Integrative medicine最新文献

{"title":"The Effect of a Dietary Supplement Containing Rhamnan Sulfate from <i>Monostroma nitidum</i> on Carotid Atherosclerotic Plaque: A Case Series.","authors":"Kristine L Burke, Ian G Jennings","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report on 6 patients in our care who were harboring atherosclerotic plaque in the carotid arteries. This condition poses a risk of acute ischemic stroke and indicates potential atherosclerosis elsewhere in the vascular system. The plaque was revealed by routine ultrasound measurement of carotid intima-medial thickness (CIMT) defined as the distance between the lumen-intima interface and the media-adventitia interface. Recent improvements in image resolution and edge detection algorithms have resulted in improved reliability and clinical usefulness of the technology. The patients were enrolled in a systems-based functional medicine program of cardiology prevention to address root causes. The program provided personalized interventions that included drug therapy, dietary supplements, and lifestyle modification. The 6 patients followed the integrative regimen, which successfully managed existing cardiovascular symptoms and risk factors while keeping various biomarkers under control. However, they continued to exhibit carotid plaque with no improvement. A novel dietary supplement that targets endothelial glycocalyx regeneration was added to the personalized intervention programs. The supplement contains a proprietary extract of rhamnan sulfate from the green seaweed <i>Monostroma nitidum.</i> The 6 participants consumed the supplement daily, and their plaque burden was measured after 6 months using the same CIMT technology. In every case, the total plaque burden was reduced, with an average reduction in the 6 patients of 5.55 mm, which is statistically significant. Significant reductions in maximum carotid plaque thickness were also observed at the end of the 6 months. The study suggests that rhamnan sulfate from <i>Monostroma nitidum</i> may provide a safe and effective intervention for reducing atherosclerotic plaque, and should be evaluated as an adjunct therapy for prevention and treatment of cardiovascular disease.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 6","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10886398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversation with David Brady, ND.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 6","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10886397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorocarbons (PFAS)-The Forever Chemicals.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fluorocarbons are fluorinated organic molecules widely used in industry and commerce. Nomenclature has changed over the years, with PFAS becoming the accepted umbrella term. The environment is heavily polluted with these toxins. Worldwide research shows that they contribute to almost every chronic disease. The primary source of human contamination is food packaging. There are significant concerns that the available research has not adequately addressed ultrashort-chain PFAS, which are breakdown products of longer-chain versions and accumulate in the environment at almost 100 times higher concentrations than the longer-chain versions.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 6","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10886393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplasticity Intervention, Amygdala and Insula Retraining (AIR), Significantly Improves Overall Health and Functioning Across Various Chronic Conditions.","authors":"Alexandra J Bratty","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic conditions, sometimes referred to as functional somatic disorders, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), and more recently, long COVID (LC), affect millions of people worldwide. Yet, after decades of research and testing, the etiology and treatment for many of these diseases is still unclear. Recently, a consortium of clinicians and researchers have proposed that while many different chronic conditions exist, the root cause of each may be a similar brain-body connection, as the brain responds to perceived biological threats and transmits danger signals to the body that manifest as somatic symptoms. This hypothesis suggests that treating chronic conditions requires an approach that addresses the neural networks involved. One such method, known as Amygdala and Insula Retraining (AIR), otherwise known as The Gupta Program, has shown promise in recent years for treating such conditions, including ME/CFS, FM, and LC. The present study aimed to demonstrate that AIR could be an effective approach for numerous other chronic illnesses (e.g., Lyme disease, mold illness, mast cell activation syndrome [MCAS]) and others. This novel and exploratory research examined self-reported health and functioning levels before and after using AIR. A series of paired-sample <i>t</i> tests with Bonferroni correction demonstrated that after 3+ months of using AIR (the minimum recommended time for the intervention), participants experienced a significant increase in overall health and functioning for 14 of 16 conditions tested (<i>P</i> < .001 for all but one, which was <i>P</i> = .001) and approached significance for the remaining two conditions (<i>P</i> = .039 and <i>P</i> = .005). Of the 14 signficant findings, 11 had a large effect size and three had a medium effect size. Naturally, this study has limitations. It was a cross-sectional design with a small convenience sample and self-reported data. Future research with larger samples and randomized controlled trials is needed to provide further evidence of AIR's effectiveness. Nonetheless, these preliminary findings suggest that AIR is a viable method for improving the health of people suffering from chronic conditions, and clinicians and researchers might consider incorporating AIR into their protocols for these patients.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 6","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10886399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interview with Dr. William Shaw.