Indian heart journal最新文献

{"title":"Association of non-HDL cholesterol with plaque burden and composition of culprit lesion in acute coronary syndrome. An intravascular ultrasound-virtual histology study.","authors":"Sreenivas Reddy, Raghavendra Rao K, Jeet Ram Kashyap, Vikas Kadiyala, Suraj Kumar, Debabrata Dash, Lipi Uppal, Jaspreet Kaur, Manpreet Kaur, Hithesh Reddy, Imran Ibni Gani Rather, Samir Malhotra","doi":"10.1016/j.ihj.2024.10.004","DOIUrl":"10.1016/j.ihj.2024.10.004","url":null,"abstract":"<p><strong>Objective: </strong>Lipids play key role in coronary atherosclerosis. The role of non-high-density lipoprotein cholesterol (non-HDL-C) in atherosclerotic plaques using intravascular imaging remains unclear. This study aimed to assess its relationship with coronary plaque features using intravascular ultrasound (IVUS) in acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>A total of 601 patients divided into two groups: normal non-HDL-C≤130 mg/dl (n = 410) and high non-HDL cholesterol >130 mg/dl (n = 191). IVUS performed before coronary intervention.</p><p><strong>Results: </strong>Mean age 53.18 ± 12.29 years. No significant differences in hypertension, diabetes, and smoking between groups. Plaque burden was significantly higher among normal versus high non-HDL-C groups (79.59 ± 9.98 % vs. 81.61 ± 5.39 %; p = 0.001). At minimal luminal site, fibrofatty percentage was higher in normal non-HDL-C group (p = 0.027), while necrotic core greater in high non-HDL-C group (p = 0.033). Segmental analysis, necrotic core was significantly higher in percentage (p = 0.006) and volumes (p = 0.011) in normal versus high non-HDL-C groups. Total cholesterol (r = 0.099, p = 0.015), LDL-C (r = 0.081, p = 0.046), triglycerides (r = 0.083, p = 0.041),and non-HDL-C (r = 0.099, p = 0.015) positively correlated with plaque burden. Total cholesterol (r = 0.115, p = 0.005), LDL-C (r = 0.107, p = 0.009), and non-HDL-C (r = 0.105, p = 0.010) positively correlated with necrotic core volume. Linear regression analysis showed age and non-HDL-C as predictors of higher plaque burden. Multiple linear regression analysis; age, body mass index, and non-HDL-C were predictors of larger necrotic core volume.</p><p><strong>Conclusion: </strong>Non-HDL-C levels were positively associated with plaque burden, measure of extent of atherosclerosis. It is closely associated with and is a predictor of necrotic core volume; a marker of plaque vulnerability. This IVUS study demonstrates potential role of non-HDL-C in causation of plaque in ACS.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clopidogrel resistance and its effect on clinical outcomes in acute coronary syndrome","authors":"Heemanshu Lodhi ,&nbsp;Keshavamurthy Ganapathy Bhat ,&nbsp;Vivek Singh Guleria ,&nbsp;Ratheesh Kumar Janardhana Pillai ,&nbsp;Ribhu Goel ,&nbsp;Nitin Sharma ,&nbsp;Anuka Sharma ,&nbsp;Varun Sharma","doi":"10.1016/j.ihj.2024.07.003","DOIUrl":"10.1016/j.ihj.2024.07.003","url":null,"abstract":"<div><h3>Aim</h3><p>The genetic polymorphism of CYP2C19 influences clopidogrel metabolism and resistance. Aim was to assess the association between CYP2C19 loss of function variation, clopidogrel resistance based on platelet reactivity units and clinical outcomes.</p></div><div><h3>Methods</h3><p>A total of 668 patients of Acute Coronary Sundrome (ACS) who underwent Percutaneous Coronary Intervention (PCI) were subjected to genetic screening and 143 patients undrewent platelet function test to study the association between drug metabolization and its effects based on platelet reactivity unit values.</p></div><div><h3>Results</h3><p>Clopidogrel resistance with CYP2C 19 loss of function variation was noted in 54.64% of patients. Clinical outcomes, such as target vessel revascularization, target lesion revascularization, in-stent restenosis, and stent thrombosis, were also studied.</p></div><div><h3>Conclusion</h3><p>CYP2C19 loss of function variation is strongly associated with clopidogrel resistance and adverse clinical outcomes.