Indonesian Journal of Pharmaceutical and Clinical Research最新文献_第4页

Treatment Pattern of Patients with Narcotics and Psychotropic Abuse (Case Study at the Bandung Rehabilitation Clinic) 麻醉药品和精神药物滥用患者的治疗模式(以万隆康复诊所为例)

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-09-30 DOI: 10.31869/ijpr.v1i2.2898

Lively Sergeonery

{"title":"Treatment Pattern of Patients with Narcotics and Psychotropic Abuse (Case Study at the Bandung Rehabilitation Clinic)","authors":"Lively Sergeonery","doi":"10.31869/ijpr.v1i2.2898","DOIUrl":"https://doi.org/10.31869/ijpr.v1i2.2898","url":null,"abstract":"Narcotics, psychotropics, and addictive substances abuse can cause addiction, which is a chronic disorder characterized by compulsive drug seeking and use despite adverse consequences. This is a concurrent descriptive study carried out by evaluating medical records and MMAS-8 questionnaire for assessing patients’ adherence. In addition, therapeutic success and quality of life were also evaluated using WHOQOL-BREF questionnaire. The study took place in the period of September-November 2018 at Medika Antapani Clinic. Data collected from patients under drug maintenance was used to identify the types of drug mostly used by the patients and their treatment, assess the impact of the management, and identify factor influencing therapeutic success. The results showed that there were 40 drug abusers at Medika Antapani Clinic. The abused drugs were amphetamine (80%), cannabis (72%), heroin (35%), benzodiazepine (25%), and nitrazepam (20%). Therapeutic measures used to treat drug abuse were alprazolam in 38 patients (95%), clonazepam in 33 patients (82.5%), nitrazepam in 29 patients (72.5%), lorazepam in 22 patients (55%), and diazepam in 14 patients (35%). Drug rehabilitation patients had low adherence of only 50%. Measurement of quality of life revealed social relation as the dimension with the highest score of 69 + 20.44, with most patients categorized as having moderate quality of life. Therapy with benzodiazepine has potential to cause dependence so it must be practiced with caution.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86388930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of Fruit and Leave Juice of Belimbing Wuluh (Averrhoa bilimbi L.) against Dandruff-Causing Fungi 白桦果叶汁对头皮屑真菌的抑菌活性

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-09-30 DOI: 10.31869/ijpr.v1i2.2514

B. Setiawan

引用次数: 1

Beneficial Role of Mushroom in Recovering Complications of Hypercholesterolemia 蘑菇对高胆固醇血症并发症的有益作用

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-08-09 DOI: 10.32734/idjpcr.v4i2.6467

S. Kundu, M. A. H. N. A. Khan, S. Das

{"title":"Beneficial Role of Mushroom in Recovering Complications of Hypercholesterolemia","authors":"S. Kundu, M. A. H. N. A. Khan, S. Das","doi":"10.32734/idjpcr.v4i2.6467","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6467","url":null,"abstract":"Mushrooms are considered as a valuable source of important nutrients having hepatoprotective and anti-hyperlipidemic actions. Present experimental research was done to explore the beneficial role of mushroom on health in hypercholesterolemia. Total thirty Swiss albino mice were taken and randomly divided into three groups: control A, group B and group C. Each group consisted of ten mice. The control A group was fed with normal mice pellet and fresh water. Group B was fed with hypercholesterolemic diet and group C was supplied hypercholesterolemic diet with mushroom powder (500g/kg/mice body weight) for 60 days. After the experimental tenure, mice of each group were sacrificed ethically and the samples (liver and blood) were collected for gross, histological study and lipid profile analysis. Increased liver weight, pale and hemorrhagic liver in gross observation along with some histological changes including dilation and congestion of central and portal vein, fat accumulation in hepatocyte and marked lymphocytic infiltration were found in group B, while mushroom supplementation recovered this gross and histological changes and reduced liver weight in group C. Just mild congestion and dilation was in the portal vein of group C. In lipid profile analysis, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) level significantly reduced respectively by 10%, 38% and 17% in group C than group B. High density lipoprotein (HDL) level also significantly increased by 20% in group C compared to group B. Therefore, it can be concluded that mushrooms might have potentially beneficial actions in recovering of some complications in hypercholesterolemia.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90970228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation and Evaluation of Skin Anti-aging Nanocream Containing Canola (Brassica napus L.) Oil 含油菜抗衰老纳米乳霜的配方及评价石油

