Indian heart journal最新文献

{"title":"Floating wire assisted device retrieval-a novel technique for prevention of guide-related coronary injury.","authors":"Atit A Gawalkar, Rajesh Vijayvergiya, Pragya Karki","doi":"10.1016/j.ihj.2025.08.005","DOIUrl":"10.1016/j.ihj.2025.08.005","url":null,"abstract":"<p><strong>Background: </strong>An inward force is experienced by the guide catheter during device retrieval resulting in potential risk of deep engagement into the ostio-proximal coronary segment. This undesired movement can result in coronary injury. There is no systematic data or reports of techniques to prevent such inadvertent guide movement during difficult retrieval of devices.</p><p><strong>Methods: </strong>In 25 patients undergoing percutaneous coronary intervention, where the conventional methods of guide stabilization failed to prevent deep engagement of guide catheter during device retrieval we used 'floating aortic wire' technique and reattempted retrieval. The primary endpoint was the successful retrieval of the device without deep engagement of the guide.</p><p><strong>Results: </strong>Successful retrieval was seen without deep engagement of guide in 23(92 %) patients. Left anterior descending(n = 15, 60 %) artery was the most common coronary artery. The XB guide(n = 14, 70 %) was the most commonly used guide for left coronary intervention while Judgkins right and Amplatz left were used most commonly for right coronary intervention. Stent balloon(n = 15, 60 %) was the most common device which required using floating aortic wire for retrieval. Other devices were jailed wire(n = 5,20 %), non-compliant balloon(n = 4,16 %) and cutting balloon(n = 1,4 %). Intravascular ultrasound did not show any guide related vessel injury(dissection or intramural hematoma) in any cases. The floating aortic wire failed to prevent deep engagement in two patients because of longer segment of jailed wire and long stent balloon in distal right coronary artery.</p><p><strong>Conclusion: </strong>Floating aortic wire assisted retrieval of coronary devices is a simple, reliable and safe technique that prevents deep guide engagement during difficult retrieval.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing atrial fibrillation recurrence with combination of catheter ablation and renal denervation or ganglion plexus ablation: A systematic review and network meta-analysis.","authors":"Sebastian Emmanuel Willyanto, Liliana Dewi, Rizki Hari Mulia, Imke Maria Del Rosario Puling, Nyoman Deva Pramana Giri, Derren David Christian Homenta Rampengan, Ardian Rizal","doi":"10.1016/j.ihj.2025.08.004","DOIUrl":"10.1016/j.ihj.2025.08.004","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF), affects around 2 % of the global population and is projected to rise over the next 50 years. Catheter ablation (CA) is the primary treatment for symptomatic AF resistant to drug therapy. Despite its widespread use, CA has a failure rate of 20 %-50 %, often requiring repeat procedures, due to significant long-term recurrence rates. Combining CA with renal denervation (RDN) or ganglion plexus ablation (GPA) may effectively reduce the recurrence rates of AF.</p><p><strong>Methods: </strong>Quality assessment was done using the Cochrane ROB 2.0 tool, network meta-analysis using RStudio, and comparative meta-analysis using RevMan 5.4.</p><p><strong>Results: </strong>A thorough search across seven databases resulted in 13 articles for analysis, with eight classified as low-risk and five as moderate-risk of bias. The network meta-analysis found that RDN + CA had the highest freedom from AF episodes at 12 and 24 months (OR 2.28 [1.34-3.86] and OR 1.61 [0.89-2.89]), followed by GPA + CA (OR 1.88 [0.91-3.89] and OR 1.36 [0.91-2.03]), compared to CA alone. RDN + CA also showed fewer procedure-related complications (OR 0.78 [0.30-2.02]), while GPA + CA was more prevalent (OR 3.60 [1.72-7.55]), compared to CA alone. Additionally, RDN + CA significantly reduced systolic blood pressure (SBP) (MD -5.22 [-9.91 to -0.53]), diastolic blood pressure (DBP) (MD -3.61 [-7.98 to -0.76]), and creatinine levels (MD -0.25 [-0.34 to -0.15]), while increasing estimated glomerular filtration rate (eGFR) (MD 7.98 [-1.16-17.11]) compared to the control group.</p><p><strong>Conclusion: </strong>Remarkable success in preventing AF recurrence was observed when CA was combined with RDN or GPA. However, it is noteworthy that GPA + CA was associated with a higher incidence of procedural-related complications, while RDN + CA demonstrated additional advantages by improving blood pressure regulation and renal function.