Indian Journal of Pathology and Microbiology最新文献_第8页

POEMS syndrome: A rare entity. POEMS综合征：一种罕见的疾病。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_857_21

Chaganti P Devi, Basimalla R Stephenson, P Ramana Kumari, Panchakarla G Vani, Swargam P Madhooli

引用次数: 0

Comparative evaluation of histopathological analysis, KOH wet mount and fungal culture to diagnose fungal infections in post-COVID patients. 组织病理学分析、KOH湿悬和真菌培养诊断新冠肺炎后患者真菌感染的比较评估。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_663_21

Seema N Baxi, Mayuri R Gohil, Anamika J Navadiya, Mayuri K Bapodra, Hiral R Patel

{"title":"Comparative evaluation of histopathological analysis, KOH wet mount and fungal culture to diagnose fungal infections in post-COVID patients.","authors":"Seema N Baxi, Mayuri R Gohil, Anamika J Navadiya, Mayuri K Bapodra, Hiral R Patel","doi":"10.4103/ijpm.ijpm_663_21","DOIUrl":"10.4103/ijpm.ijpm_663_21","url":null,"abstract":"Context and aim: There is increasing prevalence of post-COVID fungal infection of rhinoorbitocerebral region especially mucormycosis and aspergillosis in India.[1] Early diagnosis of these fungal infections are of utmost importance, since it may improve outcome and survival.[2],[3],[4],[5],[6],[7],[8] The objective of this study was to evaluate and compare routine laboratory diagnostic methods, that is, histopathological examination, KOH wet mount and fungal culture in the diagnosis of post-COVID fungal infections.Materials and methods: A total of 106 specimens of clinically suspected patients of post-COVID fungal infection of rhinoorbitocerebral region received in histopathology department were included in this study. The data of KOH wet mount and culture were acquired from the microbiology department after histopathological examination.Result: Approximately 88.68% of patients were diagnosed having fungal infections by one of the laboratory methods. The sensitivity of histopathological examination was highest (79.78%), followed by KOH wet mount (58.51%) and fungal culture (35.10%). Rhizopus species of zygomycetes group were the most common isolate (24.24%) on SDA culture. Overall 76% concordance was found between histopathological examination and fungal culture report for morphological identification of fungi.Conclusion: For the diagnosis of post-COVID fungal infection of Rhino-orbito-cerebral region, histopathological examination is was found to be more sensitive and rapid method to detect fungal hyphae. It leads to early treatment, prevents morbidity and mortality.","PeriodicalId":13488,"journal":{"name":"Indian Journal of Pathology and Microbiology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9975247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Teratoid Wilm's tumor with Cryptorchidism. Teratoid Wilm肿瘤伴隐睾。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_1084_21

Nishav Garg, Pavneet K Selhi, Ankita Soni

引用次数: 0

Expression of protein phosphatase 4 in different tissues under hypoxia. 缺氧条件下不同组织中蛋白磷酸酶4的表达。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_1179_21

Yanyan Ma, Jing Hou, Dengliang Huang, Yaogang Zhang, Zhe Liu, Meiyuan Tian

{"title":"Expression of protein phosphatase 4 in different tissues under hypoxia.","authors":"Yanyan Ma, Jing Hou, Dengliang Huang, Yaogang Zhang, Zhe Liu, Meiyuan Tian","doi":"10.4103/ijpm.ijpm_1179_21","DOIUrl":"10.4103/ijpm.ijpm_1179_21","url":null,"abstract":"Relevant research data shows that there is a certain degree of energy metabolism imbalance in highland residents. Protein phosphatase 4 (PP4) has been found as a new factor in the regulation of sugar and lipid metabolism. Here, we investigate the differential expression of PP4 at a simulated altitude of 4,500 m in the heart, lung, and brain tissues of rats. A hypoxic plateau rat model was established using an animal decompression chamber. A blood routine test was performed by an animal blood cell analyzer on rats cultured for different hypoxia periods at 4,500 m above sea level. Quantitative polymerase chain reaction (qPCR) and western blot were used to detect the changes of protein phosphatase 4 catalytic subunit (PP4C) gene and protein in heart, lung, and brain tissues. The PP4C gene with the highest expression level found in rats slowly entering the high altitude area (20 m-2200 m-7 d-4500 m-3 d) was about twice as high as the low elevation group (20 m above sea level). The simulated high-altitude hypoxia induced an increase of PP4C expression level in all tissues, and the expression in the lung tissue was twice as expressed as heart and brain tissue at high altitude (P < 0.05). These results suggest that the PP4 phosphatase complex is ubiquitously expressed in rat tissues and likely involved in adaptation to or disease associated with high-altitude hypoxia.","PeriodicalId":13488,"journal":{"name":"Indian Journal of Pathology and Microbiology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9975243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diagnostic utility of special stains in defining the spectrum of maxillofacial pathologies. 特殊污渍在确定颌面部病理谱中的诊断作用。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_1254_21

