Indian heart journal最新文献_第2页

Letter to the Editor on "Evolving spectrum and outcomes of infective endocarditis in North India: A comparative analysis between people who inject drugs and those who do not". 致编辑关于“印度北部感染性心内膜炎的演变谱和结果：注射吸毒者和不注射吸毒者之间的比较分析”的信。

IF 2

Indian heart journal Pub Date : 2026-09-02 DOI: 10.1016/j.ihj.2026.08.010

Deepak Kumar, Surender Deora

引用次数: 0

Atrial functional mitral regurgitation- A review with emphasis on therapeutic strategies. 心房功能性二尖瓣反流-回顾与治疗策略的重点。

IF 2

Indian heart journal Pub Date : 2026-08-29 DOI: 10.1016/j.ihj.2026.08.005

Sant Kumar, Travis Warner, Ashish Pershad

{"title":"Atrial functional mitral regurgitation- A review with emphasis on therapeutic strategies.","authors":"Sant Kumar, Travis Warner, Ashish Pershad","doi":"10.1016/j.ihj.2026.08.005","DOIUrl":"10.1016/j.ihj.2026.08.005","url":null,"abstract":"Atrial functional mitral regurgitation (AFMR) may account for a substantial proportion of functional MR, although its prevalence varies by population and diagnostic definition. AFMR increases mortality risk regardless of left ventricular (LV) function. The mechanism involves mitral annular dilation and \"atriogenic leaflet tethering.\" Key echocardiographic features include preserved left ventricular ejection fraction (LVEF; typically >50%), significant left atrial (LA) enlargement, mitral annular dilation, and minimal leaflet tethering. Medical therapy, including renin-angiotensin system inhibition/angiotensin receptor-neprilysin inhibition (ARNI) and sodium-glucose co-transporter 2 (SGLT2) inhibitors, may favorably influence LA remodeling and AFMR severity, although AFMR-specific evidence remains limited. In patients with concomitant atrial fibrillation/flutter, restoration of sinus rhythm with cardioversion or catheter ablation may improve LA function and reduce AFMR severity. Surgical mitral annuloplasty is an also an option for low-risk patients with concomitant procedures. Mitral transcatheter edge-to-edge repair (M-TEER) in AFMR has had outcomes comparable to ventricular functional MR (VFMR). Maintaining a low post-procedural mean pressure gradient (MPG < 5 mmHg) is crucial. Preliminary experience with transcatheter indirect mitral valve annuloplasty (Carillon device) has also shown feasibility. Mitral replacement platforms face challenges due to high risk of LV outflow tract obstruction and atrial migration.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bo-yang Y-incision aortic root enlargement in Indian patients undergoing surgical aortic valve replacement: A prospective single-centre feasibility series of 33 patients. Bo-Yang y切口主动脉根扩大在印度接受主动脉瓣置换术患者中的应用：一项33例患者的前瞻性单中心可行性研究。

IF 2

Indian heart journal Pub Date : 2026-08-28 DOI: 10.1016/j.ihj.2026.08.007

Ramakanta Panda, Rishabh Kapoor, Pradyot Rath, Santosh Dora, Manoj Chauhan, Rajkumar

{"title":"Bo-yang Y-incision aortic root enlargement in Indian patients undergoing surgical aortic valve replacement: A prospective single-centre feasibility series of 33 patients.","authors":"Ramakanta Panda, Rishabh Kapoor, Pradyot Rath, Santosh Dora, Manoj Chauhan, Rajkumar","doi":"10.1016/j.ihj.2026.08.007","DOIUrl":"10.1016/j.ihj.2026.08.007","url":null,"abstract":"Objective: Lower body surface area predisposes Indian patients to small aortic annuli and prosthesis-patient mismatch (PPM) after surgical aortic valve replacement, increasing late mortality. The Bo-Yang (Y-incision) technique enlarges the posterior aortic root through the aortomitral curtain and fibrous trigones, sparing the anterior mitral leaflet and conduction system, but Indian data are lacking.Methods: We prospectively enrolled 33 consecutive adults with severe aortic stenosis and small annuli (≤22 mm) undergoing SAVR with BYARE at a single Mumbai centre (2024-2026). Primary endpoints were 30-day mortality and predicted risk of PPM (predicted iEOA <0.85 cm2/m2, not measured postoperatively); secondary endpoints were annular upsizing, early extubation, and complications.Results: Patients (17 men, 16 women; mean age 53.9 ± 12.9 years; mean BSA 1.77 ± 0.19 m2) were all NYHA class ≥ III, with 7 (21.2%) redo sternotomies. Mean annular diameter was 19.7 ± 1.8 mm and prosthesis size 23.8 ± 1.9 mm (upsizing 4.1 mm). Early extubation (<6 h) occurred in 90.9% of patients, with no 30-day mortality, no paravalvular leak, and no patient predicted to be at risk of clinically significant PPM (mean predicted iEOA 1.01 ± 0.17 cm2/m2).Conclusions: BYARE is technically feasible and associated with favourable early outcomes in a heterogeneous Indian cohort, facilitating annular upsizing and minimising predicted PPM risk. PPM was estimated, not measured, and longer-term multicentre evaluation is needed to confirm durability.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal stent length change after intravascular ultrasound-guided percutaneous coronary intervention with contemporary drug-eluting stents: A prospective single-centre study. 超声引导下经皮冠状动脉介入治疗后支架纵向长度的变化：一项前瞻性单中心研究。