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in diagnosis of cardiac sarcoidosis-an observational study from tertiary care center in north India.","authors":"Asharam Panda, Sumit Kumar, Nitish Naik","doi":"10.1016/j.ihj.2025.08.003","DOIUrl":"10.1016/j.ihj.2025.08.003","url":null,"abstract":"<p><p>This retrospective observational study was conducted in a tertiary care hospital to assess the challenges involved in the diagnosis of cardiac sarcoidosis. The study included a total of 42 patients with primary cardiac manifestation of sarcoidosis and imaging evidence of patchy myocardial inflammation. Ventricular tachycardia(20) was the most common cardiac manifestation, followed by heart failure(12) and complete heart block(10). Histopathological evidence of sarcoidosis was found only in 12 patients (one endocardial biopsy, 11 extracardiac source). We could not find evidence of extracardiac involvement in the majority of patients. As the diagnostic criteria mainly stress upon the evidence of extracardiac sarcoidosis, diagnosis remains uncertain in many patients.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of rheumatic heart disease in school going children of Meghalaya - An echocardiographic study from Northeast of India.","authors":"Manish Kapoor, W Valerie Lyngdoh, Arun Kumar Gunasekaran, Vanlalsawmdawngliana Fanai, Devinder Toor, Pinak Pani Das, Denzelle Lyngdoh, Anuradha Chakraborti, Vivek Sagar","doi":"10.1016/j.ihj.2025.08.002","DOIUrl":"10.1016/j.ihj.2025.08.002","url":null,"abstract":"<p><strong>Objective: </strong>The lack of data related to the prevalence of rheumatic heart disease (RHD) in Meghalaya, India prompted us to assess the prevalence of RHD in school-going children of Meghalaya aged 5-15 years and risk factors associated with it.</p><p><strong>Methods: </strong>A cross-sectional epidemiological study was performed using World Heart Federation (WHF) echocardiographic criteria with a portable echo machine.</p><p><strong>Results: </strong>4039 children (mean age 10.18 ± 2.87 years) underwent 2D echocardiographic screening. Among them, 2100 (52.0 %) were aged 5-10 years and 1939 (48.0 %) were aged 11-15 years. Of them, 2066 (51.1 %) were female and 2488 (61.6 %) resided in rural areas. 652 (16.1 %) children were in government-run schools, 1836 (45.5 %) in private institutions. The cohort's mean BMI was 16.94 ± 2.52. Ethnically, 3818 children (94.5 %) belonged to indigenous tribes-Khasi (61.9 %), Jaintia (21.7 %), and Garo (10.9 %)-while 221 (5.5 %) were from non-native groups. Echocardiography identified subclinical RHD in 19 children (4.7 per 1000) and clinical RHD in 2 children (0.49 per 1000). Among subclinical cases, 8 were classified as definite RHD (1.98 per 1000) and 11 as borderline RHD (2.72 per 1000). RHD risk increased with age (OR = 1.16; 95 % CI: 0.98-1.37), was approximately twofold higher in females (OR = 2.07; 95 % CI: 0.79-5.47), and was more prevalent among rural children and those attending government schools.</p><p><strong>Conclusion: </strong>Subclinical RHD prevalence in Meghalaya's children is significantly higher than clinical RHD. These findings highlight the need for a national registry to monitor subclinical cases and evaluate the impact of future interventions.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular outcomes of bilateral oophorectomy: A systematic review and meta-analysis.","authors":"Tanawat Attachaipanich, Suthinee Attachaipanich, Kotchakorn Kaewboot","doi":"10.1016/j.ihj.2025.08.001","DOIUrl":"10.1016/j.ihj.2025.08.001","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) risk significantly increases in women after menopause. However, the cardiovascular (CV) outcomes in women who undergo bilateral oophorectomy remain unclear. This study aimed to evaluate the CV outcomes associated with bilateral oophorectomy.</p><p><strong>Methods: </strong>A systematic search was conducted across 4 databases, including PubMed, Embase, Web of Science, and Cochrane CENTRAL, from inception to March 25, 2025, without language restrictions. Studies comparing CV outcomes in women who underwent bilateral oophorectomy versus those who did not were included. A random-effects model was used for meta-analysis.</p><p><strong>Results: </strong>A total of 18 studies, comprising a total of 2,414,600 participants, were included. Bilateral oophorectomy was associated with a marginally increased risk of CVD compared to control (pooled HR 1.05, 95 %CI 1.00-1.11, p = 0.05). Bilateral oophorectomy was also associated with a higher risk of heart failure (pooled HR 2.25, 95 %CI 1.15-4.41, p = 0.02). When stratified by age at surgery, bilateral oophorectomy performed at a premenopausal age was associated with a higher risk of CVD (pooled HR 1.15, 95 %CI 1.02-1.30, p = 0.03) and coronary artery disease (pooled HR 1.26, 95 %CI 1.15-1.39, p < 0.01). In contrast, bilateral oophorectomy performed at postmenopausal age was not associated with an increased risk of CV events.