Infection and Drug Resistance最新文献

{"title":"Hypervirulent Carbapenem-resistant <i>Klebsiella pneumoniae</i> Infection: Epidemiology, Virulence, Resistance, and Treatment.","authors":"Jinyan Yu, Yanlei Li, Qinghua Zhang, Yan Wang","doi":"10.2147/IDR.S534490","DOIUrl":"10.2147/IDR.S534490","url":null,"abstract":"<p><p>In recent years, reports of hypervirulent (hv) carbapenem-resistant (CR) <i>Klebsiella pneumoniae</i> (Kp) (hv-CRKp) have gradually increased. hv-CRKp may emerge from hvKp acquiring mobile genetic elements carrying multiple antibiotic-resistance genes or multi-drug-resistant Kp acquiring virulence genes, with subsequent convergence of resistance and virulence. Thus, hv-CRKp simultaneously harbors resistance and virulence genes and may even show resistance to colistin and tigecycline, suggesting potential for causing severe infections and placing a serious burden on the health care system. In this study, we review and summarize published literature on the epidemiology, virulence, resistance genes, and treatment of hv-CRKp.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4689-4697"},"PeriodicalIF":2.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Web-Based Dynamic Nomogram for Early Diagnosis in Sepsis: Development and Validation with Real-World Clinical Utility.","authors":"Chaochao Chen, Zhengxian Su, Yuwei Zheng, Minya Jin, Xiaojie Bi","doi":"10.2147/IDR.S532869","DOIUrl":"10.2147/IDR.S532869","url":null,"abstract":"<p><strong>Purpose: </strong>Sepsis has high mortality and progresses rapidly, requiring early diagnosis; traditional scoring and lab parameters are limited in non-ICU settings, highlighting the need for biomarker integration and continuous monitoring to enhance diagnostic accuracy.</p><p><strong>Patients and methods: </strong>A retrospective analysis of 1,098 patients at Taizhou Hospital of Zhejiang Province identified sepsis and non-sepsis groups per Sepsis 3.0 criteria, Logistic regression analyses were used to identify the risk factors. A dynamic nomogram was built, and predictive accuracy was evaluated using calibration and decision curves. External validation for 94 patients occurred from January to March 2024, using Receiver operating characteristic (ROC) curve analysis for diagnostic evaluation.</p><p><strong>Results: </strong>Multivariate logistic regression analysis revealed eight independent risk factors significantly associated with sepsis development: hypertension (odds ratio [OR] = 1.6278, 95% confidence interval [CI], 1.2079-2.1937), renal insufficiency (OR=1.7002, 95% CI, 1.2840-2.2513), cardiac insufficiency (OR=1.8927, 95% CI, 1.2979-2.7599), interleukin-6 levels (OR=1.0003 95% CI, 1.0002-1.0005), basophil percentage (OR=0.4319, 95% CI, 0.2353-0.7926), platelet-to-lymphocyte ratio (PLR) (OR=1.0025, 95% CI, 1.0011-1.0040), platelet count (PLT) (OR=0.9939, 95% CI, 0.9912-0.9959) and D-dimer levels (OR=1.0796, 95% CI, 1.0273-1.1347). The prognostic nomogram showed significant discriminative power, with a concordance index of 0.746 (95% CI 0.709-0.772). ROC analysis further revealed a negative predictive value (NPV) of 0.832 and a positive predictive value (PPV) of 0.511. Decision curve analysis validated the clinical utility of the model, demonstrating a substantial net benefit for predicting disease progression within a clinically relevant probability threshold range of 30% - 70%. The model maintained satisfactory discriminative performance in external validation, demonstrating an area under the curve (AUC) of 0.663 (95% CI, 0.549-0.776). The interactive web-based nomogram is available at https://bixiaojie-1987.shinyapps.io/DynNomapp/.</p><p><strong>Conclusion: </strong>This web-based dynamic nomogram incorporating eight clinically readily available predictors demonstrates robust diagnostic performance for sepsis, which helps doctors make quicker decisions by providing real-time risk assessments for each patient in non-ICU departments.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4667-4676"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Prognosis, and Risk Factors for Mortality in Influenza-Associated Pulmonary Aspergillosis and COVID-19-Associated Pulmonary Aspergillosis: A Multicenter Retrospective Study.","authors":"Qiuting Jiang, Liang Xu, Wei Zhou, Lianlian Fu, Chang Zou, Hui Lou, Yake Yao, Hua Zhou, Xiaoyan Yang","doi":"10.2147/IDR.S542063","DOIUrl":"10.2147/IDR.S542063","url":null,"abstract":"<p><strong>Objective: </strong>Multiple studies have confirmed that viral pneumonia is a high-risk factor for invasive pulmonary aspergillosis (IPA), this retrospective study aims to analyze the differences in clinical characteristics, prognosis, and high-risk factors for mortality between patients with influenza virus-associated pulmonary aspergillosis (IAPA) and those with COVID-19-associated pulmonary aspergillosis (CAPA).</p><p><strong>Methods: </strong>Clinical data from IAPA and CAPA patients diagnosed at four hospitals were collected. The clinical characteristics and prognostic differences between the two groups were analyzed and compared, with Cox regression used to identify the risk factors for mortality.