Infectious Disease Reports最新文献_第7页

Beauty's Betrayal: Mycobacterium abscessus Case Series Following Aesthetic Procedures in the Brazilian Amazon. 美丽的背叛：巴西亚马逊地区美容手术后的脓肿分枝杆菌病例系列。

IF 3.4

Infectious Disease Reports Pub Date : 2024-08-07 DOI: 10.3390/idr16040055

Roberto C C Carbonell, Letícia L F Oliveira, Luis E B Galan, Eloise T M Filardi, Alysson B M Lins, Jânio J M Nattrodt, Domingos S M Dantas, Adilson C A Bernardi, Felipe A Cerni, Manuela B Pucca

{"title":"Beauty's Betrayal: Mycobacterium abscessus Case Series Following Aesthetic Procedures in the Brazilian Amazon.","authors":"Roberto C C Carbonell, Letícia L F Oliveira, Luis E B Galan, Eloise T M Filardi, Alysson B M Lins, Jânio J M Nattrodt, Domingos S M Dantas, Adilson C A Bernardi, Felipe A Cerni, Manuela B Pucca","doi":"10.3390/idr16040055","DOIUrl":"10.3390/idr16040055","url":null,"abstract":"The Brazilian market holds the second position globally in the beauty sector, poised to surpass the USD 50 billion mark in the upcoming years. Aesthetic procedures encompass a spectrum, ranging from non-invasive ones, such as drainage, radiofrequency, ultrasound, and cryolipolysis, to more invasive techniques, including fillers, botulinum toxin, microneedling, micropigmentation, carboxytherapy, and enzyme application. This wide array of treatments has yielded satisfactory cosmetic results for individuals who opt out of surgical procedures. However, despite being categorized as having low complexity, they still carry inherent risks. These risks are often exacerbated by the breach of the skin barrier, the exposure of organs and spaces, or the presence of implantable devices. Among the bacteria most isolated concerning this matter are non-tuberculous Mycobacteria. This study presents descriptive case reports involving three patients under the care of the Infectious Diseases Department at General Hospital of Roraima (HGR). These patients were diagnosed with Mycobacterium abscessus infections subsequent to undergoing enzyme application procedures. Although these cases involve the same microorganism, they exhibit varying degrees of severity, ranging from the development of locally nodular formations to a progression towards sepsis. These cases provide an opportunity to delve into the diagnostic subtleties and clinical implications of these infections while also prompting a critical evaluation of therapeutic strategies. Additionally, the report underscores the potential risks associated with routine aesthetic procedures.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"724-734"},"PeriodicalIF":3.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

eHealth and mHealth in Antimicrobial Stewardship to Reduce Mortality in Empirical Antimicrobial Therapy and a Systematic Review with a Meta-Analysis of Adequate Therapy. 电子健康和移动健康在抗菌药物管理中的应用，以降低经验性抗菌药物治疗的死亡率，并对充分治疗进行了系统回顾和 Meta 分析。

IF 3.4

Infectious Disease Reports Pub Date : 2024-08-01 DOI: 10.3390/idr16040054

Felipe Francisco Tuon, Tiago Zequinao, Marcelo Silva da Silva, Kleber Oliveira Silva

{"title":"eHealth and mHealth in Antimicrobial Stewardship to Reduce Mortality in Empirical Antimicrobial Therapy and a Systematic Review with a Meta-Analysis of Adequate Therapy.","authors":"Felipe Francisco Tuon, Tiago Zequinao, Marcelo Silva da Silva, Kleber Oliveira Silva","doi":"10.3390/idr16040054","DOIUrl":"10.3390/idr16040054","url":null,"abstract":"The urgent requirement for swift diagnostic methods in pathogen identification and antimicrobial susceptibility testing is emphasized by rising bacterial resistance and limited treatment options, which are particularly critical in sepsis management. The shift from traditional phenotype-based methods to rapid molecular and mass spectrometry techniques has significantly reduced result turnaround times, enhancing patient outcomes. In this systematic review with meta-analysis, the aspects of correct empirical antimicrobial therapy are evaluated to determine their impact on mortality. We performed a systematic review and meta-analysis on EMBASE, the Cochrane Library, Web of Science, and MEDLINE. Studies evaluating mortality associated with empirical adequate and inadequate therapy in different sites of infection were included. Outcomes included clinical cures in microbiologically evaluable patients. Among the sites of infection, the most studied were bloodstream infections (n = 9), followed by respiratory tract infections (n = 5), intra-abdominal infections (n = 5), and urinary tract infections (evaluated by 3 studies). Inadequate therapy was associated with an increase in mortality between 11 and 68%. Technologies to speed up pathogen identification are extremely necessary to reduce mortality.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"707-723"},"PeriodicalIF":3.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11353792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Pseudomonas straminea Blood Stream Infection in an Elderly Woman with Cellulitis. 一名患有蜂窝组织炎的老年妇女的血流假单胞菌感染病例。

