Innovations in clinical neuroscience最新文献_第9页

Sociodemographic Factors and Consanguinity in Intellectual Disability: A Pilot Study. 智力残疾的社会人口因素与血缘关系：一项初步研究。

Innovations in clinical neuroscience Pub Date : 2024-12-01 eCollection Date: 2024-10-01

Yousra Benmakhlouf, Achraf Laghmich, Kaoutar Ben Makhlouf, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita

{"title":"Sociodemographic Factors and Consanguinity in Intellectual Disability: A Pilot Study.","authors":"Yousra Benmakhlouf, Achraf Laghmich, Kaoutar Ben Makhlouf, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Arab populations have a long tradition of consanguinity. In Morocco, consanguineous marriages are culturally favored. In this study, we assessed the effect of consanguinity on the occurrence of intellectual disability (ID) and investigated its association to education level and professional status in a series of Moroccan families.Design: In total, 186 patients with ID were included in this study. Data were processed and analyzed with the IBM SPSS.Results: The rate of consanguinity among the parents of children with ID was 34.95 percent. Marriages between first cousins accounted for 24.19 percent of consanguineous unions (FI=0.02). In the general population (n=300), 27.3 percent of marriages were consanguineous, with 22.66 percent being marriages between first cousins. Marriage between first cousins was the most common type of consanguineous marriage. The illiteracy rate was greater among women, compared to men (56.9% vs. 37.87%). The majority of mothers (81.11%) were housewives. A predominance of low professional status was observed among the men (62.22% of population, 22.7%). There was a high correlation between consanguinity and ID. The association between education level, professional status, and consanguinity rate in ID was not statistically significant (p>0.05).Conclusion: The consanguinity rate in Moroccan families remains important. More strategies and efforts must be taken and reinforced for a better understanding and awareness of consanguinity risks to significantly reduce this practice.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 10","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11709441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Levels of Vitamin D, Beta-Amyloid 42, Indoxyl Sulfate, and Serum Parathyroid Hormone in Hemodialysis Patients with Cognitive Impairment. 血液透析伴认知障碍患者血清维生素D、β -淀粉样蛋白42、硫酸吲哚酚和甲状旁腺激素水平分析

Innovations in clinical neuroscience Pub Date : 2024-12-01 eCollection Date: 2024-10-01

Yuliarni Syafrita, Harnavi Harun, Restu Susanti, Syarif Indra

{"title":"Analysis of Levels of Vitamin D, Beta-Amyloid 42, Indoxyl Sulfate, and Serum Parathyroid Hormone in Hemodialysis Patients with Cognitive Impairment.","authors":"Yuliarni Syafrita, Harnavi Harun, Restu Susanti, Syarif Indra","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Cognitive impairment is a recurrent complication in people with chronic kidney disease (CKD), which includes those undergoing hemodialysis (HD). Researchers aimed to analyze vitamin D levels, beta-amyloid 42, indoxyl sulfate, and serum parathyroid hormone (PTH) in patients with cognitive impairment who underwent HD.Design: This comparative, cross-sectional study was conducted at the HD unit of Dr. M Djamil Padang Hospital. This study enrolled 60 patients with CKD who underwent routine HD and 20 normal subjects as controls. In both groups, serum levels of vitamin D, beta-amyloid 42, indoxyl sulfate, and PTH were measured using the enzyme-linked immunosorbent assay method, and cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment neuropsychological test.Results: The mean±standard deviation age of the study subjects was 51.48±11.44 years, with 53.4 percent being male. Vitamin D levels were higher in the control group, compared to the case group (p<0.05). The case group had higher levels of beta-amyloid, indoxyl sulfate, and PTH, compared to the control group (p<0.05). Significant differences were found in vitamin D and indoxyl sulfate levels between the groups with and without cognitive impairment (p<0.05).Conclusion: Lower levels of vitamin D and higher levels of indoxyl sulfate were observed in the group with cognitive impairment when compared to the group without cognitive impairment.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 10","pages":"44-47"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11709437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Management: Fires, Floods, Hurricanes, Oh My! The Importance of Disaster Planning. 风险管理：火灾、洪水、飓风，哦，我的天！灾害规划的重要性。

Innovations in clinical neuroscience Pub Date : 2024-09-01 eCollection Date: 2024-07-01

Akemini Kem Isang

引用次数: 0

Overview of Psychiatric Medications in the Pipeline in Phase III Trials as of June 1, 2024: A Systematic Review. 截至 2024 年 6 月 1 日正在进行 III 期临床试验的精神科药物概览：系统回顾。

Innovations in clinical neuroscience Pub Date : 2024-09-01 eCollection Date: 2024-07-01