</p><p><strong>Conclusions: </strong>Bilateral oophorectomy is associated with an increased risk of CV events, particularly when performed at a premenopausal age. Further research is warranted to determine appropriate prevention strategies and risk stratification in this population.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features, imaging characteristics, and genetic profile of hypertrophic cardiomyopathy patients in India.","authors":"Mohit Dayal Gupta, Brijesh Kumar, Shekhar Kunal, Varun Sharma, Girish Mp, Ankit Bansal, Vishal Batra, Dixit Goyal, Bhawna Mahajan, Pranav Gupta, Sandeep Kadyan, Kalpana Bansal, Poonam Narang, Rakesh Yadav, Nitish Naik, Jamal Yusuf","doi":"10.1016/j.ihj.2025.07.004","DOIUrl":"10.1016/j.ihj.2025.07.004","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder characterized by left ventricular hypertrophy and variable clinical manifestations, including asymptomatic states and sudden cardiac death (SCD). Data on its phenotype and genotype in the Indian population remain limited.</p><p><strong>Methods: </strong>We studied 113 patients diagnosed with HCM. All underwent clinical assessment, 24-h Holter monitoring, echocardiography, and cardiac MRI. Genetic testing was performed in 80 patients. Clinical and imaging features were compared between genotype-positive and genotype-negative groups.</p><p><strong>Results: </strong>The mean age was 47 ± 10.8 years, with 82.6 % being males. Dyspnoea and chest pain were the most frequent symptoms. Obstructive HCM was seen in 70 (61.9 %) patients. Cardiac MRI showed late gadolinium enhancement >15 % in 13 (23.2 %) and apical aneurysms in 2 (3.5 %). Genetic mutations were detected in 40 (50 %) patients, with MYBPC3 (33 %) and MYH7 (26.8 %) being most common. Genotype-positive individuals more frequently had chest pain, a family history of SCD, and more severe hypertrophy.</p><p><strong>Conclusion: </strong>In this Indian HCM cohort, the condition predominantly affected males. Genotype-positive patients exhibited more severe hypertrophy and adverse clinical profiles, underscoring the importance of genetic screening in risk stratification.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic evaluation of Takayasu arteritis including speckled tracking echocardiography and aortic stiffness.","authors":"Sumang Mohan, Aditya Kapoor, Arpita Katheria, Harshit Khare, Arshad Nazir, Ankit Kumar Sahu, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari","doi":"10.1016/j.ihj.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.ihj.2025.07.003","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the burden of Takayasu's arteritis (TA) in India, data on LA, LV and RV strain and aortic stiffness is scanty.</p><p><strong>Aims: </strong>We assessed these in 100 TA patients (mean age 29.8 years, 70 % females) and correlated with disease activity and duration.</p><p><strong>Methods and results: </strong>Mean illness duration was 6.34 years, Numano V and III angiographic type was seen in 42 and 20 %. Global LVEF was normal and 6 % had LVEF <50 %. TA patients had significantly lower LVGLS (-16.09 vs -18.9 %), peak atrial longitudinal strain (PALS: 25.03vs 27.1 %), RV-FWS (23.42 vs 25.2 %), and higher mean aortic stiffness (8.39 vs 7.44 m/s) vs controls. The % of patients with LV GLS > -16 %, PALS < -25 %, RV-FWS > -23 % and aortic stiffness (>12 m/s) was 32, 26, 14 and 17 % respectively. Those with LVGLS > -16 % had longer symptom duration (7.02 vs 5.66 years), higher ITAS score (4.96 vs 4.44), higher % prevalence of impaired RV strain (28 % vs 7 %) and impaired PALS (29 % vs 18 %). Those with abnormal aortic stiffness had higher mean ITAS scores (5.58 vs 3.62), higher chance of active disease (ITAS-2010 ≥ 2, 64 % vs 40 %) and longer disease duration.</p><p><strong>Conclusion: </strong>Despite normal global LVEF, 15-32 % patients with TA had impaired LVGLS, RVFWS, PALS and aortic stiffness. Impaired LVGLS and Aortic stiffness correlated with longer disease duration and higher disease activity. These preliminary findings suggest that strain and aortic stiffness evaluation in TA may help in early identification of subclinical ventricular dysfunction.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144617404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is transplantation an option for adult Eisenmenger syndrome?Is the grass on the other side of fence greener?","authors":"I Sathyamurthy","doi":"10.1016/j.ihj.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.ihj.2025.07.002","url":null,"abstract":"<p><p>Patients of Eisenmenger syndrome are a heterogeneous group of subjects with varying underlying cardiac defects, longevity, and quality of life. The optimal transplantation strategy, ie, single lung, bilateral lung with intra-cardiac repair, or combined heart-lung transplantation remains a matter of debate, requiring careful consideration of the specific cardiac defect, age at presentation, ventricular function, organ availability, and resources available at the treating centre. The introduction of pulmonary vasodilator therapy has improved the survival curves and led to better quality of life even without transplantation. This review aims to discuss the merits, demerits, optimal timing, and type of transplantation options for adult patients with ES, particularly in countries with resource limitations such as ours (India).