Integrative medicine最新文献

{"title":"Reversal of Irritable Bowel Syndrome, Sleep Disturbance, and Fatigue With an Elimination Diet, Lifestyle Modification, and Dietary Supplements: A Case Report.","authors":"Stephanie Davis","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>A 53-y-old Caucasian patient presented in August 2015 with chief complaints of irritable bowel syndrome (IBS; gas/bloating, gastroesophageal reflux), fatigue, and sleep disturbances. He also noted a history of chronic sinusitis, seasonal allergies, multiple chemical sensitivities, and right knee pain (3 surgeries). His primary care physician, in 2014, diagnosed prediabetes based on an elevated hemoglobin A_1c and high-sensitivity C-reactive protein, which was treated with diet and lifestyle modification.</p><p><strong>Case/intervention: </strong>In the course of 6 mo, the patient was treated using an elimination diet, lifestyle modifications, botanicals, and dietary supplements. By addressing the underlying cause of issues, his symptoms decreased and quality of life increased, resulting in the resolution of his IBS symptoms, improved sleep, and increased energy levels.</p><p><strong>Conclusion: </strong>This case illustrates the potential diagnostic importance of early testing for gut microbiome imbalances and gastrointestinal infections in the management of IBS as well as the usefulness of a systems-based approach for diagnostic assessment and management of a complex chronic case.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"15 5","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Of Carica Papaya Leaf Extract On Platelet Count In Chronic Immune Thrombocytopenic Purpura: A Case Series.","authors":"Katherine E. Hampilos, Joshua Corn, W. Hodsdon, P. Wagner, R. Roop, Anderes Elise, L. Troy","doi":"10.1182/BLOOD.V126.23.4660.4660","DOIUrl":"https://doi.org/10.1182/BLOOD.V126.23.4660.4660","url":null,"abstract":"The leaves of Carica papaya have been used to treat thrombocytopenia in Dengue fever in areas where the virus is endemic. This case series describes the use of C. papaya leaf liquid extract (CPLE) as an adjunctive therapy for four patients receiving standard-of-care treatment for chronic immune thrombocytopenic purpura (ITP). The cases presented here indicate that CPLE may prove beneficial in the management of chronic ITP for patients interested in alternative therapy before progressing to second-line treatments. A larger clinical trial is warranted to evaluate CPLE as an adjunctive therapy in chronic ITP.","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"31 1","pages":"30-35"},"PeriodicalIF":0.0,"publicationDate":"2015-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91240295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol Oil for Decreasing Addictive Use of Marijuana: A Case Report.","authors":"Scott Shannon, Janet Opila-Lehman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This case study illustrates the use of cannabidiol (CBD) oil to decrease the addictive use of marijuana and provide anxiolytic and sleep benefits. Addiction to marijuana is a chronic, relapsing disorder, which is becoming a prevalent condition in the United States. The most abundant compound in the marijuana, which is called tetrahydrocannabinol (THC), has been widely studied and known for its psychoactive properties. The second most abundant component-CBD-has been suggested to have the medicinal effects of decreasing anxiety, improving sleep, and other neuro-protective effects. The mechanism of action for CBD has been suggested to be antagonistic to the psychoactive properties of THC in many locations within the central nervous system. Such action raises the issue of whether it might be beneficial to use CBD in isolation to facilitate withdrawal of marijuana use. The specific use of CBD for marijuana reduction has not been widely studied. The patient was a 27-y-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana use. In the described intervention, the only change made to the patient's treatment was the addition of CBD oil with the dosage gradually decreasing from 24 to 18 mg. With use of the CBD oil, the patient reported being less anxious, as well as settling into a regular pattern of sleep. He also indicated that he had not used any marijuana since starting the CBD oil. With the decrease in the dosage to 18 mg, the patient was able to maintain his nonuse of marijuana. </p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 6","pages":"31-5"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Therapies and Cardiovascular Disease in the Breast Cancer Population: A Review, Part 2.","authors":"Khara Lucius, Kristen Trukova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Part 1 of the current review, the cardiotoxicity of standard breast cancer treatment was reviewed. Part 2 presents a comprehensive review of the current evidence for lifestyle factors, including nutrition and exercise. Part 2 