Indian journal of cancer最新文献_第7页

A rare case of concurrent intrahepatic splenosis and pancreatic adenocarcinoma following splenectomy. 脾切除术后并发肝内脾肿大和胰腺癌的罕见病例。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2023-05-02 DOI: 10.4103/ijc.IJC_70_21

Jiangbin Li, Li He, Nianan Luo, Rui Dong

引用次数: 0

Pancreatic neuroendocrine tumor with abundant mitochondria. 线粒体丰富的胰腺神经内分泌肿瘤。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI: 10.4103/ijc.ijc_679_21

Divya Shetty, Aditi Raj, Anjali Amarapurkar

引用次数: 0

Efficacy and safety of apatinib for elderly patients with previously treated extensive-stage colorectal cancer patients and the prognostic significance of common adverse reactions. 阿帕替尼对曾接受过广泛期结直肠癌治疗的老年患者的疗效和安全性以及常见不良反应的预后意义。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_1368_20

Yongjun Yu, Yuwei Li, Chen Xu, Weihua Zhang

{"title":"Efficacy and safety of apatinib for elderly patients with previously treated extensive-stage colorectal cancer patients and the prognostic significance of common adverse reactions.","authors":"Yongjun Yu, Yuwei Li, Chen Xu, Weihua Zhang","doi":"10.4103/ijc.IJC_1368_20","DOIUrl":"10.4103/ijc.IJC_1368_20","url":null,"abstract":"Background: This study was designed to investigate the efficacy and safety of apatinib monotherapy in the treatment of elderly patients with advanced colorectal cancer (CRC) who have progressed on the standard regimens.Methods: The data of 106 elderly patients with advanced CRC who have progressed on standard treatment were analyzed. The primary endpoint of this study was progression-free survival (PFS), the secondary endpoints were objective response rate (ORR), disease control rate (DCR), and overall survival (OS). The safety outcomes were assessed by the proportion and severity of adverse events.Results: Efficacy was assessed using the best overall response of patients during treatment with apatinib, including 0 patients with complete response, 9 patients with partial response, 68 patients with stable disease, and 29 patients with progressive disease. ORR and DCR were 8.5 and 72.6%, respectively. The median PFS of 106 patients was 3.6 months, and the median OS was 10.1 months. The most frequent adverse reactions of elderly patients with advanced CRC receiving apatinib treatment were hypertension (59.4%) and hand-foot syndrome (HFS) (48.1%). The median PFS of patients with and without hypertension was 5.0 and 3.0 months, respectively ( P = 0.008). The median PFS of patients with and without HFS was 5.4 and 3.0 months, respectively ( P = 0.013).Conclusions: The clinical benefit of apatinib monotherapy was observed in elderly patients with advanced CRC who have progressed on the standard regimens. The adverse reactions of hypertension and HFS were positively related to treatment efficacy.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"317-323"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bartholin's gland adenoid cystic carcinoma: Report of three cases and the review of literature. 巴氏腺腺样囊性癌：三例病例报告及文献综述。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI: 10.4103/ijc.ijc_359_21

Zeynep Güral, Serap Yücel, Fulya Agaoglu

引用次数: 0

Misconducts in research and methods to uphold research integrity. 研究中的不当行为和维护研究诚信的方法。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI: 10.4103/ijc.ijc_4_23

Karthik N Rao, Manish Mair, Ripu D Arora, Prajwal Dange, Nitin M Nagarkar

{"title":"Misconducts in research and methods to uphold research integrity.","authors":"Karthik N Rao, Manish Mair, Ripu D Arora, Prajwal Dange, Nitin M Nagarkar","doi":"10.4103/ijc.ijc_4_23","DOIUrl":"10.4103/ijc.ijc_4_23","url":null,"abstract":"Research misconduct refers to deliberate or accidental manipulation or misrepresentation of research data, findings, or processes. It can take many forms, such as fabricating data, plagiarism, or failing to disclose conflicts of interest. Data falsification is a serious problem in the field of medical research, as it can lead to the promotion of false or misleading information. Researchers might engage in p-hacking - the practice of using someone else's research results or ideas without giving them proper attribution. Conflict of interest (COI) occurs when an individual's personal, financial, or professional interests could potentially influence their judgment or actions in relation to their research. Nondisclosure of COI can be considered research misconduct and can damage the reputation of the authors and institutions. Hypothesis after results are known can lead to the promotion of false or misleading information. Cherry-picking data is the practice of focusing attention on certain data points or results that support a particular hypothesis, while ignoring or downplaying results that do not. Researchers should be transparent about their methods and report their findings honestly and accurately. Research institutions should have clear and stringent policies in place to address scientific misconduct. This knowledge must become widespread, so that researchers and readers understand what approaches to statistical analysis and reporting amount to scientific misconduct. It is imperative that readers and researchers alike are aware of the methods of statistical analysis and reporting that constitute scientific misconduct.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"354-359"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ominous cause of hirsutism: Adrenocortical carcinoma. 多毛症的不祥之因：肾上腺皮质癌