Waguih William IsHak, Ashley Meyer, Luiza Freire, Jayant Totlani, Nathalie Murphy, Sabrina Renteria, Mohamed Salem, Tiffany Chang, Rasha Abdelsalam, Rida Khan, Thomas Chandy, Thomas Parrish, Drew Hirsch, Bhumika Patel, Alexander J Steiner, Sarah Kim, Rebecca Hedrick, Robert N Pechnick, Itai Danovitch

{"title":"Overview of Psychiatric Medications in the Pipeline in Phase III Trials as of June 1, 2024: A Systematic Review.","authors":"Waguih William IsHak, Ashley Meyer, Luiza Freire, Jayant Totlani, Nathalie Murphy, Sabrina Renteria, Mohamed Salem, Tiffany Chang, Rasha Abdelsalam, Rida Khan, Thomas Chandy, Thomas Parrish, Drew Hirsch, Bhumika Patel, Alexander J Steiner, Sarah Kim, Rebecca Hedrick, Robert N Pechnick, Itai Danovitch","doi":"","DOIUrl":"","url":null,"abstract":"Objective: This systematic review provides an overview of psychiatric medications in the late stages of development (Phase III clinical trials) as of June 1, 2024. It details the mechanisms of action, efficacy, dosing, and adverse effects of these medications.Methods: We searched the PubMed database for Phase III studies of psychiatric medications published until June 1, 2024, using the keywords \"psychiatric\" OR \"psychopharm*\" AND \"medic*\" OR \"pharm*\". Our review encompassed medications currently undergoing Phase III clinical trials and those that have completed Phase III but are awaiting approval from the United States Food and Drug Administration (FDA). We independently analyzed the identified studies and reached a consensus on the medications to be included in this systematic review.Results: As of June 1, 2024, a total of 89 pipeline drug trials were identified, including nine for schizophrenia, five for bipolar disorders, 25 for depressive disorders, 11 for anxiety disorders, five for post-traumatic stress disorder (PTSD), one for obsessive compulsive disorder (OCD), two for eating disorders, two for sleep-wake disorders, three for sexual dysfunctions, one for substance-related and addictive disorders, 22 for neurocognitive disorders, and three for neurodevelopmental disorders, specifically attention deficit hyperactivity disorder (ADHD).Conclusion: The psychiatric medications in the pipeline as of June 1, 2024, demonstrate significant promise in treating psychiatric disorders.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 7-9","pages":"27-47"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of the serotonergic neurotransmission is a double-edged sword in the treatment of burning mouth syndrome. 激活血清素能神经递质是治疗灼口综合征的一把双刃剑。

Innovations in clinical neuroscience Pub Date : 2024-09-01 eCollection Date: 2024-07-01

Takahiko Nagamine

引用次数: 0

Literary Prescriptions: Applying Bibliotherapy in a Psychotherapeutic Context. 文学处方：在心理治疗背景下应用书目疗法。

Innovations in clinical neuroscience Pub Date : 2024-09-01 eCollection Date: 2024-07-01

Andrew B Correll, Terry L Correll, Matthew C Correll

{"title":"Literary Prescriptions: Applying Bibliotherapy in a Psychotherapeutic Context.","authors":"Andrew B Correll, Terry L Correll, Matthew C Correll","doi":"","DOIUrl":"","url":null,"abstract":"Bibliotherapy, a relatively underutilized lifestyle intervention in psychotherapy, is a unique cost-effective avenue of treatment that empowers patients by integrating therapeutic reading into their treatment plan. This approach strategically uses empirically validated cognitive-behavioral and self-help literature to facilitate the application of therapeutic topics outside of psychotherapy sessions. Bibliotherapy's range of administration styles highlights its potential as an adjunct to medication, psychotherapy, and/or healthy lifestyle interventions in a comprehensive treatment plan. Most meta-analyses conducted so far regarding bibliotherapy in a clinical setting consist of studies that use minimal patient interaction via short phone calls or emails. Despite this, meta-analyses show medium-to-large effect sizes that are comparable to traditional psychotherapy modalities for common disorders, most notably depression. This article explores the practical implementation of bibliotherapy research via an example psychotherapy session with a patient who has a diagnosis of major depressive disorder (MDD). An evidence-based reading list is proposed alongside a decision tree and actionable clinical insights for the effective implementation of bibliotherapy.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 7-9","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropsychological Functioning Among Patients with OCD in Asian Countries: A Systematic Review. 亚洲国家强迫症患者的神经心理功能：系统回顾

Innovations in clinical neuroscience Pub Date : 2024-09-01 eCollection Date: 2024-07-01