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S001948322400155X/pdfft?md5=2de61b95e95ec8bc0b931d5592adf0a9&pid=1-s2.0-S001948322400155X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and outcomes of Australian and Indian ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI)","authors":"M.L. Savage ,&nbsp;K. Hay ,&nbsp;H. Sundar ,&nbsp;R. Maharajan ,&nbsp;D.J. Murdoch ,&nbsp;K. Latchumanadhas ,&nbsp;D.M. Ezhilan ,&nbsp;U. Kalaichelvan ,&nbsp;R. Denman ,&nbsp;I. Ranasinghe ,&nbsp;V. Subban ,&nbsp;D.L. Walters ,&nbsp;A. Mullasari ,&nbsp;O.C. Raffel","doi":"10.1016/j.ihj.2024.08.001","DOIUrl":"10.1016/j.ihj.2024.08.001","url":null,"abstract":"<div><h3>Introduction</h3><p>The incidence of STEMI and subsequent mortality has been reported to be higher in Indian populations compared to developed countries. However, there is limited data directly comparing contemporary primary percutaneous coronary intervention (pPCI) treatment strategies and clinical outcomes for STEMI patients between developed and developing countries.</p></div><div><h3>Materials and methods</h3><p>We compared population demographics, procedural characteristics, times to reperfusion and mortality in STEMI patients treated with pPCI between two tertiary referral centers in India and Australia respectively over a 3-year period (1st Jan 2017–31st Dec 2019).</p></div><div><h3>Results</h3><p>A total of 1293 STEMI presentations (896 Indian vs 397 Australian) were included. On average, Indian patients had lower median BMI than Australian patients (BMI 25.4 vs 27.8; p &lt; 0.001), were significantly younger (mean age 56.0 vs 63.2 years; p &lt; 0.001), more likely male (84 % vs 80 %; p = 0.046) and diabetic (48 % vs 18 %); p &lt; 0.001). Radial access (50 % vs 88 %; p &lt; 0.001) and TIMI III flow post PCI was also significantly lower (85 % vs 96 %; p &lt; 0.001) with median door-to-balloon time significantly shorter in the Indian cohort (20mins vs 43mins; p &lt; 0.001); however, median symptom to balloon time was significantly longer (245mins vs 160mins; p &lt; 0.001). No significant differences in 30-day mortality (4.0 % vs 2.8 % Australian; p = 0.209) or 1-year mortality (6.5 % vs 4.3 %; p = 0.120) were observed.</p></div><div><h3>Conclusion</h3><p>Significant differences in demographics and presentation characteristics exist between Indian and Australian STEMI patients treated with pPCI. Indian patients had significantly longer pre-hospital delays and lower achievement of TIMI III flow post PCI, yet shorter in-hospital time to treatment.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001640/pdfft?md5=9ef3411441635ad43ff583a4aad4167d&pid=1-s2.0-S0019483224001640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional and socio-demographic variation in laboratory-based predictions of 10-year cardiovascular disease risk among adults in north and south India","authors":"Richard S. Chaudhary ,&nbsp;Nikhil Srinivasapura Venkateshmurthy ,&nbsp;Manisha Dubey ,&nbsp;Prashant Jarhyan ,&nbsp;Dorairaj Prabhakaran ,&nbsp;Sailesh Mohan","doi":"10.1016/j.ihj.2024.07.004","DOIUrl":"10.1016/j.ihj.2024.07.004","url":null,"abstract":"<div><h3>Objective</h3><p>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in India. There is no laboratory-based CVD risk data among Indians from different regions and backgrounds. This study estimated laboratory-based 10-year CVD risk across different population sub-groups.</p></div><div><h3>Methods</h3><p>Data from UDAY derived from cross-sectional surveys of rural and urban populations of northern (Haryana) and southern (Andhra Pradesh) India were analysed. World Health Organization/International Society of Hypertension laboratory-based equations calculated 10-year CVD risk among participants without CVD history. Wilcoxon rank sum test analyzed average CVD risk across subgroups. Chi-square test compared population proportions in different CVD risk categories. Regression analysis assessed the association between CVD risk and participant characteristics.