Immunogenetics最新文献

Genetic and evolutionary characteristics of the major histocompatibility complex class II β-chain genes of a large colony of captive king penguins (Aptenodytes patagonicus). 大型圈养帝企鹅（Aptenodytes patagonicus）主要组织相容性复合体ⅱ类β-链基因的遗传和进化特征

IF 2.9 4区医学

Immunogenetics Pub Date : 2026-04-29 DOI: 10.1007/s00251-026-01398-y

Reona Dei, Yukie Miyazawa, Natsumi Ota, Hiroki Narashima, Eri Kikkawa, Shingo Suzuki, Atsuko Shigenari, Sayaka Ito, Tomi T Tsuda, Jerzy K Kulski, Takashi Shiina, Yuki F Kita

引用次数: 0

The digital keystone: how artificial intelligence is reshaping HLA research and clinical practice. 数字基石：人工智能如何重塑HLA研究和临床实践。

IF 2.9 4区医学

Immunogenetics Pub Date : 2026-04-27 DOI: 10.1007/s00251-026-01397-z

Gamze Sonmez, Yigit Yazarkan, Deniz Cagdas

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Evolution of CCR1 and CCR1L1 reveals complex duplication scenarios in Muroids and Ruminants. CCR1和CCR1L1的进化揭示了类人猿和反刍动物中复杂的复制场景。

IF 2.9 4区医学

Immunogenetics Pub Date : 2026-04-25 DOI: 10.1007/s00251-026-01399-x

João Pedro Marques, Ana Pinheiro, Pedro José Esteves

引用次数: 0

Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19. 在单细胞分辨率上解读免疫细胞功能的遗传控制：COVID-19疾病特异性Cis-eQTLs分析。

IF 2.9 4区医学

Immunogenetics Pub Date : 2026-03-31 DOI: 10.1007/s00251-026-01396-0

E I Romanova, D I Tychinin, A M Shaymardanov, V E Akimov, A V Korobeinikova, V V Shiryagin, N I Guskova, V A Astafieva, A S Shingaliev, O A Antonova, L A Golubnikova, S I Mitrofanov, K S Grammatikati, V S Yudin, S M Yudin, A V Makhotenko, A A Keskinov, S A Kraevoy, E A Snigir, P Yu Volchkov, D V Svetlichnyy, V I Skvortsova

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Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues. 在免疫和非免疫组织中切换类牛超长CDR H3扩增子与典型扩增子。

IF 2.9 4区医学

Immunogenetics Pub Date : 2026-02-23 DOI: 10.1007/s00251-026-01395-1

Karina L Hissen, Morgan Sheppard, Jeannine A Ott, Kerstin K Landrock, Casey Whitley, Nicholas Ebert, J M Cody Horton, Nicole A Glenn, Yoonsung Jung, Vaughn V Smider, Michael F Criscitiello

引用次数: 0

NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis. NKG2D基因变异与癌症易感性：将病例对照证据与荟萃分析相结合。

IF 2.9 4区医学

Immunogenetics Pub Date : 2026-01-06 DOI: 10.1007/s00251-025-01393-9

Nguyen Hoang Viet, Le Thanh Dong, Do Tung Dac, Hai Ha Long Le, Le Thi Phuong, Pham Phuong Thao, Hoang Thao Giang Nguyen, J Luis Espinoza

