Indian Journal of Gastroenterology最新文献

{"title":"Start where risk is highest: FIT-first CRC detection with quality-anchored colonoscopy in India.","authors":"Marcin Juchimiuk, Kamil Safiejko, Lukasz Szarpak","doi":"10.1007/s12664-026-01993-7","DOIUrl":"https://doi.org/10.1007/s12664-026-01993-7","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastro-intestinal infections and stewardship practices-A call for action to practising GI professionals.","authors":"Prasan Kumar Panda, Ujjala Ghosal, Rohit Gupta","doi":"10.1007/s12664-026-01991-9","DOIUrl":"https://doi.org/10.1007/s12664-026-01991-9","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Clostridioides difficile superinfection a major causative factor for acute flares associated with moderate to severe ulcerative colitis in northern India?","authors":"Hitesh Panchal, Sukrit Sud, Rajesh Puri, Sonam Singla, Amarender S Puri","doi":"10.1007/s12664-026-01985-7","DOIUrl":"https://doi.org/10.1007/s12664-026-01985-7","url":null,"abstract":"<p><strong>Background: </strong>The natural history of ulcerative colitis is characterized by the occurrence of recurrent flares. Flares in ulcerative colitis may be attributed to the natural history of the disease or other extraneous factors. Two important causes for iatrogenic flares are Clostridioides difficile infection and cytomegalovirus (CMV) colitis. We evaluated the prevalence of Clostridioides difficile infection in patients with moderate to severe ulcerative colitis admitted to a tertiary care hospital.</p><p><strong>Methods: </strong>This prospective study carried out at a tertiary care center in India evaluated patients of ulcerative colitis who presented with an acute flare of the disease over a 13-month period from May 2023 to May 2024. An enquiry of antibiotic exposure in the preceding eight weeks prior to the current admission was obtained. Simultaneous testing of glutamate dehydrogenase (GDH) and Clostridioides difficile toxin assay was done in all patients within 24 hours of admission by the enzyme-linked immunosorbent assay (ELISA) technique.</p><p><strong>Results: </strong>Of the 140 patients with an acute flare associated with ulcerative colitis who were evaluated for Clostridioides difficile infection, four tested positive for both GDH and toxin A and/or B giving an overall prevalence of 2.9%. Two of these four (50%) patients had prior exposure to antibiotics at the time of admission. Each of the four patients with Clostridioides difficile infection had an uneventful recovery post treatment with oral vancomycin and metronidazole.</p><p><strong>Conclusion: </strong>Our data suggests that C. difficile is not a major causative factor for flares in patients with moderate to severe ulcerative colitis at a tertiary care hospital in northern India.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic stricture management in inflammatory bowel disease: Present and future.","authors":"Partha Pal, Harsimar Singh, Gursimran Singh Kochhar","doi":"10.1007/s12664-025-01950-w","DOIUrl":"https://doi.org/10.1007/s12664-025-01950-w","url":null,"abstract":"<p><p>Endoscopic stricture management has revolutionized the care of inflammatory bowel disease (IBD), particularly Crohn's disease (CD), offering minimally invasive options to delay or replace surgery. Endoscopic balloon dilation (EBD), endoscopic stricturotomy (ES) and self-expanding metal stents (SEMS) are the mainstays for fibrotic or mixed strictures. Hybrid techniques such as combining EBD/SEMS and ES or adjunctive use of novel drug-coated balloons are evolving approaches. However, recurrence remains a major challenge with EBD, with up to two-thirds of patients requiring re-intervention. ES has higher long-term efficacy than EBD. Fully covered and partially covered self-expanding metal stents (SEMS) may be useful in long and refractory strictures whereas lumen-apposing metal stents (LAMS) can be used in short and anastomotic strictures. This manuscript reviews the present modalities, their outcomes and promising future advancements in endoscopic stricture management in CD. Interventional IBD (IIBD) plays a key role in the multi-disciplinary management of complex IBD acting as a bridge between medical and surgical therapy for properly selected IBD patients.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cricopharyngeal POEM: A minimally invasive option for cricopharyngeal achalasia and bar.","authors":"Jahnvi Dhar, Zaheer Nabi, Rahul Thakur, Pankaj Gupta, Cherring Tandup, Satish Subbiah Nagaraj, Saroj Kant Sinha, Stefano Francesco Crinò, Jayanta Samanta","doi":"10.1007/s12664-026-01988-4","DOIUrl":"https://doi.org/10.1007/s12664-026-01988-4","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet in treatment of inflammatory bowel disease: A systematic review and meta-analysis.","authors":"Arjun Singh, Urvashi Rana, Sanjay Chandnani, Arshdeep Singh, Dawesh P Yadav, Himanshu Narang, Kiran Josy, Tarini Shankar Ghosh, Abhirup Chatterjee, Saurabh Kedia, Mathew Phillip, Ajit Sood, Vineet Ahuja, Vishal Sharma","doi":"10.1007/s12664-026-01966-w","DOIUrl":"https://doi.org/10.1007/s12664-026-01966-w","url":null,"abstract":"<p><strong>Background: </strong>The Mediterranean diet is a nutritional approach reported to be beneficial in various diseases. We performed a systematic review about its role in the treatment of inflammatory bowel disease (IBD).