Indian Journal of Psychological Medicine最新文献

{"title":"Prolonged Delirium During Alcohol Withdrawal: A Case of Delirium Tremens Lasting 25 Days and a Review of Related Reports.","authors":"Santhini Ajay, Anirudh Bakam, Hafeez Hameed, Sindhu Toomukuntla, Bhargav Ram A, Kalyani Surya Dhana Lakshmi S, Barikar C Malathesh, Mamidipalli Sai Spoorthy, Sai Krishna Tikka","doi":"10.1177/02537176251381552","DOIUrl":"10.1177/02537176251381552","url":null,"abstract":"","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251381552"},"PeriodicalIF":2.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Insights into Cannabis-induced Psychosis: Role of CNR1 Gene Mutation (rs1049353) and Implications- A Cross-sectional Study.","authors":"Sujata Sahoo, Sarada Prasanna Swain, Abhishek Samal, Mamta Jena, Pragyna Paramita Das","doi":"10.1177/02537176251377498","DOIUrl":"10.1177/02537176251377498","url":null,"abstract":"<p><strong>Background: </strong>Considering the effects of environmental factors and genetic predispositions on mental health outcomes, the current work concentrated on the cannabinoid receptor 1 (CNR1) gene single-nucleotide polymorphism (SNP) rs1049353 as one of the primary genetic markers for cannabis-induced psychosis (CIP). By analyzing this SNP, the study contributes to the corpus of information to identify genetic traits that ultimately predict the response of an evolving disease following exposure to a particular substance after gene and environmental interaction and risk of a particular disease.</p><p><strong>Methods: </strong>Grouped by CIP, cannabis use without psychosis, schizophrenia unlinked to cannabis use, and a healthy control group, a thorough investigation was conducted on a cohort of 120 patients at SCB Medical College, Cuttack. Standardized data collection within a cross-sectional study framework included socio-demographic profiles and genetic tests.</p><p><strong>Results: </strong>Demographic analysis showed no significant differences in education, marital status, religion, occupation, housing, and family type between the groups. Genetic analysis done by real-time polymerase chain reaction (RT-PCR) to detect the prevalence of the CNR1 gene polymorphism among CIP patients was found to be 27.3% (95% CI: 12.1%-42.5%) for the heterogeneous allele and 72.7 % (95% CI: 57.5%-87.9%) for the homogenous allele. CIP patients showed a significant rise in homogenous allele expression in comparison to schizophrenia cases (<i>p</i> value: <.01; chi-square test).</p><p><strong>Conclusions: </strong>The study found that a major contribution to the CIP risk in the CNR1 gene is an SNP, rs1049353. This result helps justify the need to include genetic elements in individual risk of developing a particular disease by linking gene and environmental interaction in cannabis related psychosis and accordingly the treatment plans and public health policy.</p>","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251377498"},"PeriodicalIF":2.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Cognitive, and Motivational Correlates of Short-term Outcomes in Alcohol Dependence: A Prospective Observational Study.","authors":"Sushmitha T Nachiyar, Balaji Bharadwaj, Sharmi Bascarane","doi":"10.1177/02537176251376994","DOIUrl":"10.1177/02537176251376994","url":null,"abstract":"<p><strong>Background: </strong>Alcohol dependence occurs in about 9% of men in India. It is a major contributor to premature death and disability. Several clinical factors may play a role in the short-term outcomes of alcohol dependence.</p><p><strong>Methods: </strong>A total of <i>N</i> = 122 male patients with alcohol dependence as per ICD-10 DCR criteria were recruited in this study. They were assessed on socio-demographic and clinical parameters such as severity of alcohol dependence (SADQ), motivation to quit alcohol (SOCRATES), and global cognition (MoCA) and frontal cognition (FAB). The patients were then followed up at 1- and 3-month time points using the timeline follow-back method of enquiry into their last 30 days of drinking.</p><p><strong>Results: </strong>The mean age of the patients was about 40.6 (SD = 7.6) years. The duration of alcohol use was 18.56 years (SD = 7.22), and the average use was 14.14 units (SD = 8.62) per day. They had moderately severe dependence with SADQ scores of 25.13 (SD = 12.01). Two-thirds (<i>n</i> = 82) (67.2%) had low MoCA scores, and nearly one-fourth (<i>n</i> = 27) (22.1%) scored low on FAB. About 30% of patients relapsed at 1 month, and 50% relapsed by the end of 3 months. Earlier age at dependence (<i>p</i> = .012) was associated with relapse at 1 month. At 3 months, patients who were married (<i>p</i> = .040), had previous abstinence attempts (<i>p</i> = .003), and had higher MoCA scores (>26) (<i>p</i> = .042) were more likely to remain abstinent.