{"title":"Infectious agents, protein electrophoresis and immunoglobulin levels in patients with coronary artery ectasia","authors":"Gulay Yetkin , Didem Tascioglu , Selcuk Ozturk , Bilal Cuglan , Kenan Yalta , Ertan Yetkin","doi":"10.1016/j.ihj.2025.09.004","DOIUrl":"10.1016/j.ihj.2025.09.004","url":null,"abstract":"<div><h3>Background</h3><div>Although the mechanism of coronary artery ectasia (CAE) shares the common pathophysiologic steps resembling those of atherosclerosis, there are certain discrepancies or aspects incompatible with atherosclerosis. Therefore, we hypothesize that the pathophysiology of CAE might differ from that of atherosclerosis in terms of inflammatory parameters, infectious agents and the read out of protein electrophoresis.</div></div><div><h3>Materials and methods</h3><div>Seventy patients with coronary artery disease (CAD) and 30 patients with both CAD and CAE comprised the study populations. Blood samples were centrifuged for the measurement of IgG antibodies against <em>C.pneumoniae and H.Pylori</em>, alongside with total IgE, IgG levels and protein electrophoresis.</div></div><div><h3>Results</h3><div>There were not statistically significant differences between patients with and without CAE regarding the <strong>complete blood counting and routine biochemical</strong> laboratory parameters except hemoglobin levels. Among <strong>other studied</strong> laboratory parameters, IgE, Alpha 2 macroglobulin, Beta-1 globulin levels were found to be higher in patients with CAE + CAD than those of CAD alone. Logistic regression analysis by including the variables IgE, Hb, Alpha 2 macroglobulin, beta-1 globulin, and gender, revealed that Ig E (Odd ratio:1.004 85 % CI: 1.000–1.008, <em>p</em> = 0.01) and alpha 2 macroglobulin (Odds ratio: 9.41, 95 %CI: 1.69–52.28, <em>p</em> = 0.028<strong>)</strong> were independently and positively associated with the presence of CAE.</div></div><div><h3>Conclusion</h3><div>Independent association of serum IgE levels and alpha2 globulins with the presence of CAE underlines the divergent features of pathophysiology of CAE compared with atherosclerosis or CAD alone. Comparable activity of humoral immunity measured by IgG antibody against C.Pneumoniae, and H. Pylori has suggested that these infectious agents do not play an additional role in the pathogenesis of CAE.</div></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"78 1","pages":"Pages 9-13"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applying the 2025 AACE dyslipidemia guideline in South Asian populations.","authors":"Likith Kumar Nuchina Kumar, Shashank S Koundinya","doi":"10.1016/j.ihj.2025.12.001","DOIUrl":"10.1016/j.ihj.2025.12.001","url":null,"abstract":"","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian heart journalPub Date : 2025-12-01Epub Date: 2025-12-03DOI: 10.1016/j.ihj.2025.11.089
Rajat Chaudhary, Girish M. P, Jamal Yusuf, Mohit Gupta, Subrat Muduli
{"title":"Morphological characteristics of coronary plaque as assessed by optical coherence tomography in women presenting with acute coronary syndrome","authors":"Rajat Chaudhary, Girish M. P, Jamal Yusuf, Mohit Gupta, Subrat Muduli","doi":"10.1016/j.ihj.2025.11.089","DOIUrl":"10.1016/j.ihj.2025.11.089","url":null,"abstract":"","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"77 ","pages":"Pages S36-S37"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145658406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian heart journalPub Date : 2025-12-01Epub Date: 2025-12-03DOI: 10.1016/j.ihj.2025.11.007
Prayaag Kini, Reeta Varyani, Subramanian M, R Raghunatha Sarma, Barooah B
{"title":"Next-Gen Cardiology: Use of CNN Image Segmentation for prediction of CRT response- A look into Precision-guided Cardiology","authors":"Prayaag Kini, Reeta Varyani, Subramanian M, R Raghunatha Sarma, Barooah B","doi":"10.1016/j.ihj.2025.11.007","DOIUrl":"10.1016/j.ihj.2025.11.007","url":null,"abstract":"","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"77 ","pages":"Page S2"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145658659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}