</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Framingham cardiovascular disease risk scores with 10-year risk of cardiovascular mortality: a retrospective cohort study in South India.","authors":"Midhun Sasikumar, Reija Autio, Swapna Deshpande, Venkata Raghava Mohan, Sathish Thirunavukkarasu, Kuryan George, Anu Mary Oommen","doi":"10.1016/j.ihj.2025.07.001","DOIUrl":"10.1016/j.ihj.2025.07.001","url":null,"abstract":"<p><strong>Background: </strong>Few cohort studies examine the association of cardiovascular risk scores with cardiovascular mortality in India. This study assessed the association of baseline Framingham Risk Scores (FRS) with 10-year incidence of fatal CVD events in rural Tamil Nadu, India.</p><p><strong>Methods: </strong>Using a retrospective cohort study design, we analysed the association of baseline FRS categories assessed in 2011-12 through a STEPS risk factor survey, with CVD deaths over 10 years. Causes of death for the survey participants aged 30-64 years at baseline (2011-12), were obtained through established vital event surveillance, while baseline FRS CVD scores were calculated using original and published recalibration equations.</p><p><strong>Results: </strong>3418 participants (1480 males, 1938 females), free of CVD at baseline, were followed up for mortality for 10.22 years (median). The CVD mortality rate was 3.01 per 1000 person-years among males and 1.36 in females. Those with baseline original lipid-based FRS ≥20 % had higher CVD mortality risk (Hazard Ratio males: 11.18, 95 % CI: 4.67-26.79; females: 17.51, 95 % CI: 6.07-50.55) compared to those with scores <10 %, with similar results using recalibrated scores. Discrimination statistics (Harrell's C) were 0.755 and 0.751 for original and recalibrated lipid-based scores in males, compared to 0.734 and 0.842 in females.</p><p><strong>Conclusions: </strong>FRS had good predictive validity for cardiovascular mortality in a rural Indian population, confirming its clinical usefulness.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden cardiac death in young: A cardiac-focused autopsy and molecular study to identify the cause.","authors":"Sudheer Arava, Ansh Goswami, Jay Narayan Pandit, Surabhi Jain, Shivangi Dagar, Sunil Kumar Mallick, Kusuma Harisha, Nafees Alam, Abilash Srinivasamurthy, Reisha Rijal, Chittaranjan Behera, Abhishek Yadav, Jatin Bodwal, Amit Katiyar, Ambuj Roy, Ruma Ray","doi":"10.1016/j.ihj.2025.06.007","DOIUrl":"10.1016/j.ihj.2025.06.007","url":null,"abstract":"<p><strong>Introduction: </strong>Sudden cardiac death in young (SCDY) is a rare and important public health concern which needs to be addressed and documented. The present study was undertaken to identify the various cardiovascular causes and genetic factors leading to sudden cardiac death (SCD) in young individuals in North India.</p><p><strong>Methodology: </strong>All the suspected SCD cases meeting the inclusion criteria in the age group between 18 and 45 years, received at the forensic mortuary were studied over a period of four years (October 2019-November 2023). Detailed verbal and conventional autopsy, gross and microscopic examination of the heart with whole-exome genetic sequencing (WEGS) was performed to identify all the possible causes of death in these individuals.</p><p><strong>Results: </strong>A total of 59 cases were included. Mean age was 33.7 years with male predominance. Sudden unexplained death (SUD)/negative autopsy was the commonest (n = 21, 35.6 %), followed by coronary artery disease (CAD) with myocardial infarction (MI) (n = 17, 28.8 %) and structural cardiomyopathies (n = 15, 25.4 %). Hypertrophic cardiomyopathy (HCM) was the commonest structural cardiomyopathy. Congenital anomalies constituted 5 %. Isolated cases include myopericarditis, severe aortic stenosis, arrhythmogenic cardiomyopathy, post-partum cardiomyopathy, and cardiac rupture. Molecular yield in SUDs was 42.8 %. Sarcomeric genes (30.4 %) and Z-disk protein genes (21.7 %) constituted the most significant proportion, followed by genes associated with channelopathies and junctional proteins.</p><p><strong>Conclusion: </strong>Negative autopsy/SUD constituted the most common observation in sudden young deaths, followed by CAD/MI. Molecular autopsy in sudden unexplained deaths in young will give a definitive molecular yield of 14.3 %.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}