Infectious Diseases in Obstetrics and Gynecology最新文献_第10页

Acceptability and Feasibility of Integrating Point-of-Care Diagnostic Testing of Sexually Transmitted Infections into a South African Antenatal Care Program for HIV-Infected Pregnant Women. 将性传播感染的即时诊断检测纳入南非艾滋病毒感染孕妇产前护理方案的可接受性和可行性。

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2018-05-09 eCollection Date: 2018-01-01 DOI: 10.1155/2018/3946862

E Morikawa, M Mudau, D Olivier, L de Vos, D Joseph Davey, C Price, J A McIntyre, R P Peters, J D Klausner, A Medina-Marino

{"title":"Acceptability and Feasibility of Integrating Point-of-Care Diagnostic Testing of Sexually Transmitted Infections into a South African Antenatal Care Program for HIV-Infected Pregnant Women.","authors":"E Morikawa, M Mudau, D Olivier, L de Vos, D Joseph Davey, C Price, J A McIntyre, R P Peters, J D Klausner, A Medina-Marino","doi":"10.1155/2018/3946862","DOIUrl":"10.1155/2018/3946862","url":null,"abstract":"Background: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections may increase the risk of vertical transmission of the human immunodeficiency virus (HIV). In resource-limited settings, symptomatic screening, and syndromic management of sexually transmitted infections (STIs) during pregnancy continue to be the standard of care. In the absence of diagnostic testing, asymptomatic infections in pregnant women go untreated.Objective: To describe the acceptability and feasibility of integrating diagnostic STI screening into first antenatal care visits for HIV-infected pregnant women.Methods: HIV-infected pregnant women were recruited during their first antenatal care visit from three antenatal care clinics in Tshwane District, South Africa, between June 2016 and October 2017. Self-collected vaginal swabs were used to screen for CT, NG, and TV with a diagnostic point-of-care (POC) nucleic acid amplification test. Those with STIs were provided treatment per South African national guidelines.Results: Of 442 eligible women, 430 (97.3%) agreed to participate and were tested. Of those with a positive STI test result (n = 173; 40.2%), 159 (91.9%) received same-day results and treatment; 100% of STI-infected women were treated within seven days.Conclusions: Integration of POC diagnostic STI screening into first-visit antenatal care services was feasible and highly acceptable for HIV-infected pregnant women.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2018 ","pages":"3946862"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/3946862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9294913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Hepatitis B Virus Testing and Care among Pregnant Women Using Commercial Claims Data, United States, 2011-2014. 使用商业索赔数据的孕妇乙肝病毒检测和护理，美国，2011-2014。

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2018-04-01 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4107329

Aaron M Harris, Cheryl Isenhour, Sarah Schillie, Claudia Vellozzi

{"title":"Hepatitis B Virus Testing and Care among Pregnant Women Using Commercial Claims Data, United States, 2011-2014.","authors":"Aaron M Harris, Cheryl Isenhour, Sarah Schillie, Claudia Vellozzi","doi":"10.1155/2018/4107329","DOIUrl":"10.1155/2018/4107329","url":null,"abstract":"Introduction: Pregnant women should receive hepatitis B virus (HBV) testing with hepatitis B surface antigen (HBsAg), but it is unclear whether HBV-infected pregnant women are linked to care.Methods: We analyzed MarketScan™ commercial insurance claims. We included pregnant women, aged 10-50 years, with 42 weeks of continuous enrollment before (predelivery) and 6 months after (postdelivery) the first delivery claim for each unique pregnancy between 1/1/2011 and 6/30/2014. We identified claims for HBsAg testing by CPT code and described the care continuum among pregnancies with an associated ICD-9 HBV diagnosis code by demographic and clinical characteristics, including HBV-directed care ([HBV DNA or hepatitis B e antigen] and ALT test codes) and antiviral treatment (claims for tenofovir, entecavir, lamivudine, adefovir, or telbivudine) pre- and postdelivery.Results: There were 870,888 unique pregnancies (819,752 women) included. Before delivery, 714,830 (82%) pregnancies had HBsAg test claims, but this proportion decreased with subsequent pregnancies (p < 0.0001): second (80%), third (71%), and fourth (61%). We identified 1,190 (0.14%) pregnancies with an associated HBV diagnosis code: most were among women aged ≥ 30 years (76%) residing in the Pacific (34%) or Middle Atlantic (18%) regions. Forty-two percent of pregnancies with an HBV diagnosis received HBV-directed care (42% predelivery and 39% postdelivery). Antiviral treatment was initiated before delivery in 128 (13%) of 975 pregnancies and postdelivery in 16 (1.6%) pregnancies.Conclusions: While most of these commercially insured pregnant women received predelivery HBV screening, we identified gaps in HBV testing and the HBV care continuum which highlight potential targets for public health interventions.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":" ","pages":"4107329"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4107329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36135313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Universal Rapid Human Immunodeficiency Virus Screening at Delivery: A Cost-Effectiveness Analysis. 分娩时普遍进行人体免疫缺陷病毒快速筛查：成本效益分析。

