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2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)最新文献

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Modelling of therapeutic cold plasma generator using finite element method 治疗性冷等离子体发生器的有限元建模
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526045
Ivan Moštak, Domagoj Prebeg, M. Cifrek
{"title":"Modelling of therapeutic cold plasma generator using finite element method","authors":"Ivan Moštak, Domagoj Prebeg, M. Cifrek","doi":"10.23919/EMF-MED.2018.8526045","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526045","url":null,"abstract":"The cold plasma generator is a complex system in which many interrelated physical processes occur. The therapeutic device producing cold plasma is based on high-voltage high-frequency Tesla coil coupled with gas-filled glass plasma electrodes. The device is used for therapeutic purpose and thus highest level of safety is required. Simulations are a fast and efficient way to verify the measurements and to provide deeper insight into the problem. The aim of this study was to perform simulation and analysis of such system by finite element method using COMSOL Multiphysics. Key values of high importance were obtained and evaluated. 2-D axisymmetric and 3-D models of Tesla coil were made. Time dependent study was performed, values of magnetic and electric field were observed. Stationary analysis was performed for 3-D model, inductance and resistance of the coil were calculated.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131323592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of nerve cathodal block for the percutaneous auricular vagus nerve stimulation 经皮耳迷走神经刺激的神经阴极阻滞效果评价
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526068
A. Samoudi, Tom Van de Steene, E. Tanghe, L. Martens, W. Joseph
{"title":"Assessment of nerve cathodal block for the percutaneous auricular vagus nerve stimulation","authors":"A. Samoudi, Tom Van de Steene, E. Tanghe, L. Martens, W. Joseph","doi":"10.23919/EMF-MED.2018.8526068","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526068","url":null,"abstract":"Nerve cathodal block mechanism for the percutaneous auricular vagus nerve stimulation is investigated. The response of individual axons to stimulation will be assessed in terms of excitation, blocking and propagation of action potentials in order to optimize stimulation patterns. It was seen that the response obeyed the activating function remarkably well. The found sensitivity indices of the blocking threshold for variations in diameter and temperature (61 % and 15 % respectively) are significantly higher than for the excitation threshold. Finally, the threshold needed for cathodal block (around -5 V) is far from the amplitudes used to stimulate the nerves (around -1 V). More investigations by performing an uncertainty analysis varying axonal trajectories and electrode placement can lead to the conclusion that cathodal block is less likely to occur when stimulating with clinically used amplitudes in pVNS.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134524748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring of Microwave Ablation treatment with Electrical Impedance Tomography 电阻抗断层扫描监测微波消融治疗
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526043
Konstantinos Katrioplas, T. Samaras
{"title":"Monitoring of Microwave Ablation treatment with Electrical Impedance Tomography","authors":"Konstantinos Katrioplas, T. Samaras","doi":"10.23919/EMF-MED.2018.8526043","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526043","url":null,"abstract":"Microwave ablation (MWA) is an increasingly used thermal therapy to treat cancer, operating typically at frequencies around 2.45 GHz. Higher temperatures and treatment of larger volumes can be achieved compared to radiofrequency ablation, not to mention the absence of the heat-sink effect. However, a simple and inexpensive method to assess the treated area with MWA in real time has not been implemented, yet. In the present computational study we show that it is feasible to use electrical impedance tomography to evaluate the treatment volume, taking advantage of the changes in tissue conductivity with temperature.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124493753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Linear Regression for Estimating Bladder Volume with Voltage Signals 用电压信号估计膀胱体积的线性回归
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526019
Eoghan Dunne, A. Santorelli, Brian McGinley, M. O’halloran, E. Porter
