Infectious Diseases and Therapy最新文献

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Gender Disparities Among Award and Grant Recipients in Annual Infectious Disease Society Meetings. 传染病学会年度会议中奖助金接受者的性别差异。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1007/s40121-025-01144-z
Digbijay Kunwar, Ili Margalit, Elda Righi, Asma Nasim, Dafna Yahav, Noam Tau
{"title":"Gender Disparities Among Award and Grant Recipients in Annual Infectious Disease Society Meetings.","authors":"Digbijay Kunwar, Ili Margalit, Elda Righi, Asma Nasim, Dafna Yahav, Noam Tau","doi":"10.1007/s40121-025-01144-z","DOIUrl":"10.1007/s40121-025-01144-z","url":null,"abstract":"<p><strong>Introduction: </strong>Gender inequity in medical academic forums persists despite attempts to ensure better gender equality. In this study, we aimed to assess the proportion of female award and grant winners in both the ESCMID global and IDWeek conferences.</p><p><strong>Methods: </strong>Female award and grant winners in infectious diseases conferences (2009-2023) were evaluated. Data were collected from the conferences' program book and websites. Gender for each award or grant recipient was assessed using Genderize.io or, if inconclusive, manually. We summarized proportions of women award/grant winners by society and over time.</p><p><strong>Results: </strong>Between 2009 and 2023, 39% (34/88) of ESCMID award winners and 57% (858/1504) of grant winners were women; For IDWeek, 32% (39/122) of award winners and 68% (17/25) of grant winners were women. For both societies there was a clear increase in women's representation from 2009 to 2014, with stabilization thereafter.</p><p><strong>Conclusions: </strong>Representation of women in conferences has vastly improved over the years, though additional policies and programs are needed to reduce the remaining gender disparities.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1369-1373"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Literature Review of the Epidemiology of Complicated Urinary Tract Infection. 复杂性尿路感染流行病学的系统文献综述。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-06-01 Epub Date: 2025-04-24 DOI: 10.1007/s40121-025-01149-8
Edward Broughton, Meryem Bektas, Ann Colosia, Kristi Kuper, Maria M Fernandez, Amer Al-Taie, Ramy Kotb
{"title":"A Systematic Literature Review of the Epidemiology of Complicated Urinary Tract Infection.","authors":"Edward Broughton, Meryem Bektas, Ann Colosia, Kristi Kuper, Maria M Fernandez, Amer Al-Taie, Ramy Kotb","doi":"10.1007/s40121-025-01149-8","DOIUrl":"10.1007/s40121-025-01149-8","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary tract infections (UTIs) are common bacterial infections and present with heterogeneous clinical phenotypes. Whereas many uncomplicated UTIs resolve spontaneously or with antibiotic treatment, a complicated UTI (cUTI) presents with greater morbidity and a higher risk of treatment failures. The goal of this study was to estimate the real-world epidemiology of cUTI, including acute pyelonephritis (AP) and catheter-associated UTIs (CAUTIs), and its associated mortality internationally.</p><p><strong>Methods: </strong>A systematic literature search was conducted using PubMed, Embase, Cochrane, and EconLit databases for relevant articles published between July 2013 and July 2023 covering Europe and the following countries: France, Italy, Germany, Spain, the UK, China, Japan, and the US (US). Search terms relating to cUTI, AP, CAUTI, outcomes of interest (epidemiology), and real-world research designs were used. There were no language limitations (protocol registry: PROSPERO-CRD42023454794).</p><p><strong>Results: </strong>Database searches yielded 1014 unique records, of which 91 met the prespecified inclusion criteria; bibliography and conference abstract searches yielded 27 additional records for a total of 118 records for inclusion. Disease presentation and reported outcomes varied widely across studies, and most studies reporting incidence and prevalence of cUTI were from the US (21 of 29). No studies reporting incidence or prevalence rates of cUTI in China, Germany, or the UK were identified. Overall, high antibiotic resistance rates were reported in both inpatient and outpatient settings. The inpatient cohort mortality rates were highly variable (0-50%) depending on the patient population.