Indian Journal of Medical Research最新文献

{"title":"Efficacy & safety of stem cell therapy for treatment of acute myocardial infarction: A systematic review & meta-analysis.","authors":"Pravesh Aggarwal, Ranu R Oza, Hitendrapal Solanki, Jaykaran Charan, Rimple Jeet Kaur, Surender Deora, Lokesh Saini, Deepak Kumar, Rahul Choudhary, Pankaj Bhardwaj, Tanuj Kanchan, Siddhartha Dutta","doi":"10.25259/IJMR_2185_2024","DOIUrl":"10.25259/IJMR_2185_2024","url":null,"abstract":"<p><p>Background & Objectives Stem cell based therapeutic treatments have been used as a management strategy for acute myocardial infarction (AMI), a common primary factor causing death globally. We aimed to undertake a meta-analysis of studies including randomised controlled trials (RCTs) examining different stem cell preparations in AMI, as a definitive answer from this therapeutic approach is yet to emerge. Methods Following PROSPERO registration (CRD42024628552), a systematic search was conducted through PubMed database, Embase, Cochrane, and Web of Science. Data was analysed using RevMan 5.4.1. Primary outcomes included all-cause mortality, recurrent myocardial infarction (Re-MI), severe adverse events (SAEs), hospitalisation for heart failure, cancer incidence, and left ventricular ejection fraction (LVEF). A fixed-effect model was used to assess six outcomes: all-cause mortality, Re-MI, SAEs, heart failure hospitalisation, cancer incidence, and stroke. A model based on random effects depending on heterogeneity was used to assess LVEF. Results From 9,516 records, 48 studies were included for analysis based on available endpoints. No notable changes in all-cause mortality were observed between patients receiving stem cell therapy and those in the control group, according to the meta-analysis. [Risk Ratio (RR) 0.73], SAEs (RR 0.93), Re-MI (RR 0.67), HF-related hospitalisation (RR 0.79), cancer (RR 0.82), or stroke (RR 0.81). Echocardiographic LVEF improved significantly at study end [Mean difference (MD) 2.53%] and difference from baseline (MD 3.89%), with high heterogeneity (I2 - 76%). MRI-assessed LVEF showed no significant change at study end (MD 0.83%) but improved from baseline (MD 1.37%). Heterogeneity was low except for LVEF, with serious bias risk for most outcomes and very serious for Re-MI and SAEs, though their objective nature limits bias Interpretation & conclusions Analysis done found no significant benefit of stem cell-based therapies on clinical endpoints in AMI patients.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"647-664"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of peripheral neuropathy in type 2 diabetic adults in central Kerala: A cross-sectional study.","authors":"Kripa Soman, Anitha Bhaskar, Geetha Devi M, Sobha A, Sairu Philip, Ashish T, Rajina K R","doi":"10.25259/IJMR_1779_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1779_2024","url":null,"abstract":"<p><p>Background & objectives Diabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of diabetes mellitus. It is usually insidious in onset, sometimes asymptomatic, predisposing to foot ulcers, muscle and joint diseases. This results in severe disability and impaired quality of life. Hence, this study undertook to estimate the prevalence of DPN among diabetic individuals aged 30 yr and above in Ettumanoor municipality and to explore association with selected factors. Methods A semi-structured interview and examination was conducted among 526 diabetic individuals aged 30 yr and above through cluster sampling. DPN was assessed using the Michigan Neuropathic Screening Instrument (MNSI). Data was coded and entered in MS Excel and analysed using IBM SPSS software version 20. Results Mean age of study participants was 62.72 +/-9.01 yr with a median duration of diabetes of seven years, with an IQR of 10 yr. Prevalence of DPN as per the MNSI Examination tool was found to be 34.2 per cent [95% confidence interval (C.I.): 30.2-38.4]. In binary logistic regression, factors found to be independent predictors of DPN were age above 60 yr, education below high school education, unemployed status, height >160 cm, insulin use, and presence of nephropathy. Interpretation & conclusions Prevalence of DPN among the study population was found to be 34.2 per cent. It was found to be associated with various sociodemographic factors, treatment-related factors, other co-morbidities, and microvascular complications. Overall, it is suggested based on the findings that community-based initiatives are necessary for the timely screening, diagnosis, and treatment of DPN.