Indian heart journal最新文献

{"title":"Navigating the lipid landscape: A special issue unveiling lipid in cardiovascular care specially for Indian context","authors":"Rakesh Yadav, Geetika Yadav","doi":"10.1016/j.ihj.2024.02.006","DOIUrl":"10.1016/j.ihj.2024.02.006","url":null,"abstract":"","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 ","pages":"Page S1"},"PeriodicalIF":1.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224000385/pdfft?md5=b90465c232f5adc987b2ecd7cecad182&pid=1-s2.0-S0019483224000385-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional and novel non-statin lipid-lowering drugs","authors":"Peeyush Jain","doi":"10.1016/j.ihj.2023.11.003","DOIUrl":"10.1016/j.ihj.2023.11.003","url":null,"abstract":"<div><p>Non-statin drugs find utility in the management of dyslipidaemia in mixed dyslipidaemia, patients with statin intolerance, and when guidelines directed low-density lipoprotein cholesterol (LDL-C) target cannot be achieved despite maximally tolerated statin. The most definite indication of fenofibrate monotherapy is fasting serum triglyceride &gt;500 mg/dl to reduce the risk of acute pancreatitis It offers a modest reduction in cardiovascular events. The statin-ezetimibe combination is commonly used for lipid lowering particularly after ACS. Fish oils reduce serum triglycerides by about 25 %. EPA (and not DHA) seems to have cardioprotective effects. Despite cardiovascular outcome benefits, bile-exchange resins have limited use due to poor tolerance. Bempedoic acid added to maximally tolerated statin therapy is approved to lower LDL-C in adults with primary hypercholesterolemia or mixed dyslipidaemias, HeFH, in patients with ASCVD who require additional lowering of LDL-C, and in patients who are statin-intolerant. Inclisiran is a long-acting double-stranded small interfering RNA (siRNA) that inhibits the transcription of PCSK-9 leading to a decrease in PCSK9 generation in hepatocytes and an increase in LDL receptor expression in the liver cell membrane leading to about 50 % reduction in serum LDL-C levels. Lomitapide lowers plasma levels of all ApoB-containing lipoproteins, including VLDL, LDL, and chylomicrons by inhibiting the enzyme microsomal triglyceride transfer protein (MTP) and approved for the treatment of adult patients with homozygous familial hypercholesterolemia (HoFH). Close monitoring for hepatotoxicity is required. Mipomersen is a single-stranded synthetic antisense oligonucleotide (ASO) that affects the production and secretion of apoB-containing lipoproteins with demonstrated efficacy in both homozygous and heterozygous FH patients. It is approved for restricted use due to risk of hepatotoxicity. Pelacarsen is an antisense oligonucleotide that reduces the production of apo(a) in the liver.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 ","pages":"Pages S38-S43"},"PeriodicalIF":1.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483223001761/pdfft?md5=ae06a7d3b147777831baa8a48bdfbe59&pid=1-s2.0-S0019483223001761-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling HPV's hidden link: Cardiovascular diseases and the viral intrigue","authors":"Preyangsee Dutta,&nbsp;Dwaipayan Saha,&nbsp;Mrudul Earle,&nbsp;Chandra Prakash Prasad,&nbsp;Mayank Singh,&nbsp;Mrinalini Darswal,&nbsp;Vipul Aggarwal,&nbsp;Nitish Naik,&nbsp;Rakesh Yadav ,&nbsp;Abhishek Shankar ,&nbsp;Abhijit Chakraborty","doi":"10.1016/j.ihj.2024.02.001","DOIUrl":"10.1016/j.ihj.2024.02.001","url":null,"abstract":"<div><p>Cardiovascular diseases (CVD) remain a major global health challenge, with an escalating impact on mortality despite advancements in managing conventional risk factors. This review investigates the intricate relationship between human papillomavirus (HPV) and CVD, shedding light on a novel aspect of cardiovascular health. Despite significant progress in understanding and managing traditional CVD risk factors, a substantial proportion of CVD cases lack these conventional markers. Recent research has unveiled HPV, a prevalent sexually transmitted infection, as a potential unconventional risk factor for CVD.