</p><p><strong>Results: </strong>A total of 106 patients were included in this study. Compared to CAPA patients, IAPA patients had a higher proportion of chronic obstructive pulmonary disease comorbidities, lower rates of history of solid organ transplantation, and a shorter time from viral infection to aspergillosis development. CAPA patients exhibited lower levels of white blood cells, and C-reactive protein. The CAPA group also received longer courses of antibiotic and corticosteroid therapy. Compared to IAPA, the CAPA group exhibited a higher incidence of complications, including bacterial infections, deep vein thrombosis in the lower limbs, gastrointestinal bleeding, and heart failure. The mortality rate was also higher in the CAPA group. The survival curve of IAPA was more favorable than that of CAPA. Cox regression analysis identified ICU admission at diagnosis as an independent risk factor for mortality in IAPA patients (OR= 9.578).</p><p><strong>Conclusion: </strong>The IAPA group had a higher proportion of patients with COPD, a more acute disease onset, Admission to the ICU at diagnosis was identified as a risk factor for IAPA-related mortality. In comparison, the CAPA group had a higher proportion of immunodeficient patients, received more corticosteroid treatment, and was more susceptible to complications such as bacterial infections, thrombosis, and gastrointestinal bleeding, all of which contributed to an increased risk of death.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4621-4631"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiological Profiles and Antibiotic Resistance of Urinary Tract Infections Among Different Age Categories in Children: A Retrospective Study of Xiamen Single-Center.","authors":"Zhuqin Zhan, Jianying Liao, Xiaoliang Lin, Guangbo Li, Dequan Su, Jinhua Zeng, Qian Shen","doi":"10.2147/IDR.S537033","DOIUrl":"10.2147/IDR.S537033","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the distribution of pathogens and drug resistance in children with urinary tract infections (UTIs) in a single center in Xiamen and to guide the selection of empirical antibiotics in the clinic.</p><p><strong>Methods: </strong>Clinical data of 2001 children with UTIs in Xiamen Children's Hospital between 2014 and 2022 were retrospectively analyzed, grouped by age and comorbidities. Differences in pathogen distribution and drug sensitivity were compared with the chi-square test applied and significance set at p < 0.05.</p><p><strong>Results: </strong>Of 2001 urine samples collected, 965 (42.73%) had positive results for common infections. Gram-negative bacteria predominated (644/965; 66.74%), with Escherichia coli being the most prevalent (432/965; 44.77%). The top five pathogens were Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa. The percentage of Escherichia coli was higher in simple UTIs than complex (54.01% vs 45.35%), and Pseudomonas aeruginosa (9.59% vs 2.74%) and fungi (7.27% vs 1.96%) were higher in complex UTIs (p < 0.05). Predominance of Pseudomonas aeruginosa and Enterococcus faecalis in boys and Enterococcus faecalis in girls. Escherichia coli had a significantly lower rate of resistance to ampicillin than Klebsiella pneumoniae (p < 0.001), and both had a high rate of resistance to cephalosporins (over 95% to cefazolin), but a low rate of resistance to amikacin and furotoxin. Pseudomonas aeruginosa had 100% resistance to most cephalosporins, but less than 7% to ceftazidime, cefepime and piperacillin tazobactam. Enterococcus faecalis had over 90% resistance to Ampicillin, Penicillin, Linezolid and 91.53% to tetracycline. No Tigecycline/Vancomycin-resistant enterococci were found. Both Gram-negative and Gram-positive bacteria maintained relatively low rates of resistance to Nitrofurantoin.</p><p><strong>Conclusion: </strong>Pediatric UTIs in Xiamen show gender-based pathogen differences, mainly gram-negative. Nitrofurantoin is preferred for mild cases, and the clinical selection should be individualized by combining the regional pathogen spectrum and drug sensitivity.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4677-4688"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges of Six-Pathogen Detected by mNGS in an Immunocompromised ICU Patient with Severe Community-Acquired Pneumonia-Induced Sepsis: A Case Report and Literature Review.","authors":"Junjie Zhao, Junnan Ye","doi":"10.2147/IDR.S550784","DOIUrl":"10.2147/IDR.S550784","url":null,"abstract":"<p><strong>Introduction: </strong>Severe community-acquired pneumonia (SCAP) in immunocompromised patients is often caused by rare atypical pathogens, which are difficult to detect using conventional microbiological tests (CMTs) and can progress to sepsis in severe cases. Metagenomic next-generation sequencing (mNGS), an emerging pathogen detection technique, enables rapid identification of mixed infections and provides valuable guidance for clinical treatment decisions. SCAP-induced sepsis caused by a six-pathogen co-infection has not been previously reported, but interpretation remains a challenge.