Indian Journal of Medical Research最新文献

{"title":"ICMR-MDRF Diabetes Biosamples: Cohort profile.","authors":"Ranjit Mohan Anjana, Mohan Deepa, Rajendra Pradeepa, Anandakumar Amutha, Kothandapani Sridevi, Sekar Sathishraj, Sadasivam Menaka, Santhappan Vijayabaskar, Nirmal Elangovan, Kumar Parthiban, Lakshamanan Dhanasekaran, Saite Hemavathy, Nikhil Tandon, Tanvir Kaur, Rupinder Singh Dhaliwal, Ranjit Unnikrishnan, Viswanathan Mohan","doi":"10.25259/IJMR_1036_2024","DOIUrl":"10.25259/IJMR_1036_2024","url":null,"abstract":"<p><p>Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR). The ICMR-INDIAB study is the largest epidemiological study on diabetes in India, encompassing a nationally representative sample of individuals aged 20 yr and older from urban and rural areas in every State across the country. The ICMR-YDR is the first national-level, multicentric clinic-based registry focusing on youth-onset diabetes in India, aiming to understand the disease patterns and variations in youth-onset diabetes across different country regions. Results Key operations at the MDRF biobank include collecting and processing samples, where serum and whole blood samples are aliquoted and transferred through a cold chain to the central laboratory, and then stored in Siruseri (29 km from the capital city of Chennai, Tamil Nadu). Samples are barcoded, linked to subject information, and stored in freezers or liquid nitrogen (LN2) vessels, with inventory tracked via software for easy retrieval. A register records access to the biobank, ensuring sample integrity and compliance with regulatory requirements. The biobank adheres to the ICMR's National Ethical Guidelines for Biomedical and Health Research involving human participants. Interpretation & conclusions The biobank enables the analysis of biomarkers in stored samples, aiding in scientifically sound decisions, treating patients, and potentially curing diabetes.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"514-526"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cascade of care for people with positive symptoms of common cancers in selected primary health centres of Puducherry: An explanatory mixed-method study.","authors":"Srijeeta Mitra, Swaroop Kumar Sahu, Subitha Lakshminarayanan, Kalaiarasi Raja, Sunitha V C","doi":"10.25259/ijmr_34_24","DOIUrl":"10.25259/ijmr_34_24","url":null,"abstract":"<p><p>Background & objectives Cancer is a leading cause of death worldwide and constitutes a public health priority. Delays in diagnosis and treatment of cancer can adversely impact survival, recovery, and cost of treatment. The objective of this study was to estimate the proportion seeking timely care among those having early warning signals for oral, breast or cervical cancer and to explore the facilitators and barriers to early detection. Methods The study was conducted among 241 participants, including those having early signals for selected cancers and women who underwent opportunistic cervical cancer screening in the selected health facilities. Information regarding symptom appearance, presentation to any registered medical practitioner, confirmatory diagnosis, and treatment initiation were obtained from medical records. In-depth Interviews (IDIs) were conducted among six participants to explore facilitators and barriers to cancer detection. Results Among 7300 people screened using the Community Based Assessment Checklist (CBAC), 128 (1.7%) had warning signals for any one of the cancers. The percentage of people who sought medical care for oral, breast and cervical cancer symptoms were 80 per cent, 82 per cent and 57 per cent, respectively. Among those who underwent opportunistic cervical cancer screening in health centres (113), the screen positivity rate was 11 per cent, and adherence to referral for confirmation was 80 per cent. The median pre-diagnostic and diagnostic delays for the three cancers were 79 [Interquartile range (IQR): 44-126] and 27 (IQR: 13-73) days. One individual was diagnosed with oral cancer, and the treatment delay was 27 days. Facilitators identified for early seeking of care were encouragement by family and low-cost treatment at public facilities. Major barriers identified were neglect of symptoms by participants and their responsibilities towards family. Interpretation & conclusions Although very few people were identified to have early warning symptoms using CBAC, a substantial proportion of them sought medical care and underwent confirmatory diagnosis. Screen positivity rate and treatment-seeking behaviour were better among women undergoing opportunistic cervical cancer screening in the health centres. Measures need to be taken to improve health literacy among people to reduce diagnostic delay for cancers.