{"title":"Linear Regression for Estimating Bladder Volume with Voltage Signals","authors":"Eoghan Dunne, A. Santorelli, Brian McGinley, M. O’halloran, E. Porter","doi":"10.23919/EMF-MED.2018.8526019","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526019","url":null,"abstract":"Urinary incontinence is a common condition that can severely impact the lives of those who have it. Bladder volume monitoring solutions that exploit the electrical differences of different tissues in the pelvis have the potential to help medical personnel in the decision-making process with urinary incontinence. In this work, we investigate linear regression as a means of assigning bladder volume to the measured voltage values. We found that linear regression outperforms the previously studied machine learning regression algorithms by nearly a factor of 4. This linear regression approach is also more effectively able to handle volumes outside the training boundaries in comparison to previous work in the field. More work is needed to further improve the estimate of bladder volume based on the voltage signals, especially at high noise levels.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"217 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126037943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cisplatin in-vitro activity with co-exposure to MRI 顺铂体外活性与共暴露于MRI
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526080
Pol-Edern Le Renard, B. Nimmervoll, F. Fellner, P. Oppelt
{"title":"Cisplatin in-vitro activity with co-exposure to MRI","authors":"Pol-Edern Le Renard, B. Nimmervoll, F. Fellner, P. Oppelt","doi":"10.23919/EMF-MED.2018.8526080","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526080","url":null,"abstract":"In the present work, we investigate the influence of concomitant exposure to a clinical magnetic resonance imaging (MRI) electromagnetic environment together with cisplatin (CDDP) on the in-vitro chemosensitivity of cell lines from the ovarian cancer panel (SW626, PA-1, Caov3, SK-OV-3). CDDP treatment concentration was close to half of the maximal inhibitory concentration (IC50). We used a MRI-compatible incubation set-up for applying electromagnetic exposures consisting in three different imaging sequences generated by a 3-T clinical instrument: a T2-weighted 2D turbo-spin echo (TSE), a 3D TSE, and, a gradient-recalled echo (GRE). We assessed cell viability at 68-h after the joint chemical and electromagnetic treatment. Overall, our results do not show significant impact of simultaneous MRI and CDDP exposure on the in-vitro activity in various ovarian cancer cell lines, suggesting that it is pharmacologically safe. Overall, the implemented set-up revealed high performances.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129285542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetotactic bacteria and biogenic magnetite nanocrystals as potential contrast agents in magnetic resonance imaging 趋磁细菌和生物源磁铁矿纳米晶体在磁共振成像中的潜在造影剂
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526044
I. Ardelean, S. Miclaus, I. Ardelean, C. Moisescu
{"title":"Magnetotactic bacteria and biogenic magnetite nanocrystals as potential contrast agents in magnetic resonance imaging","authors":"I. Ardelean, S. Miclaus, I. Ardelean, C. Moisescu","doi":"10.23919/EMF-MED.2018.8526044","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526044","url":null,"abstract":"In the present work we examine the efficiency of magnetotactic bacteria and biogenic magnetite nanocrystals as potential contrast agents in magnetic resonance imaging. The tests include transverse and longitudinal relaxation measurements on two suspensions of magnetic particles prepared with magnetotactic bacteria and magnetosomes at the same concentration. We observed a strong reduction of the transverse relaxation time by the presence of magnetic particles. On the other hand, only a small influence on the longitudinal time is detected.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124570964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Ex-vivo evaluation of magnetite magnetic nanoparticles as magnetic hyperthermia carriers 磁性纳米颗粒作为磁热疗载体的体外评价
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526067
N. Maniotis, E. Myrovali, Zoi Kalpaxidou, Charoula Iliaskou, M. Angelakeris, T. Samaras
{"title":"Ex-vivo evaluation of magnetite magnetic nanoparticles as magnetic hyperthermia carriers","authors":"N. Maniotis, E. Myrovali, Zoi Kalpaxidou, Charoula Iliaskou, M. Angelakeris, T. Samaras","doi":"10.23919/EMF-MED.2018.8526067","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526067","url":null,"abstract":"In this work, two types of magnetic nanoparticles samples were injected to bovine liver and their heating efficiency was studied. The first type consists of 10 nm superparamagnetic iron-oxide nanoparticles while the second one of 40 nm ferrimagnetic ones. Aqueous solutions of 5 mg/mL magnetic nanoparticles were injected to 1 mL of bovine liver and subjected to an alternating magnetic field of 30 mT/ 765 kHz to evaluate experimentally their heating efficiency. The theoretical simulation of the heating sequence was carried out by using the COMSOL software. With the implementation of adequate magnetic models, the magnetic field and temperature distributions in the liver tissue together with the magnetic hyperthermia curves were extracted and compared to the experimental ones, outlining the validity of the corresponding theoretical models.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124537567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Multiclass SVM for Bladder Volume Monitoring using Electrical Impedance Measurements 基于电阻抗测量的膀胱容积监测多类支持向量机
