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The Untold/Hidden History of Western Medicine-Part 2. 西方医学不为人知/隐藏的历史——第二部分。
Integrative medicine Pub Date : 2025-12-01
Joseph Pizzorno
{"title":"The Untold/Hidden History of Western Medicine-Part 2.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this second part of my editorial on the untold/hidden history of Western medicine, I look at the many efforts of the past 2 centuries to balance disease medicine with health medicine. Many brave and visionary men and women founded and promoted health medicine movements, but few were successful. I present here an overview of the key movements, why most failed, and what changed to allow health medicine (by whatever name) to finally endure.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-Brain Axis: The Role of Gastrointestinal Issues in Parkinson's Disease. 肠脑轴：胃肠道问题在帕金森病中的作用。
Integrative medicine Pub Date : 2025-12-01
Cemile Armas, Patricia Kaufman
{"title":"Gut-Brain Axis: The Role of Gastrointestinal Issues in Parkinson's Disease.","authors":"Cemile Armas, Patricia Kaufman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parkinson's Disease (PD) is a complex neurodegenerative disorder traditionally identified by motor symptoms. However, non-motor manifestations such as lower gastrointestinal (GI) disturbances are increasingly recognized as early indicators and contributors to disease progression. This review examines the gut-brain axis and the role of lower GI issues, particularly constipation and gut dysbiosis, in the pathogenesis and management of PD. The \"bottom-up\" hypothesis suggests that PD may originate in the gut, with misfolded alpha-synuclein aggregating in the enteric nervous system before appearing in the brain. This pathological process is closely associated with gut dysbiosis, which contributes to increased intestinal permeability, systemic inflammation, and neuroinflammation via the vagus nerve and disrupted blood-brain barrier. Dysbiosis not only alters microbial diversity but also leads to the overproduction of neurotoxic metabolites, like lipopolysaccharides (LPS) and short-chain fatty acids (SCFAs). These biochemical changes create a pro-inflammatory environment that accelerates neurodegeneration. The review examines integrative interventions, including dietary strategies such as the Mediterranean diet and supplementation with probiotics, prebiotics, and synbiotics, which have shown promise in modulating gut microbiota and reducing inflammation. Lifestyle factors, such as exercise and stress reduction, also support gut health and symptom management, with structured multimodal exercise regimens showing significant benefit in motor function.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"20-27"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creating a Revolution in Brain Health. 创造大脑健康的革命。
Integrative medicine Pub Date : 2025-12-01
Sheldon Baker
{"title":"Creating a Revolution in Brain Health.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"32-34"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postbiotic Metabolites: A Paradigm Shift in Microbiome Science. 后生物代谢物：微生物组科学的范式转变。
Integrative medicine Pub Date : 2025-12-01
Ross Pelton
{"title":"Postbiotic Metabolites: A Paradigm Shift in Microbiome Science.","authors":"Ross Pelton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"16-19"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whey Protein Concentrate as a Tryptophan-Based Nutritional Intervention for Premenstrual Dysphoric Disorder (PMDD): A 3-Month Case Study. 乳清蛋白浓缩物作为一种基于色氨酸的经前烦躁障碍（PMDD）营养干预：一项为期3个月的案例研究。
Integrative medicine Pub Date : 2025-12-01
Fay Kazzi
{"title":"Whey Protein Concentrate as a Tryptophan-Based Nutritional Intervention for Premenstrual Dysphoric Disorder (PMDD): A 3-Month Case Study.","authors":"Fay Kazzi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Premenstrual dysphoric disorder (PMDD) is a hormone-sensitive mood disorder characterized by cyclical emotional and functional impairment in the luteal phase. Serotonergic dysregulation contributes to its pathophysiology.</p><p><strong>Case presentation: </strong>A 38-year-old registered dietitian with clinically diagnosed PMDD consumed 5 tablespoons of whey protein concentrate (WPC) blended into a carbohydrate-rich smoothie daily for 8 days before menstruation, across 3 consecutive cycles.</p><p><strong>Outcomes: </strong>The subject perceived substantial symptom relief (~ 80-95%), compared to her prior cycles and years of consistent symptoms. No adverse effects were reported.</p><p><strong>Discussion: </strong>WPC provides a food-based source of tryptophan; co-ingestion with carbohydrates enhances tryptophan transport into the brain by increasing the Trp/LNAA ratio.</p><p><strong>Conclusion: </strong>WPC may offer an effective and well-tolerated nutritional intervention for PMDD. Controlled trials are warranted.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"28-30"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Paradigm-Shifting Future of Health Care: Rise of Predictive, Personalized Lifestyle Medicine. 医疗保健范式转变的未来：预测性、个性化生活方式医学的兴起。
Integrative medicine Pub Date : 2025-12-01
Jeffrey S Bland
