Integrative medicine最新文献

{"title":"Unilateral Facial Swelling in a One-Month-Old Male - An Atypical Presentation of Infantile Hemangioma: Case Report.","authors":"Vasudha Kota","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Infantile hemangiomas are common benign vascular tumors in the pediatric population, but they rarely present as unilateral facial swelling in infants, making such cases atypical and warranting further investigation. This case report presents a one-month-old male with unilateral facial swelling, raising suspicion for an atypical infantile hemangioma and possible PHACE syndrome, which includes posterior fossa malformations, hemangioma, arterial anomalies, coarctation of aorta or cardiac defects, and eye abnormalities.</p><p><strong>Case presentation: </strong>A one-month-old male presented with right-sided facial swelling without systemic symptoms. Initial imaging suggested mild parotitis, but the persistence and progression of swelling led to a reassessment, ultimately diagnosing a hemangioma.</p><p><strong>Discussion: </strong>This case emphasizes the need for early imaging and multidisciplinary care in atypical cases to address potential syndromic associations, such as PHACE syndrome, which can carry significant morbidity if overlooked. Treatment with propranolol gradually reduced swelling, and multidisciplinary follow-up is ongoing to monitor for complications.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Therapeutic Challenges in Lyme Disease and Co-Infections: Unraveling Neuropsychiatric and Neurological Complexities-A Comprehensive Case Series Analysis.","authors":"Kunal Garg, Rachael Booth, Aiven Cobey, Leona Gilbert, Aylin Ozdemir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background/objectives: </strong>Lyme disease (LD) and its co-infections present significant diagnostic and treatment challenges due to their complex interplay with neurological symptoms, immune responses, autoimmune reactions, and mental health conditions. Standard two-tier LD testing often fails to detect cases, necessitating expanded serologic and functional testing. Following CARE Guidelines, this case series examines ten clinical narratives of LD, highlighting the limitations of standard diagnostic methods, the potential benefits of specialized testing, and the need for an effective paradigm for LD management.</p><p><strong>Methods: </strong>A multidisciplinary approach grounded in integrative medicine was adopted. Diagnostic methods included advanced serological panels (e.g., TICKPLEX^®), co-infection testing, functional immune markers, Cunningham Panel testing for neuropsychiatric Lyme presentations, and imaging. Treatments included traditional antibiotics, botanical antimicrobials (Cryptolepis, Artemisinin, Biocidin), mitochondrial and neuroprotective support (CoQ10, NAD+, magnesium), nutritional therapies, detox support, immune system support protocols, pulsed electromagnetic field therapy, and methylene blue protocols.</p><p><strong>Results: </strong>The findings from this case series demonstrate the heterogeneity of LD manifestations across different ages, genders, and backgrounds. Compared to promising specialized testing, standard laboratory tests often misdiagnose LD and its co-infections as Parkinson's disease, multiple sclerosis, lupus, autism, and psychiatric disorders. Furthermore, integrating diverse treatment modalities, including combination and rotational antibiotic therapy, IV ceftriaxone for neurological cases, detoxification support (glutathione IV, vitamin C IV), and immune modulation with intravenous immunoglobulin, helped manage symptoms. Herxheimer reactions were effectively managed with antioxidant and detox therapies. Patients receiving long-term maintenance therapies, including herbal antimicrobials and gut microbiome support, showed fewer relapses.</p><p><strong>Conclusions: </strong>This case series advocates for a holistic, patient-centered approach. It emphasizes the necessity of comprehensive diagnostics that consider external factors, including post-vaccine symptom exacerbations, immune dysregulation, personalized treatment strategies, and ongoing research to improve LD management. These findings provide an evidence-based framework for physicians to integrate conventional and natural medicine strategies to optimize LD care.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"10-27"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Lisa Lavine Nagy: Tackling Environmental Health Medicine One Day at a Time.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"38-44"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Gastrointestinal, Metabolic, and Thyroid Biomarkers through Advanced Diagnostic Techniques and Functional Nutrition Approach in 40-Year-Old Female: A Case Report.","authors":"Anitta Joseph, Prerna Shahani, Mugdha Pradhan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Functional nutrition is a holistic approach that uses advanced diagnostics to treat diseases based on a root cause analysis, followed by personalised dietary interventions, supplements, physical exercise, stress management, and environmental modifications.</p><p><strong>Objectives: </strong>This case report discusses the functional nutrition approach adopted to manage gastrointestinal and thyroid dysfunctions in a 40-year-old female. The approach included root cause analysis and advanced diagnostic tests such as gastrointestinal microbial array tests (GI-MAP) and pathogen-associated immune reactivity screen (Array 12).</p><p><strong>Case presentation: </strong>Root cause analysis of the patient presented with gastrointestinal symptoms, chronic fatigue; sleep issues, and hives, revealed inflammation, infection, dysbiosis, and thyroid disorders. The comprehensive approach included an initial three-month protocol, followed by six-month maintenance and thyroid protocols. Interventions included elimination and anti-inflammatory diets, nutraceutical regimens, and lifestyle modifications such as exercise. Post protocol, the patient lost 10 kg with improved gastrointestinal symptoms, better energy levels, relief from skin problems, and sound sleep.</p><p><strong>Discussion: </strong>Resolving the underlying infection and inflammation with a personalized diet and essential nutraceuticals improved gut health, sleep patterns, energy levels, and body weight.</p><p><strong>Conclusion: </strong>Advanced diagnostics combined with functional nutrition principles can potentially lead to successful management of gastrointestinal and thyroid disorders.