IF 3.4

Infectious Disease Reports Pub Date : 2024-07-29 DOI: 10.3390/idr16040053

Leopold Böhm, Marius Eberhardt Schaller, Carsten Balczun, Andreas Krüger, Timo Schummel, Alexander Ammon, Niklas Klein, Dario Lucas Helbing, Rüdiger Eming, Frieder Fuchs

引用次数: 0

Frequency of SARS-CoV-2 Infections among Healthcare Workers in Germany: 3-Year Follow-Up Study. 德国医护人员感染 SARS-CoV-2 的频率：3 年随访研究。

IF 3.4

Infectious Disease Reports Pub Date : 2024-07-19 DOI: 10.3390/idr16040047

Christian Stammkötter, Laura Thümmler, Johannes Korth, Beate Marenbach, Peer Braß, Peter A Horn, Monika Lindemann, Ulf Dittmer, Oliver Witzke, Hana Rohn, Adalbert Krawczyk

{"title":"Frequency of SARS-CoV-2 Infections among Healthcare Workers in Germany: 3-Year Follow-Up Study.","authors":"Christian Stammkötter, Laura Thümmler, Johannes Korth, Beate Marenbach, Peer Braß, Peter A Horn, Monika Lindemann, Ulf Dittmer, Oliver Witzke, Hana Rohn, Adalbert Krawczyk","doi":"10.3390/idr16040047","DOIUrl":"10.3390/idr16040047","url":null,"abstract":"The emergence of SARS-CoV-2 in 2019 led to a global pandemic with a significant impact on healthcare systems. Healthcare workers were particularly vulnerable due to frequent contact with COVID-19 patients. Despite vaccination, they remained at higher risk as the vaccines provided limited protection against infection with viral variants, like Delta or Omicron BA.1 and BA.5. Three years after the onset of the pandemic, we evaluated SARS-CoV-2 infection frequencies among healthcare workers with varying levels of patient contact: high-risk (frequent COVID-19 patient contact), intermediate-risk (non-COVID-19 patient contact), and low-risk (no patient contact). We assessed their cellular and humoral immune responses based on their vaccination status and number of prior infections. SARS-CoV-2-specific antibodies were measured by immunoglobulin ELISA, and neutralizing antibody titers were determined against the viral variants D614G, Delta, and Omicron BA.1 and BA.5. Cellular immune responses were analyzed using an interferon-γ ELISpot. Notably, three years into the pandemic, healthcare workers in daily contact with COVID-19 patients did not have higher infection rates compared to healthcare workers with non-COVID-19 patient contact or no patient contact. Immune responses were similar across all groups, highlighting the effectiveness of vaccination and current hygiene standards in preventing virus transmission from patients to staff.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"615-627"},"PeriodicalIF":3.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Varicella Infection in a Young Adult from the Democratic Republic of the Congo: A Case Report and Mini-Review. 刚果民主共和国一名青年的原发性水痘感染：病例报告与微型综述。

IF 3.4

Infectious Disease Reports Pub Date : 2024-07-19 DOI: 10.3390/idr16040048

Andrew McNaughton, Nessika Karsenti, Jason Kwan, Asal Adawi, Saniya Mansuri, Andrea K Boggild

