Immunogenetics最新文献_第10页

A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors. 斑马鱼中高度多样化的新型免疫球蛋白样转录本（NILT）基因表明，它们具有与哺乳动物受体关系复杂的多种功能。

IF 2.9 4区医学

Immunogenetics Pub Date : 2023-02-01 Epub Date: 2022-07-23 DOI: 10.1007/s00251-022-01270-9

Dustin J Wcisel, Alex Dornburg, Sean C McConnell, Kyle M Hernandez, Jorge Andrade, Jill L O de Jong, Gary W Litman, Jeffrey A Yoder

{"title":"A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors.","authors":"Dustin J Wcisel, Alex Dornburg, Sean C McConnell, Kyle M Hernandez, Jorge Andrade, Jill L O de Jong, Gary W Litman, Jeffrey A Yoder","doi":"10.1007/s00251-022-01270-9","DOIUrl":"10.1007/s00251-022-01270-9","url":null,"abstract":"Multiple novel immunoglobulin-like transcripts (NILTs) have been identified from salmon, trout, and carp. NILTs typically encode activating or inhibitory transmembrane receptors with extracellular immunoglobulin (Ig) domains. Although predicted to provide immune recognition in ray-finned fish, we currently lack a definitive framework of NILT diversity, thereby limiting our predictions for their evolutionary origin and function. In order to better understand the diversity of NILTs and their possible roles in immune function, we identified five NILT loci in the Atlantic salmon (Salmo salar) genome, defined 86 NILT Ig domains within a 3-Mbp region of zebrafish (Danio rerio) chromosome 1, and described 41 NILT Ig domains as part of an alternative haplotype for this same genomic region. We then identified transcripts encoded by 43 different NILT genes which reflect an unprecedented diversity of Ig domain sequences and combinations for a family of non-recombining receptors within a single species. Zebrafish NILTs include a sole putative activating receptor but extensive inhibitory and secreted forms as well as membrane-bound forms with no known signaling motifs. These results reveal a higher level of genetic complexity, interindividual variation, and sequence diversity for NILTs than previously described, suggesting that this gene family likely plays multiple roles in host immunity.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"75 1","pages":"53-69"},"PeriodicalIF":2.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10756952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual copy number variation and extensive diversity between major MHC-DAB1 allelic lineages in the European bitterling. 欧洲苦鱼主要MHC-DAB1等位基因谱系的个体拷贝数变异和广泛多样性。

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-10-01 Epub Date: 2022-01-11 DOI: 10.1007/s00251-021-01251-4

Lorenzo Talarico, Anna Bryjová, Dagmar Čížková, Karel Douda, Martin Reichard

{"title":"Individual copy number variation and extensive diversity between major MHC-DAB1 allelic lineages in the European bitterling.","authors":"Lorenzo Talarico, Anna Bryjová, Dagmar Čížková, Karel Douda, Martin Reichard","doi":"10.1007/s00251-021-01251-4","DOIUrl":"https://doi.org/10.1007/s00251-021-01251-4","url":null,"abstract":"Polymorphism of the major histocompatibility complex (MHC), DAB1 gene was characterized for the first time in the European bitterling (Rhodeus amarus), a freshwater fish employed in studies of host-parasite coevolution and mate choice, taking advantage of newly designed primers coupled with high-throughput amplicon sequencing. Across 221 genotyped individuals, we detected 1-4 variants per fish, with 28% individuals possessing 3-4 variants. We identified 36 DAB1 variants, and they showed high sequence diversity mostly located within predicted antigen-binding sites, and both global and codon-specific excess of non-synonymous mutations. Despite deep divergence between two major allelic lineages, functional diversity was surprisingly low (3 supertypes). Overall, these findings suggest the role of positive and balancing selection in promotion and long-time maintenance of DAB1 polymorphism. Further investigations will clarify the role of pathogen-mediated selection to drive the evolution of DAB1 variation.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"74 5","pages":"497-505"},"PeriodicalIF":3.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39686604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sex differences in immune gene expression in the brain of a small shorebird. 小滨鸟大脑中免疫基因表达的性别差异。

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-10-01 Epub Date: 2022-01-27 DOI: 10.1007/s00251-022-01253-w

José O Valdebenito, Kathryn H Maher, Gergely Zachár, Qin Huang, Zhengwang Zhang, Larry J Young, Tamás Székely, Pinjia Que, Yang Liu, Araxi O Urrutia

{"title":"Sex differences in immune gene expression in the brain of a small shorebird.","authors":"José O Valdebenito, Kathryn H Maher, Gergely Zachár, Qin Huang, Zhengwang Zhang, Larry J Young, Tamás Székely, Pinjia Que, Yang Liu, Araxi O Urrutia","doi":"10.1007/s00251-022-01253-w","DOIUrl":"https://doi.org/10.1007/s00251-022-01253-w","url":null,"abstract":"Males and females often exhibit differences in behaviour, life histories, and ecology, many of which are typically reflected in their brains. Neuronal protection and maintenance include complex processes led by the microglia, which also interacts with metabolites such as hormones or immune components. Despite increasing interest in sex-specific brain function in laboratory animals, the significance of sex-specific immune activation in the brain of wild animals along with the variables that could affect it is widely lacking. Here, we use the Kentish plover (Charadrius alexandrinus) to study sex differences in expression of immune genes in the brain of adult males and females, in two wild populations breeding in contrasting habitats: a coastal sea-level population and a high-altitude inland population in China. Our analysis yielded 379 genes associated with immune function. We show a significant male-biased immune gene upregulation. Immune gene expression in the brain did not differ in upregulation between the coastal and inland populations. We discuss the role of dosage compensation in our findings and their evolutionary significance mediated by sex-specific survival and neuronal deterioration. Similar expression profiles in the coastal and inland populations suggest comparable genetic control by the microglia and possible similarities in pathogen pressures between habitats. We call for further studies on gene expression of males and females in wild population to understand the implications of immune function for life-histories and demography in natural systems.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"74 5","pages":"487-496"},"PeriodicalIF":3.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39964069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity. 新冠肺炎：对公共卫生的影响以及对遗传易感性和严重程度的假设驱动调查。

