive methods such as dissection. This limitation presents a significant obstacle to both artificial breeding and conservation efforts for the species. Herein, we performed transcriptome and proteome sequencing to identify sex-biased genes of H. bleekeri. A total of 25 258 significantly differentially expressed genes (DEGs) were identified in gonadal tissues, including 15 071 up-regulated male-biased DEGs. Proteomics analysis identified 2937 differentially expressed proteins (DEPs). Integrated analysis identified several key DEGs, including sdY, CYP11A1, 3β-HSD1, CYP17A1, CYP11B, CYP19A1A, 17β-HSD1, and 17β-HSD8, in which CYP11A1, 3β-HSD1, CYP17A1, and CYP11B exhibited high expression in the testis. Furthermore, the cDNA sequence of the sdY gene was obtained, and in situ hybridization revealed that sdY is exclusively expressed in the Sertoli cells of the testis. In addition, one pair of sdY primers was designed to screen sex-linked markers, and the results confirmed that sdY can serve as a sex-specific marker in H. bleekeri. The present study would provide a foundation for future research on genes involved in sex determination, differentiation, and artificial breeding in H. bleekeri.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA Virus Diversity, Cross-Species Transmission, and Molecular Constraints in Two Closely Related Rat Species. RNA病毒多样性、跨种传播和两种亲缘关系密切的大鼠的分子限制。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-25 DOI: 10.1111/1749-4877.70104

Zhiming Li, Mingyu Zhang, Ruidong Cao, Chengmin Shi, Le Yang, Jianxu Zhang, Yaohua Zhang

{"title":"RNA Virus Diversity, Cross-Species Transmission, and Molecular Constraints in Two Closely Related Rat Species.","authors":"Zhiming Li, Mingyu Zhang, Ruidong Cao, Chengmin Shi, Le Yang, Jianxu Zhang, Yaohua Zhang","doi":"10.1111/1749-4877.70104","DOIUrl":"https://doi.org/10.1111/1749-4877.70104","url":null,"abstract":"Viral infection involves co-evolution with hosts, yet the molecular determinants that constrain viral cross-species transmission remain poorly understood. Here, we established conspecific and heterospecific co-housing models for two closely related rat species, Rattus norvegicus (RN) and Rattus tanezumi (RT), both maintained in laboratory settings for over 10 generations, together with wild-caught RT individuals. Using meta-transcriptomic sequencing and population genomic analyses, we compared their RNA virus profiles and investigated the potential molecular constraints on cross-species viral transmission. From 63 rats, we characterized an extensive RNA virome comprising more than 600 viruses, including 7 zoonotic viruses, 29 viruses with cross-species transmission potential, and 335 novel viruses. Notably, the prevalence of Seoul orthohantavirus (SEOV) was significantly higher in RN than in RT. Population genomic analysis revealed that RN exhibited higher heterozygosity in Itgb3 (the gene encoding the SEOV receptor, β3-integrin) and Tlr7 (the gene encoding the receptor for viral ssRNA, Toll-like receptor 7) compared to RT. These genetic variations likely represent the molecular determinants responsible for the differential susceptibility to SEOV between the two species. Our findings clarify the diversity and prevalence of RNA viruses in closely related rodent species and highlight host genetic barriers that may influence zoonotic spillover risk.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adapting to Urban Heights: Multidimensional Gradients Drive Nest-Selection Plasticity and Trade-Offs in a Human-Commensal Sparrow. 对城市高地的适应：多维梯度驱动人类共生麻雀的筑巢选择可塑性和权衡。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-24 DOI: 10.1111/1749-4877.70111

Yang Wang, Guanqun Kou, Fangyuan Liu, Xu Liu, Juyong Li, Jie Wang, Qian Zhang, Yuan Yin, Limin Wang, John C Wingfield, Fumin Lei, Dongming Li