引用次数: 0

Clinical Ramifications of Bacterial Aggregation in Pleural Fluid. 胸腔积液中细菌聚集的临床影响

IF 3.4

Infectious Disease Reports Pub Date : 2024-07-18 DOI: 10.3390/idr16040046

James B Doub, Nicole Putnam

{"title":"Clinical Ramifications of Bacterial Aggregation in Pleural Fluid.","authors":"James B Doub, Nicole Putnam","doi":"10.3390/idr16040046","DOIUrl":"10.3390/idr16040046","url":null,"abstract":"Background: Bacterial aggregation has been well described to occur in synovial fluid, but it is unknown if bacteria form aggregates in body fluids beyond the synovial fluid. Consequently, this translational study evaluated the ability to form bacterial aggregates in different pleural fluids. Methods: Four of the most common causes of thoracic empyema-Streptococcus mitis, Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa-were used here. The different pleural fluids included one transudative and two exudative pleural fluids. Twenty-four-well microwell plates were used to form the aggregates with the aid of an incubating shaker at different dynamic conditions (120 RPM, 30 RPM, and static). The aggregates were then visualized with SEM and evaluated for antibiotic resistance and the ability of tissue plasminogen activator (TPA) to dissolve the aggregates. Statistical comparisons were made between the different groups. Results: Bacterial aggregates formed at high shaking speeds in all pleural fluid types, but no aggregates were seen in TSB. When a low shaking speed (30 RPM) was used, only exudative pleural fluid with a high protein content formed aggregates. No aggregates formed under static conditions. Furthermore, there was a statistical difference in the CFU/mL of bacteria present after antibiotics were administered compared to bacteria with no antibiotics (p < 0.005) and when TPA plus antibiotics were administered compared to antibiotics alone (p < 0.005). Conclusions: This study shows that bacteria can form aggregates in pleural fluid and at dynamic conditions similar to those seen in vivo with thoracic empyema. Importantly, this study provides a pathophysiological underpinning for the reason why antibiotics alone have a limited utility in treating empyema.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"608-614"},"PeriodicalIF":3.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proprotein Convertase Subtilisin/Kexin Type 9 Induction in COVID-19 Is Poorly Associated with Disease Severity and Cholesterol Levels. COVID-19 中的前蛋白转化酶 Subtilisin/Kexin 9 型诱导与疾病严重程度和胆固醇水平关系不大。

IF 3.4

Infectious Disease Reports Pub Date : 2024-07-17 DOI: 10.3390/idr16040045

Patricia Mester, Pablo Amend, Stephan Schmid, Jürgen J Wenzel, Marcus Höring, Gerhard Liebisch, Sabrina Krautbauer, Martina Müller, Christa Buechler, Vlad Pavel

{"title":"Proprotein Convertase Subtilisin/Kexin Type 9 Induction in COVID-19 Is Poorly Associated with Disease Severity and Cholesterol Levels.","authors":"Patricia Mester, Pablo Amend, Stephan Schmid, Jürgen J Wenzel, Marcus Höring, Gerhard Liebisch, Sabrina Krautbauer, Martina Müller, Christa Buechler, Vlad Pavel","doi":"10.3390/idr16040045","DOIUrl":"10.3390/idr16040045","url":null,"abstract":"SARS-CoV-2 infection was shown to induce proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma levels in sepsis. Here, we investigate the association between serum PCSK9 levels and disease severity. PCSK9 was measured in serum of 55 controls, 40 patients with moderate and 60 patients with severe COVID-19 disease. Serum PCSK9 was elevated in moderate COVID-19 compared to controls and further increased in severe cases. PCSK9 levels were not associated with C-reactive protein, bacterial superinfections, interventions, or survival in patients with severe COVID-19. PCSK9 regulates circulating cholesterol levels, and 15 cholesteryl ester (CE) species and free cholesterol (FC) were quantified by direct flow injection analysis using a high-resolution hybrid quadrupole-Orbitrap mass spectrometer. Most CE species with shorter fatty acid chains were decreased in severe compared to moderate COVID-19, and none of the CE species were correlated with PCSK9 in patients with severe COVID-19. Levels of all CE species negatively correlated with C-reactive protein in severe COVID-19 patients. Notably, FC was induced in severe compared to moderate COVID-19. The FC/CE ratio correlated positively with inflammatory markers and was associated with non-survival. The current study suggests that the imbalance between CE and FC levels is associated with disease severity and mortality in patients with COVID-19.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"593-607"},"PeriodicalIF":3.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features and Characteristics of Hand, Foot, and Mouth Disease Caused by Recent Coxsackievirus A6: Five Cases in Japan from 2019 to 2022. 近期柯萨奇病毒 A6 引起的手足口病的临床特征和特点：2019 年至 2022 年日本的五例病例。

IF 3.4

Infectious Disease Reports Pub Date : 2024-06-29 DOI: 10.3390/idr16040044

Kyohei Naomiya, Takashi Ito, Ayumi Saito, Tsukasa Igarashi, Tetsuo Nakayama, Kazuhiko Katayama, Kenji Ishikura

引用次数: 0

Saps1-3 Antigens in Candida albicans: Differential Modulation Following Exposure to Soluble Proteins, Mammalian Cells, and Infection in Mice. 白色念珠菌中的 Saps1-3 抗原：暴露于可溶性蛋白、哺乳动物细胞和小鼠感染后的差异调节。

IF 3.4

Infectious Disease Reports Pub Date : 2024-06-28 DOI: 10.3390/idr16040043

Pedro F Barbosa, Diego S Gonçalves, Lívia S Ramos, Thaís P Mello, Lys A Braga-Silva, Marcia R Pinto, Carlos P Taborda, Marta H Branquinha, André L S Santos