</p><p>This review delves into the underlying mechanisms linking HPV to CVD pathogenesis. HPV's influence on vascular endothelium and induction of systemic inflammation are key contributors. Additionally, HPV disrupts host lipid metabolism, further exacerbating the development of atherosclerosis. The link between HPV and CAD is not merely correlative; it encompasses a complex interplay of virological, immunological, and metabolic factors. Understanding the connection between HPV and CVD holds transformative potential. Insights from this review not only underscore the significance of considering HPV as a crucial risk factor but also advocate for targeted HPV screening and vaccination strategies to mitigate CVD risks. This multidisciplinary exploration bridges the gap between infectious diseases and cardiovascular health, emphasizing the need for a comprehensive approach to combating the global burden of cardiovascular disease. Further research and clinical guidelines in this realm are essential to harness the full scope of preventive and therapeutic interventions, ultimately shaping a healthier cardiovascular landscape.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 1-5"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224000191/pdfft?md5=89fed878ea9f1e25be032be8dd47739c&pid=1-s2.0-S0019483224000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Brugada electrocardiographic pattern in adult population - A community-based study from Kerala, South India","authors":"Mangalath Narayanan Krishnan ,&nbsp;Zachariah Geevar ,&nbsp;Krishnan Nair Venugopal ,&nbsp;Padinhare Purayil Mohanan ,&nbsp;Sivadasanpillai Harikrishnan ,&nbsp;Ganapathi Sanjay ,&nbsp;Kavumpurathu Raman Thankappan","doi":"10.1016/j.ihj.2024.01.002","DOIUrl":"10.1016/j.ihj.2024.01.002","url":null,"abstract":"<div><p>There is no data for Brugada electrocardiographic pattern (BrEP) from India. In a cross-sectional study of men and women between the ages 20–79 years, electrocardiograms were analyzed following the 2002 consensus. The overall prevalence of BrEP was 1.06 % (95 % CI 0.76, 1.35). There were two cases type I (0.04 %; 95 % CI 0.01, 0.06) and forty-seven type II/III (1.01 %; 95 % CI 1.02, 1.35); the pattern was markedly higher in men. In this study, BrEP was slightly less prevalent compared to South Asia but more than in the west.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 54-56"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224000026/pdfft?md5=de65c80dddb8b29acbd381b5e84af5e8&pid=1-s2.0-S0019483224000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary artery disease in patients with rheumatic valvular heart disease- An analysis from eastern India","authors":"Avik Karak ,&nbsp;Novonil Deb ,&nbsp;Dibbendu Khanra ,&nbsp;Santanu Guha ,&nbsp;Anindya Mukherjee","doi":"10.1016/j.ihj.2023.11.268","DOIUrl":"10.1016/j.ihj.2023.11.268","url":null,"abstract":"<div><h3>Introduction</h3><p>There is insufficient information on the angiographic characteristics of individuals with rheumatic valvular heart disease (VHD) from eastern India. The objective of this research is to gather important data in this area to aid the best surgical outcomes for patients with rheumatic VHD.</p></div><div><h3>Materials and methods</h3><p>978 consecutive patients with rheumatic VHD, scheduled for surgical intervention, were recruited.</p></div><div><h3>Result and conclusion</h3><p>Mitral valve involvement was observed in 66.1 %, aortic valve in 7.3 % and both valves in 26.6 %. Patients with CAD had significantly higher proportions of severe aortic stenosis (AS). Therefore, addressing the risk factors for CAD is crucial in patients with rheumatic VHD.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 48-50"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483223004595/pdfft?md5=9d54f1b1debf1e50de4dcf54da5b5ba6&pid=1-s2.0-S0019483223004595-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F- FDG PET/CT in reclassifying the probable diagnosis of IE - A review","authors":"I. Sathyamurthy ,&nbsp;Indirani Elangovan","doi":"10.1016/j.ihj.2024.01.003","DOIUrl":"10.1016/j.ihj.2024.01.003","url":null,"abstract":"<div><p>In the diagnosis of infective endocarditis (IE), Modified Duke's criteria, coupled with clinical suspicion, serve as the guiding framework. For cases involving prosthetic valve endocarditis and infections affecting implantable devices, the use of metabolic imaging with 18 F–FDG PET/CT scans has gained prominence, as per the recommendations of the European Society of Cardiology guidelines. This imaging modality enhances sensitivity and specificity by identifying infective foci within the heart and extracardiac locations. Early utilization of these scans is crucial for confirming or ruling out IE, although caution is required to mitigate false positive responses, especially in the presence of ongoing inflammatory activity. A standardized ratio of ≥2.0 between FDG uptake around infected tissues and the blood pool has demonstrated a sensitivity of 100 % and specificity of 91 %. It is noteworthy that the sensitivity of FDG PET/CT varies, being lower for native valve and lead infections but considerably higher for prosthetic valve and pulse generator infections. This review provides a comprehensive overview of the advantages offered by FDG PET/CT in achieving a definitive diagnosis of IE.