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"710-717"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of circulating p38 inhibited cutaneous squamous cell carcinoma-associated long non-coding RNA in rheumatoid arthritis: A descriptive study.","authors":"Vinit Sharma, Aditya Aggarwal, Justin Jacob, Mayank Sharma, Shivangani Lohani, Ankita Semwal, Ankita Arora, Sakshi Bansal, Anjali Aggarwal","doi":"10.25259/IJMR_2109_2024","DOIUrl":"https://doi.org/10.25259/IJMR_2109_2024","url":null,"abstract":"<p><p>Background & objectives Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint destruction. Long non-coding RNAs (lncRNAs) have emerged as key regulators in RA pathogenesis. This study explores the serum expression of p38-inhibited cutaneous squamous cell carcinoma-associated lncRNA (PICSAR lncRNA) as a potential non-invasive biomarker for RA. Methods PICSAR lncRNA expression was measured in serum samples from 36 individuals with RA and 20 healthy individuals using qRT-PCR over a 24 h time course. Correlation analyses with demographic and biochemical parameters, American College of Rheumatology (ACR) scores, and ROC analysis were conducted to evaluate the diagnostic potential of PICSAR lncRNA. Results We observed significant upregulation of PICSAR lncRNA in individuals with RA at 0 h (448.9±358.6, P=0.0059) and 6 h (202.0±121.2, P=0.0005) compared to healthy individuals, with stable levels maintained up to 24 h. The ROC analysis yielded a substantial AUC value of 0.74 for PICSAR lncRNA in individuals with RA. In females with RA, PICSAR lncRNA levels showed a positive correlation with ACR scores and a negative correlation with age. Interpretation & conclusions PICSAR lncRNA is implicated in RA pathogenesis and may serve as a potential non-invasive diagnostic biomarker for RA.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"738-743"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, treatment patterns, & outcomes of heart failure: A comparative analysis across age groups from the heart failure registry in India.","authors":"Deepadarshan Huliyappa, Vani Srinivas, Vaitheeswaran Kulothungan, Ravichandran Edwin, K S Sadananda, Rama Chandra Barik, Rajeev Marwaha, Pramod Kumar Pareek, Prashant Mathur","doi":"10.25259/IJMR_1931_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1931_2024","url":null,"abstract":"<p><p>Background & objectives Heart failure is a major health burden globally. While the prevalence of heart failure is increasing, limited research has focused on the specific characteristics and outcomes of patients with heart failure belonging to different age groups in India. This study aimed to describe the clinical characteristics, treatment patterns and outcomes of patients with heart failure in India with a focus on comparing these aspects among young (16 to 40 yr), middle-aged (41-64 yr), and elderly (≥ 65 yr) individuals. Methods A multicentre, hospital-based study was conducted in five small- to medium-sized cities in India. Participants included admitted cases of heart failure between June 2018 and March 2022. Demographic and clinical information, including comorbidities, and data on aetiology, treatment, and outcomes, were collected using a standardised proforma. Statistical analyses were conducted to compare variables across age groups. Results Out of 6018 participants, 613 (10.2%) were young adults, 3207 (53.3%) were middle-aged, and 2198 (36.5%) belonged to the elderly age group. Most of the patients (>60%) were from rural areas. Ischemic heart disease (IHD) was the most common aetiology across all three age groups (52.4%, 75.1%, and 76.9%), and the 90-day mortalities for the three age groups were 12.6, 13.4 and 19 per cent, respectively. Young patients presented with milder symptoms, distinct aetiologies, and fewer comorbidities than older age groups. Treatment patterns varied across age groups. Young patients had longer hospital stays and higher in-hospital mortality rates. However, long-term mortality rates were higher among the older age groups. Interpretation & conclusions This study provides valuable insights into the clinical characteristics, treatment patterns and mortality rates of individuals with heart failure in India, particularly from rural areas. The findings highlight the need for tailored approaches for different age groups in the prevention and management of heart failure, with a special focus on the young and rural population.