</p></div><div><h3>Results</h3><p>The mean (SD) age of the participants (<em>n</em> = 8448) was 53.2 (9.2) years. Males in Haryana had increased CVD risk compared to those in Andhra Pradesh (<em>p</em> &lt; 0.01). In both states, female gender was shown to have a protective effect on CVD risk (<em>p</em> &lt; 0.01). Age correlated with increased risk (<em>p</em> &lt; 0.01). Education level did not affect CVD risk however employment status may have. Hypertension, diabetes, hyperlipidemia, smoking, and insufficient exercise were associated with increased CVD risk (<em>p</em> &lt; 0.01). Residence (urban versus rural) and wealth index did not largely affect CVD risk.</p></div><div><h3>Conclusion</h3><p>Minor differences exist in the distribution of laboratory-based CVD risk across Indian population cohorts. CVD risk was similar in urban wealthy participants and rural poor and working-class communities in northern and southern India. Public health efforts need to target all major segments of the Indian population to curb the CVD epidemic.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001573/pdfft?md5=4f6931970b49d9ccbe649760326fb84c&pid=1-s2.0-S0019483224001573-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulant and antiplatelet treatment effects on the incidence of major cardiovascular events in patients with coronary artery ectasia: An updated systematic review","authors":"Afshin Amirpour ,&nbsp;Reihaneh Zavar ,&nbsp;Manizheh Danesh ,&nbsp;Seyedeh Mahnaz Mirbod ,&nbsp;Erfan Zaker ,&nbsp;Fatemeh Moslemi ,&nbsp;Zahra Amini ,&nbsp;Masoumeh Sadeghi","doi":"10.1016/j.ihj.2024.07.001","DOIUrl":"10.1016/j.ihj.2024.07.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Coronary artery ectasia (CAE), widenings in sections of the arteries, is a rare condition found in up to 3–5% of angiography cases. Sometimes recurrence of major adverse cardiac events (MACE) has been reported in the CAE subjects. The present systematic review aims to collect and summarize reports on whether the use of anticoagulants in addition to single antiplatelet/dual antiplatelet therapy (SAPT/DAPT) in CAE patients with significant occlusion/heavy thrombus is efficient and safe in decreasing the incidence/recurrence of MACE.</p></div><div><h3>Material and methods</h3><p>A systematically comprehensive search was performed covering PubMed, Scopus, ISI Web of Science, and Google Scholar databases.</p></div><div><h3>Results</h3><p>Twenty-five studies were found including 20 case reports, four case series, and one randomized clinical trial. Of 20 case reports 15 were male (75 %), and five were female (25 %). Of the four the case series, all showed positive outcomes after DAPT plus anticoagulant in more than 50 % of patients; two took only DAPT and 13 took anticoagulant ± DAPT, and five compared both. Cases received DAPT only experienced recurrences of MACE. The other cases were uneventful with less MACE and better outcomes after the use of anticoagulant ± DAPT. Results of these case-series included 457 CAE patients showed that more than 80 % of subjects were male, and in all studies tailored pharmacological interventions, including antiplatelet and anticoagulant (warfarin) therapies, resulted in less MACE and mortality.</p></div><div><h3>Conclusion</h3><p>It can be concluded that antiplatelet (SAPT/DAPT) must be applied in combination with anticoagulants to provide more efficient protection against MACE in CAE patients. However, further high-quality randomized clinical trials are needed to confirm the results.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001536/pdfft?md5=76f4c01b79a493adee92048162a28828&pid=1-s2.0-S0019483224001536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of corrected QT (QTc) interval of electrocardiogram calculated from various formulas","authors":"Himel Mondal ,&nbsp;Shaikat Mondal ,&nbsp;Bhagyajyoti Priyadarshini","doi":"10.1016/j.ihj.2024.07.006","DOIUrl":"10.1016/j.ihj.2024.07.006","url":null,"abstract":"<div><p>QT interval in an electrocardiogram (ECG) is interpreted after correction (QTc) by various formulas. This study aimed to compare the QTcs calculated by nine formulas. <strong>S</strong>inus rhythm ECG reports of 1140 anonymous subjects showed uncorrected QT interval of 388.49 ± 42.74 ms. The QTc calculated by Bazett (443.96 ± 57.58 ms), Fridericia (424.37 ± 50.1 ms), Dmitrienko (433.59 ± 53.37 ms), Framingham (422.59 ± 45.55 ms), Schlamowitz (433.89 ± 48.05 ms), Hodges (421.6 ± 46.4 ms), Ashman (434.33 ± 54.05 ms), Rautaharju (427.75 ± 47.4 ms), and Sarma (429.22 ± 48.67 ms) showed a significant difference <em>F</em> (8, 10251) = 22.78 <em>p</em> &lt; 0.0001. Hence, ECG should contain the formula for proper reporting and ease of interpretation by clinicians.