Indian Journal of Gastroenterology最新文献

{"title":"Beyond bowel wall thickness: Is the international bowel ultrasound segmental activity score ready for prime time in Crohn's disease?","authors":"Partha Pal, Kayal Vizhi Nagarajan","doi":"10.1007/s12664-026-02077-2","DOIUrl":"https://doi.org/10.1007/s12664-026-02077-2","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative management of groove pancreatitis: Defining success while preserving diagnostic vigilance.","authors":"Merve Eren Durmuş, Gökhan Köker, Ayhan Hilmi Çekin","doi":"10.1007/s12664-026-02088-z","DOIUrl":"https://doi.org/10.1007/s12664-026-02088-z","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastic gum as an adjunct to bismuth quadruple therapy for Helicobacter pylori eradication.","authors":"Christos Zavos","doi":"10.1007/s12664-026-02092-3","DOIUrl":"https://doi.org/10.1007/s12664-026-02092-3","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel habits and functional bowel disorders in Sri Lankan adults: A cross-sectional study.","authors":"Piyumi Perera, Dileesha Wickramasinghe, Randeve Wannakuwatta, Dakshitha Praneeth Wickramasinghe","doi":"10.1007/s12664-026-02049-6","DOIUrl":"https://doi.org/10.1007/s12664-026-02049-6","url":null,"abstract":"<p><strong>Background: </strong>Definitions of normal bowel habits vary across populations and are influenced by diet, lifestyle and cultural factors. Sri Lanka lacks population-level data describing normative bowel habits and the prevalence of functional bowel disorders.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted among 501 Sri Lankan adults (aged 18-80 years) utilizing a hospital attendant-based sample with community representation. Data was collected using a structured interviewer-administered questionnaire incorporating the Bristol Stool Form Scale and ROME-IV diagnostic criteria.</p><p><strong>Results: </strong>The median bowel frequency was seven (IQR 7-14) bowel movements per week, with 56.7% reporting a bowel movement once daily and 25.3% twice daily. Most stools were Bristol type IV. Although 79.8% perceived their bowel habits as regular, 36.1% reported feeling constipated and 28.3% had sought medical attention. Only 12.5% fulfilled both ROME IV and self-reported constipation criteria, while 25.5% met ROME-IV criteria for functional constipation and 15.4% for IBS. There was no significant association between bowel frequency and the feeling of constipation, but straining, hard stools and incomplete evacuation were strongly associated with perceived constipation (p < 0.001). Hydration was a key associated factor: participants with adequate water intake (≥ 2.5 L/day) were more likely to report regular bowel habits (p < 0.001). Frequent use of water-assisted toileting practices was a notable cultural finding.</p><p><strong>Conclusions: </strong>Sri Lankan adults demonstrate bowel habit patterns similar to other Asian populations, but distinct from western norms. Cultural perceptions and hydration practices strongly influence bowel regularity. These findings underscore the importance of culturally adapted diagnostic frameworks when assessing bowel disorders in South Asian populations.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor necrosis factor-like cytokine 1 A antagonists for inflammatory bowel disease: A systematic review and meta-analysis.","authors":"Mukesh Sharma Paudel, Vishal Sharma, Kumud Bhattarai, Chhagan Lal Birda, Khushboo Goel, Ajay Yadav, Shivaom Chaurasia, Milan Shrestha, Mukesh Kumar Ranjan","doi":"10.1007/s12664-026-02078-1","DOIUrl":"https://doi.org/10.1007/s12664-026-02078-1","url":null,"abstract":"<p><p>BACKGROUND AND OBJECTIVES: The therapeutic paradigm in inflammatory bowel disease (IBD) is rapidly evolving. Tumor necrosis factor-like cytokine 1A (TL1A) antagonists are agents with potential to mitigate both inflammation and fibrosis. Available studies show early signals of efficacy of this novel therapeutic class. We summarize the available literature on the use anti-TL1A, through this systematic review and meta-analysis.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis to assess the outcome of TL1A antagonists in patients with ulcerative colitis and Crohn's disease. We searched PubMed, EMBASE, Scopus and CENTRAL electronic databases for eligible studies through October 10, 2025. All studies with TL1A antagonists reporting outcome in adult IBD patients were included. We assessed clinical response, clinical remission, endoscopic improvement and remission and Histologic Endoscopic Mucosal Improvement (HEMI). We also assessed the adverse events (AEs) with anti-TL1A use.</p><p><strong>Results: </strong>Of the 431 studies screened, 12 were included in the final analysis. The pooled clinical response rate was seen in 67% of patients with ulcerative colitis and 58% of patients with Crohn's disease, with an odds ratio (OR) of 4.07 (95% CI 1.55-10.70) and 2.96 (95% CI 1.36-6.42), respectively. Anti-TL1A appeared to achieve clinical remission with OR 3.75 (95% CI 2.04-6.89). The pooled proportion of UC patients with endoscopic improvement and remission were 41% (95% CI 0.36-0.46) and 13% (95% CI 0.10-0.17), respectively. Patients with UC on anti-TL1A had an odds of achieving HEMI of 5.51 (95% CI 1.86-16.34). The most common reported adverse events (AEs) were mild and included infections and infestations. AEs occurred in 48.3% patients with UC and 49.2% of patients with CD with serious AEs reported in 3.9% patients with UC and 4.6% patients with CD.