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"609-616"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence & determinants of soil-transmitted helminth infection among 1-15 year-olds in a tribal-dominated district of Odisha, India.","authors":"Sunil Kumar Sethi, Nityananda Mandal, Manisha Jnyanajyoti, Srikanta Kanungo, Sudhansu Sekhar Gouda, Ananya Anurakta Pattanaik, Khushboo Sharma, Harpreet Kaur, Debdutta Bhattacharya, Subrata Kumar Palo, Sanghamitra Pati","doi":"10.25259/IJMR_1457_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1457_2024","url":null,"abstract":"<p><p>Background & objectives Soil-transmitted helminth (STH) infections are a significant public health concern, affecting over 1.5 billion people worldwide. STH infection among children leads to stunted growth, impaired cognitive development, and reduced productivity. In India, while multi-prong efforts are being made to control STH infections including mass drug administration (MDA) programme, the problem is still prevalent. This study aimed to investigate the prevalence, type of STH and determinants associated with STH infection among children (1-15 yr) in a tribal dominated district of Odisha, India. Methods A cross-sectional survey was carried out among 2320 children aged 1-15 yr in the Nabarangapur district of Odisha, sampling 30 clusters from five blocks using the Probability Proportional to Size (PPS) method. Participants were randomly selected from each cluster for screening, which included anthropometric measurements to assess nutritional status and cognitive evaluation using the Vineland Maturity Test scale (VSMS). Morning stool samples from 1927 children were collected, processed and examined microscopically to detect STH infections and Kato Katz thick smear technique was used for STH-positive cases to count the eggs. Results Of the 1927 children, 255 (13.2%) were found infected with one or more STH species. Among the STH positives, hook worm was the most common with a prevalence of 71.3 per cent, followed by Ascaris lumbricoides (round worm) at 28.2 per cent. The mean age (±standard deviation) of STH positive children was 6.5 (± 3.29) yr. Practicing open defecation, was significantly associated with higher STH infection rate. Based on the egg count of STH-positive cases, majority (90.5%) had mild infection, 4.7 per cent moderate and 4.3 per cent severe infection. Interpretation & conclusions The present study indicated that school-going children in the study setting, especially from tribal areas, carried considerable risk of STH infection. Identifying the prevalent risk factors, developing multi-prong integrated strategies could be effective in preventing and controlling STH infection in these areas. The interventions need to focus on improving awareness on STH, ensuring hygiene and sanitation practices and compliance to biannual administration of albendazole under health programmes.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"617-626"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a novel bundled information, education, & communication video on preoperative anxiety in paediatric patients: A randomised controlled trial.","authors":"Rishabh Jaju, Pooja Bihani, Naveen Paliwal, T Mirthun Thomas","doi":"10.25259/IJMR_1800_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1800_2024","url":null,"abstract":"<p><p>Background & objectives Preoperative anxiety affects 40-75 per cent of children undergoing surgery, leading to postoperative complications. While pharmacological methods have limitations, informational videos have shown promise in reducing anxiety. This pilot study aimed to evaluate the impact of a novel Hindi animated Information, Education, and Communication (IEC) video on preoperative anxiety in Indian children undergoing elective surgeries. The study hypothesised that the video would significantly reduce anxiety scores. Methods A pilot randomised controlled trial was conducted with 30 children aged 5-10 yr scheduled for elective surgeries under general anaesthesia. Participants were randomly assigned to a video intervention group (VI) or a control group (C). Baseline and preoperative anxiety were measured using the Modified Yale Preoperative Anxiety Scale (m-YPAS), Child Fear Scale (CFS), and State-Trait Anxiety Inventory (STAI) for parents. Postoperative emergence delirium and behavioural changes were assessed using the Paediatric Emergence Delirium (PAED) score and Post-Hospitalisation Behaviour Questionnaire (PHBQ). Results Children in the VI group showed significantly lower preoperative anxiety (m-YPAS: 47.9 (10.23) vs. 77.08 (8.38); P<0.001) and heart rates compared to the C group. CFS and STAI-S scores were also significantly lower in the VI group. Although the VI group showed reduced anxiety, there was no significant impact on emergence delirium or postoperative behaviour by day 30. Interpretation & conclusions The Hindi animated IEC video effectively reduced preoperative anxiety in children, highlighting the need for culturally and linguistically appropriate interventions. However, its impact on postoperative outcomes requires further investigation with a larger sample size.