</p><p><strong>Methods: </strong>Electronic databases (PubMed, Embase and Scopus) were searched on 10th February 2025 to identify reports on the use of the Mediterranean diet in the treatment of IBD. We extracted data with respect to clinical response, remission and endoscopic and histological responses with the use of the Mediterranean diet in the treatment of IBD. Pooled clinical response rates and remission rates were calculated.</p><p><strong>Results: </strong>Eight studies were eventually included. Seven studies involving 223 participants provided information about the induction of remission. The pooled clinical remission rate with Mediterranean diet was 0.62 (95% CI = 0.39-0.80, I² = 78.6%). A sub-group analysis showed similar remission rates for Crohn's disease (CD) (RR = 0.67, 95% CI = 0.38; 0.87) and ulcerative colitis (0.56, 95% CI = 0.24-0.84), (p = 0.7531). Compared to control diets, Mediterranean diet showed no significant advantage in inducing remission (pooled OR = 0.98, 95% CI = 0.74-1.30, I² = 42.9%). No studies reported outcomes for endoscopic or histological responses.</p><p><strong>Conclusion: </strong>The Mediterranean diet in conjunction with standard medical therapy is associated with a clinical remission rate of approximately 62% in IBD, with comparable efficacy in CD and ulcerative colitis. The studies on Mediterranean diet are compromized by heterogenous study, definitions of disease activity and outcomes and concurrent use of medical therapies. Further high-quality randomized trials are needed to evaluate the impact of the Mediterranean diet on objective disease markers and long-term outcomes in IBD.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of albumin-bilirubin grade in patients with pancreatic cancer: A systematic review and meta-analysis.","authors":"Mahyaar Omouri-Kharashtomi, Mohammad Mohammadi, Iman Menbari Oskouie, Faraz Mahdizadeh, Amir Anushiravani","doi":"10.1007/s12664-025-01945-7","DOIUrl":"https://doi.org/10.1007/s12664-025-01945-7","url":null,"abstract":"<p><strong>Background: </strong>With a five-year survival rate near 10%, pancreatic cancer is among the cancers with poor survival. Understanding the prognostic factors provides clinical insights for better decision-making. This meta-analysis aims to assess the prognostic value of the albumin-bilirubin (ALBI) grade in patients with pancreatic cancer.</p><p><strong>Method: </strong>A comprehensive search using \"pancreatic cancer\" and \"ALBI grade\" as keywords was conducted on the PubMed, Web of Science, Embase and Scopus until August 14, 2025. Studies investigating the prognostic value of the ALBI grade in patients with pancreatic cancer were included. The prognostic value was assessed through the hazard ratio (HR) with a 95% confidence interval (95% CI). The meta-analysis was performed using R version 4.2.3.</p><p><strong>Results: </strong>The meta-analysis comprised six studies with 1665 patients for overall survival (OS) analysis and three studies with 936 patients for recurrence-free survival/disease-free survival (RFS/DFS). A higher ALBI grade was associated with decreased OS in patients with pancreatic cancer (HR = 2.14, 95% CI [1.53, 3.00]). A higher ALBI grade was associated with decreased RFS/DFS (HR = 2.39, 95% CI [1.02, 5.58]). A sub-group analysis based on ALBI grade revealed that no significant differences between different grading approaches (high vs. low, 2 vs. 1 and 3 vs. 1) were observed in predicting OS.</p><p><strong>Conclusion: </strong>A higher ALBI grade was significantly associated with decreased OS and RFS/DFS in patients with pancreatic cancer. The ALBI grade could be considered a reliable prognostic marker for clinical applications in patients with pancreatic cancer.</p>","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to correspondence on \"Non-selective beta blockers are well tolerated in pregnancy with portal hypertension\".","authors":"Vijay Alexander, Ashish Goel","doi":"10.1007/s12664-025-01960-8","DOIUrl":"https://doi.org/10.1007/s12664-025-01960-8","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta-blockers aren't the true \"blockers\" in pregnancy.","authors":"H S Yashavanth","doi":"10.1007/s12664-026-01981-x","DOIUrl":"https://doi.org/10.1007/s12664-026-01981-x","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological profile of diabetic versus non-diabetic patients with MASLD-related hepatocellular carcinoma.","authors":"Buddhima Erandi Premaratne, Suchintha Bandara Tillakaratne, Mahiman Bhagya Gunathilake, Anuradha Dassanayake, Madunil Niriella, Uditha Dassanayake, Chinthaka Appuhamy, Rohan Chaminda Siriwardana","doi":"10.1007/s12664-026-01978-6","DOIUrl":"https://doi.org/10.1007/s12664-026-01978-6","url":null,"abstract":"","PeriodicalId":13404,"journal":{"name":"Indian Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}