Innovations in clinical neuroscience最新文献_第2页

Risk Management: EHR Use and Emerging Risks. 风险管理：电子病历的使用和新出现的风险。

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Justin A Pope

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GLP-1 Agonists Can Affect Mood: A Case of Worsened Depression on Ozempic (Semaglutide). GLP-1 激动剂会影响情绪：一例服用 Ozempic（赛马鲁肽）后抑郁加重的病例。

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Senthil Vel Rajan Rajaram Manoharan, Rohit Madan

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Responding to Correspondence on "Clinical Outcome Assessment Instruments in Schizophrenia: A Scoping Literature Review with a Focus on the Potential of Patient-reported Outcomes". 回复关于 "精神分裂症的临床结果评估工具：以患者报告结果的潜力为重点的范围界定文献综述"。

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Leslie Citrome, Marko A Mychaskiw, Alma Cortez, Mark Opler, Liza Sopina, Sameer Kotak

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Urdu Adaptation and Validation of Social Interaction Anxiety Scale: A Confirmatory Factor Analysis. 乌尔都语社交互动焦虑量表的改编和验证：确认因素分析

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Uzma Ilyas, Saima Dawood

{"title":"Urdu Adaptation and Validation of Social Interaction Anxiety Scale: A Confirmatory Factor Analysis.","authors":"Uzma Ilyas, Saima Dawood","doi":"","DOIUrl":"","url":null,"abstract":"The Social Interaction Anxiety Scale (SIAS) is a globally used scale for clinical diagnostic purposes for social anxiety disorder (SAD). This article investigates the psychometric properties of the SIAS, followed by its adaptation and validation in Urdu. The study consisted of two phases. The initial phase involved the translation of the scale, and the second phase was of a cross-sectional nature and consisted of evaluating factor structure and psychometric properties of the scale. For this purpose, the study enrolled a purposive sample of 573 adults aged between 18 to 45 years (mean [standard deviation (SD)] age: 23.68 [4.28] years) with a diagnosis of SAD. The sample was recruited from educational institutes, hospitals, and clinics in Lahore, Pakistan. The data was collected using a demographic form and the Urdu version of the SIAS, along with the Multidimensional Psychological Flexibility Inventory (MPFI). The analyses of the study were carried out using SPSS V27 and AMOS V24. Confirmatory factor analysis revealed a single factor structure of the Urdu version of the SIAS consisting of 16 items. The psychometric values of the scale shown were excellent, as Cronbach's alpha equaled 0.91, convergent validity r equaled 0.37 at p less than 0.01 with psychological inflexibility, and discriminant validity r equaled -0.47 at p less than 0.01 with psychological flexibility. The study concluded that the Urdu version of the SIAS was a valid and reliable measure for the assessment of social anxiety in the Pakistani population.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 4-6","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Should Therapists Treat Patients who are so Altruistic They Regularly Harm Themselves for the Sake of Others? 治疗师应该如何治疗那些利他主义严重、经常为了他人而伤害自己的病人？

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Edmund Howe

{"title":"How Should Therapists Treat Patients who are so Altruistic They Regularly Harm Themselves for the Sake of Others?","authors":"Edmund Howe","doi":"","DOIUrl":"","url":null,"abstract":"Mental health providers sometimes encounter patients who are exceptionally altruistic toward others and, at the same time, are willing to ignore their own needs and even significantly harm themselves to best achieve these ends for others. Traditionally, therapists have seen it to be their role to discern patients' negative symptoms, then seek to reduce them. This article reviews gains based on positive psychology that highlight the importance of therapists giving priority to supporting patients' strengths, particularly the sources of meaning they have in their lives. As is consistent with this view, it is suggested that therapists working with this group of self-harming, altruistic patients not only support their altruism, but particularly consider and remain cautious as to whether or not they should explore unconscious factors with the patient that might fuel their altruism. It is suggested that the discovery of such factors might be harmful because it could risk decreasing the degree to which these patients continue to show and personally value their altruism, thus potentially decreasing the meaning they derive from their altruism.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 4-6","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compulsive Biting and Chewing with Mixed Amphetamine Salts: A Case Report. 混合安非他明盐强迫性咬嚼：病例报告

Innovations in clinical neuroscience Pub Date : 2024-06-01 eCollection Date: 2024-04-01