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2018-03-14 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6024698

Rachel K Scott, Stacia Crochet, Chun-Chih Huang

{"title":"Universal Rapid Human Immunodeficiency Virus Screening at Delivery: A Cost-Effectiveness Analysis.","authors":"Rachel K Scott, Stacia Crochet, Chun-Chih Huang","doi":"10.1155/2018/6024698","DOIUrl":"10.1155/2018/6024698","url":null,"abstract":"Objective: To determine the cost-effectiveness of universal maternal HIV screening at time of delivery to decrease mother-to-child transmission (MTCT), by comparing the cost and quality-adjusted life years (QALYs) of universal rapid HIV screening at time of delivery to two current standards of care for prenatal HIV screening in the United States.Study design: We conducted a cost-effectiveness analysis to compare the cost and QALY of universal intrapartum rapid HIV screening with two current standards of care: (I) opt-out rapid HIV testing limited to patients without previous third-trimester screening and (II) opt-out rapid HIV testing limited to patients without any prenatal screening. We developed a decision-tree model and performed sensitivity analyses to estimate the impact of variances in QALY, estimated lifetime medical costs, HIV prevalence, and cumulative incidence.Results: The incremental cost-effectiveness ratio for universal screening was $7,973.45/QALY. The results remained robust to sensitivity analysis, except for annual cumulative incidence. In areas with an annual cumulative incidence rate of <0.02% for reproductive-age women, the incremental cost-effectiveness ratio for the expanded program would exceed $89,926.94/QALY, approaching the commonly applied cost-effectiveness thresholds ($100,000/QALY).Conclusions: Intrapartum universal rapid HIV screening to decrease MTCT appears cost-effective in populations with high HIV incidence in the United States.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":" ","pages":"6024698"},"PeriodicalIF":0.0,"publicationDate":"2018-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36076620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Rezafungin (CD101)在阴道模拟培养基中对氟康唑敏感和耐药白色念珠菌和非白色念珠菌的时间杀伤动力学

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2018-02-22 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7040498

Jeffrey B Locke, Amanda L Almaguer, Joanna L Donatelli, Ken F Bartizal

{"title":"Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species.","authors":"Jeffrey B Locke, Amanda L Almaguer, Joanna L Donatelli, Ken F Bartizal","doi":"10.1155/2018/7040498","DOIUrl":"https://doi.org/10.1155/2018/7040498","url":null,"abstract":"Background: While echinocandins demonstrate excellent efficacy against Candida species in disseminated infections and demonstrate potent minimal inhibitory concentration (MIC) values under standard susceptibility testing conditions, investigation under conditions relevant to the vaginal environment was needed. We assessed the antifungal activity and time-kill kinetics of the novel echinocandin rezafungin (formerly CD101) under such conditions, against Candida species relevant to vulvovaginal candidiasis (VVC).Methods: Susceptibility testing of fluconazole-susceptible and fluconazole-resistant C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei was performed in RPMI at pH 7.0 and in vagina-simulative medium (VSM) at pH 4.2 for topical rezafungin, terconazole, fluconazole, and amphotericin B. Time-kill kinetics were evaluated for rezafungin and terconazole at 2, 8, 32, and 128 μg/ml over 72 hours.Results: Rezafungin MIC values were the same or 2-fold higher in VSM/pH 4.2 versus RPMI/pH 7.0. Some C. albicans terconazole MIC values were lower, but most were significantly higher in VSM than in RPMI. Rezafungin was fungicidal against 11/14 strains and near-fungicidal against the others. Terconazole (128 μg/ml) was fungicidal against C. krusei and near-fungicidal against susceptible C. parapsilosis but fungistatic versus all other strains evaluated.Conclusion: Rezafungin retained anti-Candida activity and fungicidal activity under in vitro conditions relevant to VVC.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":" ","pages":"7040498"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7040498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36031589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Genital Tract Infections in an Isolated Community: 100 Women of the Príncipe Island. 孤立社区的生殖道感染:Príncipe岛上的100名妇女。

