Integrative medicine最新文献

{"title":"Enhancement of Vagal Tone, Cognitive Processing, and Self-Regulation Through Short-Term Audible Mantram Repetition Practice in Novice Meditators.","authors":"V R Damerla, K Madhavan, S Mittal, M Pathania, A Kumar, S Sharma, V Gupta, P Pothu, R Pillai, T Nesbitt, P Sharma, V Bhatia, P Matreja, D B Wolf, B D Goldstein, L Dajak, H Medley, D L McCluskey, K Patel, N Patterson","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic stress, widely acknowledged as a cause of lifestyle-related diseases, is associated with impaired relaxation capacity, reduced heart rate variability, and diminished emotional resilience and self-regulation. This study investigated the effects of short-term daily audible repetition of the Hare Krishna Mantram on heart rate variability, psychological resilience, and cognitive processing among novice practitioners in a university health care setting.</p><p><strong>Methods: </strong>This is a randomized three-group study of healthy, meditation-naïve participants in a health care setting (mean age 26.63 years). All participants (n=39) engaged in audible repetition of the Hare Krishna Mantram for 30 minutes daily for 4 weeks. After a two-week washout period, some participants (n=13) switched to a placebo/sham mantram for 4 weeks, and others (n=12) practiced silent contemplative practice daily for 4 weeks. Heart rate variability parameters were recorded weekly using HeartMath emWave Pro sensors. At intake and the end of each phase, cognitive processing was assessed using an 8-channel Nihon Kohden EEG system (P300), executive function via the Color Stroop test, and self-regulation via psychological measures.</p><p><strong>Results: </strong>The Hare Krishna Mantram phase showed statistically significant improvements in heart rate variability (<i>P</i> < .0001), P300 latency (<i>P</i> = .0052) and amplitude (<i>P</i> = .0370), Stroop task average neutral (<i>P</i> = .0012) and emotional (<i>P</i> = .0096) reaction times, and self-regulation scores (<i>P</i> < .0001). The sham phase and, to a lesser degree, during silent contemplative practice, showed significant changes in heart rate variability; however, these effects were not evident in cognitive and self-regulation measures.</p><p><strong>Conclusion: </strong>Short-term, daily audible repetition of the Hare Krishna Mantram is a promising non-pharmacological approach to improving heart rate variability, brain executive function, self-regulation, and relaxation capacity among novice practitioners. These findings support the potential of Audible Mantram Repetition to manage chronic stress, cognitive function, and restore autonomic balance.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 4","pages":"22-33"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13567168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental Disorder Associated with Aluminum-Adsorbed Vaccines: Reanalysis of Data from a Danish Nationwide Cohort Study.","authors":"Karl Jablonowski, Brian Hooker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Andersson et al. published \"Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood: A Nationwide Cohort Study\" with a discussion and conclusion that contradict the data. Aluminum adjuvant safety studies are largely underwhelming, irrelevant to injectable aluminum, and are not designed to study neurodevelopmental disorders. The manuscript matches the original supplemental, in which many neurodevelopmental diagnoses were deleted, but not the updated supplemental, which shows an association with neurodevelopmental disorder. Neurodevelopmental disorders such as Asperger syndrome (now Level 1 autism spectrum disorder), other pervasive developmental disorders, autistic disorder, and autism spectrum disorder are all found to be statistically significantly associated with a higher cumulative dose of vaccine-derived aluminum.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 4","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13567156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Perspective on Integrative Oncology in India: Survival Conversations, Multidisciplinary Collaboration, and Healing Environments.","authors":"Pradeep Mk Nair, Karishma Silwal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Integrative oncology combines conventional cancer treatments with evidence-based complementary therapies to address the multidimensional needs of cancer patients. While existing literature largely focuses on therapeutic interventions and clinical outcomes, limited attention has been given to the lived experiences and professional realities of integrative oncology practitioners, particularly within the Indian healthcare context.</p><p><strong>Objective: </strong>This perspective paper aims to explore practical, emotional, and interdisciplinary dimensions of practicing integrative oncology, while emphasizing patient communication, multidisciplinary collaboration, and healing-centered clinical environments.</p><p><strong>Discussion: </strong>Practitioners in integrative oncology function at the intersection of biomedical science, supportive care, and patient-centered communication. Beyond managing symptoms and treatment-related toxicities, clinicians frequently engage with patients' existential concerns, prognostic uncertainties, emotional distress, and hopes for healing. The paper discusses three interconnected domains: (1) navigating complex conversations related to suffering, meaning, prognosis, and uncertainty; (2) working within multidisciplinary oncology ecosystems that may include differing perspectives regarding complementary therapies; and (3) cultivating healing-oriented clinical environments that support psychological resilience, trust, dignity, and overall well-being. Drawing from experiential insights in an integrative oncology setting in India, the paper highlights both the opportunities and challenges involved in delivering holistic and compassionate cancer care.</p><p><strong>Conclusion: </strong>Integrative oncology extends beyond the integration of therapies, encompassing the integration of communication, empathy, multidisciplinary collaboration, and healing-centered care practices. Recognizing the human dimensions of oncology practice may contribute to more compassionate, patient-centered, and psychologically supportive cancer care models. This perspective underscores the importance of fostering interdisciplinary understanding and holistic care approaches in contemporary oncology practice.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 4","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13567163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cure or Suppression.","authors":"Joseph Pizzorno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Regardless of the school of thought, each profession has established its own criteria for determining whether or not an intervention is successful. How a profession defines intervention success profoundly impacts actual clinical practice. I assert here that inappropriate criteria for defining intervention success and patient healing are foundational to the chronic disease epidemic society is suffering.