血液透析伴认知障碍患者血清维生素D、β -淀粉样蛋白42、硫酸吲哚酚和甲状旁腺激素水平分析

Q3 Medicine
Innovations in clinical neuroscience Pub Date : 2024-12-01 eCollection Date: 2024-10-01
Yuliarni Syafrita, Harnavi Harun, Restu Susanti, Syarif Indra
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引用次数: 0

摘要

目的:认知障碍是慢性肾脏疾病(CKD)患者的复发性并发症,包括接受血液透析(HD)的患者。研究人员旨在分析患有认知障碍的HD患者的维生素D水平、β -淀粉样蛋白42、硫酸吲哚酚和血清甲状旁腺激素(PTH)。设计:这项比较的横断面研究是在Dr. M Djamil Padang医院的HD部门进行的。这项研究招募了60名CKD患者,他们接受了常规的HD治疗,20名正常受试者作为对照。在两组中,使用酶联免疫吸附法测量血清维生素D、β -淀粉样蛋白42、硫酸吲哚酚和甲状旁腺激素水平,并使用印度尼西亚版的蒙特利尔认知评估神经心理测试评估认知功能。结果:研究对象的平均±标准差年龄为51.48±11.44岁,男性占53.4%。结论:与无认知障碍组相比,认知障碍组的维生素D水平较低,硫酸吲哚酚水平较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Levels of Vitamin D, Beta-Amyloid 42, Indoxyl Sulfate, and Serum Parathyroid Hormone in Hemodialysis Patients with Cognitive Impairment.

Objective: Cognitive impairment is a recurrent complication in people with chronic kidney disease (CKD), which includes those undergoing hemodialysis (HD). Researchers aimed to analyze vitamin D levels, beta-amyloid 42, indoxyl sulfate, and serum parathyroid hormone (PTH) in patients with cognitive impairment who underwent HD.

Design: This comparative, cross-sectional study was conducted at the HD unit of Dr. M Djamil Padang Hospital. This study enrolled 60 patients with CKD who underwent routine HD and 20 normal subjects as controls. In both groups, serum levels of vitamin D, beta-amyloid 42, indoxyl sulfate, and PTH were measured using the enzyme-linked immunosorbent assay method, and cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment neuropsychological test.

Results: The mean±standard deviation age of the study subjects was 51.48±11.44 years, with 53.4 percent being male. Vitamin D levels were higher in the control group, compared to the case group (p<0.05). The case group had higher levels of beta-amyloid, indoxyl sulfate, and PTH, compared to the control group (p<0.05). Significant differences were found in vitamin D and indoxyl sulfate levels between the groups with and without cognitive impairment (p<0.05).

Conclusion: Lower levels of vitamin D and higher levels of indoxyl sulfate were observed in the group with cognitive impairment when compared to the group without cognitive impairment.

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Innovations in clinical neuroscience
Innovations in clinical neuroscience Medicine-Psychiatry and Mental Health
CiteScore
2.10
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