</p><p><strong>Case presentation: </strong>This report describes a case of SCAP-induced sepsis detected six pathogens by mNGS in a patient with IgA nephropathy who developed immunosuppression following long-term treatment with rituximab and corticosteroids. Bronchoalveolar lavage fluid (BALF) mNGS detected six pathogens, including <i>Pneumocystis jirovecii, Klebsiella pneumoniae</i>, Primate bocaparvovirus 1, Cytomegalovirus, <i>Elizabethkingia anophelis</i>, and <i>Candida albicans</i>. The patient was admitted to the intensive care unit (ICU) and received a combination of meropenem, trimethoprim-sulfamethoxazole, ganciclovir, piperacillin-tazobactam, and caspofungin. Following appropriate treatment, the patient recovered and was successfully discharged.</p><p><strong>Conclusion: </strong>mNGS offers significant advantages for the diagnosis and identification of mixed infections in immunocompromised patients with SCAP-induced sepsis. It enables clinicians to initiate timely and targeted antimicrobial therapy, which facilitates early recovery, reduces the overuse of broad-spectrum antibiotics, and ultimately improves patient prognosis. Nevertheless, its interpretation requires caution, as distinguishing true pathogens from colonizers or contaminants still relies on clinical correlation and complementary diagnostic methods.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4659-4665"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Risk Factors and Development of Clinical Prediction Model for Nocardiosis in Lung Transplant Recipients.","authors":"Hengyu Zhao, Zhibin Xu, Xiaohua Wang, Yu Xu, Yi Lu, Jiaqi Chen, Qiaoyu Ye, Xuan Li, Yanhua Wen, Chunrong Ju","doi":"10.2147/IDR.S536103","DOIUrl":"10.2147/IDR.S536103","url":null,"abstract":"<p><strong>Purpose: </strong>Nocardiosis is an opportunistic infection in lung transplant recipients but is often misdiagnosed or overlooked. This study aimed to identify risk factors and develop an effective predictive model for nocardiosis in this population.</p><p><strong>Patients and methods: </strong>This single-center retrospective study analyzed 679 lung transplant recipients from January 1, 2015, to July 9, 2024. Twenty patients with nocardiosis were compared with 40 matched controls. Feature selection was performed using LASSO regression, and logistic regression identified risk factors. Model performance was assessed via ROC curves, calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>Decreased CD4⁺ T cells, elevated CD8⁺ T cells, and reduced IgA levels were significantly associated with nocardiosis (P < 0.05). The model incorporating these factors demonstrated strong predictive ability with an area under the ROC curve of 0.955.</p><p><strong>Conclusion: </strong>CD4⁺ T cells, CD8⁺ T cells, and IgA are independent risk factors for nocardiosis post-lung transplantation. The developed model effectively distinguishes nocardiosis cases, aiding early clinical identification.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4527-4537"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Diagnostic Performance of Culture, Histopathology, and mNGS for Periprosthetic Joint Infection Using Periprosthetic Tissue Samples: A Prospective Clinical Study.","authors":"Lan Wei, Yali Yu, Shaohua Wang, Guixiang Dong, Yanli Niu","doi":"10.2147/IDR.S544455","DOIUrl":"10.2147/IDR.S544455","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the applicability of histopathology, culture, and Metagenomic next-generation sequencing (mNGS) in diagnosing periprosthetic joint infection (PJI).</p><p><strong>Methods: </strong>In this prospective trial, 215 consecutive patients with suspected knee PJI were enrolled. Tissue specimens were aseptically collected and processed for histopathological analysis, culture, and mNGS. PJI diagnosis was primarily based on the 2011 MSIS criteria, with reference to the 2018 ICM criteria for improved diagnostic accuracy. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) of each diagnostic method were calculated.</p><p><strong>Results: </strong>Among 58 patients included in the final analysis, 38 were diagnosed with PJI and 20 without PJI. The mNGS assay demonstrated a sensitivity of 63.2% (95% CI: 53.6-77.7%), specificity of 80.0% (75.7-90.1%), PPV of 85.7% (76.4-95.3%), NPV of 53.3% (44.6-61.2%), PLR of 1.84 (1.22-2.77), and NLR of 0.27 (0.10-0.40). Culture showed higher specificity at 95.0% (84.6-99.8%) and PPV at 96.5% (88.7-99.7%), with sensitivity of 68.4% (58.2-78.9%). Histopathology exhibited 52.6% sensitivity and perfect specificity (100%). The most commonly detected pathogens by both culture and mNGS were <i>Staphylococcus aureus</i> and coagulase-negative Staphylococci, which are frequently implicated in PJI.</p><p><strong>Conclusion: </strong>mNGS shows promise as a complementary tool for diagnosing PJI, especially in culture-negative or atypical cases. However, it did not outperform conventional methods in accuracy. Its limitations-including a high false-positive rate, interpretive challenges, and lack of susceptibility data-warrant cautious use. Further large-scale studies are needed to define its role in clinical decision-making.