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"593-599"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of adverse events associated with medical devices among respiratory disorder patients at a tertiary care hospital.","authors":"Sasikasri Veeramani, Sri Ram Murugesh, Girish A M, Shilpa Palaksha","doi":"10.25259/IJMR_1755_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1755_2024","url":null,"abstract":"<p><p>Background & objectives Medical devices (MDs) play a vital role in delivering healthcare to critically ill individuals, which sometimes may also lead to adverse events ranging from serious to non-serious. So, this study was undertaken to assess the pattern of adverse events associated with MDs among individuals with respiratory disorder and to determine the predictors associated with MD related adverse events. Methods A cross-sectional study was carried out among individuals with respiratory disorders admitted to the Intensive Care Unit of a tertiary care teaching hospital between August 2022 and July 2023. Individuals were monitored for MD-related adverse events (MDAEs) daily through interviews, case-sheet reviews, and interaction with healthcare professionals. The reported MDAEs were assessed for causality, severity, and device disposition based on the Materiovigilance Programme of India (MvPI). The MDAEs were assessed, categorised, and presented based on MDs, device risk classification, and type of events. The predictors were calculated at 95 per cent confidence interval (CI) using Chi-square tests. Results A total of 152 MDAEs were reported among 90 individuals; the majority were males [60 (66.7%)], and elderly between the ages of 61-70 yr experienced the majority of MDAEs [20 (22.2%)]. Ventilator-associated pneumonia (VAP) was higher among mechanical ventilator users [59 (38.8%)] with non-implantable devices [114 (75%)]. Regarding device risk classification [106 (69.7%)], category C was frequently reported. The causality assessment revealed that the majority of events were categorized as 'probable' [84 (55.2%)]. Subsequently, the severity of the events was classified based on criteria such as death, life-threatening conditions, disability, hospitalization, or the need for intervention to prevent permanent impairment. Among the total MDAEs, 118 (77.6%) were classified as non-serious, while 34 (22.4%) were identified as serious. Almost all MDAEs [71 (46.7%)] were device-associated and were disposed off within healthcare facilities [96 (63.2%)]. In terms of patient outcomes, 141 participants (92.7%) achieved recovery. The presence of comorbidities and hyperpolypharmacy significantly affected the adverse events caused by the MDs [P=0.04]. Interpretation & conclusions MDAEs among individuals with respiratory disorder compromise the prognosis and complicate therapeutic outcomes. Individuals with a comorbid condition and hyper polypharmacy experienced significantly high MDAEs suggesting that such individuals, should be monitored for early detection of MD associated adverse drug events to restrict their implications on patient care.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"672-678"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' response.","authors":"Vani Srinivas, Vinay Urs, Suresh Kumar N, Narendra Kumar Arora, Pankaja Raghav, Sarangi Das, Abhiruchi Galhotra, Praveen Kulkarni, Binod Kumar Patro, Ananth Ram, Swetha R, Saurabh Singh, Pradeep Joshi, Ravivarman Lakshmanasamy, Prashant Mathur","doi":"10.25259/IJMR_1758_2025","DOIUrl":"https://doi.org/10.25259/IJMR_1758_2025","url":null,"abstract":"","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 6","pages":"749-750"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exome sequencing uncovers promising candidate genes for foetal structural malformations.","authors":"Digumarthi Vs Sudhakar, Shaini Joseph, Vandana Bansal, Akshay Gangurde, Neha Nitin Minde, Harshvardhan Gawde, Shailesh Shankar