IF 2

Indian heart journal Pub Date : 2026-08-27 DOI: 10.1016/j.ihj.2026.08.006

Qayoom Yousuf, Imran Hafeez, Aamir Rashid, Jan Mohammad Sheikh, Iqbal Mohammad Dar, Syed Bilal, Ishrath Syeed

{"title":"Longitudinal stent length change after intravascular ultrasound-guided percutaneous coronary intervention with contemporary drug-eluting stents: A prospective single-centre study.","authors":"Qayoom Yousuf, Imran Hafeez, Aamir Rashid, Jan Mohammad Sheikh, Iqbal Mohammad Dar, Syed Bilal, Ishrath Syeed","doi":"10.1016/j.ihj.2026.08.006","DOIUrl":"10.1016/j.ihj.2026.08.006","url":null,"abstract":"Objective: Contemporary thin-strut drug-eluting stents (DES) frequently undergo a change in longitudinal length after deployment. Contemporary intravascular ultrasound (IVUS)-guided in-vivo data from South-Asian populations remain limited.Methods: We prospectively studied 80 consecutive de-novo coronary lesions treated by IVUS-guided percutaneous coronary intervention. Stent length was measured by edge-to-edge (E-E) and area-to-area (A-A) IVUS techniques, compared with the manufacturer box-stated length, and classified as elongated, shortened or unchanged.Results: Mean age was 58.3 ± 11.8 years (88.8% male). Stent length change occurred in 66 of 80 stents (82.5%) - elongation in 44 (55.0%), shortening in 22 (27.5%), unchanged in 14 (17.5%), with mean length differences of +1.23, -1.00, and +0.02 mm. Elongation exceeded 1 mm in 24 stents (30.0%) and 2 mm in 6 (7.5%); shortening exceeded 1 mm in 10 (12.5%). Reference lumen diameter (p = 0.030) and area (p = 0.011) differed across groups. On multivariable regression, both post-dilation pressure (p = 0.004) and reference lumen diameter (p = 0.026) remained independently associated with length change. All six stents with elongation >2 mm occurred at post-dilation pressures ≥20 atm; half were in left main-left anterior descending (LM-LAD) stents, and the three longest elongations were all in LM-LAD stents. Shortening was more than twice as common in LM-LAD than non-LM-LAD stents (45.0% vs 21.7%; Fisher p = 0.080).Conclusions: Longitudinal stent length change is common on post-PCI IVUS assessment, with elongation predominating. LM-LAD stents showed a bimodal pattern, with both the largest elongations and disproportionate shortenings clustering at this location. Higher post-dilation pressure and smaller reference vessel size were associated with greater elongation.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status on the role of beta blocker in HFpEF: A Reappraisal. 受体阻滞剂在HFpEF中的作用现状：重新评估。

IF 2

Indian heart journal Pub Date : 2026-08-25 DOI: 10.1016/j.ihj.2026.08.004

Saumitra Ray, Srina Ray, Satyavir Yadav, Nitish Naik

{"title":"Current status on the role of beta blocker in HFpEF: A Reappraisal.","authors":"Saumitra Ray, Srina Ray, Satyavir Yadav, Nitish Naik","doi":"10.1016/j.ihj.2026.08.004","DOIUrl":"10.1016/j.ihj.2026.08.004","url":null,"abstract":"Background: Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases and is increasingly recognized as a complex clinical syndrome driven by diverse pathophysiological mechanisms and multiple comorbidities. Despite its growing prevalence, evidence supporting disease-modifying therapies in HFpEF remains limited. Beta-blockers continue to be widely used in this population, largely for indications such as hypertension, atrial fibrillation, ischemic heart disease, and elevated heart rate; however, their therapeutic value in HFpEF itself remains uncertain.Method: This narrative review summarizes current clinical evidence on role of beta blocker in phenotype driven HFpEF management. A thorough search of Pubmed has been done using the key words \"heart failure with preserved ejection fraction\", \"heart failure comorbidities\", and \"beta blockers in heart failure\".Result: It was found that an all HFpEF trials for new pharmacological agents like SGLT2I, ARNI, MRA and nsMRA, beta blocker therapy had been there during screening in 80-90% of patients with HFpEF. Neither the reasons were explored nor the Beta blockers were withdrawn for inclusion in the studies.Conclusion: Current evidence suggests that beta-blockers can be prescribed based on comorbidity profiles rather than as HFpEF specific therapy. Well-designed randomized studies particularly those incorporating phenotype-based patient selection are needed to clarify the therapeutic role of beta-blockers.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strengthening propensity-matched inferences in elderly off-pump CABG: caliper width, events-per-variable, and the missing frailty axis. 老年人停泵CABG的强化倾向匹配推断：卡钳宽度，每个变量的事件和缺失的脆弱轴。