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001597/pdfft?md5=4debe7eaf85c320fb27a4b45c6904970&pid=1-s2.0-S0019483224001597-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis value of heart rate variability measured by Camera HRV application in patients after acute myocardial infarction","authors":"Tien Anh Hoang ,&nbsp;Nhat Long Tran ,&nbsp;Nguyen Trung Nguyen ,&nbsp;Linh Thi Huyen Hoang ,&nbsp;Ngoc Thi Minh Vo ,&nbsp;Vu Xuan Nguyen","doi":"10.1016/j.ihj.2024.07.008","DOIUrl":"10.1016/j.ihj.2024.07.008","url":null,"abstract":"<div><p>A prospective cohort study was conducted to assess the prognostic significance of heart rate variability (HRV) measured by the HRV Camera application in predicting major adverse cardiovascular events (MACE) and all-cause mortality within 3 months after percutaneous coronary intervention (PCI). Of 101 patients, 25 developed MACE and 6 died. Low HRV (SDNN and rMSSD) is associated with increased MACE (<em>p</em> &lt; 0.001 and <em>p</em> = 0.014, respectively) and all-cause mortality rates (<em>p</em> = 0.025 and <em>p</em> = 0.032, respectively). Our study concludes that HRV measured by smartphone applications has significant potential as predictive indicators of MACE and all-cause mortality after PCI, particularly SDNN.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001561/pdfft?md5=8e2802d350597269273f47583de799d0&pid=1-s2.0-S0019483224001561-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic utility of B-type natriuretic peptide and 6-min walk test in patients with acute decompensated heart failure","authors":"Deepak Verma,&nbsp;Ranjit Kumar Nath,&nbsp;Neeraj Pandit,&nbsp;Parag Rahatekar,&nbsp;Deepankar Vatsa,&nbsp;Mohit Bhutani","doi":"10.1016/j.ihj.2024.07.011","DOIUrl":"10.1016/j.ihj.2024.07.011","url":null,"abstract":"<div><h3>Background</h3><p>We aimed to assess the utility of B-type natriuretic peptide (BNP) and 6-min walk test (6 MWT) together as predictors of re-hospitalization and mortality in acute decompensated heart failure (ADHF) patients.</p></div><div><h3>Methods</h3><p>This prospective, observational, comparative study was conducted at a tertiary care center in India between October 2016 and March 2018. Patients (aged≥18 years) with ADHF and left ventricular systolic dysfunction were included in this study. The study group (N = 100 patients) consisted of patients undergoing a second BNP test along with the 6 MWT at the time of discharge and at 3-months of discharge. The control group (N = 100 patients) consisted of patients who did not undergo these tests at discharge and/or at 3-months of discharge. Study endpoints were re-hospitalization within 6-months, and in-patient and 6-month mortality.</p></div><div><h3>Results</h3><p>Total 200 patients diagnosed with ADHF were enrolled. Mean age was 53.46 ± 10.12 years in the study group and 52.98 ± 9.88 years in the control group. ROC analysis of BNP level to predict re-hospitalization revealed AUC of 0.935 (<em>p</em> &lt; 0.001) at admission, 0.915 (<em>p</em> &lt; 0.001) at discharge, and 0.783 (<em>p</em> &lt; 0.001) at 3-months. Similarly, at discharge, ROC analysis of 6 MWT to predict death gave AUC of 0.670 (<em>p</em> = 0.011), and at 3-months, it was 0.838 (<em>p</em> &lt; 0.001). ROC analysis of BNP level to predict mortality showed AUC of 0.960 (<em>p</em> &lt; 0.001) at admission, 0.947 (<em>p</em> &lt; 0.001) after discharge, and 0.960 (<em>p</em> = 0.002) at 3-months.</p></div><div><h3>Conclusion</h3><p>BNP levels and 6 MWT have good prognostic utility in ADHF patients, and thus may be beneficial in making therapeutic adjustments and taking precautionary measures in these patients.