Chronic myeloid leukemia during pregnancy complicated by dengue infection and pulmonary embolism.

Abstract

Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the rearrangement of long arm of chromosomes 9 and 22, resulting in the Philadelphia chromosome, creating the fusion oncogene BCR-ABL1. Median age of onset of CML is 67 years. However, approximately a third of patients are of reproductive age at diagnosis. CML presenting during pregnancy is extremely rare, and there are no randomized controlled trials to address the optimal management of CML during pregnancy. We report a 38-year-old woman diagnosed with CML during her routine antenatal clinic booking visit, which was further complicated by dengue fever and pulmonary embolism during pregnancy. She was successfully managed by a multidisciplinary team, which resulted in the delivery of a healthy baby boy. This case adds to the literature on CML in pregnancy and reflects the importance of a multidisciplinary team approach when managing complicated patients who require timely rational interventions.