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"40-43"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing Personalized Dietary Interventions for Immune-Mediated Inflammatory Diseases.","authors":"Thomas G Guilliams, Jill Weintraub","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The epidemiological association between various dietary patterns and the risk for chronic diseases is reasonably well established, including those for autoimmune and immune-mediated inflammatory diseases (IMIDs). However, when population data used to develop these associations for particular groups are used to predict risk in specific individuals, other complicating factors often affect the risk assessment. Additionally, understanding which components of any given dietary pattern are responsible for or protect against the risk of a specific health/disease outcome is complicated and hotly debated. This is especially true for autoimmune disorders and IMIDs. Furthermore, when these dietary associations are tested as preventative or interventional therapies in clinical trials, the results are often equivocal or difficult to interpret. Predictably, guideline recommendations for dietary intervention (for IMIDs and other chronic diseases) are limited and are often ignored in clinical practice, an oversight that prevents patients with IMIDs from realizing lasting remission and tissue healing. Emerging data on the mechanisms connecting dietary intake with changes in the gut microbiome, intestinal permeability, and dysfunctional immune reactivity have shed light on the role of dietary intervention as adjunctive therapies for IMIDs. However, leveraging this emerging data involves personalized dietary assessments and recommendations, often requiring the services of a nutritional specialist trained to understand the complexity of food-driven systemic inflammation. This paper summarizes the published data connecting diet patterns, individual dietary assessment, and dietary interventions for specific IMIDs. When personalized and implemented with other lifestyle interventions (e.g., stress reduction, movement, etc.), nutritional interventions should be considered foundational therapy for chronic immune-mediated inflammation.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interview with Steve Mister, President, Council for Responsible Nutrition.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"10-13"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking About Berberine.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The alkaloid berberine is a constituent of several medicinal herbs with centuries of use. Emerging research is documenting many effective clinical applications. It has been shown to improve blood sugar control, lower cholesterol, inhibit infectious microorganisms, decrease inflammation, ameliorate inflammatory bowel disease, lower blood pressure, facilitate weight loss, and even inhibit cancer cells. However, it is important to recognize that relying solely on berberine as a treatment because it is a natural molecule ignores the need to address causes of the diseases and dysfunctions the patient is suffering.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Utilization of Herbal and Dietary Supplements in Patients with Chronic Liver Disease During the SARS-CoV2 Pandemic.","authors":"Avleen Kaur, Ahyoung Kim, Lisa R Yanek, Yisi Liu, Xueting Tao, Anna Peeler, Douglas Mogul, James Peter Adam Hamilton, Gerard E Mullin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>We studied the pattern of herbal and dietary supplement (HDS) use in patients with chronic liver disease (CLD) during the first year of the COVID-19 pandemic.</p><p><strong>Methods: </strong>A questionnaire/survey was sent to hepatology patients with CLD under the care of hepatologists at Johns Hopkins University School of Medicine.</p><p><strong>Results: </strong>The 5 most taken dietary supplements during the pandemic included vitamin B12 (27.7%), vitamin C (32.4%), vitamin D (54.6%), zinc (25.4%) and green tea extract (20.8%). Most participants (82.3%) did not discuss their HDS use with their hepatology providers.</p><p><strong>Conclusions: </strong>Healthcare providers should be mindful of potential HDS use in patients with CLD.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"14-17"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Plant-Based Dietary Supplement Improves Measures of Metabolic Detoxification and the Quality of Life: A Phase II Multicenter Randomized, Blinded, Placebo-Controlled Clinical Trial.","authors":"Bassem F El-Khodor, Wei Zang, Heather Gorby, Ashley Dominique, Meghan Hamrock, Brandon Metzer, Alessandra Pecorelli, Saradhadevi Varadharaj, Giuseppe Valacchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Persistent accumulation and hindered clearance of toxins from tissues over time may promote the development and exacerbation of several diseases. Hepatic metabolic detoxification is a key physiological process responsible for the clearance of toxic substances from the body. A healthy diet with nutritional dietary supplementation may support metabolic detoxification and help mitigate the negative effects of toxin burden.</p><p><strong>Methods: </strong>A multicenter, randomized, single-blind, controlled trial was conducted to test the effects of a dietary detoxification product (detox; n = 20) versus an active dietary control product (active control; n = 20) on selected biomarkers of metabolic detoxification, general health, and well-being following 28 days of dietary supplementation. Study participants displayed multiple symptoms commonly associated with elevated toxin burden, but otherwise healthy.</p><p><strong>Results: </strong>The detox group displayed significantly decreased levels of red blood cell total toxic metals, decreased urine total porphyrins, and decreased urine mutagenicity potency compared with baseline. Both the detox and active control groups showed improvements in the symptoms attributed to elevated toxin burden. Fatigue and sleep disruption scores were significantly reduced in the detox group compared with baseline. No significant differences in anthropometric measures and vital signs, and no adverse events or side effects were detected in either group over the study period.</p><p><strong>Conclusions: </strong>This study demonstrates the benefit of nutritional intervention for supporting metabolic detoxification, evidenced by significant changes in multiple detoxification biomarkers and improvement in questionnaire scores related to quality of life, general health, and well-being.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"22 5","pages":"28-39"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}