{"title":"Mesothelioma carcinogenesis of chrysotile and forsterite compared and validated by intraperitoneal injection in rat.","authors":"Ayako Takata, Hiroshi Yamauchi, Kiyotsugu Yamashita, Masahito Aminaka, Toshiaki Hitomi, Tadao Toya, Norihiko Kohyama","doi":"10.2486/indhealth.2024-0025","DOIUrl":"10.2486/indhealth.2024-0025","url":null,"abstract":"<p><p>Asbestos, especially chrysotile, continues to be exposed to humans globally. Hence, it should be disposed properly to prevent asbestos-related diseases, including mesothelioma and lung cancer. This study aimed to verify whether forsterite, a heating product of chrysotile, can cause carcinogenicity, particularly mesothelioma. Forsterite (FO-1000) and enstatite (EN-1500) produced by heating chrysotile at 1,000°C and 1,500°C, respectively, were subjected. We injected 10 mg of chrysotile, FO-1000, or EN-1500 in rats intraperitoneally and observed the development of peritoneal mesothelioma until 24 months. The incidence of peritoneal mesothelioma in the chrysotile group was 91.2%, whereas in the FO-1000 and EN-1500 groups, peritoneal mesothelioma did not develop. Urinary 8-hydroxy-2'-deoxyguanosine and serum N-ERC/mesothelin concentrations significantly increased in the chrysotile group that developed peritoneal mesothelioma, while they only temporarily changed in the FO-1000 or EN-1500 groups during early treatment. Furthermore, there was a significant homozygous deletion of the CDKN2A/p16 gene in the chrysotile group compared to the control group, in contrast to no significant difference in the FO-1000 and EN-1500 groups. Therefore, this study provides clear evidence that forsterite is a nonmesothelioma carcinogen and suggests that forsterite and enstatite are sufficient substances for chrysotile detoxification.</p>","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":" ","pages":"14-28"},"PeriodicalIF":1.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Industrial HealthPub Date : 2025-01-24Epub Date: 2024-05-20DOI: 10.2486/indhealth.2024-0027
Tianchang Ji, May Young Loh, Jan DE Jonge, Maria C W Peeters, Toon W Taris, Maureen F Dollard
{"title":"\"Are you feeling safe?\": an investigation of psychosocial safety climate in the relations of job characteristics and employee exhaustion and engagement.","authors":"Tianchang Ji, May Young Loh, Jan DE Jonge, Maria C W Peeters, Toon W Taris, Maureen F Dollard","doi":"10.2486/indhealth.2024-0027","DOIUrl":"10.2486/indhealth.2024-0027","url":null,"abstract":"<p><p>Psychosocial safety climate (PSC) is defined as the corporate climate in relation to employees' perceptions of organizational policies, procedures, and practices for the protection of employee psychosocial safety and well-being. The present study was based on the Demand-Induced Strain Compensation (DISC) Model and proposed that the interplay between identical job demands and resources would be conditioned by PSC. Particularly, high levels of PSC would enable employees to optimally perceive and utilize more job resources in dealing with corresponding job demands. A study was conducted among 406 Chinese workers from various occupational sectors. The findings of hierarchical regression analyses suggested that PSC a) mitigates the negative relation between emotional resources and exhaustion, b) enhances the positive relation between emotional resources and work engagement, and c) mitigates the negative relation between emotional demands and work engagement. We also found that PSC is a compensatory factor for low cognitive resources and demands encouraging high work engagement. Although we did not find the proposed three-way interactions, the present findings support the idea that high PSC is a fundamental contextual factor conducive to workers' health and well-being, especially in perceiving and obtaining emotional resources.</p>","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":" ","pages":"3-13"},"PeriodicalIF":1.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enriching caregivers for the elderly through workplace improvement.","authors":"Masaya Takahashi","doi":"10.2486/indhealth.63_400","DOIUrl":"10.2486/indhealth.63_400","url":null,"abstract":"","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":"63 4","pages":"318"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effective management for the duration and quality of working time.","authors":"Masaya Takahashi","doi":"10.2486/indhealth.63_100","DOIUrl":"10.2486/indhealth.63_100","url":null,"abstract":"","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":"63 1","pages":"1-2"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Smile at work to achieve the level of comfort in the workplace.","authors":"Masaya Takahashi","doi":"10.2486/indhealth.63_200","DOIUrl":"10.2486/indhealth.63_200","url":null,"abstract":"","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":"63 2","pages":"107"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Industrial HealthPub Date : 2024-11-26Epub Date: 2024-09-10DOI: 10.2486/indhealth.2024-0115
Mayumi Saiki, Wendie Robbins, Dante Anthony Tolentino, Paul M Macey, Akinori Nakata, Jian Li
