Integrative medicine最新文献

{"title":"Clinical Utility of Urine Hormone Metabolite Testing in Personalized Medicine: A Case Report of a Male Patient with Low Testosterone.","authors":"Mark S Newman, Jaclyn Smeaton, Azra Jaferi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Customizing dietary supplementation for each patient based on biomarker testing could maximize a supplement's health benefits and minimize safety-related issues. This case report demonstrates an integrative provider's use of hormone testing to guide personalized supplement recommendations for their patient.</p><p><strong>Case presentation: </strong>The patient was a healthy 47-year-old man who expressed interest in obtaining information about his testosterone levels. He underwent sex hormone testing using baseline serum measurement, as well as an at-home four-spot dried urine collection kit (DUTCH Test, Precision Analytical, Inc.) at baseline and before and after each intervention. Baseline serum free testosterone and urinary testosterone levels were at the low end of the age-dependent male reference range. Available genetic results also showed a catechol-O-methyltransferase (COMT) V158M polymorphism. The provider recommended human chorionic gonadotropin (HCG) to address low testosterone.</p><p><strong>Outcome: </strong>After HCG treatment, testosterone increased as desired. A simultaneous above-range increase in estradiol prompted the provider to recommend a supplement containing calcium D-glucarate (CDG) and diindolylmethane (DIM). While CDG+DIM normalized estradiol, it elevated 2-hydroxyestrone (2-OH-E1) and 4-hydroxyestradiol (4-OH-E2) above range. In addition, the ratio of 2-methoxyestrone (phase-2 estrogen metabolite) to 2-OH-E1 (phase-1 estrogen metabolite) continued to decline further with each intervention, indicating a reduced capacity for estrogen detoxification, possibly related to the patient's COMT variant. To improve methylation activity, trimethylglycine was added, which normalized the 2-methoxyestrone/2-OH-E1 ratio. Finally, sex hormone and metabolite levels were within range, without any adverse events.</p><p><strong>Discussion: </strong>Sex hormone and hormone metabolite testing before and after each intervention enabled careful step-by-step additions of supplements, which helped to improve testosterone levels while maintaining healthy estrogen metabolism. Given the patient's genetic background, this approach also ensured that any unintended effects on methylation were minimized. The convenience of the at-home dried urinary sampling method facilitated before-and-after testing.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 5","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine Prescribing Update.","authors":"Joseph Pizzorno, Lara Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirteen years ago, <i>IMCJ</i> published editorial 11.1, \"How Much Iodine Should We Prescribe?\" We explored the controversy around the safety and efficacy of supplemental iodine. We looked at the incidence of deficiency, epidemiological population studies of thyroid disorders, safety of various dosages, the need of special populations for larger dosages, and the unreliability of laboratory measures to determine an individual's iodine deficiency. We also sought the guidance of several highly experienced doctors of nutritional/integrative/functional/natural medicine. Their opinions ranged from conservative recommendations to aggressive supplementation in those with specific conditions. In this editorial we reviewed the research to help advance our understanding of iodine supplementation.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 5","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mark Blumenthal: The Herb Guru.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 4","pages":"36-39"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Narrative Review of Curcumin in Pain Medicine: The Need for Further Study.","authors":"Thomas Shelton, Lukas Croner, Adam Alluis, Lindsay Aldrich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Complementary, alternative, and integrative medicine (CAIM) techniques, such as dietary interventions and herbal supplements, are frequently used by patients as a method of treating pain. The use of turmeric, or <i>Curcuma longa</i>, has gained popularity among patients in recent years, and as such, has become of particular interest to clinicians. While there are a growing number of studies on turmeric for specific painful conditions, there has not been a study summarizing the overall breadth of the literature on the use of turmeric in the field of pain medicine. This study aims to provide a scoping review of the use of turmeric in conditions, including but not limited to arthritis, neuropathic pain, and other related topics in pain medicine. This study found that most clinical research on the use of turmeric in pain control has been in the setting of knee osteoarthritis. Limited studies were found on the use of turmeric in osteoarthritis outside of the knee, neuropathic pain, acute postoperative pain, and in the pain-related conditions of anxiety and depression. Given the efficacy of turmeric in pain control of knee osteoarthritis, our findings suggest that more clinical research is needed on turmeric in additional areas of pain medicine.