Innovations in clinical neuroscience最新文献_第8页

RISK MANAGEMENT: "Covering" Your Bases: Managing Risk While Away from Your Practice or Filling in for a Colleague. 风险管理：“覆盖”你的基础：在离开你的诊所或代替同事时管理风险。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Ann L McNary

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Depersonalization/Derealization Disorder and Neural Correlates of Trauma-related Pathology: A Critical Review. 创伤相关病理学的人格解体/Derealization障碍和神经相关性：一项批评性综述。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Rachael J Murphy

{"title":"Depersonalization/Derealization Disorder and Neural Correlates of Trauma-related Pathology: A Critical Review.","authors":"Rachael J Murphy","doi":"","DOIUrl":"","url":null,"abstract":"Depersonalization and derealization refer to an estranged state of mind that involves a profound feeling of detachment from one's sense of self and the surrounding environment, respectively. The phenomena co-occur on a continuum of severity, ranging from a transient experience as a normal reaction to a traumatic event to a highly debilitating condition with persistent symptoms, formally described as depersonalization/derealization disorder (DPDR). Lack of awareness of DPDR is partly due to a limited neurobiological framework, and there remains a significant risk of misdiagnosis in clinical practice. Earlier literature has focused on several brain regions involved in the experience of depersonalization and derealization, including adaptive responses to stress via defense cascades comprising autonomic functioning, the hypothalamic-pituitary-adrenal (HPA) axis, and various other neurocircuits. Recent evidence has also demonstrated the role of more complex mechanisms that are bolstered by dissociative features, such as emotional dysregulation and disintegration of the body schema. This review intends to abridge the prevailing knowledge regarding structural and functional brain alterations associated with DPDR with that of its heterogenic manifestations. DPDR is not merely the disruption of various sensory integrations, but also of several large-scale brain networks. Although a comprehensive antidote is not available for DPDR, a holistic route to the neurobiological context in DPDR may improve general understanding of the disorder and help afflicted individuals re-establish their sense of personal identity. Such information may also be useful in the development of novel pharmacological agents and targeted psychological interventions.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"20 1-3","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132272/pdf/icns_20_1-3_53.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Existential Issues in Psychotherapy. 心理治疗中的存在问题。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Brent Schnipke, Michael MacKay

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Open Bite Malocclusion Following Aripiprazole Treatment in Children and Adolescents. 儿童和青少年阿立哌唑治疗后的开牙合错。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Takahiko Nagamine

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Bipolar I Disorder Exacerbation and COVID-19 Vaccination: Correspondence. 双相情感障碍I加重与新冠肺炎疫苗接种：对应。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit

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Development of a Symbol Cancellation Test to Evaluate Attention in a School-aged Zambian Population. 开发一种符号消除测试来评估赞比亚学龄人口的注意力。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Franco di Cesare, Cristiana di Carlo, Leonardo di Cesare

{"title":"Development of a Symbol Cancellation Test to Evaluate Attention in a School-aged Zambian Population.","authors":"Franco di Cesare, Cristiana di Carlo, Leonardo di Cesare","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The assessment of child cognitive health in Sub-Saharan developing countries poses significant challenges, including the paucity of valid diagnostic tools. We report the development and the initial validation of the Zambia Symbol Cancellation Test (ZSCT), a psychometric test to evaluate selective attention in a pediatric, school-aged population.Design: ZSCT reliability and validity were assessed in a field trial. A total of 409 children, aged 5 to 17 years, were recruited at multiple Zambian clinical sites and schools. The ZSCT provides a visuomotor processing index (VMPI), a measure of effortful processing to deliver accurate task response.Results: The VMPI reliability estimate at test-retest was found to be adequate for a clinical use (intraclass correlation coefficient [ICC]: 0.79, ICC-95% confidence interval [CI]: 0.69-0.86). Age showed a large effect on VMPI (n=323, r=-0.62, p=0.000). Impaired visuo-perceptual-motor processing, as measured by VMPI, was associated with poor health status (i.e., chronic neurologic or medical disease or prolonged exposure to psychosocial stress and deprivation). A two-way ANOVA found significant and small health status and age group effects [F (7, 408): 33.24, p=0.0000, η2=0.367]; the main effect of health status [F (1, 408): 37.79, p=0.000, η2=0.09], age group [F (3, 408): 35.06, p=0.000, η2=0.21], and their interaction was not significant (p=0.364).Conclusion: Study findings indicate that the ZSCT has satisfactory reliability, validity, and clinical utility to evaluate cognitive development and the effect of health conditions on attention. Study results warrant further research to validate its use in healthcare and clinical research settings.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"20 1-3","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132269/pdf/icns_20_1-3_46.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9760820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of TNF-α -308G/A Polymorphism in Bipolar Disorder and its Relationship with Clinical and Demographic Variables. TNF-α-308G/A多态性在双相情感障碍中的作用及其与临床和人口学变量的关系。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Shama Akram, Moazzam Ali, Zeeshan Mutahir, Nabeel Ibad, Sana Sarmad, Sumaira Mehboob, Mahjabeen Saleem

