{"title":"Autosomal Dominant Polycystic Kidney Disease in Older Adults.","authors":"Henry H L Wu, Grahame Wood, Rajkumar Chinnadurai","doi":"10.25259/ijn_561_23","DOIUrl":"10.25259/ijn_561_23","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vijoy Kumar Jha, Ramanjit Singh Akal, Bhanu Pratap Singh, Gurpreet K Walia, Tejesh B S, Debasish Mahapatra
{"title":"Rhinovirus Pneumonia, Rhabdomyolysis-Induced Acute Kidney Injury, and Post-Viral Forme Fruste Lupus.","authors":"Vijoy Kumar Jha, Ramanjit Singh Akal, Bhanu Pratap Singh, Gurpreet K Walia, Tejesh B S, Debasish Mahapatra","doi":"10.4103/ijn.ijn_16_23","DOIUrl":"10.4103/ijn.ijn_16_23","url":null,"abstract":"<p><p>Viral interstitial pneumonia is rarely associated with rhabdomyolysis-induced acute kidney injury (AKI) and evolving systemic lupus erythematosus (SLE) with no lupus flare. Here, we report an adult male with human rhinovirus-associated viral pneumonia and rhabdomyolysis-related AKI requiring dialysis. He was detected to be anti-nuclear, anti-Smith, and anti-U1 ribonucleoprotein antibodies positive. His kidney biopsy revealed normal glomeruli, with immunofluorescence showing a full-house pattern. Renal function and lung function gradually improved to normal without any immunosuppressants.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11328052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46829608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priya Padmanabhan Mavoor, Sunil George, Ravindran Chetambath, M V Poornima
{"title":"A Rare Parasitic Infection from the Common Cockroach: A Case of Lophomonas Blattarum from a Tertiary Center in Kerala.","authors":"Priya Padmanabhan Mavoor, Sunil George, Ravindran Chetambath, M V Poornima","doi":"10.25259/ijn_520_23","DOIUrl":"10.25259/ijn_520_23","url":null,"abstract":"<p><p>Immunocompromised patients are prone to various opportunistic infections. Most of the infections are easily detectable through staining, culture, and polymerase chain reaction techniques. Nevertheless, it is also important to have wet smear examinations of samples. We present a case of pneumonia in a post-transplant recipient who was on immunosuppressants and detected to have an infection from the parasite, lophomonas blattarum, which usually resides in the hindgut of cockroaches.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Selvanathan, R. Parthasarathy, A. Rohit, Siddharth Venkataramanan, C. Dsouza
{"title":"Neutralizing Anti-SARS-CoV-2 Antibody Response to COVID-19 Vaccines—ChAdOx1-nCoV-19 and BBV152 Among Hemodialysis Patients","authors":"D. Selvanathan, R. Parthasarathy, A. Rohit, Siddharth Venkataramanan, C. Dsouza","doi":"10.25259/ijn_30_2024","DOIUrl":"https://doi.org/10.25259/ijn_30_2024","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Kidney Transplantation in a Young Male with Type 2 Xanthinuria.","authors":"Mahesh Kota, Rajasekara Chakravarthi Madarasu, Vijay Varma Penmetsa, Srinivas Gutta, Aniketh Naidu","doi":"10.25259/ijn_509_23","DOIUrl":"10.25259/ijn_509_23","url":null,"abstract":"<p><p>Type-II Xanthanuria is an genetic disorder associated with diminished serum uric acid levels. Patients with xanthanuria has absence of xanthine oxidase or xanthine dehydrogenase activity, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid. Deficiency of these enzyme leads to elevated levels of xanthine in urine which further leads to precipitation of xanthine in urine which further helps to formation of renal stones and ultimately leads to chronic kidney disease and end stage renal disease. We report a 23 years old male, who reached ESRD due to Type 2 xanthinuria, which was confirmed by genetic studies, who later successfully underwent renal transplant surgery and currently having normal life with functioning graft.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tushar J Vachharajani, V. Bhargava, Adrian Sequeira, P. Meena
{"title":"Existing and Evolving Therapies for Arteriovenous Fistula and Graft Dysfunction","authors":"Tushar J Vachharajani, V. Bhargava, Adrian Sequeira, P. Meena","doi":"10.25259/ijn_528_23","DOIUrl":"https://doi.org/10.25259/ijn_528_23","url":null,"abstract":"A functional vascular access (VA) is of paramount importance to patients on hemodialysis therapy. While arteriovenous fistula (AVF) remains the preferred VA, their long-term patency is unpredictable. A dysfunctional VA contributes to a high morbidity rate, an increased susceptibility to major adverse cardiovascular events, recurrent hospitalization, and a poor quality of life. The recent innovations in devices and technologies have significantly expanded our options to create and prolong VA patency. Endovascular devices such as WavelinQ and Ellipsys are recent additions to creating a VA. The endovascular creation of AVF helps reduce the wait time and potentially avoids or reduces the duration of catheter use. The bioengineered graft and immediate access arteriovenous graft offer reasonable alternatives in a select group of patients. There is growing evidence that covered stents and drug-coated balloons offer options to prolong the VA patency. Finally, the role of stem cell therapy in VA is currently being explored. This article presents a comprehensive review of the conventional and current developments in the management of a dysfunctional VA.","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joel Mathew John, Lam Samuel Prabhu Mithra, Yeddula Gnanendra Reddy, A. Selvaraj, Prabhu Premkumar, V. Samuel