{"title":"NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis.","authors":"Nguyen Hoang Viet, Le Thanh Dong, Do Tung Dac, Hai Ha Long Le, Le Thi Phuong, Pham Phuong Thao, Hoang Thao Giang Nguyen, J Luis Espinoza","doi":"10.1007/s00251-025-01393-9","DOIUrl":"10.1007/s00251-025-01393-9","url":null,"abstract":"Lymphomas are biologically heterogeneous malignancies with multifactorial etiologies involving genetic, environmental, and immune dysregulation. The functional variant rs1049174 SNP in the KLRK1 gene (encoding NKG2D) regulates NKG2D expression and modulates NK cells immune surveillance pathways, which may influence lymphoma susceptibility. We investigated this association through a two-stage case-control study and meta-analysis. First, we analyzed 246 diffuse large B-cell lymphoma (DLBCL) patients and 599 healthy controls (exploratory cohort), followed by a confirmatory cohort of 234 non-Hodgkin lymphoma (NHL)/Hodgkin lymphoma (HL) patients. Genotype frequencies were assessed via chi-square tests, with odds ratios (ORs) calculated for risk associations. A systematic review and meta-analysis of 10 studies, including our cohorts (3,785 cases and 4,129 controls), testing rs1049174 and cancer risk was also conducted. In the exploratory cohort, the GG genotype showed no significant association with overall lymphoma risk (OR = 0.83; 95% CI: 0.61-1.13; *p* = 0.25). However, in NHL, the GG genotype was underrepresented (OR = 0.75; 95% CI: 0.57-0.99; *p* = 0.02). Pooled lymphoma analysis revealed a protective effect (OR = 0.78; 95% CI: 0.62-0.99; *p* = 0.03). Meta-analysis confirmed a significant protective role of the GG genotype against cancer (OR = 0.71; 95% CI: 0.63-0.79), despite heterogeneity and potential publication bias. Our findings suggest that the rs1049174 GG genotype is associated with reduced lymphoma susceptibility, particularly in NHL, underscoring the importance of immunogenetic variants in lymphomagenesis. Further functional and clinical studies are needed to elucidate the mechanistic basis of this association.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"78 1","pages":"2"},"PeriodicalIF":2.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease? 简单的鸡MHC能否为自身免疫和传染病的平衡提供洞见？

IF 2.9 4区医学

Immunogenetics Pub Date : 2025-12-29 DOI: 10.1007/s00251-025-01394-8

Enock M Mararo, Anastasia Goryanin, Jim Kaufman

{"title":"Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease?","authors":"Enock M Mararo, Anastasia Goryanin, Jim Kaufman","doi":"10.1007/s00251-025-01394-8","DOIUrl":"https://doi.org/10.1007/s00251-025-01394-8","url":null,"abstract":"The major histocompatibility complex (MHC) plays a central role in immune responses, with strong links to both infectious disease resistance and autoimmune conditions. In typical mammals, such as humans, the MHC is large and complex, comprising many genes and exhibiting weak associations with infectious diseases, but strong associations with autoimmunity. In contrast, the chicken MHC is small and simple, with only one dominantly-expressed class I and class II gene, and strong associations with resistance to infectious pathogens; however, its role in autoimmunity is less well understood. This raises a question: Does the simplicity of the chicken MHC reduce the risk of autoimmunity? In this speculative review, we explore the question by comparing chickens and typical mammals, and by considering the spectrum of MHC alleles from promiscuous generalists to fastidious specialists. We suggest that comparing the spectrum of alleles within a single species, such as chickens, may offer a way to test the link between MHC complexity and autoimmunity. Although much work remains, this approach could provide new insights into the balance between immune protection and self-tolerance.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"78 1","pages":"1"},"PeriodicalIF":2.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145849878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates. 对非人类灵长类动物抗体重链特征进行注释的必要性。

IF 2.9 4区医学

Immunogenetics Pub Date : 2025-12-15 DOI: 10.1007/s00251-025-01392-w

Aafke Aartse, Jacco G J Bakx, Daniella Mortier, Sam Hofman, Petra Mooij, Mathieu Claireaux, Dirk Eggink, Willy M Bogers, Edmond J Remarque, Martin M Corcoran, Gunilla B Karlsson Hedestam, Ronald E Bontrop, Marit J van Gils, Gerrit Koopman