describes the results of several dietary interventions in breast cancer survivors. Specific dietary factors that may promote cardiovascular health in this population, including essential fatty acids and plant phytosterols, are also reviewed. In addition, the mechanisms by which exercise may provide a benefit are discussed, and evidence for the important role of attainment and maintenance of a healthy weight is outlined. Finally, recommendations for lifestyle changes in the survivor population are discussed, and opportunities for future research in this population are identified. </p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 5","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrete and Coalescing Pustules Masking Severe Recalcitrant Rosacea Due to Demodex.","authors":"M. Vissing, Chase L Wilson, N. Mousdicas, S. Ali","doi":"10.4172/2155-9554.10000298","DOIUrl":"https://doi.org/10.4172/2155-9554.10000298","url":null,"abstract":"Context\u0000Rosacea is a frequent and often easily treatable condition in dermatological practice. The clinical manifestations of rosacea are hypothesized to be the result of a dysregulation of the innate immune system. The roles played by outside factors, such as the presence of Demodex or localized immunosuppression in the pathogenesis of rosacea, are under considerable debate.\u0000\u0000\u0000Objective\u0000The current study intended to examine the contribution of immunosuppression to a case of recalcitrant rosacea and the effects of nutritional status in the resolution of the skin disease.\u0000\u0000\u0000Design\u0000The research team designed a case study.\u0000\u0000\u0000Setting\u0000The study took place at the dermatology clinic of the Department of Dermatology at Indiana University (Indianapolis, IN, USA).\u0000\u0000\u0000Participant\u0000The participant was a 36-y-old male patient at the clinic with a recalcitrant dermatosis of the face and neck. This patient's disease had persisted despite multiple standard treatments for facial dermatitis, rosacea, and granulomatous rosacea with a high Demodex burden.\u0000\u0000\u0000Intervention\u0000The intervention included a tapering course of cyclosporin, 3 mg of ivermectin daily for 3 wk, 500 mg daily of ascorbic acid, 1000 units daily of cholecalciferol, and green smoothies.\u0000\u0000\u0000Outcome Measures\u0000The study measured the patient's levels of immunoglobulin M (IgM), 25 hydroxyvitamin D, and ascorbic acid.\u0000\u0000\u0000Results\u0000The testing showed isolated IgM deficiency and low levels of 25 hydroxyvitamin D and ascorbic acid. The rash resolved following the tapering course of cyclosporin and vitamin repletion through supplements and dietary alteration.\u0000\u0000\u0000Conclusions\u0000The case was one with multiple confounding variables: (1) the presence of Demodex, (2) iatrogenic immunosuppression due to prolonged systemic and topical steroid use, and (3) vitamin deficiency. The case demonstrates the multifactorial pathogenesis of a recalcitrant dermatosis of the face and neck, and the research team encourages providers to consider a holistic approach when patients do not respond to standard medical therapy.","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2015-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84763259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Casey Health Institute: Integrative Center Marches Into PCMH and ACO Worlds … plus more.","authors":"John Weeks","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 4","pages":"16-9"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hard to be Healthy in North America.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 3","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Continuum of Health Professions.","authors":"Clyde B Jensen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The large number of health care professions with overlapping scopes of practice is intimidating to students, confusing to patients, and frustrating to policymakers. As abundant and diverse as the hundreds of health care professions are, they possess sufficient numbers of common characteristics to warrant their placement on a common continuum of health professions that permits methodical comparisons. From 2009-2012, the author developed and delivered experimental courses at 2 community colleges for the purposes of creating and validating a novel method for comparing health care professions. This paper describes the bidirectional health professions continuum that emerged from these courses and its potential value in helping students select a health care career, motivating health care providers to seek interprofessional collaboration, assisting patients with the selection of health care providers, and helping policymakers to better understand the health care professions they regulate. </p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 3","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional and Metabolic Biomarkers in Autism Spectrum Disorders: An Exploratory Study.","authors":"Anna E Esparham, Teri Smith, John M Belmont, Michael Haden, Leigh E Wagner, Randall G Evans, Jeanne A Drisko","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Context: </strong>Autism spectrum disorder (ASD) is currently on the rise, now affecting approximately 1 in 68 children in the United States according to a 2010 surveillance summary from the Centers for Disease Control and Prevention (CDC). This figure is an estimated increase of 78% from the figure in 2002. The CDC suggests that more investigation is needed to understand this astounding increase in autism in such a short period.