Uzma Ilyas, Sabeela Saher, Ayesha Ahmad Khan, Anam Shahid, Zarmin Tariq

{"title":"Neuropsychological Functioning Among Patients with OCD in Asian Countries: A Systematic Review.","authors":"Uzma Ilyas, Sabeela Saher, Ayesha Ahmad Khan, Anam Shahid, Zarmin Tariq","doi":"","DOIUrl":"","url":null,"abstract":"Objective: This systematic review aimed to identify the effect of obsessive compulsive disorder (OCD) on cognitive processes, such as memory, executive functioning, and cognitive flexibility, among the adult populations of Asian countries.Methods: The systematic review progressed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. It is comprised of articles sourced from Asian countries published from 2018 to 2022, and literature about deficits in memory, executive functioning, and cognitive flexibility in the OCD population was gathered from five electronic databases, including Google Scholar, PubMed, Research Gate, Science Direct, and Wiley Online Library. Full-text impact factor articles in the English language were considered in this study.Results: This study screened 44 articles; five were included based on the eligibility criteria for the present systematic review. Four articles found cognitive deficits in the domains of executive functioning, memory, and cognitive flexibility among patients with OCD, whereas results of one article showed normal cognitive performance of the patients. Demographic variables showed no significant differences between patients with OCD and healthy controls.Conclusion: This systematic review indicated deficits specifically in the cognitive functioning and flexibility of patients with OCD. Despite a noticeable prevalence of OCD in Asian countries, the literature on correlates and neurological functioning is scarce. Further studies are required to examine the effects on the larger population and provide knowledge in those countries and areas where people are suffering because of minimal knowledge regarding OCD.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 7-9","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Clinical Characteristics of Intellectual Disability in Morocco. 摩洛哥智力残疾临床特征研究。

Innovations in clinical neuroscience Pub Date : 2024-09-01 eCollection Date: 2024-07-01

Houda Bekkari, Yousra Benmakhlouf, Naima Ghailani Nourouti, Amina Barakat, Mohcine Bennani Mechita

{"title":"Study of Clinical Characteristics of Intellectual Disability in Morocco.","authors":"Houda Bekkari, Yousra Benmakhlouf, Naima Ghailani Nourouti, Amina Barakat, Mohcine Bennani Mechita","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Intellectual disability (ID) is considered one of the most common human disorders characterized by significant deficits in cognition and functional and adaptive skills. The aims of this study were to describe the demographic and clinical features of a group of Moroccan individuals with ID living in the Tangier-Tetouan region.Design: This was a retro-prospective and descriptive exploratory monocentric study realized between November 2020 and August 2023. A total of 109 patients with ID were included. They were selected at four mental health centers in the Tangier-Tetouan region. Our data were treated and analyzed using the IBM SPSS version 26.Results: A male predominance of patients with ID was observed in our series (54.4% male vs. 42.6% female). The male-to-female ratio was 1.34. The mean±standard deviation (SD) age of our patients was 11.75±4.87 years, ranging from 1 to 35 years. The mean ages of mothers and fathers at the births of their children with ID were 28.36 and 35.6 years, respectively. Many co-occurring medical conditions were noted in our data (speech delay: 20.5%, concentration problems: 15.1%, hyperactivity: 11.1%, ambulation difficulties: 8.8%, aggressiveness: 8%, vision problems: 6.3%, epileptic seizures: 4%). The consanguinity rate was 26.9 percent.Conclusion: ID associated with genetic causes was significantly correlated with the consanguinity rate in the Moroccan population.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 7-9","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "ChatGPT and Transcranial Direct Current Stimulation for Chronic Pain". 回应 "ChatGPT 和经颅直流电刺激治疗慢性疼痛"。

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

The Impact of High-density Lipoprotein Cholesterol (HDL-C) Levels and Risk of Movement Disorders in Patients Taking Antipsychotics. 高密度脂蛋白胆固醇 (HDL-C) 水平与服用抗精神病药物患者运动障碍风险的影响。

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Carolyn O'Donnell, Tammie Lee Demler, Eileen Trigoboff, Claudia Lee

{"title":"The Impact of High-density Lipoprotein Cholesterol (HDL-C) Levels and Risk of Movement Disorders in Patients Taking Antipsychotics.","authors":"Carolyn O'Donnell, Tammie Lee Demler, Eileen Trigoboff, Claudia Lee","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Well-known adverse events of antipsychotics are movement disorders, or extrapyramidal symptoms, such as drug-induced parkinsonism and tardive dyskinesia.Objective: With new evidence suggesting a link between low high-density lipoprotein cholesterol (HDL-C) and risk of Parkinson's disease, this study sought to investigate if that link also translated to patients taking antipsychotics with low HDL-C and an increased risk for developing a movement disorder.Design: Adult patients (n=89) at an inpatient state psychiatric facility taking at least one antipsychotic with at least one HDL-C level were assessed for signs of a movement disorder through their history and physical, progress notes, and Abnormal Involuntary Movement Scale (AIMS) score.Results: There was no statistical significance when comparing a patient's movement disorder, AIMS scores, and HDL-C levels to suggest that the HDL-C level influenced a patient's movement disorder.Conclusion: This study did not show a correlation between HDL-C levels and a patient's risk of developing a movement disorder while taking an antipsychotic.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 4-6","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0