</p><p><strong>Conclusions: </strong>About 30% of patients with alcohol dependence relapse within 1 month, whereas 50% relapse by the end of 3 months. Early age at onset of dependence predicted relapse at 1 month, and married status, past abstinent attempts, and intact global cognition predicted abstinence at 3 months.</p>","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251376994"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated Right Dorsolateral Prefrontal Transcranial Magnetic Stimulation for Persistent Obsessive-compulsive Symptoms: A Case Series.","authors":"Jithin Thekkelkuthiyathottil Joseph, Ashok Jammigumpula, Abhiram N Purohith, Sonia Shenoy, Samir Kumar Praharaj","doi":"10.1177/02537176251372541","DOIUrl":"10.1177/02537176251372541","url":null,"abstract":"","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251372541"},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Changes of the Retina in Alcohol Use Disorder: A Systematic Review and Meta-analysis of Studies Using Optical Coherence Tomography.","authors":"Mamidipalli Sai Spoorthy, Barikar C Malathesh, Siddharam S Janti, Shushank Tej Tekupalli, Raj Kiran Donthu, Sindhu Toomukuntla, Sai Krishna Tikka","doi":"10.1177/02537176251377494","DOIUrl":"10.1177/02537176251377494","url":null,"abstract":"<p><strong>Purpose of the review: </strong>Chronic alcohol use is associated with various structural and functional changes in the brain. Retinal morphology assessed by optical coherence tomography (OCT) non-invasively detects alcohol related damage to the brain and can be a disease marker.</p><p><strong>Collection and analysis of data: </strong>A systematic review of studies comparing retinal morphology using OCT, between alcohol use disorder (AUD) patients and healthy controls (HC) from PubMed, Scopus and Embase databases was performed (on 15/April/2025). Random effects meta-analyses were conducted for the thickness of retinal parameters, at both disc and macula: Retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), ganglion cell-inner plexiform layer (GCIPL), choroid thickness (CT), macular thickness (MT) and macular volume (MV). The Newcastle-Ottawa Scale was used for risk of bias (RoB) assessment. Publication bias, sensitivity analysis and certainty of evidence (CoE) was assessed using Doi plots, the leave-one-out method and the GRADE approach, respectively.</p><p><strong>Results: </strong>Of the 2,416 records screened, eight studies (<i>n</i> = AUD = 6,276 eyes; HC = 2,695 eyes) were included in meta-analyses. They revealed significant thinning of the total (pooled SMD = -0.41; 95% CI = -0.68, -0.14; <i>I</i> ² = 75%; <i>k</i> = 6) and nasal (pooled SMD = -0.36; 95% CI = -0.58, -0.13; <i>I</i> ² = 56%; <i>k</i> = 6) peripapillary RNFL in AUD patients. Significantly lower average MT (pooled SMD = -0.62; 95% CI = -0.95, -0.29; <i>I</i> ² = 50%; <i>k</i> = 3) and macular GCIPL thickness (pooled SMD = -0.19; 95% CI = -0.33, -0.06; <i>I</i> ² = 67%; <i>k</i> = 3) were shown. CoE was 'moderate' for total peripapillary RNFL thinning, but was 'very low' for other outcomes, owing to heterogeneity and publication bias. RoB assessment showed one study with unsatisfactory quality.</p><p><strong>Conclusions: </strong>Evidence for thinning of retinal layers, especially the peripapillary RNFL, as AUD disease-markers is promising, but preliminary. Our results align with the hypothesis that chronic alcohol consumption induces neurodegenerative changes in the retina and, therefore, the brain.</p>","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251377494"},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"An Observational Case-control Study for BDNF Val66Met Polymorphism and Serum BDNF in Patients with Major Depressive Disorder (MDD)\".","authors":"Santhini Ajay, Sristi Lakshmi, Mamidipalli Sai Spoorthy","doi":"10.1177/02537176251375300","DOIUrl":"10.1177/02537176251375300","url":null,"abstract":"","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251375300"},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comments Received on our Published Article \"An Observational Case-control Study for BDNF Val66Met Polymorphism and Serum BDNF in Patients with Major Depressive Disorder (MDD)\".","authors":"Raja Babu Ramawat, Rizwana Quraishi, Raman Deep, Ram Kumar, Ashwani Kumar Mishra, Raka Jain","doi":"10.1177/02537176251375295","DOIUrl":"10.1177/02537176251375295","url":null,"abstract":"","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251375295"},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of SPRING, an Integrated Mother-Child Focused Psychosocial Home-visiting Intervention, on Postpartum Depression in Rural India: A Cluster Randomized Controlled Trial.","authors":"Divya Kumar, Shay Soremekun, Reetabrata Roy, Deepali Verma, Sunil Bhopal, Kamal Kant Sharma, Gauri Divan, Betty Rosamund Kirkwood, Bilal Iqbal Avan","doi":"10.1177/02537176251370961","DOIUrl":"10.1177/02537176251370961","url":null,"abstract":"<p><strong>Background: </strong>Post-partum depression (PPD) adversely affects maternal and child health, yet evidence for integrated mother-child interventions remains limited in low-resource settings. We evaluated the impact of SPRING (Sustainable Programme Incorporating Nutrition and Games), an integrated mother-child psychosocial home-visiting intervention, on PPD outcomes in rural India.