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-07-13 DOI: 10.4103/ijc.ijc_86_22

Pankaj Singhania, Rana Bhattacharjee, Subhankar Chowdhury

引用次数: 0

The clinical efficacy and safety of TACE combined with apatinib for advanced hepatocellular carcinoma: A propensity score matching analysis. TACE联合阿帕替尼治疗晚期肝细胞癌的临床疗效和安全性：倾向评分匹配分析。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2022-11-30 DOI: 10.4103/ijc.IJC_967_20

Cheng Chen, Xiaoting Duan, Yanfeng Shen, Guiying Li

{"title":"The clinical efficacy and safety of TACE combined with apatinib for advanced hepatocellular carcinoma: A propensity score matching analysis.","authors":"Cheng Chen, Xiaoting Duan, Yanfeng Shen, Guiying Li","doi":"10.4103/ijc.IJC_967_20","DOIUrl":"10.4103/ijc.IJC_967_20","url":null,"abstract":"Background: The combined treatment of transcatheter arterial chemoembolization (TACE) and apatinib had beneficial effects on the survival of patients with advanced hepatocellular carcinoma (HCC), but the efficacy of this regimen is still controversial and needs further investigation.Materials and methods: The clinical records of advanced HCC patients between May 2015 and December 2016 were collected from our hospital. They were categorized into the TACE monotherapy group and the combination of TACE and apatinib group. After propensity score matching (PSM) analysis, the disease control rate (DCR), objective response rate (ORR), progression-free survival (PFS), and occurrence of adverse events were compared between the two treatments.Results: There were 115 HCC patients included in the study. Among them, 53 received TACE monotherapy and 62 were treated with TACE plus apatinib. After PSM analysis, 50 pairs of patients were compared. The DCR of the TACE group was significantly lower than that of the combination of TACE and apatinib group (35 [70%] versus 45 [90%], P < 0.05). The ORR of the TACE group was also significantly lower than that of the combination of TACE and apatinib group (22 [44%] versus 34 [68%], P < 0.05). Patients who received the combined treatment of TACE and apatinib had longer PFS compared with those in the TACE monotherapy group ( P < 0.001). Moreover, hypertension, hand-foot syndrome, and albuminuria were more common in the combination of TACE and apatinib group ( P < 0.05), although all adverse events were well tolerated.Conclusions: The combined treatment of TACE and apatinib showed beneficial effects on tumor response, survival outcomes, and tolerance to treatment, which may be used as a routine regimen for advanced HCC patients.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"390-395"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer pattern in Varanasi district from Uttar Pradesh state of India, a foundation for cancer control based on the first report of the population-based cancer registry. 印度北方邦瓦拉纳西地区的癌症模式--基于首份人口癌症登记报告的癌症控制基础。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_44_21

Atul M Budukh, Satyajit Pradhan, Virendra B Singh, Divya Khanna, Sonali S Bagal, Priyal S Chakravarti, Anand N Sharma, Rajesh K Vishwakarma, Shraddha S Shinde, Naveen C Khargekar, Pankaj Chaturvedi, Rajesh P Dikshit, Vijay K Shukla, Rajendra A Badwe

{"title":"Cancer pattern in Varanasi district from Uttar Pradesh state of India, a foundation for cancer control based on the first report of the population-based cancer registry.","authors":"Atul M Budukh, Satyajit Pradhan, Virendra B Singh, Divya Khanna, Sonali S Bagal, Priyal S Chakravarti, Anand N Sharma, Rajesh K Vishwakarma, Shraddha S Shinde, Naveen C Khargekar, Pankaj Chaturvedi, Rajesh P Dikshit, Vijay K Shukla, Rajendra A Badwe","doi":"10.4103/ijc.IJC_44_21","DOIUrl":"10.4103/ijc.IJC_44_21","url":null,"abstract":"Background: The cancer registry provides reliable data from the population. In this article, we provide cancer burden and its patterns from the Varanasi district.Methods: The method adopted by the Varanasi cancer registry is community interaction along with regular visits to more than 60 sources to collect data on cancer patients. The cancer registry was established by the Tata Memorial Centre, Mumbai, in 2017 covering 4 million population (57% rural and 43% urban population).Results: The registry has recorded 1,907 incidence cases (1,058 male and 849 female). The age-adjusted incidence rate per 100,000 population in male and female of Varanasi district is 59.2 and 52.1, respectively. One in 15 male and one in 17 female are at risk of developing the disease. Mouth and tongue cancers are the predominant cancers in male, whereas breast, cervix uteri, and gallbladder are the leading cancer sites among the female. In female, cervix uteri cancer is significantly higher (double) in rural areas when compared with urban areas (rate ratio [RR] 0.5, 95% confidence interval [CI; 0.36, 0.72]), whereas in male, mouth cancer is higher in urban areas when compared with rural areas (RR 1.4, 95% CI [1.11, 1.72]). More than 50% of cancer cases in male are due to tobacco consumption. There may be underreporting of the cases.Conclusion: The results of the registry warrant policies and activities related to early detection services for the mouth, cervix uteri, and breast cancers. The Varanasi cancer registry is the foundation for cancer control and will play an important role in the evaluation of the interventions.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"383-389"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10815015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of tobacco counseling training module (TCTM) in enhancing the knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling among undergraduate dental students - An interventional study. 烟草咨询培训模块（TCTM）在提高口腔医学本科生烟草咨询知识、态度、识别口腔表现能力、自信心和技能（KAASS）方面的效果--一项干预性研究。