{"title":"Adapting to Urban Heights: Multidimensional Gradients Drive Nest-Selection Plasticity and Trade-Offs in a Human-Commensal Sparrow.","authors":"Yang Wang, Guanqun Kou, Fangyuan Liu, Xu Liu, Juyong Li, Jie Wang, Qian Zhang, Yuan Yin, Limin Wang, John C Wingfield, Fumin Lei, Dongming Li","doi":"10.1111/1749-4877.70111","DOIUrl":"https://doi.org/10.1111/1749-4877.70111","url":null,"abstract":"Urbanization is reshaping ecosystems worldwide, driving wildlife to navigate and adapt to novel and highly dynamic environments. The Eurasian tree sparrow (Passer montanus, ETS) serves as an exemplary human commensal, thriving in cities through exceptional behavioral and ecological flexibility. Here, we systematically investigated the nest-site selection strategies of ETSs across 645 residential buildings across 22 cities in northern China, integrating climatic, geographic, biotic, and anthropogenic variables at a macroecological scale. We found that both the availability and use of nest height preference increased with building height, underscoring ETSs' capacity to exploit vertical resources in dense urban landscapes. Notably, the preference for lower nest heights when nest sites were abundant suggests a strategy to reduce intraspecific competition and energy expenditure. Negative associations between nest-site use or preference and the normalized difference vegetation index indicate that ETSs favor anthropogenic over vegetated resources, likely to circumvent interspecific competition in urban green spaces. Additionally, altitudinal gradients modulated ETSs' nesting responses: At lower elevations, higher building heights promoted nesting, whereas increased economic development (gross domestic product per cell) and noise suppressed it-signaling an avoidance of intense anthropogenic disturbance. Conversely, ETSs showed reduced competition at higher altitudes and increasingly relied on resources linked to urban prosperity. These findings reveal context-dependent patterns of nest-site selection in ETSs across multidimensional urban gradients. Our study documents behavioral plasticity in a highly successful urban-commensal species and highlights the need for future research linking such patterns to individual fitness, population persistence, and broader biodiversity management in cities.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Large-Scale Surveying and Monitoring of Large Wild Animals Using Unmanned Aerial Vehicles. 基于无人机的大型野生动物大规模调查与监测研究进展。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-23 DOI: 10.1111/1749-4877.70108

Songtao Guo, Gang He, Hengguang Fu, Yule Xie, Shiyu Jin, Mengya Han, Tongzuo Zhang, Guofan Shao, Ya Wen, Derek W Dunn, Ruliang Pan, Linshan Yang, Huihui Du, Jia Jia, Liyuan Hao, Fuwen Wei, Baoguo Li

{"title":"Advances in Large-Scale Surveying and Monitoring of Large Wild Animals Using Unmanned Aerial Vehicles.","authors":"Songtao Guo, Gang He, Hengguang Fu, Yule Xie, Shiyu Jin, Mengya Han, Tongzuo Zhang, Guofan Shao, Ya Wen, Derek W Dunn, Ruliang Pan, Linshan Yang, Huihui Du, Jia Jia, Liyuan Hao, Fuwen Wei, Baoguo Li","doi":"10.1111/1749-4877.70108","DOIUrl":"https://doi.org/10.1111/1749-4877.70108","url":null,"abstract":"As the number of endangered animal species increases, their conservation requires effective methods for the surveying and monitoring of the spatial and temporal distributions of targeted species, often on a large scale. Traditional methods often fail to meet the requirements for effective, large-scale surveying and monitoring due to inherent limitations. The use of unmanned aerial vehicles (UAVs) for wild animal surveys presents a promising alternative to traditional ground-based methods, particularly for large-scale monitoring. However, its application has been predominantly limited to open landscapes, leaving a significant gap for surveys in complex, forested environments that host numerous elusive and endangered large vertebrate species. This review synthesizes recent advancements and critically assesses the challenges of UAV-based surveys for large vertebrates. We systematically evaluate suitable survey strategies (e.g., absolute/relative and overall/sampling), platform types (fixed-wing vs. rotary-wing), and airborne detectors (RGB, thermal, and multispectral) for different contexts. We conclude that the future of large-scale wildlife monitoring in rugged, mountainous regions relies on the integration of three key technologies: (1) developing long-endurance UAV platforms, (2) employing multi-spectral detection equipment to acquire multimodal data, and (3) establishing efficient, artificial intelligence-driven data processing pipelines. By addressing these priorities, UAV technology can fully realize its potential to provide accurate, efficient, and non-invasive monitoring solutions for large vertebrate populations in their most challenging habitats.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Earliest Feathers from the Lower Cretaceous Dabeigou Formation of North Hebei: Implications for the Early Evolution of the Jehol Biota. 冀北下白垩统大北沟组最早的羽毛：对热河生物群早期演化的启示

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-22 DOI: 10.1111/1749-4877.70106