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2017-01-01 Epub Date: 2017-11-13 DOI: 10.1155/2017/3058569

Pedro Vieira-Baptista, Svitrigaile Grinceviciene, Gert Bellen, Carlos Sousa, Conceição Saldanha, Davy Vanden Broeck, John-Paul Bogers, Gilbert Donders

{"title":"Genital Tract Infections in an Isolated Community: 100 Women of the Príncipe Island.","authors":"Pedro Vieira-Baptista, Svitrigaile Grinceviciene, Gert Bellen, Carlos Sousa, Conceição Saldanha, Davy Vanden Broeck, John-Paul Bogers, Gilbert Donders","doi":"10.1155/2017/3058569","DOIUrl":"https://doi.org/10.1155/2017/3058569","url":null,"abstract":"Objective: To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe).Methods: Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap test, high risk human papillomavirus [HR-HPV], N. gonorrhea [NG], T. vaginalis [TV], and C. trachomatis [CT]) were obtained.Results: TV, NG, CT, and HIV were found in 8.0%, 2.0%, 3.0%, and 2.0%, respectively, and were more prevalent in younger women. HR-HPV was positive in 36.7%; 2 were positive for HPV18, but none for HPV16. Coinfection of HPV with other STIs was 8.3%. Prevalence of abnormal vaginal flora (AVF) was 82.5%, mostly bacterial vaginosis (BV) 54.6%, and moderate/severe aerobic vaginitis (msAV) 25.8%. HR-HPV was not related to BV (p = 0.67). The association of abnormal Pap test with msAV was not significant (p = 0.08).Conclusion: The prevalence of NG, CT, TV, and HR-HPV was according to expected, while that of HR-AVF was higher. The surprisingly low prevalence of HPV16 and HPV18 must be considered in the design of programs for prevention and vaccination; this setting can be useful as a model for postvaccination scenarios.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2017 ","pages":"3058569"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3058569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35672711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005-2014). 意大利伦巴第10年(2005-2014年)妊娠相关李斯特菌病的流行病学和分子分型

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2017-01-01 Epub Date: 2017-03-19 DOI: 10.1155/2017/6479121

Virginia Filipello, Ettore Amato, Maria Gori, Pol Huedo, Giulia Ciceri, Sara Lomonaco, Mirella Pontello

{"title":"Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005-2014).","authors":"Virginia Filipello, Ettore Amato, Maria Gori, Pol Huedo, Giulia Ciceri, Sara Lomonaco, Mirella Pontello","doi":"10.1155/2017/6479121","DOIUrl":"https://doi.org/10.1155/2017/6479121","url":null,"abstract":"In developed countries, pregnancy-related listeriosis accounts for 20-43% of total invasive listeriosis. This work describes the first pregnancy-related listeriosis survey in Italy based on two data sources, that is, mandatory notification system and regional laboratory-based network. Out of 610 listeriosis cases reported over a 10-year period, 40 were pregnancy-related (6.6%). Among these, 29 pregnancy-related isolates were available and have been analysed with serotyping, Pulsed-Field Gel Electrophoresis, and Multi-Virulence-Locus Sequence Typing. No maternal fatality was recorded, but 11 (29.7%) pregnancies resulted in a foetal death, a miscarriage, or a birth of a foetus dying immediately after birth. The average incidence of pregnancy-related listeriosis was 4.3 cases per 100000 births, and the proportion of pregnancy-associated listeriosis among ethnic minorities was significantly higher compared to the general population (30.0% versus 3.5%, P < 0.01). L. monocytogenes isolates belonged to serotypes 1/2a, 1/2b, and 4b, with the latter significantly more prevalent among pregnancy-related isolates. Twenty different pulsotypes were distinguished and 16 out of the 29 isolates were classified into seven clusters. A total of 16 virulence types (VTs) were identified. Five VTs accounted for 45% of the total cases and coincided with those of previously described Epidemic Clones (ECs) of L. monocytogenes.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2017 ","pages":"6479121"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6479121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34912107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Knowledge of Human Cytomegalovirus Infection and Prevention in Pregnant Women: A Baseline, Operational Survey. 孕妇巨细胞病毒感染知识及预防:一项基线、操作调查。