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 4","pages":"6-8"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13567155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversation with Joe Ladapo, MD, PhD.","authors":"Chris D'Adamo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 4","pages":"40-43"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13567162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multimodal Lifestyle and Mind-Body Intervention in Rural Primary Care: Implications for Metaflammation in an Appalachian Population.","authors":"Jessica Riggleman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic metabolic diseases such as obesity, hypertension, type 2 diabetes, and mood disorders frequently cluster in under-resourced communities. Increasing evidence suggests these conditions may be influenced by persistent low-grade systemic inflammation (sometimes referred to as metaflammation), as well as cumulative physiologic stress and environmental constraints. Rural Appalachian populations experience a disproportionate burden of these conditions, often compounded by poverty, food deserts, limited healthcare access, and restricted availability of preventive services.</p><p><strong>Objective: </strong>To describe clinical and functional outcomes of a multimodal lifestyle and stress-regulation intervention implemented within routine primary care in a rural Appalachian population with multimorbidity.</p><p><strong>Setting: </strong>A rural primary care clinic serving an under-resourced Appalachian community in the United States.</p><p><strong>Participants: </strong>Thirty adults with multimorbidity participated in a 12-week clinic-based intervention; 22 participants completed the program and were followed through six months.</p><p><strong>Intervention: </strong>The intervention integrated lifestyle education, hydration optimization, nutrition awareness adapted to food-desert constraints, and mindfulness-based cognitive-somatic practices designed to support stress regulation and behavioral awareness.</p><p><strong>Primary outcome measures: </strong>Clinical and patient-reported outcomes, including body weight, blood pressure, depressive symptoms (PHQ-9), anxiety symptoms (GAD-7), sleep quality, energy levels, cognitive clarity, medication burden, and available laboratory markers, including HbA1c and fasting glucose.</p><p><strong>Results: </strong>Participants demonstrated improvements across metabolic, psychological, and functional domains. Mean PHQ-9 and GAD-7 scores decreased from approximately 18-22 at baseline to 6-9 at 12 weeks, with improvements largely sustained at six months. Weight reduction ranged from approximately 11-30 lb over the 12-week intervention period, with greater reductions observed among a subset of participants. Blood pressure and glycemic control improved, along with improvements in sleep quality, energy levels, and cognitive clarity.</p><p><strong>Conclusions: </strong>The pragmatic lifestyle and stress-regulation intervention was associated with improvements across metabolic, psychological, and functional outcomes, indicating its potential as a complementary strategy for addressing chronic disease in underserved communities.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 4","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13567161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diamine Oxidase Supplementation for Histamine Regulation in Constipation-Predominant Irritable Bowel Syndrome: A Case Report.","authors":"Cari Pierce, Oscar Coetzee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since 2016, irritable bowel syndrome has been defined by a grouping of primary symptoms and no longer requires invasive testing for diagnosis. Abdominal pain related to bowel movements or relieved by having a bowel movement is the primary symptom of this functional gastrointestinal disorder. Through expanding appreciation of functional gastrointestinal disorders and the increasing understanding of gastrointestinal tract-brain interactions, a growing body of research is discussing the symptom overlap between IBS and histamine intolerance, as well as other issues of histamine metabolism and related neuroimmune regulation in the pathophysiology of IBS. Visceral hypersensitivity, exacerbated by increased histamine levels, may disrupt the intricate signaling between the central nervous system and enteric nervous system. This case report illustrates the use of supplemental diamine oxidase combined with trigger food avoidance to nearly completely abate IBS symptoms in a 46-year-old Japanese American female.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 3","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coenzyme Q10: A Life Extension Nutrient & The Crystallization Problem.","authors":"Ross Pelton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 3","pages":"34-36"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron at the Crossroads of Thyroid Function and Detoxification in Women: Clinical Implications for Diagnosis and Management.","authors":"Angela D Mazza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Iron deficiency is one of the most prevalent micronutrient disorders worldwide and disproportionately affects women across the lifespan. While its hematologic consequences are well recognized, the broader endocrine and metabolic implications of iron status remain underappreciated in routine clinical care. Iron is a critical cofactor in thyroid hormone synthesis and metabolism and plays a central role in hepatic detoxification pathways, mitochondrial energetics, and hormone regulation. Disruptions in iron homeostasis may therefore contribute to thyroid dysfunction, impaired detoxification capacity, and symptom patterns that overlap with hypothyroidism, particularly in women with increased physiologic demands such as menstruation, pregnancy, and perimenopause. This narrative review examines the interconnected roles of iron in thyroid physiology and detoxification systems, with a focus on clinical implications for women's health. We discuss mechanisms linking iron deficiency to altered thyroid hormone production, hepatic cytochrome P450 activity, estrogen metabolism, and mitochondrial function. Diagnostic challenges, including the interpretation of ferritin and iron indices in thyroid patients, are reviewed alongside evidence-informed therapeutic strategies. A systems-based clinical framework is proposed to guide screening, evaluation, and management of iron deficiency in women with thyroid disorders. Recognizing iron as a central regulator at the intersection of thyroid and detox pathways may improve patient outcomes and inform more comprehensive approaches to endocrine care.</p>","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 3","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition Education in Medical School: <i>What Should It Include?</i>","authors":"Jeffrey S Bland","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13593,"journal":{"name":"Integrative medicine","volume":"25 3","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13377775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}