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Nucleotide Polymorphisms and Vitamers.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Animal and human biochemistry and physiology developed over millennia under widely varying environments and available sources of nutrition. The genome evolved to optimize survival and reproduction in surprisingly diverse ways. A clinically important aspect of this evolution is that SNP manifestations changed to match the variants in food molecules required for life such as vitamins. This editorial discusses the interaction between SNPs and vitamers, the varied forms in which vitamins occur.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 3","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Neurotoxins Are Driving the Neurodegeneration Panpidemic.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The world is suffering a pandemic of neurodevelopment and neurodegenerative disorders. Autism, attention-deficit/hyperactivity disorder, dementia, Alzheimer disease, Parkinson disease-the list is long-have all increased relentlessly the past few decades. The primary cause appears to be the saturation of the environment with microbial, chemical, and metal neurotoxins. This editorial reviews the research on commonly found neurotoxins and attempts to assess their contribution to neurodegeneration and its prevalence in the population.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 2","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Jacob Teitelbaum Looks at Effectively Treating Long Covid.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 2","pages":"30-32"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specnova Announces the Next Generation Ashwagandha: NooGandha^®.","authors":"Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 2","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long COVID Response to Classical Chinese Medicine.","authors":"Louis A Kazal, Karen L Huyck, Brendan Kelly","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Long COVID remains a significant burden for patients, clinicians, employers, and the U.S. healthcare system. Despite substantial resources and scientific studies directed at understanding and treating long COVID, its cause, and thus targeted treatment remains elusive. Conventional medicine focuses on symptom evaluation to rule out other etiologies. Intervention typically offers the patient current understanding and education and provides reassurance and context for their symptoms. Treatment is mostly supportive care directed at symptom management to improve quality of life, including occupational and physical therapy, breathing exercises, pulmonary rehabilitation, and mental health therapy. Classical Chinese Medicine (CCM) can help make sense of an individual's response to COVID-19 infection, as each pathophysiological change caused by COVID can be correlated with CCM principles, therefore a corresponding treatment approach is available.</p><p><strong>Methods: </strong>A case series of four representative patients with long COVID treated with CCM is presented. Symptom complex, CCM diagnoses and treatment, and response to treatment are provided for each case, and the rationale for the selected therapy approach is explained.</p><p><strong>Results: </strong>All four patients recovered fully from long COVID after treatment with CCM therapy. These cases are representative of 56 patients successfully treated thus far with CCM for long COVID.</p><p><strong>Conclusion: </strong>There is no single treatment for long COVID in Western or Chinese medicine. Western medical treatment centers around reassurance and supportive care, whereas CCM treatment can be more directly targeted and individualized to underlying causes and increase the probability of recovery. These cases indicate the potential of CCM for treating long COVID. However, more research is needed to evaluate the effectiveness of this approach to long COVID recovery.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 2","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Walking on a Foot Reflexology Path on Autonomic Function: A Feasibility Study.","authors":"H L Nanjeshgowda, Geetha B Shetty, K J Sujatha, Prashanth Shetty","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Traditional foot reflexology impacts autonomic function by applying pressure to the foot. However, evidence of walking on foot reflexology path and its influence on autonomic function was limited.</p><p><strong>Primary study objective: </strong>The study aimed to ascertain whether walking on a foot reflexology path was feasible and how this would affect autonomic function.</p><p><strong>Methods: </strong>This was a randomized, counterbalanced, open-label crossover trial. 24 healthy volunteers recruited, aged 18 - 26 years, were randomly assigned into 2 groups (n = 12 in each). After a washout period of 2 days, they switched to receive the opposite phase of intervention.</p><p><strong>Setting: </strong>A holistic health centre in southern India.</p><p><strong>Intervention: </strong>Walking on a foot reflexology path or walking on a plain surface for 15 minutes.</p><p><strong>Outcome measures: </strong>Measures include feasibility, blood pressure, and heart rate variability. Participants were assessed at baseline, during walking, and 5 minutes after intervention.</p><p><strong>Results: </strong>All participants completed the study with no adverse events, indicating the feasibility of the study. Participants were comfortable walking without any deviation in the horizontal and vertical accelerometry. There was a significant decrease in mean RR interval and percentage of differences between adjacent normal heartbeats that are greater than 50 milliseconds during walking on foot reflexology path and walking on plain surface compared to pre-intervention values (<i>P</i> < .05). At post-intervention, a significant increase in mean RR and percentage of differences between adjacent normal heartbeats that are greater than 50 milliseconds (<i>P</i> < .05) was noted, along with a significant decrease in heart rate, systolic blood pressure, and diastolic blood pressure only after walking on reflexology path when compared with pre-intervention values (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>The findings indicate that walking on foot reflexology path is feasible and potentially helps to regulate cardiac vagal tone by reducing blood pressure and increasing heart rate variability compared to walking on plain surface.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"24 2","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}