</p><p><strong>Conclusions: </strong>Anti-TL1A agents appear to be a promising therapeutic option in patients with IBD. Overall, anti-TL1A demonstrated an acceptable short-term safety profile, although mild adverse events were reported in almost half of treated patients.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the use of biologic agents and their persistence rates in inflammatory bowel disease in India.","authors":"Sidharth Harindranath, Devendra Desai, Philip Abraham, Saee Patil, Vinita Patil, Tarun Gupta","doi":"10.1007/s12664-026-02048-7","DOIUrl":"https://doi.org/10.1007/s12664-026-02048-7","url":null,"abstract":"<p><strong>Background: </strong>Biologic agents revolutionized the treatment of inflammatory bowel disease (IBD), yet their usage rates in India have historically been among the lowest globally. This is primarily attributed to cost. Data is scarce regarding the proportion of Indian patients with IBD needing biologics, actually receiving them and the persistence with therapy.</p><p><strong>Aim: </strong>To evaluate the proportions of patients with IBD needing a biologic agent, receiving it, continuing or discontinuing it and reasons for these.</p><p><strong>Methods: </strong>This observational cohort study enrolled 697 patients with IBD from a single center: 297 patients in a prospective arm and 400 patients in a retrospective arm. Demographic data and data on the need for biologics, receipt of therapy, duration of use and specific reasons for discontinuation were recorded.</p><p><strong>Results: </strong>Biologics were indicated in 95 (31.9%) patients in the prospective arm and 16 (4%) in the retrospective arm. In the former, 80 (26.9%) patients received biologics whereas in the latter 13 (3.2%) received it. On follow-up, 51 (17.1%) in the prospective arm and 10 (2.5%) in the retrospective arm continued biologics for median duration of 13.5 (IQR 44) months and 18.5 (IQR 23) months, respectively. Major reasons for discontinuation in the prospective cohort included primary non-response and secondary loss of response (31%), whereas the retrospective arm was driven by non-affordability.</p><p><strong>Conclusion: </strong>About 16% (111/697) of our patients with IBD needed biologics; of these, 16% (18/111) did not receive it. About a third of patients discontinued it. Strategies must focus on cost reduction and optimizing the use of biologics.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is new in Rome V?: Redefining diagnostic criteria and clinical pathways in disorders of gut-brain interaction.","authors":"Manjeet Kumar Goyal, Omesh Goyal, Tanisha Sehgal, Ashita Rukmini Vuthaluru, Kartikay Goyal, Ajit Sood","doi":"10.1007/s12664-026-02044-x","DOIUrl":"https://doi.org/10.1007/s12664-026-02044-x","url":null,"abstract":"<p><p>The Rome-V criteria represent a major evolution in the conceptualization and clinical application of disorders of gut-brain interaction (DGBIs). Building upon the biologically grounded framework established in Rome IV, Rome V moves beyond rigid symptom-based definitions toward a multi-dimensional, clinically operational model that integrates symptom patterns, temporal characteristics, physiological testing and psycho-social context. A central advance is the transition from categorical classification to dimensional phenotyping, recognizing the continuum and overlap inherent to DGBIs. The recalibration of diagnostic thresholds, most notably the re-introduction of abdominal discomfort and the requirement for symptom intermittency in irritable bowel syndrome, restores diagnostic sensitivity while improving mechanistic specificity. Rome V further introduces Rome Clinical Criteria, addressing the substantial sub-diagnostic population and enabling earlier, context-driven diagnosis in routine practice. Across organ systems, diagnostic definitions are refined to align more closely with underlying pathophysiology and clinical decision-making. This is exemplified by the integration of physiological frameworks in esophageal disorders, temporal stratification in gastroduodenal syndromes, the redefinition of centrally mediated abdominal pain and the incorporation of motor-sensory phenotyping in anorectal disorders. In parallel, Rome V emphasizes harm reduction in biliary disorders and introduces greater continuity across pediatric and adult frameworks. Despite these advances, challenges remain, including the absence of validated biomarkers, variability in global applicability and the need for further validation of new constructs. Overall, Rome V represents a shift from static diagnostic criteria to dynamic clinical pathways, providing a robust platform for mechanism-informed and increasingly individualized care in DGBIs.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocytic gastritis presenting as varioliform lesions: Resolution following Helicobacter pylori eradication.","authors":"Kartik Balankhe, Akanksha Rastogi, Anugrah Dhooria, Samir Mohindra","doi":"10.1007/s12664-026-02057-6","DOIUrl":"https://doi.org/10.1007/s12664-026-02057-6","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Congress of Gastroenterology Abstracts (WCOG - 2026).","authors":"","doi":"10.1007/s12664-026-02070-9","DOIUrl":"10.1007/s12664-026-02070-9","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":"1-399"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging role of the PLiST model in acute-on-chronic liver failure.","authors":"Apirat Angsubhakorn, Sakkarin Chirapongsathorn","doi":"10.1007/s12664-026-02052-x","DOIUrl":"https://doi.org/10.1007/s12664-026-02052-x","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}