Indian journal of cancer最新文献

{"title":"Carbimazole-induced acute myeloid leukemia: A very rare case report and review of the literature.","authors":"Lalchand Mittal, Sandeep Jasuja","doi":"10.4103/ijc.ijc_366_21","DOIUrl":"10.4103/ijc.ijc_366_21","url":null,"abstract":"<p><strong>Abstract: </strong>Neutropenia is a common side effect in hyperthyroid patients with long-term use of antithyroid drugs. Antithyroid drugs have been used for the management of hyperthyroidism and rarely may cause life-threatening side effects such as pancytopenia and very rarely may cause acute leukemia. The current case report is of a 34-year-old man diagnosed with hyperthyroidism who presented with pancytopenia after treatment with carbimazole for past 7 months; he initially improved with supportive treatment. The patient restarted treatment with carbimazole but with a reduced dose. He was readmitted for fever and high total leukocyte counts after 3 months of restarting carbimazole. The patient was thoroughly investigated, and bone marrow aspiration examination showed acute myeloid leukemia. This presentation of acute myeloid leukemia was likely attributed to the reexposure to carbimazole, although the association of acute myeloid leukemia with autoimmune thyroid disease cannot be denied.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"142-144"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News in oncology.","authors":"Prahlad H Yathiraj, Anuja Raniwala, Ritika Harjani Hinduja","doi":"10.4103/ijc.ijc_3_25","DOIUrl":"https://doi.org/10.4103/ijc.ijc_3_25","url":null,"abstract":"","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"175-176"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonoperative management in low-lying rectal cancers undergoing chemoradiation.","authors":"Debanjali Datta, Reena Engineer, Avanish Saklani, Ashwin D'souza, Akshay Baheti, Suman Kumar, Rahul Krishnatry, Vikas Ostwal, Anant Ramaswamy, Prachi Patil","doi":"10.4103/ijc.ijc_1248_21","DOIUrl":"10.4103/ijc.ijc_1248_21","url":null,"abstract":"<p><strong>Background: </strong>To evaluate outcomes of postneoadjuvant chemoradiotherapy (NACTRT) wait and watch strategy (WWS) in distal rectal cancers.</p><p><strong>Methods: </strong>All consecutive patients from December 2012 to 2019 diagnosed with distal rectal tumors (T2-T4 N0-N+) having a complete or near-complete response (cCR or nCR respectively) post-NACTRT and wished for nonsurgical treatment option of WWS were included in this study. Patients were observed with 3 monthly MRI, sigmoidoscopy, and digital rectal examination (DRE) for 2 years and 6 monthly thereafter. Organ preservation rate (OPR), local regrowth rate (LRR), nonregrowth recurrence-free survival, and overall survival (OS) were estimated using the Kaplan-Meier method, and factors associated with LRR were identified on univariate and multivariate analysis using the log-rank test (P < 0.05 significant).</p><p><strong>Results: </strong>Sixty-one consecutive patients post-NACTRT, achieving cCR [44 (72%)] and nCR [17 (28%)], respectively, were identified. All patients received pelvic radiotherapy to a dose of 45-50Gy conventional fractionation with concurrent Capecitabine. Additional boost dose with either external beam or brachytherapy was given to 39 patients. At a median follow-up of 39 months, 11 (18%) patients had local regrowth, of which seven were salvaged with surgery and the rest are alive with disease, as they refused surgery. The overall OPR, nonregrowth recurrence-free survival, OS was 83%, 95%, and 98%, respectively. Seven (11%) patients developed distant metastasis, of which six underwent metastasectomy and are alive and well. LRR was higher in patients with nCR versus cCR (P = 0.05).</p><p><strong>Conclusion: </strong>The wait-and-watch strategy is a safe nonoperative alternative management for selected patients attaining cCR/nCR after NACTRT with excellent outcomes.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"76-81"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demystifying the conundrum of medullary thyroid cancers and providing a brief review of literature.","authors":"Arvind Krishnamurthy, Srikamakshi Kothandaraman, Mss Keerthi, Krishna Kumar Ramachandran","doi":"10.4103/ijc.ijc_992_21","DOIUrl":"10.4103/ijc.ijc_992_21","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the clinicopathological features, patterns of care, and the survival outcomes of patients with medullary thyroid cancers (MTCs) treated at our tertiary care center.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of all patients with a histological diagnosis of MTC and who had been treated at our tertiary care center from August 1, 1986 through November 31, 2019.