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 10-15"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224000038/pdfft?md5=09e592e5f1cfaff7d280a3416f27ee17&pid=1-s2.0-S0019483224000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain imaging as an early predictor in acute myocardial infarction – An augmented cross-sectional study","authors":"Dhananjay Kumar ,&nbsp;Manish Saha ,&nbsp;Santanu Guha ,&nbsp;Tirthankar Roy ,&nbsp;Rohit Kumar ,&nbsp;Abhirup K. Sinha","doi":"10.1016/j.ihj.2024.01.001","DOIUrl":"10.1016/j.ihj.2024.01.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Cardiac fibres are affected invariably in myocardial infarction, with longitudinal strain being the earliest to be detected in the ischaemic cascade. The present study aims to assess strain imaging in acute myocardial infarction (AMI) patients admitted to the cardiology department at our institute and correlate GLS and DESL findings with other markers for myocardial function.</p></div><div><h3>Methods and material</h3><p>This augmented cross-sectional study was conducted amongst the patients admitted with diagnosis of AMI. During the study period, 157 subjects were sampled through convenience sampling, and examined as well as tested with routine investigations at baseline. The subjects were then followed through at first, third and six months, and findings noted. Chi-square was used to assess the crude association between sample characteristics. Pearson correlation and student <em>t</em>-test were used to find association between continuous variables.</p></div><div><h3>Results</h3><p>After screening 564 patients, 157 patients were included in the study after fulfilment of inclusion and exclusion criteria. A significant difference was found in baseline GLS scores and NTproBNP levels at 6 months in alive patients with STEMI, t (21.728) = −5.717, p &lt; .001. Out of the 50 NSTEMI patients, 35 (70 %) were positive for ESL, similarly out of 43 STEMI patients without any RWMA, ESL was positive in 39 (90.02 %) patients.</p></div><div><h3>Conclusions</h3><p>GLS by STE has good correlation with LVEF, WMSI and NT pro-BNP and it is an independent predictor of mortality and heart failure among patients with AMI.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 31-35"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224000014/pdfft?md5=df5ccf5671a7da01b02c58ce71eec9f9&pid=1-s2.0-S0019483224000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic kidney disease's impact on revascularization and subsequent major adverse cardiovascular events in patients with chronic coronary syndrome","authors":"Shereen Ibrahim Farag ,&nbsp;Shaimaa Ahmed Mostafa ,&nbsp;Hamza Kabil ,&nbsp;Mohamed Reda Elfaramawy","doi":"10.1016/j.ihj.2023.11.006","DOIUrl":"10.1016/j.ihj.2023.11.006","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the impact of CKD on the completeness of revascularization and major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS).</p></div><div><h3>Patients and methods</h3><p>The study enrolled 400 CCS patients who underwent revascularization by PCI. They were separated into two categories according to their eGFR levels: the control group: 200 patients with eGFR ≥60mL/min/1.73m^2, and the CKD Group: 200 patients with eGFR&lt; 60ml/min/1.73m.² Patients were reclassified according to revascularization into complete and incomplete revascularization groups with one-year follow-up to assess the MACE.</p></div><div><h3>Results</h3><p>CKD patients were significantly older (65.78 ± 6.41 vs. 56.70 ± 9.20 years, P=&lt;0.001). They had higher syntax scores (P = 0.005), CIN (P = 0.001), all-cause mortality (P = 0.02), MACE (P = 0.037), and heart failure (P = 0.014). After reclassification according to revascularization. GFR was significantly reduced among patients with incomplete revascularization (51.08 ± 28.15 vs. 65.67 ± 26.62, respectively, P =&lt;0.001). Repeated revascularization (P &lt; 0.001), STEMI (P = 0.003), stent thrombosis (P = 0.015), MACE (P &lt; 0.001), stroke (P &lt; 0.001), and all-cause mortality (P &lt; 0.001) were more prevalent among patients with incomplete revascularization. Multivariate regression analysis revealed eGFR (P = 0.001) and Syntax score (SS) (P=&lt;0.001) as independent predictors of incomplete revascularization. The optimal eGFR cutoff value for predicting partial revascularization is 49.50mL/min/1.73m2, with 58.8% sensitivity and 69.3 % specificity.