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2017-01-01 Epub Date: 2017-07-31 DOI: 10.1155/2017/5495927

Maria Mazzitelli, Mariella Micieli, Carmela Votino, Federica Visconti, Paola Quaresima, Alessio Strazzulla, Carlo Torti, Fulvio Zullo

{"title":"Knowledge of Human Cytomegalovirus Infection and Prevention in Pregnant Women: A Baseline, Operational Survey.","authors":"Maria Mazzitelli, Mariella Micieli, Carmela Votino, Federica Visconti, Paola Quaresima, Alessio Strazzulla, Carlo Torti, Fulvio Zullo","doi":"10.1155/2017/5495927","DOIUrl":"https://doi.org/10.1155/2017/5495927","url":null,"abstract":"Currently, the only efficient way to prevent human Cytomegalovirus (HCMV) infection in pregnancy is primary prophylaxis through hygienic measures. So, we evaluated knowledge of HCMV and its prevention in a group of pregnant women. An anonymous questionnaire with multiple-choice answers was administered to all pregnant women who were followed up at the Obstetrics and Gynecology Unit of \"Pugliese-Ciaccio Hospital,\" a third-level hospital in Catanzaro (Southern Italy), from November 2015 to March 2016. Previously prescribed serology results for HCMV were also evaluated. Three hundred and fifty women participated in the study and the results clearly demonstrated that knowledge of pregnant women about HCMV is poor. Moreover, prescribed screening procedures need to be optimized, since one out of three pregnant women has not been tested for HCMV or the screening was not performed adequately. For this reason, it is important to implement informative campaign in both pregnant women and providing physicians.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2017 ","pages":"5495927"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5495927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35340072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Evolution of Knowledge, Awareness, and Practices regarding Zika Virus from 2016 to 2017. 2016年至2017年关于寨卡病毒的知识、意识和实践的演变

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2017-01-01 Epub Date: 2017-11-20 DOI: 10.1155/2017/6350602

Quinton Katler, Prachi Godiwala, Charles Macri, Beth Pineles, Gary Simon, Aileen Chang, Homa Ahmadzia

{"title":"Evolution of Knowledge, Awareness, and Practices regarding Zika Virus from 2016 to 2017.","authors":"Quinton Katler, Prachi Godiwala, Charles Macri, Beth Pineles, Gary Simon, Aileen Chang, Homa Ahmadzia","doi":"10.1155/2017/6350602","DOIUrl":"https://doi.org/10.1155/2017/6350602","url":null,"abstract":"Objective: Our team created a knowledge, attitudes, and practice (KAP) survey in order to assess changes over time in healthcare provider and community member awareness of Zika virus symptoms, transmission, treatment, and current and future concerns.Study design: The cross-sectional survey was issued at an academic medical center in Washington, DC, and via an online link to healthcare providers and community members between June and August 2016. Survey distribution was then repeated the following year, from March to April 2017. Outcomes were compared by survey year and healthcare provider versus community member status using SAS Program Version 9.4.Results: Significant differences in knowledge, attitudes, and practices existed between 2016 and 2017 survey time points. By 2017, more respondents had knowledge of various Zika virus infection characteristics; however healthcare provider knowledge also waned in certain areas. Attitudes towards Zika virus infection displayed an overall decreased concern by 2017. Practice trends by 2017 demonstrated fewer travel restrictions to Zika-endemic areas and increased mosquito protective measures within the US.Conclusions: Our results provide novel insight into the transformation of knowledge, attitudes, and practice of community members and healthcare providers regarding Zika virus since its declaration as a public health emergency of international concern in 2016.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2017 ","pages":"6350602"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6350602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35749423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Pubic Hair Shaving Is Correlated to Vulvar Dysplasia and Inflammation: A Case-Control Study. 阴毛剃除与外阴发育不良和炎症相关:一项病例对照研究。