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 4","pages":"14-24"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with Electroacupuncture and Neural Therapy in Secondary Peripheral Facial Paralysis: A Case Report.","authors":"Jose Luis Lozano Villanueva, Renné Leonardo Hernández Niño","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Peripheral facial paralysis is clinically characterized by complete facial paralysis of the ipsilateral hemiface, which is accompanied by loss of the corneal reflex, and depending on the level, can affect tear secretion, salivation, taste, and cause auditory alterations.</p><p><strong>Objective: </strong>To report the results obtained from joint management with electroacupuncture and neural therapy in two cases of patients who developed peripheral facial paralysis secondary to neurosurgical procedures.</p><p><strong>Materials and methods: </strong>Two clinical cases of patients with secondary facial paralysis are presented, which were treated jointly with electroacupuncture and neural therapy.</p><p><strong>Results: </strong>The degree of facial motor dysfunction of the patients improved from severe to mild, quantified using the House-Brackmann scale.</p><p><strong>Conclusions: </strong>Joint management using neural therapy and electroacupuncture represents a relevant treatment alternative in patients with secondary facial paralysis.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 4","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking About the Complexity of Food Molecules, Nutrient Activation, and Diverse Biochemical Pathways.","authors":"Joseph Pizzorno, Lara Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The physiology of life is complex. The process of understanding its complexity necessarily required simplification and focus on the molecules and biochemical pathways required for life. This focus resulted in huge benefits for understanding life and disease. However, the simplification process itself led to missing or dismissing a lot of important physiology critical for health. The result has been a lack of recognition of many factors important to health, not just life, such as losing many plant molecules when food is grown chemically rather than organically, focusing on major pathways while missing critical secondary pathways, and lacking recognition that single nucleotide variation evolved to adapt to widely diverse food molecules and vitamers. This editorial focuses on the complexity of food molecules, nutrient activation, and biochemical pathways that have thus far lacked recognition, with particular emphasis on the B6 vitamers.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 4","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unadjusted Analysis of a Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism.","authors":"Karl Jablonowski, Brian Hooker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Madsen et al.'s unadjusted results do not support rejecting the causal link between the MMR (measles, mumps, and rubella) vaccine and autism. The summary statistics and errors in the original publication warrant the release of the raw data. Madsen et al. is a cornerstone publication that forms the basis of the claim that vaccines do not cause autism, and thus, correctness and transparency need to be ensured.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 4","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Pelvic Floor Therapy in Enhancing Muscular Function and Providing Colorectal Symptom Relief: A Case Report.","authors":"Tia Hernández","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The pelvic bowl is lined by a network of muscles that provide structural organ support and assist with bodily functions. Like other muscles of the human body, pelvic floor muscles may hold tension or exhibit diminished or excessive tone due to various causative factors. This deviation is comprehensively referred to as Pelvic Floor Dysfunction (PFD). Approximately one in five individuals in the United States will experience some manifestation of symptomatic Pelvic Floor Dysfunction. Furthermore, an estimated 10% of female-bodied patients in the United States will undergo surgery for PFD symptoms such as incontinence, pelvic organ prolapse, or both, with 30% of this subgroup undergoing multiple surgeries. These statistics underscore the substantial burden of PFD imposed on individuals within the United States and highlight the importance of exploring less invasive treatments, such as Pelvic Floor Therapy (PFT), which aim to address muscular dysfunction without the risks associated with surgical intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In July 2023, a 47-year-old female presented to the NUNM Clinic for a pelvic floor consultation for a 1.5-year history of episodic fecal incontinence, fecal urgency, and diarrhea with previous work-up yielding unremarkable results. Pelvic floor muscular assessment was conducted via digital intravaginal palpation and graded utilizing the Modified Oxford Scale. During this physical examination,markedly hypotonic pelvic floor muscles were identified as well as several areas that were tender to palpation. Subsequent pelvic floor therapy (PFT) sessions and at-home Kegel and core exercises were initiated. The PFT sessions were held weekly for 3 visits, and biweekly for the following 2 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;By the end of the first month of treatment, the patient exhibited noteworthy improvements in muscle tone andstrength as graded by a Modified Oxford Scale. She also demonstrated enhanced voluntary control of initating, holding, and releasing contractions. The patient reported no episodesof fecal incontinence after the third PFT session. These improvements remained consistent throughout the 2 month follow-up period during which PFT continued on a biweekly basisAt a follow up visit 3 months later, the patient reported no episodes of fecal incontinence since last PFT session.