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.ijc_405_21

Byalakere R Chandrashekar, Thomas V Chacko, H P Jayashankar, S Suma, K M Anand, Suvetha Kannappan

{"title":"Effectiveness of tobacco counseling training module (TCTM) in enhancing the knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling among undergraduate dental students - An interventional study.","authors":"Byalakere R Chandrashekar, Thomas V Chacko, H P Jayashankar, S Suma, K M Anand, Suvetha Kannappan","doi":"10.4103/ijc.ijc_405_21","DOIUrl":"10.4103/ijc.ijc_405_21","url":null,"abstract":"Background: Tobacco use has emerged as a major public health issue with increasing tobacco-related morbidity and mortality. Despite evidence that even brief tobacco counseling by health care professionals is effective in motivating a tobacco user to quit, there was a lack of customized tobacco counseling training module (TCTM) for students of dentistry in their existing curriculum. This study was undertaken to evaluate the effectiveness of a customized TCTM in improving KAASS in tobacco counseling among undergraduate dental students.Methods: TCTM that was previously pilot tested was implemented as a value addition in Public Health Dentistry for two academic years. Changes in knowledge, attitude, ability to identify oral manifestations, self-confidence, and skills (KAASS) in tobacco counseling were assessed before and after implementation of TCTM. Mean pre and post intervention scores were compared.Results: Mean scores for knowledge, attitude, ability to identify oral manifestations, and self-confidence (KAAS) at baseline were 4.4 ± 0.9, 5.1 ± 0.7, 4.5 ± 1.1, and 1.3 ± 0.4, respectively. Mean KAAS scores post intervention were 13.5 ± 1.0, 8.7 ± 0.4, 9.4 ± 0.7, and 3.5 ± 0.5, respectively. There was a significant improvement in the mean KAAS score post intervention compared to baseline. Tobacco counseling skills also significantly improved among the participants following implementation of the training module (68.8%) did well compared to the baseline (0%).Conclusion: TCTM was effective in enhancing knowledge, attitude, ability to identify oral manifestations, and self-confidence in tobacco counseling among undergraduate dental students.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"230-237"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum 25-hydroxy vitamin-D levels in head and neck cancer chemoradiation therapy: Potential in cancer therapeutics. 头颈癌化学放疗中的血清 25- 羟基维生素-D 水平：癌症治疗的潜力

IF 0.9 4区医学

Indian journal of cancer Pub Date : 2024-04-01 Epub Date: 2024-09-11 DOI: 10.4103/ijc.IJC_358_20

Arya Bhanu, Chaitali M Waghmare, Vandana S Jain, Hemant J Pawar

{"title":"Serum 25-hydroxy vitamin-D levels in head and neck cancer chemoradiation therapy: Potential in cancer therapeutics.","authors":"Arya Bhanu, Chaitali M Waghmare, Vandana S Jain, Hemant J Pawar","doi":"10.4103/ijc.IJC_358_20","DOIUrl":"10.4103/ijc.IJC_358_20","url":null,"abstract":"Background: To evaluate the relation between serum-25-hydroxy Vitamin-D levels (S25OHVDL) and concurrent chemoradiation therapy (CTRT) toxicities in patients of head and neck squamous cell cancer (HNSCC).Methods: After an institutional ethics committee approval, consecutive HNSCC patients who received radical/adjuvant CTRT were prospectively evaluated. Patients were assessed for CTRT toxicities using Common Terminology Criteria for Adverse Events version 5.0 (CTCAE-v5.0) and the response was evaluated according to Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST-1.1). S25OHVDL was assessed at the time of the first follow-up. Patients were divided into group A (Optimal) and group B (suboptimal) according to S25OHVDL. The treatment toxicities were correlated with S25OHVDL.Results: Twenty-eight patients were evaluated for the study. S25OHVDL was optimal in eight (28.57%) and suboptimal in 20 patients (71.42%). Mucositis and radiation dermatitis were significantly more in subgroup B ( P -value 0.0011 and 0.0505, respectively). Relatively lower but nonsignificant hemoglobin and peripheral white blood cell counts were observed in subgroup B.Conclusion: Suboptimal S25OHVDL was associated with significantly more skin and mucosal toxicities in HNSCC patients treated with CTRT.","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":"403-407"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0