Indian heart journal最新文献

{"title":"Ultra-low thickness bio-degradable polymer Vs durable polymer Everolimus eluting stents - A 24 months clinical follow-up study.","authors":"Upendra Kaul, Pushpendra Kumar Garg, Rohit Chopra, Rahul Gupta, Vivek Mathur","doi":"10.1016/j.ihj.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.ihj.2025.10.005","url":null,"abstract":"<p><p>A multicenter observational study of 2,059 PCI patients compared the ultrathin-strut BDP-EES (Eternia) with the DP-EES (Xience) over 24 months. Patients in the Eternia group were older with more chronic total occlusions. MACE rates were 3.7% (Xience) vs 3.8% (Eternia; p=0.939), with no significant differences in mortality, TVR, or stent thrombosis. No definite or probable stent thrombosis was reported in either group, and possible thrombosis rates were low (0.3% vs 0.4%). These findings suggest that biodegradable and durable polymer platforms offer similar long-term performance. The Eternia stents demonstrated equivalent safety and efficacy to Xience stents at 24 months.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and functional outcome of fractional flow reserve guided management of triple vessel coronary artery disease.","authors":"G Keshava Murthy, A Jayachandra, Ribhu Goel, J Ratheesh Kumar, Vivek Guleria, R Ananthakrishnan, Inderjit Singh Monga","doi":"10.1016/j.ihj.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.ihj.2025.10.002","url":null,"abstract":"<p><strong>Background: </strong>Fractional Flow Reserve (FFR) helps to assess the functional significance of a coronary stenosis accurately, particularly in triple vessel disease (TVD) where other modalities are ineffectual. There is dearth of data using FFR in TVD. In this study, we assessed outcome of FFR guided management in a spectrum of TVD.</p><p><strong>Methods: </strong>A prospective observational study was conducted at four tertiary care hospitals of the armed forces between Aug 2019 and Aug 2023. Patients diagnosed with intermediate TVD on coronary angiogram (CAG) were included in the study. Initial treatment strategy based on CAG was noted. Treatment was reformulated based on FFR findings. Primary end points of death, myocardial infarction, repeat revascularization and stroke were evaluated at 3, 6 and 12 months.</p><p><strong>Results: </strong>145 patients were studied. 60 % presented with acute coronary syndrome (ACS). None of the mild stenosis (30-50 %) were found to be FFR positive in any of the vessels. 4.8 % lesions in LAD, 6.2 % lesions in LCx and 2.8 % lesions in RCA were found to be functionally non-significant despite having >70 % stenosis. Post FFR treatment variation was seen in 8.3 % in PCI group and surgery was averted in 33.3 % of CABG group. All-cause mortality was 3.5 %, 1.4 % had stroke and 1.4 % of patients required repeat revascularization. 83.5 % of all patients remained asymptomatic post intervention at 12 months follow-up.</p><p><strong>Conclusions: </strong>FFR guided management lead to change of plan in a substantial 15.2 % of patients when compared to CAG based management. FFR negativity in LAD was the main reason for majority of TVD patients ending up with PCI instead of CABG.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Age-adjusted Shock indices for Predicting In-hospital outcomes in percutaneously REvascularized ST-elevation myocardial infarction - ASPIRE-STEMI study.","authors":"Bryan Jacob Koithara, Ravi Kalra, Shashikala Sangle, Supriya Barsode, Shrikant Deshmukh","doi":"10.1016/j.ihj.2025.10.004","DOIUrl":"10.1016/j.ihj.2025.10.004","url":null,"abstract":"<p><p>The ASPIRE-STEMI study prospectively evaluated 236 patients with ST-elevation myocardial infarction undergoing percutaneous revascularization to validate Age-Shock Index (Age-SI) and Age-Modified Shock Index (Age-MSI) as alternatives to the GRACE score for predicting in-hospital major adverse cardiovascular events (MACE) and all-cause mortality. For MACE (n = 60), optimal cut-offs yielded sensitivities/specificities of 76.7 %/67 % (Age-SI ≥ 36.95), 85 %/56.2 % (Age-MSI ≥45.64), and 60 %/81.9 % (GRACE ≥127.5). For all-cause mortality (n = 17), optimal cut-offs yielded sensitivity/specificity of 82.4 %/83 % (Age-SI ≥46.83), 77 %/89 % (Age-MSI ≥67.35), and 94 %/76.7 % (GRACE ≥127.5). While each index independently predicted in-hospital outcomes, Age-SI and Age-MSI offer simple, bedside risk stratification in Indian STEMI patients post-PCI.