Integrative medicine最新文献

{"title":"Implementing Personalized Dietary Interventions for Immune-Mediated Inflammatory Diseases.","authors":"Thomas G Guilliams, Jill Weintraub","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The epidemiological association between various dietary patterns and the risk for chronic diseases is reasonably well established, including those for autoimmune and immune-mediated inflammatory diseases (IMIDs). However, when population data used to develop these associations for particular groups are used to predict risk in specific individuals, other complicating factors often affect the risk assessment. Additionally, understanding which components of any given dietary pattern are responsible for or protect against the risk of a specific health/disease outcome is complicated and hotly debated. This is especially true for autoimmune disorders and IMIDs. Furthermore, when these dietary associations are tested as preventative or interventional therapies in clinical trials, the results are often equivocal or difficult to interpret. Predictably, guideline recommendations for dietary intervention (for IMIDs and other chronic diseases) are limited and are often ignored in clinical practice, an oversight that prevents patients with IMIDs from realizing lasting remission and tissue healing. Emerging data on the mechanisms connecting dietary intake with changes in the gut microbiome, intestinal permeability, and dysfunctional immune reactivity have shed light on the role of dietary intervention as adjunctive therapies for IMIDs. However, leveraging this emerging data involves personalized dietary assessments and recommendations, often requiring the services of a nutritional specialist trained to understand the complexity of food-driven systemic inflammation. This paper summarizes the published data connecting diet patterns, individual dietary assessment, and dietary interventions for specific IMIDs. When personalized and implemented with other lifestyle interventions (e.g., stress reduction, movement, etc.), nutritional interventions should be considered foundational therapy for chronic immune-mediated inflammation.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interview with Steve Mister, President, Council for Responsible Nutrition.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"10-13"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking About Berberine.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The alkaloid berberine is a constituent of several medicinal herbs with centuries of use. Emerging research is documenting many effective clinical applications. It has been shown to improve blood sugar control, lower cholesterol, inhibit infectious microorganisms, decrease inflammation, ameliorate inflammatory bowel disease, lower blood pressure, facilitate weight loss, and even inhibit cancer cells. However, it is important to recognize that relying solely on berberine as a treatment because it is a natural molecule ignores the need to address causes of the diseases and dysfunctions the patient is suffering.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Utilization of Herbal and Dietary Supplements in Patients with Chronic Liver Disease During the SARS-CoV2 Pandemic.","authors":"Avleen Kaur, Ahyoung Kim, Lisa R Yanek, Yisi Liu, Xueting Tao, Anna Peeler, Douglas Mogul, James Peter Adam Hamilton, Gerard E Mullin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>We studied the pattern of herbal and dietary supplement (HDS) use in patients with chronic liver disease (CLD) during the first year of the COVID-19 pandemic.</p><p><strong>Methods: </strong>A questionnaire/survey was sent to hepatology patients with CLD under the care of hepatologists at Johns Hopkins University School of Medicine.</p><p><strong>Results: </strong>The 5 most taken dietary supplements during the pandemic included vitamin B12 (27.7%), vitamin C (32.4%), vitamin D (54.6%), zinc (25.4%) and green tea extract (20.8%). Most participants (82.3%) did not discuss their HDS use with their hepatology providers.</p><p><strong>Conclusions: </strong>Healthcare providers should be mindful of potential HDS use in patients with CLD.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"14-17"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Plant-Based Dietary Supplement Improves Measures of Metabolic Detoxification and the Quality of Life: A Phase II Multicenter Randomized, Blinded, Placebo-Controlled Clinical Trial.","authors":"Bassem F El-Khodor, Wei Zang, Heather Gorby, Ashley Dominique, Meghan Hamrock, Brandon Metzer, Alessandra Pecorelli, Saradhadevi Varadharaj, Giuseppe Valacchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Persistent accumulation and hindered clearance of toxins from tissues over time may promote the development and exacerbation of several diseases. Hepatic metabolic detoxification is a key physiological process responsible for the clearance of toxic substances from the body. A healthy diet with nutritional dietary supplementation may support metabolic detoxification and help mitigate the negative effects of toxin burden.</p><p><strong>Methods: </strong>A multicenter, randomized, single-blind, controlled trial was conducted to test the effects of a dietary detoxification product (detox; n = 20) versus an active dietary control product (active control; n = 20) on selected biomarkers of metabolic detoxification, general health, and well-being following 28 days of dietary supplementation. Study participants displayed multiple symptoms commonly associated with elevated toxin burden, but otherwise healthy.</p><p><strong>Results: </strong>The detox group displayed significantly decreased levels of red blood cell total toxic metals, decreased urine total porphyrins, and decreased urine mutagenicity potency compared with baseline. Both the detox and active control groups showed improvements in the symptoms attributed to elevated toxin burden. Fatigue and sleep disruption scores were significantly reduced in the detox group compared with baseline. No significant differences in anthropometric measures and vital signs, and no adverse events or side effects were detected in either group over the study period.</p><p><strong>Conclusions: </strong>This study demonstrates the benefit of nutritional intervention for supporting metabolic detoxification, evidenced by significant changes in multiple detoxification biomarkers and improvement in questionnaire scores related to quality of life, general health, and well-being.