</p><p><strong>Results: </strong>MTC in 83 patients were managed in the said period and comprised 44 men and 39 women. The median age of the patient cohort was 45 years. Seventy-seven of 83 patients underwent upfront surgery that entailed a total thyroidectomy and a central compartment neck dissection and a lateral compartment neck dissection, as was deemed appropriate. The disease-free survival rates at 5, 10, and 20 years for the present study were 62%, 51%, and 46%, respectively, and the overall survival rates for the same periods were 85%, 80%, and 76%, respectively. A formal analysis of the various prognostic factors was made. In multivariate analysis, the factors that significantly influenced the disease-free survival included gender and lymph node ratio. Furthermore, on multivariate analysis, the factors that significantly influenced the overall survival included age and gender, with male patients and patients aged >55 years faring poorly.</p><p><strong>Conclusion: </strong>Our study has clearly demonstrated the favorable long-term survival outcomes of patients with MTCs. Furthermore, the analysis of various prognostic factors adds to our understanding of the biology of this rare form of thyroid cancer.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"23-31"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A role of silicon spacer for mandibular reconstruction in oral cavity squamous cell carcinoma- A prospective evaluation.","authors":"Dhruv G Patel, Sanjay M Desai, Vinod Dhakad, Elroy Saldanha, Bonny Joseph, Sandeep Ghosh","doi":"10.4103/ijc.ijc_824_21","DOIUrl":"10.4103/ijc.ijc_824_21","url":null,"abstract":"<p><strong>Background: </strong>Although using a free flap with a microvascular technique is the gold standard of care, its use is limited in underdeveloped nations due to a lack of experience and resources. As a result, alloplastic materials and pedicled musculocutaneous flaps are commonly used in mandibular repair. Although numerous alloplastic materials have been employed with this flap, the majority of research has shown that they have a negative effect. The aim of the study was to see how effective silicon spacers are as a replacement for alloplastic materials in mandibular reconstruction.</p><p><strong>Methods: </strong>A prospective study was conducted on patients who had mandibular reconstruction using soft-tissue repair with or without the use of a silicon spacer. The study comprised a total of 82 patients, 40 of whom had a silicon spacer and 42 of whom did not. The Chi-square test was utilized to assess the functional and cosmetic outcomes in both groups by using the EORTC head-and-neck questionnaire-35 analysis.</p><p><strong>Results: </strong>The majority of the patients were in the T3 and T4a stages. The most common sub-site was buccal mucosa. The average silicon spacer retention time was 62 days, with a retention rate of 22.5%. Infection at the local portion, with or without orocutaneous fistula, was a common reason for silicon spacer removal. Only the speech parameter improved in the silicon spacer group, according to the EORTC head-and neck-questionnaire (P = 0.0290). In 16 individuals, radiation therapy was postponed, which was also significant (P = 0.0123).</p><p><strong>Conclusion: </strong>In patients with oral cavity squamous cell carcinoma who underwent mandibular resection, using a silicon spacer in combination with soft-tissue restoration did not improve functional or cosmetic outcomes except for speech. For comprehensive mandibular reconstruction, only a myocutaneous flap is sufficient.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"3-10"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of precise management model in the maintenance of central venous indwelling catheters for cancer patients.","authors":"Hui Xu, Yibo Cai, Lingnv Xie","doi":"10.4103/ijc.ijc_1462_21","DOIUrl":"10.4103/ijc.ijc_1462_21","url":null,"abstract":"<p><strong>Background: </strong>Cancer is the leading cause of death worldwide. However, there is not a single study that has investigated the effect of a precise management model in cancer patients. This study aimed to explore the role of precise management in maintaining central venous indwelling catheters for cancer patients.</p><p><strong>Methods: </strong>In total, 106 patients with central venous indwelling catheters were randomly divided into observation and control groups. The control group was given routine nursing intervention. A precise management model was adopted for the observation group. The incidence of central venous indwelling catheter-associated complications, patient treatment compliance, anxiety and depression scores, and patient satisfaction with the nursing services were compared between the two groups.