Qian Wu, Qian-Nan Zhang, Dang-Peng Xi

{"title":"The Earliest Feathers from the Lower Cretaceous Dabeigou Formation of North Hebei: Implications for the Early Evolution of the Jehol Biota.","authors":"Qian Wu, Qian-Nan Zhang, Dang-Peng Xi","doi":"10.1111/1749-4877.70106","DOIUrl":"https://doi.org/10.1111/1749-4877.70106","url":null,"abstract":"The Middle-Late Jurassic Yanliao Biota and the Early Cretaceous Jehol Biota in northeastern China are renowned for their numerous exceptional fossils of feathered non-avian dinosaurs and early avialans, which are pivotal for elucidating the origins and evolutionary trajectories of birds. The Early Cretaceous witnessed a rapid diversification of terrestrial biotas, with the Jehol Biota serving as one of the most typical and famous assemblages in China from this era. In this report, we present two isolated feather specimens recovered from the oldest sedimentary strata of the Dabeigou Formation, located within the Luanping Basin in northern Hebei Province, China. Both feather specimens are preserved as carbonized residues, and morphological analyses indicate that they represent some of the earliest feathered theropods from the Jehol Group reported to date, potentially including avian taxa. This discovery not only enriches the evidence for diverse terrestrial vertebrate groups of the Jehol Biota but also signifies the establishment of a complex ecosystem during the biota's early evolutionary stages.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans. 转录组学揭示了Dsx1在甲壳类动物两性异形中的关键调节作用。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-22 DOI: 10.1111/1749-4877.70114

Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou

{"title":"Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans.","authors":"Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou","doi":"10.1111/1749-4877.70114","DOIUrl":"https://doi.org/10.1111/1749-4877.70114","url":null,"abstract":"Sexually dimorphic traits are involved in reproductive competition and are specified during development through sex-biased gene expression programs. Here, we test this hypothesis using RNA-seq data from male and female T3 legs throughout the development of crustacean amphipods. Through comparative transcriptome, we found that Dsx1 shows male-biased expression during development of Morinoia aosen, and explored its phylogeny. Next, we performed RNA interference on amputated males, and found that knockdown of Dsx1 cause the feminization of the regenerated dactylus of T3 legs. Finally, to understand the genetic regulation of the embryonic development of sex differences, we conducted CRISPR-Cas9 knockout in crustacean model species Parhyale hawaiensis, to validate the feminization of T3 legs in male mutants. Together, phylogenetic analyses and gene knockout experiments identified homologous genes and revealed the conserved function of Dsx1 across different species. Our study provides insight into the causal relationship between sex-biased gene expression and sexually dimorphic traits.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress. 代谢组多样性增强潮间带蛤对热胁迫的抵抗力。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-22 DOI: 10.1111/1749-4877.70107

Zhi Hu, Xiang-Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong

{"title":"Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress.","authors":"Zhi Hu, Xiang-Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong","doi":"10.1111/1749-4877.70107","DOIUrl":"https://doi.org/10.1111/1749-4877.70107","url":null,"abstract":"Global warming and marine heatwaves have devastating impacts on marine ectotherms. Clams inhabiting sandflats are frequently exposed to air and high temperatures. Different geographical species/populations facing diverse thermal environments may exhibit divergent physiological capabilities to cope with local conditions, and understanding species/population-specific physiological plasticity has been highlighted as important to fully uncover species' tolerance capacity within the highly heterogeneous spatial patterns. In the present study, we conducted metabolomic analyses of four Meretrix populations along China's coast, including three populations of Meretrix petechialis and one of Meretrix lusoria, to illustrate species/population-specific metabolomic responses to thermal stress. Our results indicated that the thermal environments of clam habitats varied along the coastlines. Metabolome responses showed species/population-specific patterns in response to high temperatures, suggesting metabolomic plasticity among species/populations. The northern populations mainly respond to high-temperature stress by enhancing antioxidant defenses and adjusting energy metabolism. Glycerophospholipid metabolism was a vital metabolic response to thermal stress in the southern species/population. GDP-L-fucose levels were positively correlated with the clams' upper thermal limits. Additionally, metabolite-based genome-wide association studies on GDP-L-fucose identified six candidate genes: neuropeptide FF receptor 2-like, E3 ubiquitin-protein ligase rnf213-alpha-like isoform X2, uncharacterized protein LOC123550816, solute carrier family 28 member 3-like isoform X1, adenylate kinase isoenzyme 5-like isoform X6, and E3 ubiquitin-protein ligase TRIM33-like, highlighting the potential roles of codon usage bias and changes in protein structure. Overall, we emphasized metabolome diversity across species/populations and stressed the importance of accounting for it when assessing the impacts of climate change on marine ectotherms.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanocortin 1 Receptor Signaling Protects Against Tubular Epithelial Cell Injury and M1 Macrophage Polarization in Acute Kidney Injury. 黑素皮质素1受体信号传导对急性肾损伤小管上皮细胞损伤和M1巨噬细胞极化的保护作用