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"28-39"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversations with Tim Eaton, Founder and Chief Executive Officer, NutraMedix.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Nutrition and Lifestyle Interventions in Systemic Lupus Erythematosus: A Case Report.","authors":"Jan Kielmann, Leandro Pucci, Aikaterini Xydis","doi":"10.2139/ssrn.3743841","DOIUrl":"https://doi.org/10.2139/ssrn.3743841","url":null,"abstract":"Background\u0000A 63-year-old male with a 4-year history of systemic lupus erythematosus (SLE) safely and successfully integrated personalized nutrition and lifestyle modifications to improve the symptomatic outcome of his illness.\u0000\u0000\u0000Case/Intervention\u0000The client presented to our nutritional practice with fatigue, acid reflux, joint pain, brain fog and skin rashes. During the nutritional intervention, he safely used a variety of nutritional interventions and supplementation, including dietary improvements, omega-3 fish oils, N-acetyl cysteine, prebiotics and intermittent fasting, along with stress reduction techniques. His symptoms decreased significantly, or disappeared, over 4 years of using these interventions.\u0000\u0000\u0000Conclusion\u0000This case demonstrates the safety and potential benefits of personalized nutrition, stress reduction techniques and targeted supplementation in helping to decrease symptoms of SLE. Our client's energy levels and overall performance improved, skin rashes and acid reflux resolved, joint pain and stiffness decreased and brain fog gradually lessened over the 4 years he was in our care.","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"65 1","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91004987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical Hypercortisolism: An Important, Unrecognized Dysfunction.","authors":"Lara Pizzorno,&nbsp;Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While Cushing syndrome is rare, but well-recognized, subclinical hypercortisolism (defined as excessive cortisol secretion without the classic manifestations of Cushing syndrome) is significantly more common. Subclinical hypercortisolism contributes to several chronic diseases, such as diabetes, osteoporosis, sarcopenia and hypertension. The incidence increases with age and correlates with body load of environmental toxins such as bisphenol A (BPA). This editorial discusses prevalence, contribution to disease, causes, diagnosis, and intervention.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":" ","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380834/pdf/imcj-21-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40718822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifiable Risk Factors for SARS-CoV-2.","authors":"Michelle Simon,&nbsp;Joseph Pizzorno,&nbsp;Joseph Katzinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As the COVID-19 pandemic has raged on, considerable research has been performed around the world evaluating the environmental, genetic, lifestyle, and nutritional factors that significantly impact the COVID-19 pandemic. Many studies have now shown that key risk factors for SARS-CoV-2 infection, severity, and even death are modifiable. Patients, whether partially vaccinated, fully vaccinated, or not vaccinated, are expecting their clinicians to provide them with evidence-based guidance and to help them prioritize the factors most important for them. In this editorial we review the current state of the research on modifiable risk factors for SARS-CoV-2 infection, disease severity, and death.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"20 5","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594967/pdf/imcj-20-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39754302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Instability of the Lipid-Soluble Antioxidant Ubiquinol: Part 2-Dog Studies.","authors":"William V Judy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Coenzyme Q10 is one of the most widely sold nutritional supplements in the United States. Coenzyme Q10 is available in both its oxidized form (ubiquinone) and its reduced form (ubiquinol). The predominant marketing of Coenzyme Q10 to physicians and patients asserts that the ubiquinol form of Coenzyme Q10 has superior absorption to the ubiquinone form. This study has been designed to compare and contrast the stability and absorption of ubiquinol supplements, as well as the claims made for ubiquinol compared with ubiquinone.Ubiquinol, the reduced state of Coenzyme Q10, is commercially available as a nutritional supplement; however, ubiquinol, by its nature as an electron donor, is much less stable than ubiquinone, the oxidized state of Coenzyme Q10. The absorption, bioavailability and efficacy of ubiquinol products has been much less often tested in clinical trials. Consequently, insufficiently documented marketing claims are being made for ubiquinol supplements.</p><p><strong>Methods: </strong>In Part 1 of this report on the instability of the lipid-soluble antioxidant ubiquinol, SIBR Research presented data from lab studies showing that oral ubiquinol is likely to be oxidized to ubiquinone and absorbed as ubiquinone. In this Part 2, SIBR Research conducted a study of the transfer and absorption of orally ingested ubiquinol in large dogs.</p><p><strong>Results: </strong>In the dog studies, the percentage of ubiquinol converted to ubiquinone increased as the capsule contents passed through the stomach and small intestines and into the lymph system.</p><p><strong>Conclusions: </strong>The dog studies demonstrate that oral ubiquinol in commercial nutritional supplements is not stable in the gastrointestinal tract of large dogs. Based on these results, it seems likely that in humans also, most of the ubiquinol from capsules will be oxidized to ubiquinone in the acid profile between the stomach and the small intestines, where there is a wide range of acidity. The ubiquinol from the supplement will be absorbed in the ubiquinone state and will pass into the lymph system as ubiquinone, where it will be reduced back to ubiquinol. It will pass from the lymph system into the blood circulation as ubiquinol.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"20 5","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594965/pdf/imcj-20-26.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39754305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}