{"title":"Associations of work-family conflict with changes in metabolic risk factors: a four-year longitudinal study.","authors":"Mayumi Saiki, Wendie Robbins, Dante Anthony Tolentino, Paul M Macey, Akinori Nakata, Jian Li","doi":"10.2486/indhealth.2024-0115","DOIUrl":"10.2486/indhealth.2024-0115","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is becoming prevalent among younger people who have dual roles at both work and home. A possible contributor to CVD is conflict between work and home life. Thus, this study investigated the impact of work-to-family conflict (WFC) and family-to-work conflict (FWC) on metabolic risk factors. We used longitudinal data with a 4-yr interval from the Midlife in Japan study. 152 participants who were employed at baseline without missing variables of interest were included. We assessed the associations of baseline WFC and FWC with changes in metabolic risk factors between baseline and follow-up using Generalized Estimating Equations. After adjusting for baseline sociodemographic, work and family-related, and lifestyle factors, the fully adjusted model showed WFC was significantly associated with changes in low-density lipoprotein cholesterol (LDL-C) and Total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio. However, FWC was not significantly associated with changes in any metabolic risk factors. Our findings indicated a significant impact of WFC on LDL-C and TC/HDL-C ratio but no significant impact of FWC on metabolic health. Since these metabolic risk factors cause CVD, understanding the physiological responses to occupational psychosocial stress could help create primary prevention interventions and assess their effects on workers' metabolic health.</p>","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":" ","pages":"367-376"},"PeriodicalIF":1.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Industrial HealthPub Date : 2024-11-26Epub Date: 2024-05-10DOI: 10.2486/indhealth.2023-0135
Madeline Evans, Meagan E Crowther, Brandon W J Brown, Sian Wanstall, Tim Rayner, Andrew Vakulin, Robert J Adams, Amy C Reynolds
{"title":"Sleep disorder risk, perceived control over sleep, and mental health symptoms in paramedicine students.","authors":"Madeline Evans, Meagan E Crowther, Brandon W J Brown, Sian Wanstall, Tim Rayner, Andrew Vakulin, Robert J Adams, Amy C Reynolds","doi":"10.2486/indhealth.2023-0135","DOIUrl":"10.2486/indhealth.2023-0135","url":null,"abstract":"<p><p>Paramedics commonly experience both poor sleep and mental health symptoms. Clarifying whether sleep or mental health symptoms are a challenge prior to commencement of employment is important, as early prevention and intervention initiatives during training could support these workers. Paramedicine students (n=53) were included, with sleep disorder screening (obstructive sleep apnea, insomnia and restless legs syndrome), and mental health outcomes (depressive symptoms: Patient Health Questionnaire-9, and anxiety symptoms: General Anxiety Disorder-7). Data were analysed using robust regression models, adjusted for age, sex, and shift work status. Meeting criteria for a sleep disorder (n=21) was associated with higher scores for anxiety (8.2 [95% CI: 5.9-10.5] v 4.6, [3.4-5.8]) and depressive symptoms (11.1 [8.6-13.6] v 4.4 [3.1-5.7)] compared to those who did not meet the criteria for a sleep disorder (n=32). Depressive symptoms were lower in those with perceived control over sleep (5.2 [3.2-7.2] v 9.8 [7.7-11.8]). There was no interaction between sleep disorder risk and perceived control over sleep on mental health symptoms. Investigation and management of factors contributing to low perceived control over sleep, together with early screening and management of sleep disorders, are likely to be important priorities to support paramedic student wellbeing prior to commencing shift work.</p>","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":" ","pages":"408-416"},"PeriodicalIF":1.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Industrial HealthPub Date : 2024-11-26Epub Date: 2024-07-30DOI: 10.2486/indhealth.2024-0092
Rachael E Potter, Michael Ertel, Maureen F Dollard, Stavroula Leka, Aditya Jain, Loic Lerouge, Irene Houtman, Birgit Aust, Won-Jun Choi, Nicholas Crooks, John Fitzgerald, Siti Nurani Hassan, Andrea Kirk-Brown, Takenori Mishiba, Ashley Spetch, Ulrich Stoetzer, Pieter VAN Dijk
{"title":"Joint ICOH-WOPS & APA-PFAW global roundtable perspectives: exploring national policy approaches for psychological health at work through the 'National Policy Index' lens.","authors":"Rachael E Potter, Michael Ertel, Maureen F Dollard, Stavroula Leka, Aditya Jain, Loic Lerouge, Irene Houtman, Birgit Aust, Won-Jun Choi, Nicholas Crooks, John Fitzgerald, Siti Nurani Hassan, Andrea Kirk-Brown, Takenori Mishiba, Ashley Spetch, Ulrich Stoetzer, Pieter VAN Dijk","doi":"10.2486/indhealth.2024-0092","DOIUrl":"10.2486/indhealth.2024-0092","url":null,"abstract":"<p><p>Worker psychological health is a significant global imperative that requires national policy action and stakeholder engagement. While national policy is a critical lever for improving worker psychological health, some countries are more progressive than others in relation to policy development and/or implementation. At the Joint Congress of the International Commission on Occupational Health, Scientific Committee on Work Organization and Psychosocial Factors and the Asia Pacific Academy for Psychosocial Factors at Work in Tokyo (September 2023), a Global Roundtable was held that to initiate international dialogue and knowledge exchange about national policy approaches for work-related psychological health. The Global Roundtable involved experts from diverse regions alongside an engaged audience of congress attendees and facilitators. Qualitative data were analysed against the five components of the National Policy Index tool comprising, policy priority, specific laws, nation-wide initiatives, sector-oriented initiatives, national survey and/or studies. Analysis revealed that while work-related psychological health is a policy priority across many countries, at the same time, there are global gaps in both legislation specificity and active regulation across different countries. For future policy development across countries, it will be beneficial to continue and deepen international discourse and for countries to share their approaches with others.</p>","PeriodicalId":13531,"journal":{"name":"Industrial Health","volume":" ","pages":"353-366"},"PeriodicalIF":1.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}