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526015
A. Santorelli, Eoghan Dunne, E. Porter, M. O’halloran
{"title":"Multiclass SVM for Bladder Volume Monitoring using Electrical Impedance Measurements","authors":"A. Santorelli, Eoghan Dunne, E. Porter, M. O’halloran","doi":"10.23919/EMF-MED.2018.8526015","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526015","url":null,"abstract":"Urinary incontinence is a common condition that impacts the quality of life from those who suffer from it. Electrical impedance measurements offer the potential for a non-invasive low-cost solution to monitor changes in the bladder volume. This work focuses on using a multiclass support vector machine (SVM) algorithm to classify the fullness of the bladder into three states; not full, full, and a boundary class. This paper applies this machine learning algorithm to both simulation and experimental data. The SVM model uses the recorded voltages from electrical impedance measurements as features, is trained and optimized using a Bayesian Optimization approach, and then 10-fold cross-tested to obtain a generalized error. This paper demonstrates that simulation data with a signal-to-noise ratio of 40 dB, and experimental data from a pelvis phantom, can be perfectly separated into the three classes defined above.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"218 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114215708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cell membrane permeabilization and cell survival after electroporation in acidic media in vitro 体外酸性介质电穿孔后细胞膜通透性和细胞存活率的研究
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526061
Tjaša Potočnik, D. Miklavčič, A. M. Lebar
{"title":"Cell membrane permeabilization and cell survival after electroporation in acidic media in vitro","authors":"Tjaša Potočnik, D. Miklavčič, A. M. Lebar","doi":"10.23919/EMF-MED.2018.8526061","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526061","url":null,"abstract":"Electroporation is a method in which electric field of sufficient amplitude and duration applied to cells causes transient permeabilization of the cell membrane. Due to possibility, that microenvironment in applications of electroporation in vivo is acid, we studied effects of acid electroporation and recovery media. We observed no difference in the permeabilization threshold of cells which were electroporated and allowed to recover in growth (pH 7.8) or acid (pH 6.5) media. In contrast, statistically significant difference was observed in survival of cells that were exposed to pulse amplitudes greater than permeabilization threshold. At equal voltages applied survival of cells was greater if acid electroporation and recovery media were used compared to survival after electroporation and recovery in growth media. Our results imply that there is difference in membrane repair effectiveness depending on extracellular pH.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115103606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells 分化与未分化髓母细胞瘤细胞的高频电泳特性研究
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) Pub Date : 2018-09-01 DOI: 10.23919/EMF-MED.2018.8526006
R. Manczak, S. Saada, M. Tanori, A. Casciati, C. Dalmay, B. Bessette, G. Bégaud, S. Battu, P. Blondy, M. Jauberteau, C. Kaynak, M. Kaynak, C. Palego, C. Merla, B. Tanno, M. Mancuso, F. Lalloué, A. Pothier
{"title":"High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells","authors":"R. Manczak, S. Saada, M. Tanori, A. Casciati, C. Dalmay, B. Bessette, G. Bégaud, S. Battu, P. Blondy, M. Jauberteau, C. Kaynak, M. Kaynak, C. Palego, C. Merla, B. Tanno, M. Mancuso, F. Lalloué, A. Pothier","doi":"10.23919/EMF-MED.2018.8526006","DOIUrl":"https://doi.org/10.23919/EMF-MED.2018.8526006","url":null,"abstract":"This paper introduces first results of characterization of medullobastoma cell lines using high frequency dielectrophoresis (HF-DEP) approach at frequencies ranging up to few hundreds of MHz. Such technique enables accessing intracellular dielectric property specificities on individual cells. Actually, the frequency dependent DEP behavior of several medullobastoma cells has been studied showing clear differences between cells from different types which correlate well the biological specificity established though cell phenotype characterization. These results should pave the way to novel and complementary cell discrimination approach based on a label free HF-DEP crossover frequency signature measurement.","PeriodicalId":134768,"journal":{"name":"2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125227524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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