IF 2

Indian heart journal Pub Date : 2026-08-12 DOI: 10.1016/j.ihj.2026.08.002

Oğulcan Özdemir, İhsan Peker

引用次数: 0

Reply to the Letter to the Editor: Strengthening propensity-matched inferences in elderly off-pump CABG. 回复编辑IHJ-D-LTE-00272。

IF 2

Indian heart journal Pub Date : 2026-08-12 DOI: 10.1016/j.ihj.2026.08.003

Kirun Gopal, Neethu Krishna, Praveen Kerala Varma

引用次数: 0

Inflammatory cytokine profiling across acute coronary syndrome subtypes: Comparison of STEMI and NSTE-ACS. 急性冠状动脉综合征亚型的炎症细胞因子谱分析：STEMI和NSTE-ACS的比较

IF 2

Indian heart journal Pub Date : 2026-08-06 DOI: 10.1016/j.ihj.2026.08.001

Ankur Mittal, Kraticka Singhal, Akash Batta, Saurabh Mehrotra, Yash Paul Sharma

{"title":"Inflammatory cytokine profiling across acute coronary syndrome subtypes: Comparison of STEMI and NSTE-ACS.","authors":"Ankur Mittal, Kraticka Singhal, Akash Batta, Saurabh Mehrotra, Yash Paul Sharma","doi":"10.1016/j.ihj.2026.08.001","DOIUrl":"10.1016/j.ihj.2026.08.001","url":null,"abstract":"Objective: This study aimed to characterize differences in clinical presentation, metabolic parameters and cytokine profiles between STEMI and NSTE-ACS patients and identify potential biomarkers of disease severity and inflammation.Methods: An exploratory study was conducted on 60 ACS patients (30 STEMI, 30 NSTE-ACS) experiencing their first episode. Clinical characteristics, routine laboratory parameters and multiplex cytokine analysis (GM-CSF, IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-9, IL-10, IL-12P70, IL-18, MCP-1, M-CSF, TNF-α) were compared. Normality was assessed using the Shapiro-Wilk test and statistical comparisons were made using t-tests or Mann-Whitney U tests for continuous variables and chi-square tests for categorical variables. Multivariable logistic regression and Benjamini-Hochberg false-discovery-rate (FDR) correction were applied.Results: Chest pain was more frequent in STEMI (28/30 [93.3%] vs 15/30 [50.0%]; p = 0.0006) with higher prevalence of diabetes mellitus (24/30 [80.0%] vs 6/30 [20.0%]; p < 0.0001), worse lipid profile and increased inflammation (CRP 126.48 [44.63 - 169.75] mg/L vs 15.98 [3.75 - 39.49] mg/L; p = 0.0001). Cytokine analysis revealed significantly higher levels of IL-6, IL-8, IL-1β, IL-18, and M-CSF in STEMI after FDR correction (all FDR < 0.05). These differences persisted in non-diabetic sensitivity analysis and after multivariable adjustment for diabetes, HbA1c and CRP. The composite cytokine panel showed modest discriminatory capacity (AUC 0.69, 95% CI 0.55 - 0.83).Conclusions: STEMI is characterized by greater inflammation, dyslipidemia and diabetes burden compared to NSTE-ACS. These differences persist after sensitivity analysis, multivariable adjustment and FDR correction revealing distinct inflammatory profiles that support the hypothesis of subtype-specific immune activation and pathways.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic performance of echocardiography for preoperative coronary artery assessment in infants with transposition physiology (transposition of the great arteries and DORV-TGA): A CT angiography comparative study. 超声心动图在婴儿冠状动脉转位（大动脉转位和DORV-TGA）术前评估中的诊断价值：一项CT血管造影比较研究。

IF 2

Indian heart journal Pub Date : 2026-08-03 DOI: 10.1016/j.ihj.2026.07.011

Himanshi Batra, Anmol Kasera, Shraddha Joshi, Munish Guleria, Akanksha Yadav, Dheeraj Deo Bhatt, Maya Batra