{"title":"Saps1-3 Antigens in Candida albicans: Differential Modulation Following Exposure to Soluble Proteins, Mammalian Cells, and Infection in Mice.","authors":"Pedro F Barbosa, Diego S Gonçalves, Lívia S Ramos, Thaís P Mello, Lys A Braga-Silva, Marcia R Pinto, Carlos P Taborda, Marta H Branquinha, André L S Santos","doi":"10.3390/idr16040043","DOIUrl":"10.3390/idr16040043","url":null,"abstract":"The secreted aspartic peptidases (Saps) of Candida albicans play crucial roles in various steps of fungal-host interactions. Using a flow cytometry approach, this study investigated the expression of Saps1-3 antigens after (i) incubation with soluble proteins, (ii) interaction with mammalian cells, and (iii) infection in immunosuppressed BALB/c mice. Supplementation strategies involving increasing concentrations of bovine serum albumin (BSA) added to yeast carbon base (YCB) medium as the sole nitrogenous source revealed a positive and significant correlation between BSA concentration and both the growth rate and the percentage of fluorescent cells (%FC) labeled with anti-Saps1-3 antibodies. Supplementing the YCB medium with various soluble proteins significantly modulated the expression of Saps1-3 antigens in C. albicans. Specifically, immunoglobulin G, gelatin, and total bovine/human sera significantly reduced the %FC, while laminin, human serum albumin, fibrinogen, hemoglobin, and mucin considerably increased the %FC compared to BSA. Furthermore, co-cultivating C. albicans yeasts with either live epithelial or macrophage cells induced the expression of Saps1-3 antigens in 78% (mean fluorescence intensity [MFI] = 152.1) and 82.7% (MFI = 178.2) of the yeast cells, respectively, compared to BSA, which resulted in 29.3% fluorescent cells (MFI = 50.9). Lastly, the yeasts recovered from the kidneys of infected immunosuppressed mice demonstrated a 4.8-fold increase in the production of Saps1-3 antigens (MFI = 246.6) compared to BSA, with 95.5% of yeasts labeled with anti-Saps1-3 antibodies. Altogether, these results demonstrated the positive modulation of Saps' expression in C. albicans by various key host proteinaceous components, as well as by in vitro and in vivo host challenges.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"572-586"},"PeriodicalIF":3.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Vascular Complications in Long COVID: The Role of ACE2 Deactivation, Microclots, and Uniform Fibrosis. 长 COVID 的持续性血管并发症：ACE2 失活、微血栓和均匀纤维化的作用。

IF 3.4

Infectious Disease Reports Pub Date : 2024-06-27 DOI: 10.3390/idr16040042

Christina-Michailia Sideratou, Christos Papaneophytou

{"title":"Persistent Vascular Complications in Long COVID: The Role of ACE2 Deactivation, Microclots, and Uniform Fibrosis.","authors":"Christina-Michailia Sideratou, Christos Papaneophytou","doi":"10.3390/idr16040042","DOIUrl":"10.3390/idr16040042","url":null,"abstract":"Angiotensin-converting enzyme 2 (ACE2), a key regulator in vasoregulation and the renin-angiotensin system, is hypothesized to be downregulated in patients with COVID-19, leading to a cascade of cardiovascular complications. This deactivation potentially results in increased blood pressure and vessel injury, contributing to the formation and persistence of microclots in the circulation. Herein, we propose a hypothesis regarding the prolonged vascular complications observed in long COVID, focusing on the role of ACE2 deactivation and/or shedding, the persistence of microclots, and the unique pattern of fibrosis induced by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Furthermore, we propose that the distinctive, uniform fibrosis associated with COVID-19, which is challenging to detect through conventional X-ray imaging, exacerbates vascular injury and impairs oxygenation. The persistence of these microclots and the unique fibrosis pattern are suggested as key factors in the extended duration of vascular complications post-COVID-19 infection, regardless of the initial disease severity. Moreover, plasma ACE2 activity has the potential to serve as prognostic or diagnostic biomarkers for monitoring disease severity and managing long COVID symptoms. Elucidating the role of ACE2 deactivation and the consequent events is vital for understanding the long-term effects of COVID-19. The experimental verification of this hypothesis through in vitro studies, clinical longitudinal studies, and advanced imaging techniques could yield significant insights into the pathophysiological mechanisms underlying long COVID, thereby improving the management of patients, particularly those with cardiovascular complications.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"16 4","pages":"561-571"},"PeriodicalIF":3.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0