</p><p><strong>Conclusions: </strong>While disease presentation and reported outcomes varied widely across studies, cUTIs represent a considerable burden in terms of incidence, prevalence, drug resistance, and mortality, yet vast knowledge gaps remain in the literature. There is a crucial need to address these gaps to effectively evaluate new treatments and improve future analyses of cUTI burden and outcomes.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1157-1181"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethanol Inhalation for Respiratory Infections due to Enveloped Viruses. 吸入乙醇治疗包膜病毒引起的呼吸道感染。
IF 5.3 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1007/s40121-025-01157-8
Pietro Salvatori, Ali Amoushahi, Aldo Venuti, Francesca Paolini
{"title":"Ethanol Inhalation for Respiratory Infections due to Enveloped Viruses.","authors":"Pietro Salvatori, Ali Amoushahi, Aldo Venuti, Francesca Paolini","doi":"10.1007/s40121-025-01157-8","DOIUrl":"10.1007/s40121-025-01157-8","url":null,"abstract":"<p><p>Ethanol has demonstrated high efficacy in inactivating enveloped viruses in vitro and in vivo (in animal and human studies). The inhalation route has been a significant method of drug administration for respiratory disorders since ancient times. Infections with enveloped viruses cause many respiratory diseases. This concise review explores the general structural characteristics of enveloped viruses and examines the potential role of inhaled ethanol as a low-cost therapy for respiratory diseases. Current literature data suggest that ethanol inhalation could be beneficial in treating respiratory infections caused by enveloped viruses. However, there is a clear gap in well-designed clinical trials assessing the safety and efficacy of ethanol inhalation in treating respiratory infections from enveloped viruses. This low-cost therapy could become an important therapeutic option, especially for large numbers of patients simultaneously infected, as was the case during the coronavirus disease 2019 (COVID-19) pandemic. In addition, inhaled ethanol could be a successful approach for vulnerable patients such as patients with cancer because it is likely to have no or minimal effects on already established life-saving treatments. Further investigation by national and international institutions is urgently needed to validate these findings and refine treatment protocols.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1143-1156"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal Timing of Vaccination: A Narrative Review of Integrating Strategies for COVID-19, Influenza, and Respiratory Syncytial Virus. 最佳接种时间:COVID-19、流感和呼吸道合胞病毒综合策略的叙述性回顾
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1007/s40121-025-01135-0
Paolo Bonanni, Jung Yeon Heo, Hitoshi Honda, Ping-Ing Lee, Aminatou Mouliom, Hoe Nam Leong, Maria Del Pilar Martin Matos, Rachel Dawson
{"title":"Optimal Timing of Vaccination: A Narrative Review of Integrating Strategies for COVID-19, Influenza, and Respiratory Syncytial Virus.","authors":"Paolo Bonanni, Jung Yeon Heo, Hitoshi Honda, Ping-Ing Lee, Aminatou Mouliom, Hoe Nam Leong, Maria Del Pilar Martin Matos, Rachel Dawson","doi":"10.1007/s40121-025-01135-0","DOIUrl":"10.1007/s40121-025-01135-0","url":null,"abstract":"<p><p>Lower respiratory tract infections caused by SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) cause a significant disease burden globally, despite the availability of effective vaccines. Certain populations, such as older adults (≥ 60 years) and individuals of all ages with particular comorbidities, are at increased risk for severe outcomes, including hospitalization and death. National administration schedules