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4647-4657"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Acute Bacterial Skin and Skin Structure Infection Following Fish Spine Injury: A Case Report and Literature Review.","authors":"Ling Yang, Zhiwen Zhang, Qing Liang, Hao Zhang, Yijin Wang, Chao Zhuo","doi":"10.2147/IDR.S545407","DOIUrl":"10.2147/IDR.S545407","url":null,"abstract":"<p><p>This study presents a rare case of severe acute bacterial skin and soft tissue infection (ABSSSI) following freshwater fish spike injury in a 73-year-old man. Within 24 hours of sustaining the wound, the patient developed septic shock and progressive necrotizing fasciitis. Despite early administration of broad-spectrum antibiotics and intensive care, his condition deteriorated, necessitating below-the-elbow amputation on hospital day four. Metagenomic next-generation sequencing (mNGS) identified Aeromonas veronii as the causative agent. Although the patient showed temporary improvement postoperatively, he later developed hospital-acquired pneumonia and succumbed to complications two months later. This case highlights the potential severity of ABSSSIs caused by aquatic pathogens, particularly in immunocompromised individuals. mNGS provides a comprehensive pathogen snapshot within hours of sample receipt, enabling timely refinement of empiric regimens prior to antimicrobial susceptibility testing availability. Early surgical intervention is essential to control infections and improve clinical outcomes.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4633-4645"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some Factors Influencing the Number of <i>Clostridioides difficile</i> Spores Detected in Hospital Wastewater.","authors":"Chun-Wei Chiu, Shiang-En Chen, Yu-Ting Lin, Ching-Chi Lee, Jen-Chieh Lee, Chin-Shiang Tsai, Wen-Chien Ko, Chih-Hsuan Tsai, Yuan-Pin Hung","doi":"10.2147/IDR.S516395","DOIUrl":"10.2147/IDR.S516395","url":null,"abstract":"<p><strong>Objective: </strong><i>Clostridioides difficile</i> is the most common cause of antibiotic-associated diarrhea. Wastewater from hospitals may be an important source of <i>C. difficile</i> transmission between hospitals and communities. The objective of this study is to quantify <i>C. difficile</i> spores and to elucidate their potential transmission risk via hospital wastewater.</p><p><strong>Methods: </strong>A prospective study of wastewater from a teaching hospital was conducted weekly, from July 2023 to June 2024. The number of <i>C. difficile</i> spores detected in wastewater from hospital settings fluctuated weekly during the study period.</p><p><strong>Results: </strong>There was a borderline association between the number of <i>C. difficile</i> spores detected in wastewater at room temperature in hospitals (<i>p</i> = 0.02) and the consumption of antimicrobial agents (<i>p value =</i> 0.04), particularly cephalosporins (<i>p</i> = 0.001). Specifically, the number of <i>C. difficile</i> spores detected in the wastewater was highly correlated with first-generation cephalosporin consumption (<i>p</i> = 0.002), particularly the consumption of first-generation intravenous cephalosporin (cefazolin) (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The number of <i>C. difficile</i> spores detected in wastewater from hospital settings is strongly associated with the consumption of antimicrobial agents, particularly cephalosporins. Further evaluation is needed to assess whether antibiotic stewardship programs can reduce the burden of <i>C. difficile</i> spores in wastewater.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4603-4613"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Naganishia albidus</i> Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed.","authors":"Kaisu Pan, Danxia Lu, Weixuan Wu, Ping Luo, Liuwei Liao, Dong Liang, Wanqing Liao, Cunwei Cao, Dongyan Zheng","doi":"10.2147/IDR.S514483","DOIUrl":"10.2147/IDR.S514483","url":null,"abstract":"<p><p>Cutaneous cryptococcosis is rarely caused by <i>Naganishia albidus</i>, especially in immunocompetent individuals. We report a unique case of perioral cutaneous infection in a 37-year-old male with scattered erythematous, pruritic, and scaly lesions lasting over a month. Initial clinical presentation mimicked common dermatological conditions, leading to potential misdiagnosis. Diagnosis was confirmed through fungal culture, fluorescence microscopy, MALDI-TOF mass spectrometry and molecular identification. The patient was successfully treated with oral itraconazole and topical fluconazole cream for six weeks. This case underscores the importance of considering rare fungal infections in atypical presentations to prevent misdiagnosis and delays in treatment.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4615-4620"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}