{"title":"Diagnostic performance of echocardiography for preoperative coronary artery assessment in infants with transposition physiology (transposition of the great arteries and DORV-TGA): A CT angiography comparative study.","authors":"Himanshi Batra, Anmol Kasera, Shraddha Joshi, Munish Guleria, Akanksha Yadav, Dheeraj Deo Bhatt, Maya Batra","doi":"10.1016/j.ihj.2026.07.011","DOIUrl":"10.1016/j.ihj.2026.07.011","url":null,"abstract":"Background: TGA accounts for 5-7% of congenital heart disease, with a prevalence of 0.2 per 1000 live births. The Modified Leiden Convention provides a standardized nomenclature for describing coronary artery anatomy across imaging and surgical practice. A thorough understanding of coronary artery anatomy is essential for planning the arterial switch operation as it is the established treatment for infants with TGA.Methods: Our study was a cross-sectional study which included 62 infants (<6 months) diagnosed with TGA or TGA-type DORV. Origin of the coronary artery anatomy was classified using the Modified Leiden Convention. Interpretation of findings were performed independently by experienced observers who were blinded to the findings of the other modality. CT angiography was considered the reference standard. Sensitivity, specificity, predictive values, diagnostic accuracy, and agreement (Cohen's kappa) were calculated.Results: CT angiography identified usual coronary anatomy in 33 patients (53.2%) and variant patterns in 29 patients (46.8%) among the 62 infants. Echocardiography demonstrated a sensitivity of 84.8% and a specificity of 31.0% in diagnosing usual coronary artery anatomy. The positive predictive value for usual anatomy was 58.3%, and the negative predictive value was 64.3%. Echocardiography demonstrated a sensitivity of only 31.0% and a specificity of 84.8% in demonstrating variant anatomy.Conclusion: Echocardiography accurately identified the usual coronary artery pattern but had limited sensitivity for coronary variants. CT angiography is a valuable complementary tool when echocardiographic findings are inconclusive or complex anatomy is suspected before arterial switch surgery.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripartum cardiomyopathy requiring tertiary care admission: Clinical course and one -year outcomes from a prospective observational cohort. 围产期心肌病需要三级护理入院：来自前瞻性观察队列的临床病程和一年结果。

IF 2

Indian heart journal Pub Date : 2026-07-31 DOI: 10.1016/j.ihj.2026.07.009

Riyaz Charaniya, Kamal Sharma, Himani Upadhayaya, Krutika Patel

{"title":"Peripartum cardiomyopathy requiring tertiary care admission: Clinical course and one -year outcomes from a prospective observational cohort.","authors":"Riyaz Charaniya, Kamal Sharma, Himani Upadhayaya, Krutika Patel","doi":"10.1016/j.ihj.2026.07.009","DOIUrl":"10.1016/j.ihj.2026.07.009","url":null,"abstract":"Background: Peripartum cardiomyopathy(PPCM) is an uncommon but potentially life-threatening cause of heart failure occurring during late pregnancy or the early postpartum period. Data describing the clinical profile and long-term outcomes of hospitalized PPCM patients remain limited.Objectives: To describe the clinical presentation, disease severity, one-year clinical and echocardiographic outcomes of women with PPCM requiring hospitalisation, and to explore factors associated with left ventricular (LV) functional recovery.Methods: A prospective observational study enrolled 47 consecutive women diagnosed with PPCM between June 2021 to June 2023 at a tertiary cardiac care hospital. The study assessed clinical characteristics, echocardiographic, electrocardiographic parameters, with the Kansas City Cardiomyopathy Questionnaire (KCCQ) scores and maternal outcomes at presentation, 6 months and 1 year follow up, with LV recovery defined as LVEF ≥45%.Results: The mean age was 29.3 ± 5.5 years. Most patients presented postpartum (83%) and with advanced heart failure; over 98% were in NYHA class III-IV, and 83% had severe LV systolic dysfunction at admission.Mean LVEF improved from 25.7 ± 6.3% at baseline to 31.8 ± 9.4% at 6 months and 38.8 ± 13.1% at 1 year (p=<0.0001).LV recovery (LVEF ≥45%) occurred in 13.3% of patients at 6 months and 42.2% at 1 year. TAPSE, NYHA class and KCCQ score were also improved significantly at 1 year (p=<0.0001). Exploratory analysis showed baseline TAPSE(OR 1.29,95% CI 1.03-1.61,p = 0.03)was independent predictor of LV recovery.Rehospitalisation occurred in 29.8% and overall, one-year mortality rate was 6.4%.Conclusions: Despite severe initial presentation, substantial improvement in ventricular function and clinical status occurs in many high risk PPCM patients with guideline-directed therapy and structured follow-up.","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0