{"title":"A Prospective Comparison of Outcomes of Brachiocephalic Versus Brachiobasilic Fistulas for Hemodialysis","authors":"Joel Mathew John, Lam Samuel Prabhu Mithra, Yeddula Gnanendra Reddy, A. Selvaraj, Prabhu Premkumar, V. Samuel","doi":"10.25259/ijn_367_23","DOIUrl":"https://doi.org/10.25259/ijn_367_23","url":null,"abstract":"\u0000\u0000Brachiocephalic fistula (BCF) and brachiobasilic fistula (BBF) are autogenous fistulas created in the arm for hemodialysis access. However, despite the differences in anatomy and surgical technique, the existing literature shows no significant statistical difference between the maturation, patency, or complications. We analyzed the outcomes of these two types of arteriovenous fistulas in our subgroup of the Indian population.\u0000\u0000\u0000\u0000A prospective observational cohort study was performed at a tertiary hospital from August 2019 to August 2021 between patients who underwent BCF and BBF. The time to maturation, 1-year primary patency, and postoperative complications were studied.\u0000\u0000\u0000\u0000Among the 236 patients, 137 and 99 underwent BCF and BBF, respectively. 53 (39%) and 37 (37.4%) patients were lost to follow-up at the end of 12 months in each arm, respectively. Each group comprised predominantly of males. There was no significant difference in age, diabetes, coronary artery disease, or peripheral arterial disease between the groups. The time to maturation within 6 weeks, more than 6 weeks, and non-maturation was 51.88% and 58.1% (p = 0.58), 38.67% and 32.55% (p = 0.04), and 9.43% and 9.3% (p = 0.74) in BCF and BBF groups, respectively. The 1-year primary patency, primary-assisted patency, and secondary patency were 69.04% and 53.22% (p <0.001), 78.3% and 59.6%, and 79.5% and 62.9% in BCF and BBF groups, respectively. Apart from venous hypertension (BCF:2(1.5%) vs BBF:7(7.1%), p = 0.026), there were no significant differences in the postoperative complications between the groups.\u0000\u0000\u0000\u0000BCFs take longer to mature but have greater primary patency than BBF. Both of these fistulas had similar postoperative complications. Larger randomized trials are needed to confirm our findings.\u0000","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sporadic Form of Glomerulocystic Kidney Disease in a Child: A Case Report.","authors":"Navpreet Kaur, Pradeep D, Ritambhra Nada, Anmol Bhatia, Lesa Dawman, Karalanglin Tiewsoh","doi":"10.4103/ijn.ijn_43_23","DOIUrl":"10.4103/ijn.ijn_43_23","url":null,"abstract":"<p><p>Glomerulocystic kidney disease (GCKD) is a rare form of cystic renal disease. We report a four-week-old baby girl born to non-consanguineous parents; their antenatal third-trimester ultrasound showed severe oligohydramnios that required amnioinfusion. Post-natal ultrasound examination showed few tiny cysts (2-3mm) involving the cortices in bilateral kidneys. Kidney biopsy showed dilatation of Bowman's space and cystically dilated glomeruli, suggestive of GCKD. Whole exome sequencing revealed no pathogenic or likely pathogenic variant.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47590449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Podocyte Infolding Glomerulopathy Masquerading as Membranous Nephropathy - A Shared Pathogenesis?","authors":"Smita Mary Matthai, Liam Hems, Yee Wah Tsang, Yogita Aggarwal, Huda Mahmoud, Kishore Gopalakrishnan","doi":"10.25259/ijn_209_23","DOIUrl":"10.25259/ijn_209_23","url":null,"abstract":"<p><p>Podocyte infolding glomerulopathy (PIG) is a rare pathological entity, diagnosed by electron microscopic demonstration of diffuse infolding of the podocytes into the glomerular basement membranes. We report the first case from United Kingdom exhibiting typical ultrastructural features of PIG in a male with Type II diabetes mellitus, hypertension and common variable immune deficiency. Renal biopsy revealed phospholipase A2 receptor (PLA2R) immunostain positive membranous nephropathy (MN) but no serum PLA2R antibodies. Diffuse infolding of the podocytes into the glomerular basement membranes along with pathognomonic microspherular and microtubular intra basement membrane clusters distributed diffusely and globally were noted on electron microscopy, diagnostic of PIG. We postulate a shared pathomechanistic link between PIG and MN, highlighting the overlapping features of both conditions.</p>","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CV Malathi, S. V. Rajkumar, K. S. J Prema, A. Kurien
{"title":"Osseous Metaplasia in Renal Allograft","authors":"CV Malathi, S. V. Rajkumar, K. S. J Prema, A. Kurien","doi":"10.25259/ijn_527_23","DOIUrl":"https://doi.org/10.25259/ijn_527_23","url":null,"abstract":"","PeriodicalId":13359,"journal":{"name":"Indian Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}