for available vaccines against respiratory viruses are not unified, and not all current guidelines are clear and directive, concerning the optimal timing of vaccination. Herein, we formulate an evidence-based position regarding the optimal timing of COVID-19, influenza, and RSV vaccination for older adults and individuals with chronic comorbidities, based on a synthesis of the literature and current guidelines. Vaccination impact and timing were found to be influenced by vaccinee risk factors, including age and comorbidities, and waning vaccine effectiveness and seasonal pathogen burden. Because COVID-19, influenza, and RSV display unique seasonal patterns within and between regions, local epidemiological surveillance of each virus is crucial for determining optimal vaccination timing and guidelines. To maximize the benefits of these respiratory virus vaccines, the timing of peak vaccine effectiveness and period of greatest risk for severe outcomes should be aligned. Thus, COVID-19, influenza, and other recommended vaccines given ahead of the start of the respiratory virus season (or other regionally appropriate time) and co-administered at a single, routine visit represent the optimal approach to protecting at-risk populations. More data will be required to establish the clinical benefit of additional RSV vaccine doses and whether these may be integrated within a seasonal schedule. Coordinated policy decisions that align with strain selection for new and annually reformulated vaccines would enable the timely raising of public health awareness, ultimately leading to enhanced vaccine uptake. Implementation strategies will require engagement of healthcare providers and strong, evidence-based public health recommendations for integrated vaccine schedules.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"911-932"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Response to: Letter to the Editor Regarding "Serum Troponin I Assessments in 5- to 30-Year-Olds After BNT162b2 Vaccination". 关于“5- 30岁接种BNT162b2疫苗后血清肌钙蛋白I评估”的致编辑信的回复。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1007/s40121-025-01138-x
Timothy E Albertson, Caitlin Hansen, Juleen Gayed, Xia Xu, Ye Feng, Hua Ma
{"title":"A Response to: Letter to the Editor Regarding \"Serum Troponin I Assessments in 5- to 30-Year-Olds After BNT162b2 Vaccination\".","authors":"Timothy E Albertson, Caitlin Hansen, Juleen Gayed, Xia Xu, Ye Feng, Hua Ma","doi":"10.1007/s40121-025-01138-x","DOIUrl":"10.1007/s40121-025-01138-x","url":null,"abstract":"","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1137-1141"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and Outcomes of Patients Treated with Carbapenem Versus Non-carbapenem Therapy for AmpC-Producing Enterobacterales Bacteremia: A Retrospective Study. 碳青霉烯与非碳青霉烯治疗产ampc肠杆菌菌血症患者的特点和结果:一项回顾性研究。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1007/s40121-025-01133-2
Shuroug A Alowais, Atheer Aldairem, Sumaya N Almohareb, Yara Alsaeed, Rema Aldugiem, Tariq Alqahtani, Rawnd Alamri, Raghad Aied, Hisham A Badreldin, Khalid Bin Saleh
{"title":"Characteristics and Outcomes of Patients Treated with Carbapenem Versus Non-carbapenem Therapy for AmpC-Producing Enterobacterales Bacteremia: A Retrospective Study.","authors":"Shuroug A Alowais, Atheer Aldairem, Sumaya N Almohareb, Yara Alsaeed, Rema Aldugiem, Tariq Alqahtani, Rawnd Alamri, Raghad Aied, Hisham A Badreldin, Khalid Bin Saleh","doi":"10.1007/s40121-025-01133-2","DOIUrl":"10.1007/s40121-025-01133-2","url":null,"abstract":"<p><strong>Introduction: </strong>Inducible AmpC β-lactamases in Gram-negative Enterobacterales pose therapeutic challenges. Although carbapenems are the preferred treatment, other antibiotics can serve as a viable alternative. Studies comparing treatment options report varied outcomes. This study evaluates 30-day mortality, treatment failure, and length of hospitalization in patients with AmpC-producing Enterobacterales bacteremia.