Akshay Gupta, Ankita Tandon, Saurabh Juneja, Nikita Gulati, Devi Charan Shetty

{"title":"Diagnostic utility of special stains in defining the spectrum of maxillofacial pathologies.","authors":"Akshay Gupta, Ankita Tandon, Saurabh Juneja, Nikita Gulati, Devi Charan Shetty","doi":"10.4103/ijpm.ijpm_1254_21","DOIUrl":"10.4103/ijpm.ijpm_1254_21","url":null,"abstract":"Background: The Fine needle aspiration cytology (FNAC) is considered as a valuable and distinguished diagnostic test in the initial assessment of the patients presenting with a mass in the head and neck region or when a recurrence is suspected after previous treatment.Aims: This study was therefore designed to elucidate the efficacy of FNAC as an alternate diagnostic tool to histopathology in head and neck swellings and evaluation of staining efficacy of PAP and MGG stain over Haematoxylin and eosin (H and E) in routine cytopathological smears.Settings and design: The study was conducted in the Department of Oral and Maxillofacial Pathology, where FNAC samples were collected from 150 patients with head and neck swellings.Materials and methods: All the slides were stained with H and E, Papanicolaou (PAP), and May Grunewald Giemsa (MGG) stains. The cytopathological diagnosis was compared with histopathological diagnosis based on H and E stained sections obtained from paraffin-embedded formalin-fixed biopsy specimen of benign and malignant neoplasms.Statistical analysis used: The resulting data were analyzed using SPSS software version 19. Differences between the variables were analyzed using Pearson Chi-square test and Kruskal-Wallis test wherever applicable.Results: The FNAC as a diagnostic tool has sensitivity of 84.8%, 72.72%, and 78.78%, specificity of 62.5%, 75%, and 75%, and accuracy of 80.48%, 73.14%, and 78.04% in H and E, MGG, and PAP stain, respectively. PAP stain was the most efficient stain when all qualitative parameters are taken into consideration with maximum sensitivity and specificity for achieving definitive cytodiagnosis.Conclusions: The FNAC is an inexpensive and minimally invasive technique to diagnose different types of head and neck swellings and complement histopathological diagnosis.","PeriodicalId":13488,"journal":{"name":"Indian Journal of Pathology and Microbiology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10296221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel case of left atrial and right lung mass turned out to be unconventional metastasis of uterine leiomyosarcoma with a review of literature. 一例新的左心房和右肺肿块是子宫平滑肌肉瘤的非常规转移，并文献复习。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_577_21

Tarang Patel, Priyanka Aswal, Ashish Jakhetiya, Virendrakumar Meena, Arun Pandey

引用次数: 0

Pediatric and adolescent chronic myeloid leukemia: A follow-up study in Western India. 儿童和青少年慢性粒细胞白血病：印度西部的一项随访研究。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_462_21

Sangita A Vanik, Dhaval Jetly, Biren Parikh, Karthik Dhandapani, Rukmini Bezbaruah

{"title":"Pediatric and adolescent chronic myeloid leukemia: A follow-up study in Western India.","authors":"Sangita A Vanik, Dhaval Jetly, Biren Parikh, Karthik Dhandapani, Rukmini Bezbaruah","doi":"10.4103/ijpm.ijpm_462_21","DOIUrl":"10.4103/ijpm.ijpm_462_21","url":null,"abstract":"Background: Chronic myeloid leukemia (CML) is relatively rare in pediatric and adolescent age groups. The purpose of this study was to evaluate the clinical, hematopathological, and biochemical parameters of CML in pediatric and adolescent age groups, along with an assessment of the treatment response with first-line tyrosine kinase inhibitors (TKI) and its correlation with the prognostic scoring systems of adults.Materials and methods: A retrospective study of 44 Breakpoint Cluster Region-Abelson leukemia virus (BCR-ABL1)-positive pediatric and adolescent CML cases registered at our hospital was done. The clinical and laboratory parameters were evaluated using hospital software. The treatment response was monitored and scoring was performed using mathematical calculations.Results: The mean age was 11.6 (±4.7) years. The median hemoglobin was 8.4 g/dL and 63.6% of the cases showed white blood cell (WBC) counts >250,000/μL. The average follow-up was 21 months. A total of 97.7 and 78.1% cases achieved complete hematological response (CHR) and molecular response, respectively, during the treatment course. The maximum number of patients had low Sokal and European treatment and Outcomes Study (EUTOS) scores. Seventy-five per cent of the cases achieved CHR at 3 months, while 73.6 and 78.6% CML-Chronic phase (CP) cases with low Sokal and EUTOS scores achieved CHR at 3 months, respectively.Conclusion: This study revealed that the CML cases in pediatric and adolescent age groups are normally present with higher WBC counts at the time of diagnosis. The association of the prognostic scoring system with treatment response was statistically insignificant. However, a larger cohort study is needed to determine the treatment response of TKI in children and adolescent CML and its correlation with the prognostic scoring systems.","PeriodicalId":13488,"journal":{"name":"Indian Journal of Pathology and Microbiology","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9921062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique coexistence of a plurihormonal pituitary adenoma with granulomatous hypophysitis. 多激素性垂体腺瘤与肉芽肿性垂体炎的独特共存。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_439_21

Sanjiban Patra, Priti Trivedi

引用次数: 0

Chrysosporium: A rare cause of allergic fungal rhinosinusitis. 金孢菌：一种罕见的过敏性真菌性鼻窦炎病因。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_555_21

Juhi Shrivastava, Kinal Shah, Navin Shah

引用次数: 0

Anaplastic (undifferentiated) carcinoma of pancreas, an uncommon variant: Diagnosed on endoscopic-guided fine needle aspiration. 胰腺无定形（未分化）癌，一种罕见的变体：经内镜引导细针抽吸诊断。

IF 1 4区医学

Indian Journal of Pathology and Microbiology Pub Date : 2023-07-01 DOI: 10.4103/ijpm.ijpm_538_21

Md Ali Osama, Pooja Bakshi, Kusum Verma

引用次数: 0