</p><p><strong>Results: </strong>We noticed that the psychological state of the patients in the two groups significantly improved after the nursing intervention compared to before the nursing intervention (P < 0.05), and this effect was more prominent in the observation group than in the control group (P < 0.05). In addition, the incidence of complications in the observation group was lower than that in the control group (P < 0.05). Moreover, we observed that treatment compliance and patient satisfaction with the nursing services were much higher in the observation group than in the control group (P < 0.05).</p><p><strong>Conclusions: </strong>In the maintenance of central venous indwelling catheters for cancer patients, the implementation of a precise management model can significantly reduce the incidence of central venous indwelling catheter-associated complications, improve treatment compliance of patients, positively modulate patients' psychological state, and harmonize the nurse-patient relationship.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"104-110"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and prognostic factors of childhood Ewing sarcoma - Experience from a cancer center in South India.","authors":"Binitha Rajeswari, V R Prasanth, Priyakumari Thankamony, Manjusha Nair, Guruprasad Chellappan Sojamani, Arun Sankar, Bhaskar Subin Sugath, K M Jagathnath Krishna, P Kusumakumary, K Jayasree","doi":"10.4103/ijc.ijc_1149_21","DOIUrl":"10.4103/ijc.ijc_1149_21","url":null,"abstract":"<p><strong>Background: </strong>Childhood Ewing sarcoma (ES) - both osseous and extraosseous - has good outcomes with aggressive treatment that includes chemotherapy, surgery, and radiation therapy (RT). In this paper, we report our experience on the survival and prognostic factors of ES.</p><p><strong>Materials and methods: </strong>Seventy-four newly diagnosed patients with ES, less than 14 years of age, registered in Pediatric Oncology Department of our center, over a period of 5 years, from July 1, 2010 to June 30, 2015, were included.</p><p><strong>Results: </strong>Mean age at presentation was 8.93 years. Primary osseous sites were the extremity (n = 30), pelvis (n = 10), chest wall (n = 9), spine (n = 7), and skull (n = 5), and the extraosseous primary site was involved in 17.6% (n = 13). Metastatic disease was present in 17 patients (23%). Also, 52 patients received three-weekly vincristine/doxorubicin/cyclophosphamide (VDC)/ifosfamide/etoposide (IE) and 21 patients received only VDC. There was no treatment-related mortality. Local control modalities were surgery alone (n = 12), definitive RT (n = 33), surgery and RT (n = 20), palliative RT (n = 4), or none (n = 4). At a median duration of follow-up of 64 months, the 5-year event-free survival (EFS) for the entire cohort was 50.4% (60.6% for localized and 17.6% for metastatic) and the 5-year overall survival (OS) was 54.6% (64.2% for localized and 23.5% for metastatic). Among the prognostic factors analyzed (age, gender, lactate dehydrogenase [LDH] levels, site, and metastases), presence of metastases was the only factor significantly associated with poorer EFS and OS.</p><p><strong>Conclusion: </strong>Localized ES has a favorable outcome even in resource-limited settings, and treatment intensification by interval-compressed chemotherapy may improve the outcomes further. Presence of metastasis at presentation confers a poor outcome.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"57-63"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Tobacco: High sugar intake as a potential risk factor for oral cavity cancers amongst non-tobacco users?","authors":"Hitesh R Singhavi","doi":"10.4103/ijc.ijc_4_25","DOIUrl":"10.4103/ijc.ijc_4_25","url":null,"abstract":"","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":"62 1","pages":"1-2"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Systemic Inflammatory Markers in Elderly Patients with Tumor-associated Venous Thromboembolism.","authors":"Na Guo, Xinxin Yan, Zhong Yi, Shuihua Yu, Helu Xiu, Yunlei Gao, Songwei Ru, Zuojuan Gong","doi":"10.4103/ijc.ijc_318_23","DOIUrl":"https://doi.org/10.4103/ijc.ijc_318_23","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Elderly tumor patients are more prone to venous thrombotic events than nontumor patients. To investigate the relationship between systemic inflammatory markers and overall survival (OS) in elderly patients with tumorassociated venous thromboembolism (TAVTE). And to evaluate the prognostic value of combined lymphocyte platelettolymphocyte ratio (PLR) with neoplasm metastasis in elderly patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A prospective