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-22 DOI: 10.1111/1749-4877.70113

Zhan Chen, Wenqing Chen, Yong Liu, Shaokang Pan, Jiayu Duan, Dongwei Liu, Jiancheng Dong, Zhangsuo Liu, Yingjin Qiao

{"title":"Melanocortin 1 Receptor Signaling Protects Against Tubular Epithelial Cell Injury and M1 Macrophage Polarization in Acute Kidney Injury.","authors":"Zhan Chen, Wenqing Chen, Yong Liu, Shaokang Pan, Jiayu Duan, Dongwei Liu, Jiancheng Dong, Zhangsuo Liu, Yingjin Qiao","doi":"10.1111/1749-4877.70113","DOIUrl":"https://doi.org/10.1111/1749-4877.70113","url":null,"abstract":"Acute kidney injury (AKI) is characterized by high incidence and mortality rates, and a lack of specific targeted therapies. Inflammatory responses mediated by immune cells and direct damage to renal tubular epithelial cells underlie AKI development. Melanocortin exerts renoprotective effects through systemic immune regulation; however, the renoprotective role of melanocortin 1 receptor (MC1R) remains unclear. MC1R-deficient (e/e) mice developed higher serum creatinine levels, more severe renal dysfunction, and greater histological damage than wild-type (WT) mice following folic acid-induced AKI. Treatment with MC1R agonist MS05 improved experimental nephritis in WT mice; however, this effect was less pronounced in e/e mice. The exacerbation of AKI in e/e mice was associated with damage to renal tubular epithelial cells and macrophage infiltration, where MC1R is highly expressed. MC1R alleviates tubular cell inflammation by inhibiting the nuclear factor-κB pathway and suppresses the polarization of M1 macrophages. Chimeric mice were generated through transplantation of bone marrow-derived macrophages after irradiation. Macrophages from e/e mice with MC1R dysfunction exacerbated kidney injury in WT mice, whereas those from WT mice mitigated kidney injury in e/e mice. Targeting MC1R in renal tubular epithelial cells and macrophages provides a novel treatment concept for AKI.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies. 多组学分析揭示了Lordiphosa蝇在基因、代谢和肠道微生物群方面的协调适应。

IF 3.7 1区生物学

Integrative zoology Pub Date : 2026-04-21 DOI: 10.1111/1749-4877.70110

Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun

{"title":"Multi-Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies.","authors":"Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun","doi":"10.1111/1749-4877.70110","DOIUrl":"https://doi.org/10.1111/1749-4877.70110","url":null,"abstract":"Herbivorous insects are among the most ecologically successful animal groups. However, the adaptive mechanisms that allow them to exploit plant hosts, which are often nutrient-poor (low in simple sugars, high in structural carbohydrates) and defended by toxic secondary metabolites, are not fully resolved. Here, we investigated the evolutionary basis of herbivory in Lordiphosa clarofinis, a drosophilid species feeding on living plant tissues, using multi-omics approaches. Behavioral experiments revealed a strong oviposition preference for Galinsoga parviflora (a host rich in secondary metabolites), accompanied by elevated expression of chemosensory genes linked to host discrimination. Comparative genomic analyses revealed lineage-specific expansions of gene families associated with detoxification (e.g., cytochrome P450s) and carbohydrate metabolism, alongside positive selection on genes involved in fatty acid utilization and glycogen synthesis. Transcriptomic data showed differential expression of energy metabolism pathways in response to low-sugar plant diets, with upregulation of genes linked to lipid oxidation and gluconeogenesis. Metagenomic profiling of gut microbiota identified key taxa (e.g., Bacteroidetes) capable of degrading plant polysaccharides and synthesizing essential vitamins, potentially complementing host nutritional intake. Our results demonstrate that herbivory in L. clarofinis is associated with coordinated genomic, transcriptional, and microbial changes, rather than being attributable to a single adaptive mechanism. This study highlights how multi-level biological features covary with plant-based feeding and provides a framework for investigating the complex evolutionary and ecological correlates of herbivory in insects.","PeriodicalId":13654,"journal":{"name":"Integrative zoology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0