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-05-28 DOI: 10.32734/idjpcr.v4i1.5821

S. Sumaiyah, Meyliana

{"title":"Formulation and Evaluation of Skin Anti-aging Nanocream Containing Canola (Brassica napus L.) Oil","authors":"S. Sumaiyah, Meyliana","doi":"10.32734/idjpcr.v4i1.5821","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5821","url":null,"abstract":"Canola (Brassica napus L.) oil high in vitamin E is good for skin care. Vitamin E is an effective antioxidant that protects our skin from free radical damage and keeps the skin elasticity, evenness, reduces blemishes, acne scars, and slows down the skin’s aging. This study aimed to formulate canola oil nano cream and find out canola oil nano cream gives a higher anti-aging effect than canola oil cream. Nanocream as anti-aging formulated in four variations of canola oil concentration 2,5%, 5%, 7,5% and 10%. Nanocream was tested IC50, and observed the characteristics and stability. Then, continue to irritation test and anti-aging activity of nanocream compared with cream on the skin of volunteers. The result showed that nanocream of variation canola oil was in a different color and distinctive smell. The preparation was stable in 12 weeks room temperature storage, homogenous, and no phase separation. Particle size was 5882.17 nm, 348.47 nm, 321.16 nm, 318.16 nm initially and increased after 12 weeks. There was no irritation, and anti-aging activity was higher than cream. Canola oil can be formulated as nanocream, stable in 12 weeks storage, and nano cream has higher anti-aging activity than cream.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73202488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poguntano Herba Extract Immunostimulant Activities (Picriafel-terraeLour). in Immunosupression Rats Infected by Staphylococcus aureus Against Total Leukocytes and Differential Leukocytes 蒲草提取物免疫刺激活性(Picriafel-terraeLour)。金黄色葡萄球菌感染免疫抑制大鼠对总白细胞和分化白细胞的影响

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-05-28 DOI: 10.32734/idjpcr.v4i1.5378

Anggitha Ningtias, Rosidah, Yuandani

引用次数: 0

Rational Use of Medicine in the Treatment of Helminth Infection : A Mini Review 寄生虫感染治疗中的合理用药:综述

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-05-28 DOI: 10.32734/idjpcr.v4i1.5375

Reqgi First Trasia

引用次数: 1

The Effctiveness Of Angiotensin Receptor Neprilysin Inhibitor On Improving The Cardiac Remodelling Compared To Ace-Inhibitor On Patients With Chronic Heart Failure 血管紧张素受体奈普利素抑制剂与ace抑制剂对慢性心力衰竭患者改善心脏重构的疗效比较

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-04-30 DOI: 10.32734/idjpcr.v4i1.5352

Muhammad Sobri Maulana

{"title":"The Effctiveness Of Angiotensin Receptor Neprilysin Inhibitor On Improving The Cardiac Remodelling Compared To Ace-Inhibitor On Patients With Chronic Heart Failure","authors":"Muhammad Sobri Maulana","doi":"10.32734/idjpcr.v4i1.5352","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5352","url":null,"abstract":"Heart failure is one of the major cause of patient’s admittance to the hospital. Primary hypertension is one of the most universal comorbidities that precedes heart failure and is one of the more common risk factors held by the majority of the population. Right now, antihypertension that are generally used is from Angiotensin-Converting Enzyme Inhibitor (ACE-I) and Angiotensin Receptor Blocker (ARB). A new group of an antihypertensive agent called “Angiotensin Receptor Neprilysin Inhibitor (ARNI)” to further improve the patient condition. This study aims to evaluate the effectivity of ARNI against ACE-I regarding its cardiac reverse remodeling effect. Search strategy was done using electronic databases, which are Pubmed, Scopus, and Cochrane. Articles included are therapeutic study that is in line with the clinical question and fulfills the inclusion and exclusion criteria. Critical appraisal was done by assessing the article’s validity, importance, and applicability according to Oxford Center of Evidence-Based Medicine 2011 to two chosen articles. 2 articles are chosen and appraised. Both of the study are shown to be valid and shows that ARNI has a significantly better result on improving cardiac reverse remodeling via the left ventricle ejection fraction compared to ACE-I. However, the applicability of ARNI is still debatable in Indonesia as it was not covered by national insurance and there is no generic form. ARNI shows to be significantly better to reverse cardiac remodeling compared to ACE-I, but its applicability has to be improved to be implemented in Indonesia.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78319094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Antyhipercholesterolemic Effect of Allium cepa L. var cepa in Atherogenic Induced Rats 大蒜对动脉粥样硬化大鼠降高胆固醇作用的评价