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk profile among industrial workers in North India: A cross-sectional study.","authors":"Bishav Mohan, Akash Batta, Sarit Sharma, Tarun Satija, Geeti Puri Arora, Sarvotham Ramanathan, Anusha Singhania, Sumeet Sharma, Navneet Kishore, R K Soni, Gautam Singal, Anshuman Gupta, Rohit Tandon, Abhishek Goyal, Shibba Takkar Chhabra, Naved Aslam, Roopa Shivashankar, Kavita Singh, Meenkashi Sharma, Gurpreet Singh Wander","doi":"10.1016/j.ihj.2025.10.001","DOIUrl":"10.1016/j.ihj.2025.10.001","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) in industrial workers are a significant but overlooked public health problem, and present study was planned to assess the prevalence of risk factors related to CVDs in industrial workers, so that active interventions can be undertaken to decrease disease burden.</p><p><strong>Methodology: </strong>This cross-sectional, field-based survey was conducted among industrial workers in Ludhiana, following approval from the Institutional Ethics Committee. Random sampling of industries from the two industrial clusters was conducted, involving the collection of data on demography, migration status, anthropometric measurements, and cardiovascular risk factors by a trained task force. Quantitative data were described in terms of frequencies, range, and mean ± SD, whereas categorical data were compared by Chi square (χ2) test. A probability value less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Mean age of the industrial workers (n = 15527) was 34.95 ± 10.96 years, and 72 % of the workforce were from outside Punjab. On screening, 22 % (n = 3395) of the study population were hypertensive, and 4.1 % (n = 644) were diabetic (DM). Out of the hypertensives, 15 % (n = 503) were previously known to have hypertension (HT), whereas 85 % (n = 2892) were newly diagnosed during the study. Among previously known HT, 56 % had uncontrolled HT, and 45 % had uncontrolled diabetic status. Alcohol intake, chewing tobacco and smoking were the most common behavioral risk factors, whereas HT and DM were the most common Cardiovascular disease-related risk factors in the study population. Prevalence of HT and DM was found to be higher in native industrial workers as compared to the migrant workers. Age ≥30 years, male gender, substance abuse (alcohol and smoking) and increased BMI were significantly associated with HT and DM.</p><p><strong>Conclusions: </strong>Screening of the industrial workforce for cardiovascular risk factors is imperative to decrease the risk of CVDs, and it requires a multifaceted approach that combines workplace interventions, policy changes, and individual-level support.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Balloon-Expandable Transcatheter Aortic Valve Implantation: Device Evolution, Technique, and Post-Operative Care\".","authors":"Amit Kumar Chaurasia, Satyavir Yadav, Nitish Naik","doi":"10.1016/j.ihj.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.ihj.2025.09.009","url":null,"abstract":"<p><p>Transcatheter aortic valve implantation (TAVI) is the treatment of choice in elderly patients with severe symptomatic aortic stenosis. Though trials have shown positive results in low-risk patients, we should be cautious, as these trials were not all comer. Studies have also shown that early intervention helps in patients with asymptomatic severe aortic stenosis as well. The first device introduced was a balloon expandable (Edward Sapien), and a self-expanding (Medtronic CoreValve) device soon followed. Presently, multiple devices are available in both balloon expandable and self-expanding categories. This review provides a brief review of balloon expandable TAVI valves and stepwise approach for performing TAVI.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distributive shock in cardiac intensive care unit patients.","authors":"Sarvesh Pal Singh","doi":"10.1016/j.ihj.2025.09.008","DOIUrl":"10.1016/j.ihj.2025.09.008","url":null,"abstract":"<p><p>Shock is a life-threatening condition of circulatory failure. Mixed shock is observed in approximately 24.5 % of patients with cardiogenic shock. In cases of out-of-hospital cardiac arrest, outcomes are worse when the predominant shock type is distributive rather than cardiogenic. Thus, distinguishing between cardiogenic and distributive phenotypes is crucial for appropriate management. A dysregulated immune response has been observed in both. This review article details the pathophysiology, diagnostic challenges, and management of distributive shock when encountered in a cardiac intensive care unit.