{"title":"Role of TNF-α -308G/A Polymorphism in Bipolar Disorder and its Relationship with Clinical and Demographic Variables.","authors":"Shama Akram, Moazzam Ali, Zeeshan Mutahir, Nabeel Ibad, Sana Sarmad, Sumaira Mehboob, Mahjabeen Saleem","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Gene-environment interactions might play a significant role in the development of bipolar disorder (BD). The objective of the current study was to investigate the association between tumor necrosis factor (TNF)-α -308 G/A polymorphism and BD and conduct a bioinformatics analysis of the protein-protein network of TNF-α. Gene-environment interactions and the relationship between stressful life events (SLEs) and substance abuse with TNF genotypes and other characteristics were analyzed.Methods: The genomic deoxyribonucleic acid (DNA) of 400 patients with BD and 200 control subjects were extracted and genotyped for TNF-α -308 G/A polymorphism. SLEs and substance abuse were evaluated using the Life Event and Difficulty Schedule (LEDS) and a self-designed substance abuse questionnaire for the events six months prior to the onset of the disease, respectively. Gene-environment interactions were assessed by multiple statistical tools. Bioinformatics analysis of the TNF-α network and its interacting proteins was carried out using STRING and Cytoscape softwares.Results: Genotyping analysis revealed a significant association between TNF-α -308 G/A polymorphism and BD (p<0.009). Furthermore, analysis of gene-environment interaction revealed a significant association between TNF-α -308 G/A and SLEs (p=0.001) and TNF-α -308 G/A and substance abuse (p=0.001). Three distinct proteins, RELA, RIPK1, and BIRC3, were identified through hub analysis of the protein network.Conclusion: TNF-α -308 G/A polymorphism is positively associated with BD. SLEs and substance abuse might trigger the early onset of BD. Proteins identified through bioinformatics analysis might contribute to the TNF-α mediated pathophysiology of BD and can be the potential therapeutic targets.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"20 1-3","pages":"60-71"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132278/pdf/icns_20_1-3_60.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9760825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Remote Cognitive Therapeutic Exercise in Facial Nerve Palsy Rehabilitation: Pandemic Tips and Tricks. 面神经麻痹康复中的远程认知治疗运动：流行病提示和技巧。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Filippo Cavallaro, Simona Portaro, Teresa Pintaudi, Mariachiara Ceccio, Angelo Alito

{"title":"Remote Cognitive Therapeutic Exercise in Facial Nerve Palsy Rehabilitation: Pandemic Tips and Tricks.","authors":"Filippo Cavallaro, Simona Portaro, Teresa Pintaudi, Mariachiara Ceccio, Angelo Alito","doi":"","DOIUrl":"","url":null,"abstract":"Facial nerve palsy is a clinical diagnosis differentiating between central upper motor neuron lesions and peripheral lower motor neuron lesions. Rehabilitation is an important issue in peripheral facial nerve palsy management. In this article, we present the case of an adult woman affected by right peripheral facial nerve palsy due to acoustic neuroma surgical excision. She immediately started a rehabilitation plan, but it was stopped due to COVID-19 lockdown and did not resume because of the fear of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, we planned to treat her palsy with remote neurocognitive rehabilitation. After 10 months of treatment, the patient underwent a follow-up physiatric assessment, confirming right facial palsy improvement. There was a slight nasolabial groove flattening and slight left oral rime deviation while smiling (House-Brackmann classification improved from Grade IV to III). Telerehabilitation represents a valid strategy for neurocognitive rehabilitation, not only in a pandemic scenario, but also in other conditions that lead to social distancing.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"20 1-3","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132273/pdf/icns_20_1-3_10.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9760819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical Student-patients: Mental Wellness During the Pandemic. 医学生-病人:流感大流行期间的心理健康

Innovations in clinical neuroscience Pub Date : 2023-01-01

Kari Harper, Nita Bhatt, Julie P Gentile

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Special Challenges in Pediatric Drug Development: First of Three Sets of Expanded Proceedings from the ISCTM Autumn Conference on Pediatric Drug Development. 儿科药物开发中的特殊挑战：ISCTM秋季儿科药物开发会议三组扩展论文集中的第一组。

Innovations in clinical neuroscience Pub Date : 2023-01-01

Philip D Harvey, Joan Busner, Gahan Pandina, H Gerry Taylor, Meg Grabb, Joohi Jimenez-Shahed

{"title":"Special Challenges in Pediatric Drug Development: First of Three Sets of Expanded Proceedings from the ISCTM Autumn Conference on Pediatric Drug Development.","authors":"Philip D Harvey, Joan Busner, Gahan Pandina, H Gerry Taylor, Meg Grabb, Joohi Jimenez-Shahed","doi":"","DOIUrl":"","url":null,"abstract":"This paper expands upon a session, entitled, \"Special Challenges in Pediatric Drug Development,\" that was presented as part of a two-day meeting on Pediatric Drug Development at the International Society for Central Nervous System (CNS) Clinical Trials and Methodology (ISCTM) Autumn Conference in Boston, Massachusetts, in October 2020. Drug development in this age group is particularly important because many illnesses have their onset in this age group, many other illnesses that are more common in adults also occur in this time period, and many rare conditions that require special consideration (i.e., orphan conditions) are commonly detected in childhood as well. The special challenges addressed by our speakers in this session were cognitive and functional capacity assessment, challenges of recruitment and assessment of children for research and development of appropriate biomarkers for use in child populations, and the special challenges in training raters to address symptoms in pediatric populations. The speakers have written summaries of their talks. The session's lead chair was Philip D. Harvey, PhD, who wrote introductory and closing comments. This paper should serve as an expert-informed reference to those interested in and involved in addressing the special challenges facing those involved in CNS pediatric drug development.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"20 1-3","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132277/pdf/icns_20_1-3_13.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0