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-04-30 DOI: 10.32734/idjpcr.v4i1.5381

Nurahmi Lumban Gaol, Yuandani, P. Sitorus

引用次数: 0

Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E 含有芦荟(L.)的生物纤维素面膜配方的抗痤疮活性棕。f)精华与维生素E结合

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-04-29 DOI: 10.32734/idjpcr.v4i1.5382

Raissa Fitri, Julia Reveny, U. Harahap, Hariyadi Dharmawan, Syahputra, N. Nasri

{"title":"Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E","authors":"Raissa Fitri, Julia Reveny, U. Harahap, Hariyadi Dharmawan, Syahputra, N. Nasri","doi":"10.32734/idjpcr.v4i1.5382","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5382","url":null,"abstract":"Abstract. Biocellulose mask sheet is a new found pharmaceutical cosmetic design that widely commercial. Mostly due to it’s biodegradable properties, provide an eco-friendly waste. Combination of Aloe vera essence (AE) and Vit E to provide and determine it’s respective anti-acne properties in biocellulose mask form. Formulation of biocellulose mask with the help of Acetobacter xylinum bacteria varied with different formulae: F1 (Vitamin E 1%), F2 (E 2.5 %), F3 (AE 5%), F4 (AE 2.5%+Vit E 1%) and F5 (AE 5%+Vit E 1%) followed antimicrobials test with common acne bacteria by diffusion disk against Propionibacterium acne (PAC) ATCC 6919 and Pseudomonas aeruginosa (PAA) ATCC 27853. Study revealed that each formulae design F1; F2; F3; F4; F5 tested against PAC diffusion disk resulted 7.86; 11.67; 10.13; 112.10; 10.33 mm respectively. As for PAA diffusion disk resulted 7.76; 11.63; 10.33; 11.67; 11.00 mm respectively. Biocellulose mask containing combination of AE 2.5% and Vit E (F4) would provide the best anti-acne activity amongst other formulae. \u0000 ","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87094885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Irritation Test and Effectiveness of The Clean Power Activated Charcoal Palm Shells (Elaeis guineensis Jacg) as Adsorbent Dirt on The Hair 清洁动力活性炭棕榈壳对头发上污垢的吸附试验及效果

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2021-03-18 DOI: 10.31869/IJPR.V1I1.2452

Uce Lastari, S. Syamsurizal, Faizar Farid

{"title":"Irritation Test and Effectiveness of The Clean Power Activated Charcoal Palm Shells (Elaeis guineensis Jacg) as Adsorbent Dirt on The Hair","authors":"Uce Lastari, S. Syamsurizal, Faizar Farid","doi":"10.31869/IJPR.V1I1.2452","DOIUrl":"https://doi.org/10.31869/IJPR.V1I1.2452","url":null,"abstract":"The dirty and itchy scalp is very annoying in appearance, which is the onset of dandruff. Dandruff is due to the accumulation of dead skin cells, dry and oily scalp as well as the presence of skin infections and fungi in the head. To avoid the onset of dirt or dandruff to hair, it is necessary to do cleaning regularly using cosmetics one of them is active charcoal-based shampoo palm kernel shells. The capability of palm kernel shells can absorb dirt twice from commercial active charcoal to cleanse the skin to the fullest. This research aims to effectively absorption of the dirt in Invitro on the active charcoal shampoo of palm shells with a concentration of 12%. Invitro tests the effectiveness of the impurities absorbent by using a turbidimetry tool with a Nephelometric Turbidity Unit value or frequency number. While the irritation test is done on 10 people panelists. Comparative control used commercial shampoo as a positive control and base shampoo as a negative control. The results showed that a 12% palm shell activated charcoal shampoo provided an NTU value of 11,400 while a commercial shampoo gave an NTU value of 786. No panelists have irritation on the scalp. From the obtained results can be concluded that the active oil palm Shell Shampoo has the absorbent power to the dirt from a commercial shampoo and safe to use.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90571601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2