Distribution and Antibiotic Resistance Analysis of 13,048 Clinically Common Isolates.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S510193

Jing Zhao, Peng Yue, Zhi-Jie Li, Ting Xu, Guo-Zheng Xing, Yan Shao, Hong-Yuan Yu

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Abstract

Objective: This study investigated the distribution and antibiotic resistance profiles of common bacteria isolated from clinical specimens at a hospital's microbiology laboratory between 2020 and 2022.

Methods: A retrospective analysis was conducted on microbial culture results from clinical specimens collected over three years, including sample types, departmental distribution, pathogen species, and resistance profiles.

Results: A total of 13,048 unique pathogenic strains were isolated, predominantly from respiratory and urine specimens. Secretion specimens exhibited the highest positive detection rate (73.6%), while blood specimens showed a lower rate (9.7%). The five most frequently isolated pathogens were: Klebsiella pneumoniae (K. pneumoniae) (19.6%), Pseudomonas aeruginosa (P. aeruginosa) (14.7%), Escherichia coli (E. coli) (9.2%), Acinetobacter baumannii (A. baumannii) (8.0%), and Candida albicans (C. albicans) (7.0%). Gram-negative bacteria constituted 53.7% of all isolates (7009/13,048). A total of 7590 multidrug-resistant organisms (MDRO) were identified, corresponding to a detection rate of 21.3% (7590/35,613). The detection rates of carbapenem-resistant Enterobacteriaceae (CRE) increased annually: 7.2% (2020), 8.6% (2021), and 14.4% (2022).

Conclusion: The annual detection rate of CRE increased during the study period, while the rate of methicillin-resistant Staphylococcus aureus (MRSA) declined. Timely and effective interventions targeting pathogenic bacteria are essential for controlling and mitigating nosocomial infection risks.

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13048株临床常见分离菌分布及耐药性分析

目的：了解2020 - 2022年某医院微生物实验室临床标本中常见细菌的分布及耐药情况。方法：对3年来临床标本微生物培养结果进行回顾性分析，包括标本类型、部门分布、病原菌种类、耐药情况。结果：共分离到独特病原菌13048株，主要来自呼吸道和尿液标本。分泌物标本检出率最高（73.6%），血液标本检出率较低（9.7%）。最常见的5种病原菌分别为肺炎克雷伯菌（19.6%）、铜绿假单胞菌（14.7%）、大肠杆菌（9.2%）、鲍曼不动杆菌（8.0%）和白色念珠菌（7.0%）。革兰氏阴性菌占53.7%（7009/ 13048）。共检出耐多药菌7590株，检出率为21.3%（7590/35,613）。耐碳青霉烯类肠杆菌科（CRE）检出率逐年上升，分别为7.2%（2020年）、8.6%（2021年）和14.4%（2022年）。结论：研究期间CRE年检出率上升，耐甲氧西林金黄色葡萄球菌（MRSA）年检出率下降。及时和有效的针对致病菌的干预措施对于控制和减轻医院感染风险至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.