{"title":"The Paradigm-Shifting Future of Health Care: Rise of Predictive, Personalized Lifestyle Medicine.","authors":"Jeffrey S Bland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For more than a century, the dominant model has been reactive: diagnose disease once symptoms arise, then apply treatments designed to manage or suppress them. But a new model-predictive, personalized, and data-driven-is rapidly emerging. This shift is propelled by the invention of new technologies that have introduced a radically different way of understanding health by integrating massive longitudinal datasets with artificial intelligence, imaging, and biomarker analysis. In doing so, it heralds the beginning of a fundamental redesign of the healthcare system itself.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"10-12"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five Myths About Dietary Supplements-And the Truth You Should Know. 关于膳食补充剂的五个误区——你应该知道的真相。
Integrative medicine Pub Date : 2025-12-01
Steve Mister
{"title":"Five Myths About Dietary Supplements-And the Truth You Should Know.","authors":"Steve Mister","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 6","pages":"14-15"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Schizophrenia and Depression Caused by Environmental Toxins and Dysbiosis: A Functional Medicine Case Study. 环境毒素和生态失调所致精神分裂症和抑郁症的治疗：一个功能医学案例研究。
Integrative medicine Pub Date : 2025-10-01
Vanessa Gourdine
{"title":"Treatment of Schizophrenia and Depression Caused by Environmental Toxins and Dysbiosis: A Functional Medicine Case Study.","authors":"Vanessa Gourdine","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The incidence of mental health disorders increased by about 40% from 2019 to 2023. The incidence of mental health disorders continues to escalate while the outcomes remain poor. The outcomes of psychopharmacology are mildly to moderately effective and rarely, if ever, result in a cure. The expectation is a lifetime use of medication for symptomatic management. The following case is an example of an integrative mind-body approach that may lead to an actual cure of psychiatric conditions when focused on neuroinflammation and not solely on neurotransmitters. The current case involves a young man who had been hospitalized seven times within seven years and treated with multiple attempts at various combinations of polypharmacy, resulting in similar outcomes and more hospitalizations. He sought a functional medicine approach due to the poor outcomes with conventional treatment. Subsequently, he was admitted to our outpatient facility utilizing a multi-systems model of an in-depth mind-body assessment. The treatment was based on inflammatory markers likely triggered by multiple toxin exposures, aimed at eliminating the sources of inflammation and introducing lifestyle and diet modifications to support detoxification. The outcomes obtained were extraordinary, with a total remission of all symptoms up to and including a post-treatment two-year follow-up assessment. This suggests that our approach to creating health outcomes needs to be personalized and integrative of both mind and body to achieve the best outcomes. The case presents an alternative approach to conventional treatment involving polypharmacy and psychiatric hospitalizations.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 5","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2025 Linus and Ava Helen Pauling Award: Deanna Minich, PhD. 2025年莱纳斯和艾娃海伦鲍林奖：迪安娜·米尼奇博士。
Integrative medicine Pub Date : 2025-10-01
Dick Benson
{"title":"2025 Linus and Ava Helen Pauling Award: Deanna Minich, PhD.","authors":"Dick Benson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 5","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Tongue: Brassica Vegetables, Distributed Taste Receptors, and Their Role in Holistic Health. 舌头之外：芸苔类蔬菜，分布的味觉感受器，以及它们在整体健康中的作用。
Integrative medicine Pub Date : 2025-10-01
Stefania C Bray, Mitul Jones
{"title":"Beyond the Tongue: Brassica Vegetables, Distributed Taste Receptors, and Their Role in Holistic Health.","authors":"Stefania C Bray, Mitul Jones","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article explores the expanded understanding of taste receptors and their role in health, with a focus on brassica vegetables. Recent research reveals that taste receptors are distributed throughout the body, influencing various physiological processes beyond simple oral taste perception. Brassica vegetables, also known as cruciferous vegetables, contain glucosinolates that convert into bioactive isothiocyanates, which interact with these widespread taste receptors. These interactions contribute to numerous health benefits, including anti-inflammatory, antioxidant, and potential chemopreventive effects. The study emphasizes the importance of educating patients about the holistic impact of brassica vegetables on health, proposing strategies to encourage their consumption despite initial taste aversions. This approach aims to reframe food as medicine within primary care settings.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 5","pages":"10-13"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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