{"title":"Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates.","authors":"Aafke Aartse, Jacco G J Bakx, Daniella Mortier, Sam Hofman, Petra Mooij, Mathieu Claireaux, Dirk Eggink, Willy M Bogers, Edmond J Remarque, Martin M Corcoran, Gunilla B Karlsson Hedestam, Ronald E Bontrop, Marit J van Gils, Gerrit Koopman","doi":"10.1007/s00251-025-01392-w","DOIUrl":"10.1007/s00251-025-01392-w","url":null,"abstract":"Non-human primates are important for preclinical vaccine evaluation. In depth characterization of the antibody response requires representative immunoglobulin (IG) germline gene databases for correct gene and allele assignments and assessment of affinity maturation of antigen-specific antibodies. Current IG-reference databases do not cover the genetic diversity observed in frequently used macaque species and it is unclear to what extent closely related animals express shared alleles at similar levels. Here, IG-germline alleles of sixteen cynomolgus macaques (CynoSet), some of which were related, were characterized and compared with previously described Mauritian and Indonesian origin cynomolgus macaque datasets. Although the CynoSet showed more overlap with the Mauritian origin dataset, compared to an Indonesian origin dataset, there were clear differences in allelic expression patterns, independent of family relationship. Calculation of somatic hypermutation levels in post-infection influenza hemagglutinin-specific B cells demonstrated the need for individualized IG-genotyping for accurate evaluation of the antigen-specific B cell response.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"77 1","pages":"35"},"PeriodicalIF":2.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of SAMD9 and SAMD9L genes in primates: a complex history of gene loss, gene duplication and pseudogenization. 灵长类动物SAMD9和SAMD9L基因的进化：基因丢失、基因复制和假原化的复杂历史

IF 2.9 4区医学

Immunogenetics Pub Date : 2025-12-08 DOI: 10.1007/s00251-025-01390-y

António Duarte, Ana Pinheiro, Pedro José Esteves

引用次数: 0

Compact genomic architecture of the axolotl MHC region: setting the record straight. 美西螈MHC区域的紧凑基因组结构：澄清事实。

IF 2.9 4区医学

Immunogenetics Pub Date : 2025-11-15 DOI: 10.1007/s00251-025-01391-x

Magdalena Migalska, Krzysztof Fluder, Katarzyna Dudek, Wiesław Babik

{"title":"Compact genomic architecture of the axolotl MHC region: setting the record straight.","authors":"Magdalena Migalska, Krzysztof Fluder, Katarzyna Dudek, Wiesław Babik","doi":"10.1007/s00251-025-01391-x","DOIUrl":"10.1007/s00251-025-01391-x","url":null,"abstract":"The Major Histocompatibility Complex (MHC) is a gene-dense genomic region essential to adaptive immunity, exhibiting both conserved features and lineage-specific rearrangements across jawed vertebrates. Amphibians, as basal tetrapods, offer critical insights into MHC evolution; however, research has largely focused on anurans (e.g., Xenopus), while urodeles remain understudied, primarily due to their exceptionally large genomes. With recent advances in sequencing technologies, chromosome-scale assemblies for urodeles are now becoming available, opening new opportunities to explore their MHC architecture. Yet, the MHC region remains notoriously challenging to annotate due to its complexity, high polymorphism, and dynamic evolutionary history. For instance, the initial annotation of the axolotl (Ambystoma mexicanum) MHC relied heavily on synteny with mammalian genomes, which led to an overestimation of its size and misinterpretation of its structure. These inaccuracies have fueled evolutionary debates regarding the ancestral genomic structure of the MHC. Here, we present a comprehensive re-annotation of the axolotl MHC, revealing a typical organization found in tetrapods other than eutherian mammals: core MHC region with several, expressed MHC class I genes, tightly linked to their antigen processing genes, and to single loci of MHC class II genes. Contrary to the previous report, class I and class II genes are not separated by class III genes, and the overall MHC region is relatively compact (by axolotl genome standards). These findings correct earlier misconceptions and emphasize the need for annotation strategies that reflect the complex and lineage-specific nature of genomic regions rich in immune genes.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"77 1","pages":"33"},"PeriodicalIF":2.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12619710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0