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2017-01-01 Epub Date: 2017-08-27 DOI: 10.1155/2017/9350307

Meike Schild-Suhren, Amr A Soliman, Eduard Malik

{"title":"Pubic Hair Shaving Is Correlated to Vulvar Dysplasia and Inflammation: A Case-Control Study.","authors":"Meike Schild-Suhren, Amr A Soliman, Eduard Malik","doi":"10.1155/2017/9350307","DOIUrl":"https://doi.org/10.1155/2017/9350307","url":null,"abstract":"Objective: The risk factors for vulvar dysplasia and infections are not fully known. In this study, we aimed to investigate the correlation between pubic hair shaving and the occurrence of vulvar inflammation, dysplasia, and cancer.Methods: This study was performed between January 2013 and December 2016 in which a standardized questionnaire concerning genital hair shaving was administered to vulvar dysplasia and cancer patients and healthy participants. The presence of human papilloma virus (HPV) infection and the occurrence of genital inflammation were documented.Results: We recruited 49 patients with vulvar dysplasia or cancer and 234 healthy women as a control group. Smoking, HPV infection, genital inflammation, and complete pubic hair removal were significantly more common in the vulvar dysplasia/cancer group. Pubic hair shaving per se presented a clear association with vulvar dysplasia/cancer. Shaving the labia majora in particular showed also an association.Conclusion: Our findings suggest that partial or complete pubic hair shaving using a razor is correlated with and could be a potential risk factor for the development of genital inflammation, vulvar dysplasia, and malignancies. These results need to be confirmed in larger studies. HPV status and genital inflammation should be documented by medical personnel.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2017 ","pages":"9350307"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9350307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35573666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador. 人类乳头瘤病毒高危基因型的流行:厄瓜多尔南部经癌前和恶性巴氏涂片检查诊断的妇女

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2017-01-01 Epub Date: 2017-06-22 DOI: 10.1155/2017/8572065

Paola Dalgo Aguilar, Cisne Loján González, Ana Córdova Rodríguez, Katherine Acurio Páez, Ana Paulina Arévalo, Jana Bobokova

{"title":"Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador.","authors":"Paola Dalgo Aguilar, Cisne Loján González, Ana Córdova Rodríguez, Katherine Acurio Páez, Ana Paulina Arévalo, Jana Bobokova","doi":"10.1155/2017/8572065","DOIUrl":"10.1155/2017/8572065","url":null,"abstract":"Human papillomavirus (HPV) is the primary infectious agent for the development of cervical cancer, although the presence of the virus alone is insufficient for viral development and proliferation; this can be attributed to the increase in potential oncogenic risk, along with other risk factors. In the present investigation, the prevalence of high-risk HPV was determined from samples of premalignant or malignant cervical cytology in women from the southern region of Ecuador. The kit we used was able to detect genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. In addition, 64.5% of the analyzed samples were positive for HPV, with genotypes 16 and 18 being the most prevalent (16 was detected in 148 samples and 18 in 108). Genotypes 58 and 51 were the third most frequent simple and multiple infections, respectively. The data are very similar to those obtained worldwide, suggesting that the strategy of sex education, and the use of vaccines as primary prevention agents, could significantly decrease the incidence and mortality rate of cervical cancer in the southern region of Ecuador.","PeriodicalId":13546,"journal":{"name":"Infectious Diseases in Obstetrics and Gynecology","volume":"2017 ","pages":"8572065"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8572065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35176735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15