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary management of calcified coronary artery disease.","authors":"Nagendra Boopathy Senguttavan, Venkatakrishnan Ramakumar, Nitish Naik, Annapoorna Kini, Samin K Sharma","doi":"10.1016/j.ihj.2025.09.007","DOIUrl":"10.1016/j.ihj.2025.09.007","url":null,"abstract":"","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular imaging-guided drug-coated balloon treatment for coronary artery disease:Evidence and practice.","authors":"Atit A Gawalkar, Gary S Mintz, Nitish Naik","doi":"10.1016/j.ihj.2025.09.006","DOIUrl":"10.1016/j.ihj.2025.09.006","url":null,"abstract":"","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious agents, protein electrophoresis and immunoglobulin levels in patients with coronary artery ectasia.","authors":"Gulay Yetkin, Didem Tascioglu, Selcuk Ozturk, Bilal Cuglan, Kenan Yalta, Ertan Yetkin","doi":"10.1016/j.ihj.2025.09.004","DOIUrl":"10.1016/j.ihj.2025.09.004","url":null,"abstract":"<p><strong>Background: </strong>Although the mechanism of coronary artery ectasia (CAE) shares the common pathophysiologic steps resembling those of atherosclerosis, there are certain discrepancies or aspects incompatible with atherosclerosis. Therefore, we hypothesize that the pathophysiology of CAE might differ from that of atherosclerosis in terms of inflammatory parameters, infectious agents and the read out of protein electrophoresis.</p><p><strong>Materials and methods: </strong>Seventy patients with coronary artery disease (CAD) and 30 patients with both CAD and CAE comprised the study populations. Blood samples were centrifuged for the measurement of IgG antibodies against C.pneumoniae and H.Pylori, alongside with total IgE, IgG levels and protein electrophoresis.</p><p><strong>Results: </strong>There were not statistically significant differences between patients with and without CAE regarding the complete blood counting and routine biochemical laboratory parameters except hemoglobin levels. Among other studied laboratory parameters, IgE, Alpha 2 macroglobulin, Beta-1 globulin levels were found to be higher in patients with CAE + CAD than those of CAD alone. Logistic regression analysis by including the variables IgE, Hb, Alpha 2 macroglobulin, beta-1 globulin, and gender, revealed that Ig E (Odd ratio:1.004 85 % CI: 1.000-1.008, p = 0.01) and alpha 2 macroglobulin (Odds ratio: 9.41, 95 %CI: 1.69-52.28, p = 0.028) were independently and positively associated with the presence of CAE.</p><p><strong>Conclusion: </strong>Independent association of serum IgE levels and alpha2 globulins with the presence of CAE underlines the divergent features of pathophysiology of CAE compared with atherosclerosis or CAD alone. Comparable activity of humoral immunity measured by IgG antibody against C.Pneumoniae, and H. Pylori has suggested that these infectious agents do not play an additional role in the pathogenesis of CAE.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Institutional experience with ductus arteriosus stenting in neonates with duct dependent pulmonary circulation: Procedural outcomes & mid-term follow up.","authors":"Bhavik Champaneri, Abhay Pota, Tarun Parmar, Jigar Surti, Shilpa Deodhar, Amit Kungwani, Suresh Bishnoi, Amit Mishra, Trushar Gajjar, Shyam S Kothari","doi":"10.1016/j.ihj.2025.09.002","DOIUrl":"10.1016/j.ihj.2025.09.002","url":null,"abstract":"<p><strong>Objective: </strong>Ductal stenting (DS) has emerged as a critical intervention for neonates with duct-dependent pulmonary circulation (DDPC), offering a less invasive alternative to surgical shunts.</p><p><strong>Methods: </strong>This retrospective study evaluates the procedural and mid-term outcomes of neonatal DS at a high-volume tertiary cardiac centre between January 2018 and August 2023.</p><p><strong>Results: </strong>The study involved 124 symptomatic neonates. Primary outcomes included procedural success, defined as achieving post-procedural oxygen saturation (SpO2) ≥85 %, and survival to planned surgical repair. Secondary outcomes assessed included unplanned re-interventions, pulmonary artery growth, and all-cause mortality within 6 months. Success rate was 98.5 %. Total hospital stay was 3.17 ± 4 days. All-cause mortality was 8.9 %. Branch PA origin stenosis was found in 42 % cases on follow up.</p><p><strong>Conclusion: </strong>The study concludes that DS is a feasible and effective strategy in a variety of different cases of DDPC. Further research is needed to explore long-term outcomes and optimal stent selection based on individual patient characteristics.</p>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}