Pande","doi":"10.25259/IJMR_1318_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1318_2024","url":null,"abstract":"<p><p>Background & objectives Prenatal ultrasonography in the first and second trimesters detects foetal structural anomalies in up to five per cent of pregnancies. These anomalies are often suspected to have a genetic cause. While conventional genetic tests such as karyotyping, fluorescent in situ hybridisation (FISH), and chromosomal microarray (CMA) have been used alongside whole-exome sequencing (WES), their combined diagnostic yield in malformed foetuses is limited to 40 per cent, leaving most cases undiagnosed. This study aimed to identify novel genetic factors linked to foetal structural malformations. Methods A total of 44 medically terminated foetuses were included in this study with severe structural malformations from a maternity hospital in the western part of India. We performed a comprehensive genetic analysis of products of conception (POC) employing karyotyping, FISH, CMA (750K resolution) and WES. Further, in cases with inconclusive genetic findings, we reanalysed the WES data using our in-house analysis pipeline and Exomiser (v13.2.1). Results Genetic anomalies identified among the 44 foetuses included trisomy 21 (n=4), trisomy 13 (n=3), and XXY mosaicism 47 (n=1) in 18.1 per cent (8 out of 44) of the cases. Further, CMA identified CNVs in 13.6 per cent (n=6) cases, of which five cases showed pathogenic CNVs. With the inclusion of WES, the diagnostic yield increased by 4.5 per cent. We reanalysed the WES data and identified six potential candidates, including RUNX2 (spinal dysraphism), PALLD (Arnold-Chiari malformation), KMT2D (Holoprosencephaly), FBN2 (structural heart and spine defects), CPLANE1 (Dandy-Walker malformation), and KMD1A (structural brain abnormality). Interpretation & conclusions This study summarises the findings of genetic evaluation of malformed foetuses in a low-resource setting, which caters to low-income groups of society. The candidate genes reported in this study offer scope for functional studies in relevant animal models to establish genotype-phenotype correlation.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 5","pages":"510-520"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development & validation of a health education module on menstrual health for adolescent girls: A Pilot study.","authors":"Anusha Rashmi, Farzana Ummer B K","doi":"10.25259/IJMR_1408_2024","DOIUrl":"https://doi.org/10.25259/IJMR_1408_2024","url":null,"abstract":"<p><p>Background & objectives Adolescent females must practise proper menstrual hygiene to avoid any misconceptions or myths about the menstrual cycle. A health education module for a school-based intervention was created with the goal of enhancing knowledge among adolescents. The study was conducted to develop and validate a health education module and to assess the feasibility of the module. Methods Following a thorough literature review, a module pertaining to various components of menstrual health for adolescent females was developed. The developed module was validated by experts. Ratings provided were used to calculate content validity index (CVI) for items, CVI for scale (S-CVI) and Universal agreement (UA). The final module was pilot tested at two schools using random sampling. Results For computation of the content validity index (CVI) [CVI for item (I-CVI) and CVI for scale (S-CVI)] and Universal agreement (UA) was used. S-CVI/Ave was found to be 1, and S-CVI/UA was found to be 1. UA was 1, and I-CVI was 1. Post health education, there was a significant increase in knowledge scores among participants (P<0.001). Among adolescents, 74.6 per cent agreed that the tables/diagrams were well presented and easy to understand and 83.6 per cent of participants comprehended the various self-care practices during the menstrual cycle. Based on the computations from the formulas employed, the module was found to be satisfactory for usage. Almost all the adolescent participants had rated either 4 or 5 on the Likert scale for acceptance of the module. Interpretations & conclusions The I-CVI, S-CVI/Ave, and S-CVI/UA meet the satisfactory level, meaning that the module's content validity was at a satisfactory level. There was a noteworthy rise in knowledge scores (P<0.001) post health education. The participants gave the module positive feedback and reported that it increased their understanding regarding menstruation.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"161 5","pages":"473-481"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}