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion/conclusion: &lt;/strong&gt;This case highlights the pivotal role of PFT in improving hypotonic pelvic floor musculature and associated symptoms. The patient's marked improvements suggest that conservative management with targeted PFT and guided exercises can offer a valuable alternative or adjunct to surgical intervention for PFD, not only for fecal incontinence but also for other symptoms that result from a hypotonic pelvic floor including, but not limited to, urinary incontinence, pelvic organ prolapse, and pelvic pain. This case study has limitations including the absence of a","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 4","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Facial Swelling in a One-Month-Old Male - An Atypical Presentation of Infantile Hemangioma: Case Report.","authors":"Vasudha Kota","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Infantile hemangiomas are common benign vascular tumors in the pediatric population, but they rarely present as unilateral facial swelling in infants, making such cases atypical and warranting further investigation. This case report presents a one-month-old male with unilateral facial swelling, raising suspicion for an atypical infantile hemangioma and possible PHACE syndrome, which includes posterior fossa malformations, hemangioma, arterial anomalies, coarctation of aorta or cardiac defects, and eye abnormalities.</p><p><strong>Case presentation: </strong>A one-month-old male presented with right-sided facial swelling without systemic symptoms. Initial imaging suggested mild parotitis, but the persistence and progression of swelling led to a reassessment, ultimately diagnosing a hemangioma.</p><p><strong>Discussion: </strong>This case emphasizes the need for early imaging and multidisciplinary care in atypical cases to address potential syndromic associations, such as PHACE syndrome, which can carry significant morbidity if overlooked. Treatment with propranolol gradually reduced swelling, and multidisciplinary follow-up is ongoing to monitor for complications.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Therapeutic Challenges in Lyme Disease and Co-Infections: Unraveling Neuropsychiatric and Neurological Complexities-A Comprehensive Case Series Analysis.","authors":"Kunal Garg, Rachael Booth, Aiven Cobey, Leona Gilbert, Aylin Ozdemir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background/objectives: </strong>Lyme disease (LD) and its co-infections present significant diagnostic and treatment challenges due to their complex interplay with neurological symptoms, immune responses, autoimmune reactions, and mental health conditions. Standard two-tier LD testing often fails to detect cases, necessitating expanded serologic and functional testing. Following CARE Guidelines, this case series examines ten clinical narratives of LD, highlighting the limitations of standard diagnostic methods, the potential benefits of specialized testing, and the need for an effective paradigm for LD management.</p><p><strong>Methods: </strong>A multidisciplinary approach grounded in integrative medicine was adopted. Diagnostic methods included advanced serological panels (e.g., TICKPLEX^®), co-infection testing, functional immune markers, Cunningham Panel testing for neuropsychiatric Lyme presentations, and imaging. Treatments included traditional antibiotics, botanical antimicrobials (Cryptolepis, Artemisinin, Biocidin), mitochondrial and neuroprotective support (CoQ10, NAD+, magnesium), nutritional therapies, detox support, immune system support protocols, pulsed electromagnetic field therapy, and methylene blue protocols.</p><p><strong>Results: </strong>The findings from this case series demonstrate the heterogeneity of LD manifestations across different ages, genders, and backgrounds. Compared to promising specialized testing, standard laboratory tests often misdiagnose LD and its co-infections as Parkinson's disease, multiple sclerosis, lupus, autism, and psychiatric disorders. Furthermore, integrating diverse treatment modalities, including combination and rotational antibiotic therapy, IV ceftriaxone for neurological cases, detoxification support (glutathione IV, vitamin C IV), and immune modulation with intravenous immunoglobulin, helped manage symptoms. Herxheimer reactions were effectively managed with antioxidant and detox therapies. Patients receiving long-term maintenance therapies, including herbal antimicrobials and gut microbiome support, showed fewer relapses.</p><p><strong>Conclusions: </strong>This case series advocates for a holistic, patient-centered approach. It emphasizes the necessity of comprehensive diagnostics that consider external factors, including post-vaccine symptom exacerbations, immune dysregulation, personalized treatment strategies, and ongoing research to improve LD management. These findings provide an evidence-based framework for physicians to integrate conventional and natural medicine strategies to optimize LD care.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"10-27"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}