Melissa Free, Hena Choi, Ritika Baweja

{"title":"Compulsive Biting and Chewing with Mixed Amphetamine Salts: A Case Report.","authors":"Melissa Free, Hena Choi, Ritika Baweja","doi":"","DOIUrl":"","url":null,"abstract":"Stimulants are the first-line pharmacological treatment for attention deficit hyperactivity disorder (ADHD). We present the unique case of a patient who developed a chewing compulsion when taking mixed amphetamine salts (MAS). A 32-year-old female patient with a past medical history of gastroesophageal reflux disease (GERD), gastroparesis, and migraines was seen for initial psychiatric assessment due to concerns for irritability. She was diagnosed with post-traumatic stress disorder (PTSD); generalized anxiety disorder; ADHD, inattentive type; and unspecified bipolar disorder. Lamotrigine was started and titrated to 25mg twice per day, with improved mood stability. MAS immediate-release (IR) was started at 2.5mg and titrated to 5mg daily for ADHD. She then experienced an uncontrollable urge to chew, finding relief when chewing on a child's teething necklace, which provided satisfaction and a reduction in anxiety. She denied jaw tightness or teeth grinding. The dose of MAS IR was reduced to 2.5mg daily with improvement in symptoms and later increased again to 5mg daily, which she was then able to tolerate. Stereotyped biting behaviors have been observed in rats with the use of amphetamines, and the onset of compulsive behavior has emerged in children with the use of dextroamphetamine. However, this is the first known case of compulsive chewing or biting movements reported in humans with MAS use. This case highlights the need to assess patients for adverse events, such as compulsive biting and chewing movements or other oral facial stereotypies, after commencement of stimulants, including MAS.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 4-6","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence and Neurorehabilitation: Fact vs. Fiction. 人工智能与神经康复：事实与虚构。

Innovations in clinical neuroscience Pub Date : 2024-03-01 eCollection Date: 2024-01-01

Nicola Fiorente, Sepehr Mojdehdehbaher, Rocco Salvatore Calabrò

引用次数: 0

RISK MANAGEMENT: Blurring the Lines- Boundary Violation. 风险管理：模糊界限--侵犯边界。

Innovations in clinical neuroscience Pub Date : 2024-03-01 eCollection Date: 2024-01-01

Akemini Kem Isang

引用次数: 0

Genesis of Mental Disorders: Could It Be Cavum Septum Pellucidum (CSP) et Vergae? A Case Report of CSP in Schizophrenia with Catatonia. 精神障碍的起源：会不会是透明隔膜（Cavum Septum Pellucidum，CSP）和Vergae？精神分裂症伴紧张症的 CSP 病例报告。

Innovations in clinical neuroscience Pub Date : 2024-03-01 eCollection Date: 2024-01-01

Allison Zuckerberg, Nitin Pothen, Adriana Fitzsimmons

引用次数: 0

Impact of COVID-19 Pandemic on Patients with Serious Mental Illness (SMI) and Nonpsychiatric Control Subjects in Clinical Trials. COVID-19 大流行对临床试验中严重精神疾病 (SMI) 患者和非精神疾病对照受试者的影响。

Innovations in clinical neuroscience Pub Date : 2024-03-01 eCollection Date: 2024-01-01

Maria Fe Garcia-Rada, Robert E Litman

{"title":"Impact of COVID-19 Pandemic on Patients with Serious Mental Illness (SMI) and Nonpsychiatric Control Subjects in Clinical Trials.","authors":"Maria Fe Garcia-Rada, Robert E Litman","doi":"","DOIUrl":"","url":null,"abstract":"Objective: This study aimed to examine the impact of the COVID-19 pandemic on patients with serious mental illness (SMI), specifically relating to psychiatric morbidity, pandemic-induced stress, and ability to cope with pandemic-related precautionary measures, restrictions, and disruptions to daily life.Design: A cross-sectional survey study of 277 clinical trial patients was conducted. This sample included nonpsychiatric controls (n=139) and patients with a diagnosis of bipolar disorder, major depressive disorder (MDD), or schizophrenia (n=138) located at five clinical trial sites across the United States. A univariate analysis was performed to obtain general frequencies of the sample. Unpaired t-tests were used in comparing the groups on numerical variables, and analysis of variance (ANOVA) was performed to identify differences when comparing three or more categories.Results: Patients with SMI were more likely to report wearing face masks, avoiding large gatherings, and endorsing the use of precautionary measures, despite receiving a COVID-19 vaccine (p<0.001). A total of 70.3 percent (n=97) of all patients with SMI reported experiencing at least one episode of symptom worsening, 48 percent reported experiencing suicidal ideation, and 66 percent reported a need for increased mental healthcare due to COVID-19-related distress. Patients with SMI reported higher levels of stress, compared to controls, with patients with MDD having the highest levels of stress (p<0.001).Conclusion: These findings demonstrate an increased vulnerability to symptom worsening in patients with SMI during a pandemic and suggest the need to account for pandemic-induced psychological stress in clinical trial design, subject selection, and symptoms ratings.","PeriodicalId":13635,"journal":{"name":"Innovations in clinical neuroscience","volume":"21 1-3","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0