</p><p><strong>Objective: </strong>The aim of this pilot study was to determine whether a group of children with ASD exhibited similar variations in a broad array of potential correlates, including medical histories, symptoms, genetics, and multiple nutritional and metabolic biomarkers.</p><p><strong>Design: </strong>This study was a retrospective, descriptive chart review.</p><p><strong>Setting: </strong>The study took place at the University of Kansas Medical Center (KUMC).</p><p><strong>Participants: </strong>Participants were 7 children with ASD who had sought treatment at the Integrative Medicine Clinic at the medical center.</p><p><strong>Results: </strong>A majority of the children exhibited an elevated copper:zinc ratio and abnormal vitamin D levels. Children also demonstrated abnormal levels of the essential fatty acids: (1) α-linolenic acid (ALA)- C13:3W3, and (2) linoleic acid (LA)-C18:2W6; high levels of docosahexaenoic acid (DHA); and an elevated ω-6:ω-3 ratio. Three of 7 children demonstrated abnormal manganese levels. Children did not demonstrate elevated urine pyruvate or lactate but did have abnormal detoxification markers. Three of 7 patients demonstrated abnormalities in citric acid metabolites, bacterial metabolism, and fatty acid oxidation markers. A majority demonstrated elevated serum immunoglobulin G (IgG) antibodies to casein, egg whites, egg yolks, and peanuts. A majority had absent glutathione S-transferase (GSTM) at the 1p13.3 location, and 3 of 7 children were heterozygous for the glutathione S-transferase I105V (GSTP1). A majority also exhibited genetic polymorphism of the mitochondrial gene superoxide dismutase A16V (SOD2).</p><p><strong>Conclusions: </strong>The findings from this small group of children with ASD points to the existence of nutritional, metabolic, and genetic correlates of ASD. These factors appear to be important potential abnormalities that warrant a case control study to evaluate their reliability and validity as markers of ASD.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 2","pages":"40-53"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Taste-intensity Visual Analog Scale: An Improved Zinc Taste-test Protocol.","authors":"Matthew J Zdilla, Leah D Starkey, Julia R Saling","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Context: </strong>Studies employing methods for measurement of zinc sulfate taste acuity have had diverse results, and although the studies have had limitations in design and implementation, they have suggested salient findings beyond the assessment of taste acuity. These findings have included, but were not limited to, relationships between zinc sulfate taste acuity and weight, levels of serum zinc, diastolic hypertension, levels of salivary carbonic anhydrase 6, and frequency of illness. However, current protocols for zinc sulfate taste assessment are problematic and warrant improvement.</p><p><strong>Objective: </strong>The current study intended to compare the ranking scale for the original Bryce-Smith and Simpson zinc taste test (BS-ZTT) with a novel, taste-intensity visual analog scale (TI-VAS) to explore the potential for improved zinc sulfate taste-acuity measurement.</p><p><strong>Design: </strong>Participants were administered a 0.1% solution of zinc sulfate and assessed using the 2 scales.</p><p><strong>Setting: </strong>The study took place at West Liberty University, in West Liberty, WV, USA.</p><p><strong>Participants: </strong>Participants were 500 West Liberty University students who volunteered to participate in the study.</p><p><strong>Results: </strong>A strong, statistically significant, positive correlation existed between the BS-ZTT and the TI-VAS scores (r s = 0.79; P < .0001; n = 491).</p><p><strong>Conclusions: </strong>The study found that the BS-ZTT offered a limited number of ordinal variable ranks and depended on an examiner's evaluation. Conversely, the TI-VAS had an expanded range of variables and was independent of the examiner. The TI-VAS can be used as a taste-acuity test for zinc sulfate and as a benchmark for future analyses of zinc sulfate taste acuity and zinc taste tests.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"14 2","pages":"34-8"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}