</p><p><strong>Methods: </strong>This retrospective cohort study included adult patients with bacteremia caused by AmpC-producing Enterobacterales. Exclusion criteria included: therapy duration < 72 h, coinfection, resistant isolates, and death within 72 h of diagnosis. Patients were divided into definitive carbapenem and noncarbapenem therapy. The primary outcome was 30-day mortality, while secondary outcomes evaluated treatment failure and length of hospitalization. Statistical analysis used descriptive statistics, group comparisons, and logistic regression.</p><p><strong>Results: </strong>Of 214 screened patients, 80 met the inclusion criteria. Enterobacter cloacae (60%) was the predominant pathogen, primarily originating from line-related infections (55%). Carbapenems were the primary empirical (45%) and definitive (75%) therapies; 30-day mortality was higher in the non-carbapenem group (20% versus 3.3%, p = 0.08). Treatment failure was significantly higher in the non-carbapenem group (20% versus 1.6%, p < 0.01). The mean hospital stay was longer in the carbapenem group (26 ± 38.40 days) than the non-carbapenem group (11.15 ± 7.15 days, p = 0.87). Older age was significantly associated with higher mortality (odds ratio (OR) 1.07, 95% confidence intervals (CI): 0.98-12.20, p = 0.015).</p><p><strong>Conclusions: </strong>Carbapenem use was significantly associated with improved survival, highlighting its importance in treatment strategies. Age significantly affects survival, stressing the need for personalized treatments. Further research and strategies are needed to address clinical failures and enhance antimicrobial stewardship.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1061-1074"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study). 慢性丙型肝炎患者接受索非布韦治疗后的长期肝脏和肝外预后(LONGHEAD研究)。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1007/s40121-025-01145-y
Chung-Feng Huang, Jeong Heo, Rong-Nan Chien, Yang-Hyun Baek, Jia-Horng Kao, Ju-Hyun Kim, Ting-Tsung Chang, Kwan-Soo Byun, Jyh-Jou Chen, Sook-Hyang Jeong, Tsung-Hui Hu, Young-Seok Kim, Cheng-Yuan Peng, Won-Young Tak, Horng-Yuan Wang, Seung-Kew Yoon, I-Shyan Sheen, Youn-Jae Lee, Yu-Chun Hsu, Hyung-Joon Yim, Pei-Chien Tsai, Ming-Lun Yeh, Sang-Hoon Ahn, Chia-Yen Dai, Seung-Woon Paik, Jee-Fu Huang, Yoon-Jun Kim, Wan-Long Chuang, Young-Suk Lim, Ming-Lung Yu
{"title":"Long-Term Hepatic and Extrahepatic Outcomes of Chronic Hepatitis C Patients After Sofosbuvir-Based Treatment (LONGHEAD Study).","authors":"Chung-Feng Huang, Jeong Heo, Rong-Nan Chien, Yang-Hyun Baek, Jia-Horng Kao, Ju-Hyun Kim, Ting-Tsung Chang, Kwan-Soo Byun, Jyh-Jou Chen, Sook-Hyang Jeong, Tsung-Hui Hu, Young-Seok Kim, Cheng-Yuan Peng, Won-Young Tak, Horng-Yuan Wang, Seung-Kew Yoon, I-Shyan Sheen, Youn-Jae Lee, Yu-Chun Hsu, Hyung-Joon Yim, Pei-Chien Tsai, Ming-Lun Yeh, Sang-Hoon Ahn, Chia-Yen Dai, Seung-Woon Paik, Jee-Fu Huang, Yoon-Jun Kim, Wan-Long Chuang, Young-Suk Lim, Ming-Lung Yu","doi":"10.1007/s40121-025-01145-y","DOIUrl":"10.1007/s40121-025-01145-y","url":null,"abstract":"<p><strong>Background/aims: </strong>Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C virus (HCV) infection. The long-term hepatic and extrahepatic outcomes of DAAs in chronic hepatitis C (CHC) patients receiving curative antivirals are elusive.</p><p><strong>Methods: </strong>CHC patients were retrieved from two phase III sofosbuvir-based clinical trials conducted from 2013-2014. Patients who achieved a sustained virological response have been followed prospectively for 5 years since 2016. A propensity score-matched interferon-based historical control with a 1:3 ratio was used for comparison. Quality of life (QoL) was measured by the SF-36, liver fibrosis was measured by electrography, and fibrosis-related markers were followed annually in the prospective cohort.