IF 2.9 4区医学

Immunogenetics Pub Date : 2022-08-01 Epub Date: 2022-03-29 DOI: 10.1007/s00251-022-01261-w

Susana David, Guillermo Dorado, Elsa L Duarte, Stephanie David-Bosne, João Trigueiro-Louro, Helena Rebelo-de-Andrade

引用次数: 0

Masanori Kasahara: Long-standing Immunogenetics co-editor steps down. Masanori Kasahara：长期担任免疫遗传学联合编辑的人辞职

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-08-01 DOI: 10.1007/s00251-022-01265-6

Martin F Flajnik

引用次数: 0

Correction to: Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish 更正：暹罗斗鱼MHC II类基因的特异性拷贝数变异

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-06-06 DOI: 10.1007/s00251-022-01267-4

Anson Tsz Chun Wong, D. Lam, Emily Shui Kei Poon, D. Chan, S. Sin

引用次数: 0

Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish. 暹罗斗鱼MHCⅱ类基因的种内拷贝数变异。

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-06-01 DOI: 10.1007/s00251-022-01255-8

Anson Tsz Chun Wong, Derek Kong Lam, Emily Shui Kei Poon, David Tsz Chung Chan, Simon Yung Wa Sin

{"title":"Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish.","authors":"Anson Tsz Chun Wong, Derek Kong Lam, Emily Shui Kei Poon, David Tsz Chung Chan, Simon Yung Wa Sin","doi":"10.1007/s00251-022-01255-8","DOIUrl":"https://doi.org/10.1007/s00251-022-01255-8","url":null,"abstract":"Duplicates of genes for major histocompatibility complex (MHC) molecules can be subjected to selection independently and vary markedly in their evolutionary rates, sequence polymorphism, and functional roles. Therefore, without a thorough understanding of their copy number variation (CNV) in the genome, the MHC-dependent fitness consequences within a species could be misinterpreted. Studying the intra-specific CNV of this highly polymorphic gene, however, has long been hindered by the difficulties in assigning alleles to loci and the lack of high-quality genomic data. Here, using the high-quality genome of the Siamese fighting fish (Betta splendens), a model for mate choice studies, and the whole-genome sequencing (WGS) data of 17 Betta species, we achieved locus-specific amplification of their three classical MHC class II genes - DAB1, DAB2, and DAB3. By performing quantitative PCR and depth-of-coverage analysis using the WGS data, we revealed intra-specific CNV at the DAB3 locus. We identified individuals that had two allelic copies (i.e., heterozygous or homozygous) or one allele (i.e., hemizygous) and individuals without this gene. The CNV was due to the deletion of a 20-kb-long genomic region harboring both the DAA3 and DAB3 genes. We further showed that the three DAB genes were under different modes of selection, which also applies to their corresponding DAA genes that share similar pattern of polymorphism. Our study demonstrates a combined approach to study CNV within a species, which is crucial for the understanding of multigene family evolution and the fitness consequences of CNV.","PeriodicalId":13446,"journal":{"name":"Immunogenetics","volume":"74 3","pages":"327-346"},"PeriodicalIF":3.2,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

IgG subclasses in New World Monkeys: an issue for debate? 新世界猴的IgG亚类:一个争论的问题?

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-05-26 DOI: 10.1007/s00251-022-01266-5

Jehymin D Parra-Montaño, Kimberly C Mateus-Rincon, Juliana V Aranguren-Borrás, Mary Medrano-Robayo, Alejandro Figueredo-López, Laura M González-Amaya, Juan D Vega-Valderrama, Luisa F González-Bautista, Andrea L Becerra-Embus, Yury Aponte-Rubio, Heliairis Alfonso-González, Sindy P. Buitrago, Diego Garzón-Ospina

引用次数: 1

Natural LILRB1 D1-D2 variants show frequency differences in populations and bind to HLA class I with various avidities 天然LILRB1 D1-D2变体在人群中显示频率差异，并以不同的亲和力与HLA I类结合

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-05-13 DOI: 10.1007/s00251-022-01264-7

Fuguo Liu, A. Cocker, J. Pugh, Zakia Djaoud, P. Parham, L. Guethlein

引用次数: 1

Fever as an evolutionary agent to select immune complexes interfaces 发烧作为选择免疫复合物界面的进化因子

IF 3.2 4区医学

Immunogenetics Pub Date : 2022-05-11 DOI: 10.1007/s00251-022-01263-8

Vlad Tofan, A. Lenghel, M. M. de Camargo, R. Stan

引用次数: 5