</p><p><strong>Method: </strong>A cluster-randomized controlled trial evaluated the intervention's impact across 120 villages (24 clusters). Mother-infant dyads were identified through house-to-house surveillance, with PPD measured at 12 months post-partum using the Patient Health Questionnaire-9 (PHQ-9). While the intervention aimed to improve child growth and development by indirectly addressing maternal mental health, this article reports specifically on PPD outcomes.</p><p><strong>Results: </strong>Among 2007 mothers completing assessments, PPD prevalence was 13.1%, with no significant difference between arms (RR = 0.98, 95% CI: 0.69-1.39, <i>p</i> = .90). No effect of intervention was found on PPD (mean PHQ-9 score 1.8 [SD 2.68] in the intervention group and 1.9 [SD 2.79] in the control group; effect size -0.02; 95% CI: -0.11, 0.07; <i>p</i> = .68). Analyses were intention-to-treat.</p><p><strong>Conclusions: </strong>The lack of measurable impact in our study highlights two key considerations. First, integrated mother-child psychosocial interventions may require more targeted strategies to address depressive symptoms and reduce PPD. Second, implementation challenges, such as coverage and uptake, likely influence effectiveness. Notably, at least one in eight mothers in our study experienced PPD at 12 months post-partum, aligning with other Indian studies. This persistent burden, alongside unmet mental health needs, emphasizes the urgency for future integrated mother-child interventions to include PPD-specific components and critically monitor implementation, especially in rural settings.</p>","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251370961"},"PeriodicalIF":2.0,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Provision of Mental Health Care by the Community Health Officers (CHOs) Through Collaborative Video Consultations: A Descriptive Analysis.","authors":"Marita Kadicheeni Paul, Rahul Patley, Prakyath Ravindranath Hegde, Gajanan Ganapati Sabhahit, Narayana Manjunatha, Channaveerachari Naveen Kumar, Suresh Bada Math","doi":"10.1177/02537176251371784","DOIUrl":"10.1177/02537176251371784","url":null,"abstract":"<p><strong>Background: </strong>The mental health (MH) treatment gap in India is particularly pronounced in underserved and rural areas. Community Health Officers (CHOs) play a crucial role in addressing this gap at the primary care level. A pan India digitally driven MH capacity-building program was designed to integrate MH care into primary care settings by training CHOs and supporting them through Collaborative Video Consultations (CVCs). We aimed to examine the profile of MH cases through CVCs by CHOs trained under a pan-India, digitally enabled MH capacity-building program, and to describe the diagnostic patterns and types of handholding provided across three Indian states.</p><p><strong>Methods: </strong>This cross-sectional study analyzed 591 CVC records from CHOs of Karnataka, Maharashtra and Bihar from November 15, 2022 to July 31, 2024, who underwent a six-session online training program on MH care, followed by real-time video consultations with MH professionals for case discussions and patient management. Descriptive statistics and crosstabulations were used for data analysis.</p><p><strong>Results: </strong>Most CVCs were from adult patients aged 19-60 years (79.69%), with women more frequently identified with common mental disorders (CMD) (25.42%) and men more commonly having severe mental disorders (SMD) (12.20%) and substance use disorders (SUD) (16.61%). Among states, Bihar had the highest number of CVCs (38.92%). CHOs provided handholding through referrals, counseling, and follow-ups.</p><p><strong>Conclusions: </strong>The program demonstrated the effectiveness of CVCs in empowering CHOs to identify and manage MH conditions. The consultation-based collaborative model facilitated accurate diagnoses and timely interventions, bridging the MH treatment gap in rural and underserved regions. Continued investment in CHO training, digital infrastructure, and follow-up care is essential for sustaining the program's impact on primary MH care.</p>","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251371784"},"PeriodicalIF":2.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Comments on 'Specific Learning Disability: Ten Challenges and Ten Recommendations in Current Indian Context'.","authors":"Ashlyn Tom, Rajendra Kiragasur Madegowda, Narayana Manjunatha, Channaveerachari Naveen Kumar, Suresh Bada Math","doi":"10.1177/02537176251370649","DOIUrl":"10.1177/02537176251370649","url":null,"abstract":"","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":" ","pages":"02537176251370649"},"PeriodicalIF":2.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}