Integrative medicine最新文献

{"title":"Failed Induction of the T_H1 System in T_H2 Dominant Patients: The Cancer-Permissive Immune Macroenvironment.","authors":"Samuel F Yanuck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tumor microenvironment infiltration by cells of the T helper cell type 1 (T_H1) system, including T_H1 cells, M1 macrophages, natural killer cells, and CD8⁺ T cells, is associated with better cancer prognosis. In contrast, tumor microenvironment infiltration by cells of the T_H2 system, including T_H2 cells, M2 macrophages, and innate lymphoid cells type 2, as well as immune suppressive myeloid-derived suppressor cells and regulatory T cells, is associated with poorer cancer prognosis. Beyond the tumor itself and a myriad of other modifying factors, such as genetic and epigenetic influences on tumorigenesis, the overall immune state of the patient, termed the macroenvironment, has also been shown to significantly influence cancer outcomes. Alterations in the tricarboxylic acid (TCA) cycle (TCA cycle breaks) involving loss of function of succinate dehydrogenase, isocitrate dehydrogenase, and fumarate hydratase have been shown to be associated with an intracellular metabolic shift away from oxidative phosphorylation and into glycolysis in cells that are transforming into cancer cells. The same loss of function of succinate dehydrogenase and isocitrate dehydrogenase has also been identified as inducing a shift in macrophages toward glycolysis that is associated with M1 macrophage polarization. M1 macrophages make interleukin 12, which stimulates T_H1 cells and natural killer cells to produce interferon gamma (IFN-γ), which in turn stimulates M1 macrophage activity, forming an activation loop. IFN-γ also drives activation of CD8⁺ T cells. Thus, M1 macrophage activation initiates and sustains activation of the T_H1 system of cells. In this fashion, TCA cycle breaks at succinate dehydrogenase and isocitrate dehydrogenase that promote cellular transformation into cancer cells are also associated with upregulation of the T_H1 system that provides anti-cancer immune surveillance. The T_H1 and T_H2 systems are known to inhibit each other's activation. It is this author's hypothesis that, in patients whose macroenvironment is sufficiently T_H2-dominant, the metabolic shift toward glycolysis induced by TCA cycle breaks that gives rise to mutagenic changes in tissue parenchymal cells is not counterbalanced by adequate activation of M1 macrophages, thus giving rise to cancer cell development. For instance, the atopic T_H2-high asthma phenotype, a T_H2 dominance-based comorbidity, is associated with a more than doubled incidence of colon, breast, lung, and prostate cancer, compared with non-asthmatics. Failure of TCA cycle breaks to induce M1 polarization of tissue-resident macrophages yields a tissue environment in which the tissue-resident macrophages fail to routinely perform M1-associated functions such as phagocytizing newly developing cancer cells. Failure of M1 phenotypic expression in both tissue-resident ma","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 2","pages":"24-35"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plastic Food Container Safety.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plastic containers are a huge part of modern life. Perhaps their use is nowhere more significant than in the storage of foods. Stored food comes in contact with plastics, plasticizers, intentional additives, and inadvertent contaminants. Plastic food containers are asserted to be safe, and the resin used in their manufacture is assigned a number to help understand their recyclability. These containers are not totally inert and leach varying levels of metals and chemicals into the foods they store-especially if subjected to elevated temperatures. The safest containers appear to be those made from resins with the ID numbers 2, 4 (except food wraps), and 5. This editorial looks at the various types of plastics used in the manufacture of food containers, their typical contaminants, their toxicity, and the median amount of migration of contaminants into food.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 2","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luke Huber, ND, Vice President, Scientific & Regulatory Affairs, Council for Responsible Nutrition.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 2","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global COVID-19 Pandemic Outcomes: A Cross-Country Comparison Study of Policy Strategies.","authors":"James A Thorp, Margery M Thorp, Elise M Thorp, Ajovi Scott-Emuakpor, K E Thorp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper explores global COVID-19 treatment and containment strategies in 108 countries worldwide, specifically the correlation between COVID-19 deaths and the countries' vaccination rates. Comparison of data across states, provinces, territories, and countries relied upon a common method to evaluate data regarding the impact of COVID-19 policies in the last three years. Data from nine different databases were analyzed to determine if there were correlations between the percentage of countrywide COVID-19 deaths/population and countries' percent vaccinated. Secondary outcome measures include the effect of other variables on COVID-19 death rates per country population, including health expenditures and annual income per capita, COVID-19 tests per 1000 people, stringency index (a measure of each country's containment strategies), hydroxychloroquine/ivermectin scores (measure country use), hypertension, obesity, diabetes, and geographic locations. COVID-19 vaccination rates ranged from 0-99% in 108 countries. Bivariate analysis demonstrates the following independent variables to correlate with COVID-19 deaths/population (Spearman correlation coefficient, p value): countrywide COVID-19 vaccination rates (moderate relationship, r=0.39, <i>P</i> < .001); healthcare expenditures per capita per annum (US dollars) (moderate relationship, r=0.46, <i>P</i> < .001), net annual income per capita (moderate relationship, r=0.50, <i>P</i> < .001), COVID-19 tests per 1000 country population (moderate relationship, r=0.36, <i>P</i> < .003); stringency index per country (moderate relationship, r=0.28, <i>P</i> < .003); hydroxychloroquine index (negative relationship, r= 0.15, <i>P</i> = .125); and ivermectin index (negative relationship, r=0.23 <i>P</i> = .018). The authors found that the higher the percentage of a country's vaccination rate, stringent containment strategies, mass testing, etc., moderately correlated with higher COVID-19 death rates/population. Future studies are required to explore the findings of this study fully.