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001639/pdfft?md5=ecd62749d84e0cc99d4b3677d073e3c6&pid=1-s2.0-S0019483224001639-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of comprehensive genetic testing in patients presenting to a multidisciplinary inherited heart disease clinic in India","authors":"Priya Chockalingam ,&nbsp;Thenral S. Geetha ,&nbsp;Sandhya Nair ,&nbsp;Nivedita Rajakumar ,&nbsp;Deep Chandh Raja ,&nbsp;Yash Lokhandwala ,&nbsp;Vivek Chaturvedi ,&nbsp;Raja J. Selvaraj ,&nbsp;Sakthivel Ramasamy ,&nbsp;Sheetal Sharda ,&nbsp;C. Sundar ,&nbsp;R. Anantharaman","doi":"10.1016/j.ihj.2024.07.002","DOIUrl":"10.1016/j.ihj.2024.07.002","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to analyze the results of comprehensive genetic testing in patients presenting to a dedicated multidisciplinary inherited heart disease clinic in India.</p></div><div><h3>Methods</h3><p>All patients presenting to our clinic from August 2017 to October 2023 with a suspected inherited heart disease and consenting for genetic testing were included. The probands were grouped into familial cardiomyopathies namely hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic cardiomyopathy (ACM) and peripartum cardiomyopathy (PPCM), channelopathies namely congenital long QT syndrome (LQTS) and Brugada syndrome (BrS), and heritable connective tissue disorder namely Marfan Syndrome (MFS). Next generation sequencing (NGS) was used, and pre-test and post-test counseling were provided to probands and cascade screening offered to relatives.</p></div><div><h3>Results</h3><p>Mean age of the subjects (<em>n</em> = 77; 48 probands, 29 relatives) was 43 ± 18 years, 68 % male and 44 % symptomatic, with 36 HCM, 3 DCM, 3 ACM, 1 PPCM, 3 LQTS, 1 BrS and 1 MFS probands. The diagnostic yield of NGS-based genetic testing was 31 %; variants of uncertain significance (VUS) were identified in 54 %; and 15 % were genotype-negative. Twenty-nine relatives from 18 families with HCM (<em>n</em> = 12), DCM (<em>n</em> = 3), ACM (<em>n</em> = 2) and MFS (<em>n</em> = 1) underwent genetic testing. The genotype positive probands/relatives and VUS carriers with strong disease phenotype and/or high risk variant were advised periodic follow-up; the remaining probands/relatives were discharged from further clinical surveillance.</p></div><div><h3>Conclusions</h3><p>Genetic testing guides treatment and follow-up of patients with inherited heart diseases and should be carried out in dedicated multidisciplinary clinics with expertise for counseling and cascade screening of family members.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001548/pdfft?md5=11e794e8cd10032527a1969a80c4ca28&pid=1-s2.0-S0019483224001548-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus endocarditis","authors":"Kirun Gopal ,&nbsp;Praveena Nediyara Bhaskaran ,&nbsp;Merlin Moni ,&nbsp;Nandita Shashindran","doi":"10.1016/j.ihj.2024.08.003","DOIUrl":"10.1016/j.ihj.2024.08.003","url":null,"abstract":"<div><p>Aspergillus endocarditis is a rare cause of fungal endocarditis caused by the hyaline mold <em>Aspergillus</em>. The disease most commonly occurs in persons who are immunosuppressed and has a high mortality. Clinical presentation is often with long standing fever, embolic manifestations, and often heart murmurs. Diagnosis of aspergillus endocarditis is often delayed due to the low propensity for <em>Aspergillus</em> to grow in blood culture. Aspergillus endocarditis is characterized by large vegetations and also by frequently being found on the walls of the heart and not on the valves and hence can be missed if not carefully looked for. Definitive diagnosis is often by a combination of microbiological culture and histopathological examination of obtained tissue. Ancillary serological tests like galactomannan assay and polymerase chain reaction also help in the diagnosis. Treatment of aspergillus endocarditis virtually always requires a combination of prolonged antifungal therapy and surgery to enable a cure for these patients.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224001664/pdfft?md5=c228d12ab8f67a0394fde7fb1c59a75f&pid=1-s2.0-S0019483224001664-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}