Innovations in clinical neuroscience最新文献_第2页

Medical Errors in Psychiatry: The Case for a Global Perspective. 精神病学中的医疗差错：全球视角的案例。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Muqadas Fatima

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Suzetrigine: A Newly FDA-Approved Non-Opioid Treatment Option for Management of Moderate to Severe Acute Pain. 舒三嗪：fda新批准的用于治疗中重度急性疼痛的非阿片类药物治疗方案。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Alexandra R Rola, Jared R Bagley, Emily E Leppien

{"title":"Suzetrigine: A Newly FDA-Approved Non-Opioid Treatment Option for Management of Moderate to Severe Acute Pain.","authors":"Alexandra R Rola, Jared R Bagley, Emily E Leppien","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The objective of this study was to review the characteristics, efficacy, and safety of suzetrigine in the treatment of acute pain.Methods: Literature was identified using PubMed and clinicaltrials.gov. Search terms included suzetrigine, Journvax, and VX-548, with further limitation to those published in English. Articles selected for inclusion were trials evaluating the safety or efficacy of suzetrigine.Results: Suzetrigine was evaluated for the treatment of moderate-to-severe acute pain in 2 published phase 2 trials and in 3 unpublished phase 3 trials. All studies report a statistically significant reduction in pain scores. High-dose suzetrigine showed statistically and clinically significant pain reduction vs placebo in abdominoplasty 48.4 (95% confidence interval [CI]: 33.6-63.1; P<0.0001), and bunionectomy 29.3 (95% CI: 14.0-44.6; P=0.0002). Additional unpublished data support potential future use in additional pain indications. Suzetrigine was well tolerated, with pruritus, muscle spasm, constipation, and headache reported as the most common side effects. Suzetrigine is a promising nonopioid alternative for acute pain and is the first of a potential new class of analgesics. However, its comparative efficacy to standard analgesics has not been established, nor has its efficacy when used beyond 14 days.Conclusion: The recent United States Food and Drug Administration approval of suzetrigine introduces a novel class of analgesics; however, its clinical impact has yet to be defined.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"23 4-6","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Navigating Desire and Danger: Examining Sexual Violence Vulnerabilities Among Men Who Have Sex With Men and the LGBTQ+ Community on Dating Apps. 导航欲望和危险：在约会应用程序上研究男男性行为者和LGBTQ+社区的性暴力脆弱性。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Rocco Salvatore Calabrò

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Intravenous Ketamine for Treatment-Resistant Depression: A Case Report From a Public Hospital in Argentina. 静脉注射氯胺酮治疗难治性抑郁症：阿根廷一家公立医院一例报告。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Micaela Dines, Paloma Bamondez, Micaela Montenegro, Pablo Diaz, Ana Laura Ramos, Irene Luis Vega, Gustavo Vazquez, Adriana Bulacia

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Nocturnal Tactile and Visual Hallucinations Associated with Clonidine Use. 与使用可乐定有关的夜间触觉和视觉幻觉。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Andrew Ligsay, Lisa Montagano

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Stroke Classification in Brain CT Images Using Transfer Learning With Fastai. 基于Fastai迁移学习的脑CT图像脑卒中分类。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Shilpa Bajaj, Manju Bala, Mohit Angurala

{"title":"Stroke Classification in Brain CT Images Using Transfer Learning With Fastai.","authors":"Shilpa Bajaj, Manju Bala, Mohit Angurala","doi":"","DOIUrl":"","url":null,"abstract":"To identify strokes, which rank among the leading global causes of death, doctors commonly employ computed tomography (CT) imaging. Researchers are increasingly applying deep learning (DL) and machine learning (ML) methods to improve the accuracy of stroke classification and detection. In particular, DL methods have demonstrated significant potential in segmenting stroke regions within brain medical images. However, training convolutional neural networks from scratch is challenging due to dataset size constraints. Achieving timely and precise stroke diagnosis remains a significant hurdle. The purpose of this research is to classify brain stroke cases using CT scan images through transfer learning strategies. Pretrained architectures including ResNet, VGG, Inception, and EfficientNet are utilized, with optimization carried out in the fastai framework to improve computational efficiency and reduce training time. We developed these artifical intelligence (AI) systems by training them with data, making adjustments throughout the process to ultimately categorize patients as having a stroke or not. We evaluated different models using measures such as accuracy, speed, and how well they differentiate normal and stroke-affected CT scans of the brain. This helped us choose the most effective model. In this research, ResNet50 outperformed other models in accuracy (88%), and DCNN was the most time-efficient model.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"23 4-6","pages":"18-36"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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An Overview of Medical Errors in Psychiatry, Part 2: Preventing and Managing Medical Errors. 精神病学医疗差错概述，第2部分：预防和管理医疗差错。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Charles D Cash

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Response to "Validation of a Pediatric Cognitive Assessment Tool to Advance Knowledge on Children's Cognitive Development, Health Risk Factors, and Health-Promoting Interventions in Sub-Saharan Regions". 对“验证儿童认知评估工具以提高对撒哈拉以南地区儿童认知发展、健康风险因素和促进健康干预措施的认识”的回应。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Kishankumar Mahida, Snehal Rajendra Jagtap

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Responding to Correspondence on "Validation of a Pediatric Cognitive Assessment Tool to Advance Knowledge on Children's Cognitive Development, Health Risk Factors, and Health-Promoting Interventions in Sub-Saharan Regions". 答复关于“验证儿童认知评估工具以提高对撒哈拉以南地区儿童认知发展、健康风险因素和促进健康干预措施的认识”的函件。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Franco Di Cesare, Cristiana Di Carlo, Leonardo Di Cesare

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A Narrative Review of Nutritional Interventions for Schizophrenia: A Pathway to Personalized Care. 精神分裂症的营养干预：通往个性化护理的途径。

Innovations in clinical neuroscience Pub Date : 2026-06-01 eCollection Date: 2026-04-01

Takahiko Nagamine

{"title":"A Narrative Review of Nutritional Interventions for Schizophrenia: A Pathway to Personalized Care.","authors":"Takahiko Nagamine","doi":"","DOIUrl":"","url":null,"abstract":"The management of schizophrenia, a complex and often debilitating mental illness, has traditionally centered on pharmacological interventions. However, the significant adverse effects of antipsychotic medications and the incomplete therapeutic response in many patients have spurred the investigation of adjunctive treatments. Nutritional psychiatry has emerged as a compelling area of interest, with a growing body of research suggesting that specific dietary and nutrient-based interventions could positively impact the underlying pathophysiology of schizophrenia. A narrative review of the scientific literature was conducted, focusing on systematic reviews, meta-analyses, and clinical trials examining nutritional interventions in individuals with schizophrenia. The evidence supporting the use of nutritional interventions in schizophrenia is, at present, largely preliminary and often inconclusive. The review also highlights significant methodological limitations across the existing literature, including small sample sizes, short intervention periods, lack of standardized dietary protocols, and failure to account for the vast individual differences in genetics, metabolism, and baseline nutritional status. Nutritional interventions hold theoretical promise as a safe and accessible adjunctive therapy for schizophrenia. However, the current evidence base is insufficient to form definitive clinical guidelines. The inherent complexity of nutritional science, with its focus on multitarget rather than single-target actions, necessitates a paradigm shift in research methodology. The path forward lies in the adoption of personalized and biomarker-guided approaches.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"23 4-6","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0