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 2","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitalism and Naturopathy in Psychedelic Medicine.","authors":"Matthew Hicks, Olivia Giguere","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Psychedelic therapy is witnessing a rapid rise in popularity both in clinical research and in the greater culture. Since it involves the use of drugs, psychology, and spirituality, professionals from a variety of backgrounds such as physicians, psychotherapists, chaplains, etc. are increasingly becoming interested or directly involved. In this article, the authors describe why naturopathic doctors, with additional training, are well suited to provide psychedelic therapy. Naturopathy is rooted in the non-materialistic metaphysics of vitalism, which is consistent with the concept of <i>inner healing intelligence</i>, which is widely accepted in the psychedelic therapy community. In addition to the compatible foundational philosophies, naturopaths also possess a wide range of clinical skills including herbalism, pharmacology, and counseling, among others, that can be directly applied to psychedelic therapy and integration.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 2","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to Recognize and Address the Serious Arsenic Problem.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic low-level exposure to arsenic has a dose-dependent relationship with many chronic diseases. However, the typical arsenic safety standards used by governmental entities and laboratories appear inconsistent with current research. This editorial reviews the research and suggests that the random first-morning-urine total arsenic threshold for increased disease risk should be 5.0 μg/g creatinine or lower.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 1","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interview with Dr. Jocelyn Strand, ND, Director of Clinical Education and Research at Biocidin Botanicals.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Trauma-Induced Multiple Sclerosis with Paleo Diet and Integrative Therapies: A Case Report.","authors":"Jasmin B Hollywood","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Trauma continues to be noted in studies as a risk factor for autoimmune diseases such as multiple sclerosis (MS). Successful therapeutic interventions that support the reduction of numbing episodes associated with MS may include diet, stress reduction techniques, and biofield therapy.</p><p><strong>Case description: </strong>This case report highlights the successful reduction of numbing episodes, stress, and fatigue in an individual 38-year-old Caucasian female patient using nutrition and body-mind-spirit practices. This individual continued conventional interventions while starting medical nutrition therapy. Over the course of 120 days, her treatment was augmented with a Paleolithic-style diet, which eliminated dairy and ultra-processed foods. Other dietary recommendations suggested were the increase of polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs), decrease of saturated fatty acids (SFAs), and increase in protein and CO₂-promoting foods. Integrative recommendations were biofield therapy and for stress reduction were psychotherapy, reduced exercise intensity, lifestyle recovery from trauma, body-mind-spirit practices, and herbal supplementation.</p><p><strong>Conclusion: </strong>Integrative therapies such as diet, stress reduction techniques, and biofield therapy may be used as therapeutic protocols for trauma-induced MS patients. Population-based clinical studies should be done to understand the role of these therapies in synchronization.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Phytoneuroendocrine System: Connecting Plants to Human Systems Biology.","authors":"Deanna M Minich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Traditional medicine, exemplified by systems such as Ayurveda, inherently adopts a holistic framework. This framework extends beyond mere consideration of the human body to encompass broader systems of health, integrating elements of nature, particularly plants. Over time, there has been a notable integration between traditional medical philosophies and modern scientific methodologies. This integration is evident in published works that blend these disciplines, resulting in the creation of innovative terminology, such as «<i>Ayurnutrigenomics</i>». Concurrently, the lexicon within medical science has evolved to highlight the connection of body systems, as illustrated by terms like «gut-brain axis», which emphasize the relationship between physiological and psychological factors. This integration of perspectives is further demonstrated by terms such as «<i>psychoneuroendocrine</i>» and «<i>mind-heart-body</i>», reflecting a holistic approach to health. Alongside the emergence of these novel terms, there has been a proliferation of literature exploring the diverse functions of plants, particularly focusing on phytonutrients such as those found in the polyphenol category of compounds. In many ways, these emerging findings suggest a fundamental relationship between humans and plants, aligning with the principles of traditional medicine and indicating a profound connection between the two. Thus, in harmony with the increasing recognition of the interconnectedness between human systems biology, the study of phytochemicals, and the ability of plants to influence neuroendocrine responses, this article proposes a new term: the phytoneuroendocrine system.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Conversion About CanXida with Rhianna Jones, RN.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"23 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}