study was conducted. A total of 172 elderly patients with TAVTE admitted to the hospital from January 2017 to December 2019 were included in the study, which were followed up for 2 years. Clinical and laboratory data were collected. All-cause mortality within after discharge were followed up. The optimal cutoff values of neutrophiltolymphocyte ratio (NLR), PLR, systemic immuneinflammation index (SII), and monocyte to highdensity lipoprotein ratio (MHR) for predicting efficacy and prognosis were determined according to receiver operating characteristic (ROC) curve and the areas under the ROC curve (AUC). Kaplan-meier curves were used to analyze the survival time. Univariate and multivariate COX logistic regression analyses were used to analyze the independent predictors of OS in elderly patients with TAVTE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The cut-off values for NLR, PLR, SII, and MHR were 3.375, 274.63, 399.73 and 0.58, respectively. And the area under the curve (AUC) was 0.639(95%CI: 0.556-0.721), 0.628(95%CI:0.544-0.712), 0.595(95%CI:0.510-0.680) and 0.596(95%CI: 0.510-0.683). Survival analysis showed that OS was longer in the NLR≤3.375 group (181.07 weeks, 95% CI: 150.11 ~ 212.03) than in the NLR &gt;3.375 group (108.95 weeks, 95%CI: 90.38 ~ 127.51) (P = 0.005). The OS of PLR≤274.63 group (160.40 weeks, 95%CI: 138.41 ~ 182.38) was longer than that of PLR &gt;274.63 group (43.85 weeks, 95%CI: 34.08 ~ 53.63) (P &lt; 0.001). The OS of SII≤399.73 group (176.62 weeks, 95%CI:147.26 ~ 205.97) was longer than that of SII&gt;399.73 group (126.55 weeks,95%CI: 105.04 ~ 148.05) (P = 0.012). The OS was longer in the MHR≤0.58 group (156.24 weeks, 95% CI: 127.05-185.43) than in the MHR&gt;0.58 group (108.11 weeks, 95%CI:86.85-129.38) (P = 0.011). Univariate and multivariate Cox analysis showed that tumor metastasis and PLR&gt;274.63 were independent predictors of the lower OS in elderly patients with TAVTE (P &lt; 0.001). According to the tumor metastasis and the cut-off value of PLR, a combined scoring system MPS (Metastasis and PLR System) was designed. The OS of the 0, 1 and 2 score groups was 184.08 weeks (95%CI:158.11-210.05), 82.60 weeks (95%CI:61.57-103.64), and 23.83 weeks (95%CI: 9.575-38.09) (P &lt; 0.001), respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings suggest that the systemic inflammatory markers (NLR, PLR, SII, MHR) may have predictive value for all-cause mortality in elderly patients with TAVTE. PLR combined with tumor metastasis may be an effective index to predict the prognosis of eld","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second primary cancers: Incidence and outcomes from a population of patients accrued in six prospective controlled trials at a tertiary cancer institute.","authors":"Abhishek Chatterjee, Sarbani G Laskar, Jayshree Deshmukh, Tejpal Gupta, Vedang Murthy, Jai Prakash Agarwal, Ashwini Budrukkar","doi":"10.4103/ijc.IJC_154_20","DOIUrl":"https://doi.org/10.4103/ijc.IJC_154_20","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to document the incidence, spectrum and outcomes of Second Primary Malignancy (SPM) in a prospectively followed-up population of Head and Neck Squamous carcinoma (HNSCC) patients accrued in six prospective trials and treated with definitive radiotherapy.</p><p><strong>Materials and methods: </strong>Patients were prospectively followed up over time and data on SPM collected after IRB approval after establishing the diagnosis of SPM based on clinical criteria. Descriptive statistics to determine clinic demographic characteristics and spectrum of SPM encountered, time to event outcomes (SPM-DFS - Disease-free survival after diagnosis of second primary, SPM-OS - Overall survival after diagnosis of second primary) and univariate analysis of factors of likely prognostic significance were performed.</p><p><strong>Results: </strong>A total of 656 individual patient records were examined. A total of 43 SPM s were detected at a median follow-up of 62 months (IQR -39-97 months), accounting for a cumulative incidence of 6.5%. The median time to development of an SPM was 48 months. The head and neck (41.84%) and the esophagus (34.8)% were the most common sites of SPM. At a median follow-up of 7 months post-diagnosis of SPM, the 1 year estimates of SPM-DFS and SPM-OS were 37.6% and 40% respectively. Radical intent treatment emerged as a significant predictor of improved SPM-OS and SPM-DFS.</p><p><strong>Conclusion: </strong>SPMs are a major cause of morbidity and mortality in HNSCC survivors. Timely detection allows for more cases to be treated with radical intent to offer chances for long term control and survival.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}