</p><p><strong>Results: </strong>A total of 160 DAA- and 480 interferon-treated patients were enrolled. Twenty-eight patients developed hepatocellular carcinoma (HCC) over a follow-up period of 4424 person-years (annual incidence: 0.6%). The incidence of HCC did not differ significantly between the DAA cohort and interferon-treated patients (P = 0.07). Cox regression analysis revealed that FIB-4 was the only factor independently associated with HCC development (hazard ratio [HR]: 95% confidence interval [CI] 3.59/1.68-7.66, P = 0.001). The incidence of newly developed cardio-cerebrovascular disease was 13.8 per 1000 person-years and 0.9 per 1000 person-years in interferon-treated patients and the DAA cohort, respectively (P < 0.001). Interferon-based patients had a significantly greater incidence of cardio-cerebrovascular disease (HR/CI 3.39/1.28-8.96, P = 0.014). There was a substantial decrease in liver stiffness (P<sub>trend</sub> = 0.08) and M2BPGi (P<sub>trend</sub> = 0.05) and a significant reduction in LOXL2 (P<sub>trend</sub> = 0.02) over 5 years. A significant decrease in QoL was observed in role limitations due to physical health and emotional problems, whereas the other parameters were maintained consistently throughout the 5 years of follow-up.</p><p><strong>Conclusions: </strong>HCV eradication by DAAs improved liver- and non-liver-related outcomes, constantly promoted liver fibrosis regression, and maintained quality of life after HCV cure.</p><p><strong>Clinical trial number: </strong>NCT03042520.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1089-1101"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characteristics of Patients Who Acquired Gram-Negative Bacteria During Ceftazidime-Avibactam Therapy. 头孢他啶-阿维巴坦治疗期间获得革兰氏阴性菌的临床特点。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1007/s40121-025-01126-1
Chien Chuang, Tzu-Chi Kao, Chih-Han Juan, Sheng-Hua Chou, Yu-Chien Ho, Szu-Yu Liu, Yi-Ru Huang, Hsiang-Ling Ho, Yi-Tsung Lin
{"title":"Clinical Characteristics of Patients Who Acquired Gram-Negative Bacteria During Ceftazidime-Avibactam Therapy.","authors":"Chien Chuang, Tzu-Chi Kao, Chih-Han Juan, Sheng-Hua Chou, Yu-Chien Ho, Szu-Yu Liu, Yi-Ru Huang, Hsiang-Ling Ho, Yi-Tsung Lin","doi":"10.1007/s40121-025-01126-1","DOIUrl":"10.1007/s40121-025-01126-1","url":null,"abstract":"<p><strong>Introduction: </strong>Ceftazidime-avibactam (CZA) is recommended to treat infections caused by carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa with difficult-to-treat resistance. The selective pressure of CZA results in the isolation of multidrug-resistant Gram-negative bacteria (MDR-GNB), causing superinfection or hospital-wide spread. We aimed to study the clinical characteristics of patients who acquired GNB during CZA treatment.</p><p><strong>Methods: </strong>Adult patients treated with CZA for ≥ 5 days for proven or suspected MDR-GNB were retrospectively enrolled at Taipei Veterans General Hospital between December 2019 and June 2021. GNB acquisition was defined as new GNB species resulting in infection or colonization isolated during the period from 5 days after the initiation of CZA until the end of treatment. Clinical features were compared between patients who acquired GNB from clinical specimen and those who did not. Multivariable analysis was used to explore risk factors for acquisition of GNB and 28-day mortality in patients who acquired GNB.</p><p><strong>Results: </strong>Among 321 patients treated with CZA, 68 GNB were identified in 55 patients (17.1%). Elizabethkingia species (n = 15) was the most common GNB, followed by Acinetobacter species (n = 13) and Burkholderia cenocepacia (n = 11). The presence of diabetes mellitus, and mechanical ventilation were independent risk factors for GNB acquisition. There was a statistically nonsignificant trend toward increased 28-day mortality in patients with GNB acquisition compared to those without (38.2% vs. 27.8%, P = 0.105). Cerebrovascular disease and acquired GNB resulting in infection were associated with 28-day mortality in patients who acquired GNB.</p><p><strong>Conclusions: </strong>Elizabethkingia species, Acinetobacter species, and B. cenocepacia were the major GNB acquired during CZA treatment. A trend toward increased mortality was observed in patients with GNB acquisition during CZA treatment. Further studies on optimal treatments for these patients were warranted.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1027-1042"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Broad-Spectrum Antimicrobials on Patients with Community-Acquired Pneumonia with Low Risk for Drug-Resistant Pathogens: Historical Cohort Study in Japan. 广谱抗菌药物对低耐药病原体风险的社区获得性肺炎患者的影响:日本的历史队列研究