</p></div><div><h3>Conclusion</h3><p>Chronic kidney disease is associated with a higher syntax score and incomplete revascularization prevalence in CCS patients. Additionally, incomplete revascularization is associated with an increased incidence of major adverse cardiac events. In patients with CCS, CKD predicts partial revascularization and subsequent MACE.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 22-26"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S001948322300192X/pdfft?md5=bf91c787043917e4d415e9c1b48dd21a&pid=1-s2.0-S001948322300192X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138433740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism in acute coronary syndrome – A prospective Indian study","authors":"Priyadarshini Arambam ,&nbsp;Shikhar Gupta ,&nbsp;Upendra Kaul ,&nbsp;Priya Ranjan ,&nbsp;Sudhir Sekhawat ,&nbsp;Rajiv Janardhanan","doi":"10.1016/j.ihj.2023.12.008","DOIUrl":"10.1016/j.ihj.2023.12.008","url":null,"abstract":"<div><h3>Background</h3><p>Evidence suggests that hypothyroidism may be associated with an increased risk of acute coronary syndrome (ACS).</p><p>The data regarding the influence of hypothyroidism on cardiovascular disease in the Asian population is conflicting. Therefore, we undertook this study to assess the overall prevalence of hypothyroidism in Acute Coronary Syndrome (ACS) patients and determine if there is a relationship between hypothyroidism, both sub-clinical and overt and other significant risk factors of ACS in an Indian population.</p></div><div><h3>Methods</h3><p>We studied 487 hospitalized patients between March 2018 and February 2021 with a diagnosis of ACS to determine the prevalence of hypothyroidism, both clinical and sub-clinical and their relationship with other known coronary risk factors. Thyroid function Tests - free T3, free T4 and TSH were collected from all the patients within 24 h of their admission to the coronary care unit (CCU) of 2 major hospitals in New Delhi and Imphal (Manipur).</p></div><div><h3>Results</h3><p>Subclinical hypothyroidism was prevalent in 44 (9 %), followed by overt hypothyroidism in 25 (5.2 %).</p><p>Subclinical hypothyroidism was more common in females, whereas overt hypothyroidism was more common in males. ST Elevation Myocardial Infarction (STEMI) (52 %), followed by Non-ST-Elevation Myocardial Infarction (NSTEMI) (25 %), was the commonest diagnosis at presentation. Patients with overt hypothyroidism showed a higher proportion of increased triglyceride levels.</p><p>Patients with hypothyroidism had no differences in the prevalence of concomitant diabetes hypertension and other coronary risk factors.</p></div><div><h3>Conclusions</h3><p>Patients with ACS without known thyroid disorders should be screened for hypothyroidism since it is found frequently. There might be a case to treat their thyroid dysfunction appropriately.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 44-47"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483223004777/pdfft?md5=7fb215e44a9892894f3da28e51e57a97&pid=1-s2.0-S0019483223004777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the association of inflammatory markers, cell-adhesion molecules, and endothelial dysfunction biomarkers with ACS in Indian population","authors":"Keshav Kale,&nbsp;Harshad Rajage,&nbsp;Kane G R","doi":"10.1016/j.ihj.2024.01.016","DOIUrl":"10.1016/j.ihj.2024.01.016","url":null,"abstract":"<div><p>The observational study aims to evaluate inflammatory markers, cell adhesion molecules (CAM) and endothelial dysfunction markers as biomarkers in Indian ACS patients with no conventional risk factors. The study population included 110 healthy individuals and 102 ACS patients without any history of conventional risk factors, except smoking and alcoholism, were included. Patient history, biochemical parameters and levels of biomarkers were estimated. ACS patients had a significant elevation in the circulatory levels of biomarkers, such as IL-6, TNF-α, MCP1, MMP9, VCAM1, ICAM1 and E-selectin. CAM, inflammatory and endothelial biomarkers could help devise strategies for early, effective treatment of ACS.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 1","pages":"Pages 63-66"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0019483224000178/pdfft?md5=aa6201fc6a9a28ba4aab0071b2abeb0f&pid=1-s2.0-S0019483224000178-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}