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-04 DOI: 10.1007/s40121-025-01142-1
Takahiro Takazono, Naoki Hosogaya, Yoshiyuki Saito, Masahiko Takemura, Naoki Iwanaga, Noriho Sakamoto, Junichi Hirayama, Rie Ueno, Hiroshi Mukae
{"title":"Effects of Broad-Spectrum Antimicrobials on Patients with Community-Acquired Pneumonia with Low Risk for Drug-Resistant Pathogens: Historical Cohort Study in Japan.","authors":"Takahiro Takazono, Naoki Hosogaya, Yoshiyuki Saito, Masahiko Takemura, Naoki Iwanaga, Noriho Sakamoto, Junichi Hirayama, Rie Ueno, Hiroshi Mukae","doi":"10.1007/s40121-025-01142-1","DOIUrl":"10.1007/s40121-025-01142-1","url":null,"abstract":"<p><strong>Introduction: </strong>Broad-spectrum antimicrobials are commonly administered for community-acquired pneumonia (CAP); however, unnecessary administration may cause adverse events and poor outcomes. This study aimed to understand the impact of broad-spectrum anti-pseudomonal β-lactam use on clinical outcomes and healthcare resource utilization (HCRU) in inpatients with CAP and a low risk of drug-resistant pathogens (DRPs).</p><p><strong>Methods: </strong>This historical cohort study reviewed Japan's hospital claims database (January to December of 2018) and included inpatients aged ≥ 20 years who received intravenous antimicrobial therapy for CAP. Those with high DRP risk were excluded. According to the initial antimicrobial regimen, patients were divided into broad-spectrum (anti-pseudomonal β-lactam therapy) and narrow-spectrum (non-anti-pseudomonal β-lactam therapy) groups. This study evaluated 30-day hospital mortality as a primary outcome using inverse probability of treatment weighting (IPTW) to adjust for differences between both groups and HCRU as an exploratory analysis.</p><p><strong>Results: </strong>A total of 15,617 patients were analyzed (2627 in the broad-spectrum group and 12,990 in the narrow-spectrum group). In the broad-spectrum group, the 30-day mortality rate was 10.6%, which was higher than that in the narrow-spectrum group (5.3%). Furthermore, it was associated with an increased 30-day mortality compared with the narrow-spectrum group after IPTW (adjusted odds ratio, 1.77; 95% confidence interval, 1.52-2.06; p < 0.001). The mean inpatient cost was USD 6139 and USD 5184 for the broad- and narrow-spectrum groups, respectively.</p><p><strong>Conclusions: </strong>The initial use of anti-pseudomonal β-lactams for CAP with low DRP risk is associated with poor outcomes, including death and high HCRU. Thus, initial antimicrobials should be judiciously selected for CAP management.</p>","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1043-1059"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor Regarding "Serum Troponin I Assessments in 5- to 30-Year-Olds After BNT162b2 Vaccination" by Albertson et al. 2024. 关于Albertson et al. 2024年发表的“5- 30岁接种BNT162b2疫苗后血清肌钙蛋白I评估”的致编辑信。
IF 4.7 3区 医学
Infectious Diseases and Therapy Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1007/s40121-025-01136-z
Ivan Pourmir, Adrian Alanis, Niccolò Clemente
{"title":"Letter to the Editor Regarding \"Serum Troponin I Assessments in 5- to 30-Year-Olds After BNT162b2 Vaccination\" by Albertson et al. 2024.","authors":"Ivan Pourmir, Adrian Alanis, Niccolò Clemente","doi":"10.1007/s40121-025-01136-z","DOIUrl":"10.1007/s40121-025-01136-z","url":null,"abstract":"","PeriodicalId":13592,"journal":{"name":"Infectious Diseases and Therapy","volume":" ","pages":"1133-1136"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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