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"457-465"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of cancer pattern in 2020 & prediction to 2040 among older adults.","authors":"Manoj Kalita, Devaraja M, Indranil Saha, Amit Chakrabarti","doi":"10.25259/ijmr_1729_23","DOIUrl":"10.25259/ijmr_1729_23","url":null,"abstract":"<p><p>Background & objectives Cancer is one of the leading causes of death among older adults worldwide. The global burden of cancer among older individuals is increasing due to the ageing population. The increasing burden of cancer among older adults will pose significant social and economic challenges for the delivery of healthcare services. Materials Estimated cancer new cases, deaths, age-standardized truncated incidence and mortality rate per 100,000 for older adults (60 yr or above) were reported using GLOBOCAN 2020 estimates (gco.iarc.fr). Mortality to Incidence ratio (M/I ratio) expressed in percentage by gender and continent was provided. Results Globally, of all cancer cases, 11.3 million cases (representing 62.3%) and 7.5 million deaths (representing 71.2%) were seen among older adults. The top five leading sites of cancer account for 62.2 per cent of older men and 55.9 per cent of older women; however, a widespread geographical variation across world regions is observed. The number of new cancer cases among older adults is expected to rise from 11.3 to 19.8 million (a 75.2% increase) and deaths from 3.99 to 7.3 million (82.8% increase) by 2040. Interpretation & conclusions The expected rise will bring exceptional challenges to healthcare systems, especially in lower- or lower-medium-income countries where resources are limited. Data on cancer among older adults will help health planners and policymakers develop global geriatric cancer control policies.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"397-406"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of T cell responses by anesthetic drugs-propofol & isoflurane in perioperative breast cancer patients: A prospective hospital-based study.","authors":"Priyanka Saha, Deepanwita Das, Santosh Kumar Behera, Deepak Bhatia, Sunil Kumar, Srabanti Hajra, Dipkana Das, Deepa Chakrabarti, Dona Sinha","doi":"10.25259/jmr_2382_23","DOIUrl":"10.25259/jmr_2382_23","url":null,"abstract":"<p><p>Background & objectives The choice of anesthetic for better perioperative conservation of immune responses has always been contentious. This study investigated the differential impact of the intravenous anesthetic, propofol, and the volatile anesthetic, isoflurane on the T cell immune responses, if any, among individuals going through perioperative breast cancer. Methods Perioperative blood samples (preoperative, intraoperative and postoperative) collected from participants with breast cancer in two arms namely isoflurane arm (n=50) and the propofol arm (n=50) were analyzed for T cell immune response using flow cytometry and ELISA. The interactions of anesthetics with CD4/CD8 were probed with molecular docking and molecular dynamic (MD) simulations. Results Linear mixed model analysis showed that isoflurane in comparison to propofol inhibited CD4+ helper (Th) [β-coefficient: -8.75; 95% CI: -13.00 to -4.51] and CD19+ B cell (β: -7.51; 95% CI: -15.46 to 0.44) frequencies during the intraoperative period in perioperative breast cancer patients. Further, interleukin (IL)-10 and IL-12 were significantly increased during the intra- and postoperative periods in the isoflurane group as compared to the propofol group. Molecular docking (MD) validated propofol's better binding energy with CD4/CD8 than isoflurane. MD simulations propagated that in contrast to isoflurane, propofol formed a more compact and stabilized structure with CD4/CD8, making the amino acid residues on the surface of CD4/CD8 inaccessible for any interaction. Interpretation & conclusions The clinical observations and the in silico findings exhibited that propofol in comparison to isoflurane better regulated T cell immuno-inflammatory response in perioperative breast cancer patients.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"489-500"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-the-spot spirometry & combined salbutamol & glycopyrronium reversibility testing in obstructive airway disease: A real-world appraisal.","authors":"Parthasarathi Bhattacharyya, Srijita Sen, Shuvam Ghosh, Debkanya Dey, Sayoni Sengupta, Sayanti Karmakar, Dipanjan Saha, Avishek Kar, Rajat Banerjee","doi":"10.25259/ijmr_2404_23","DOIUrl":"10.25259/ijmr_2404_23","url":null,"abstract":"<p><p>Background & objectives Spirometric glycopyrronium responsiveness, a new advent, needs to be examined at in terms of degree and frequency in different obstructive-airway diseases diagnosed in real world practise. Methods Serial and willing symptomatic affected individuals of suspected airway disease underwent a pragmatic post-consultation spirometry-protocol on the same day with salbutamol followed by glycopyrronium bromide. The diagnosis of asthma (FEV1-reversibility ≥ 200 ml + 12%), chronic obstructive pulmonary disease (COPD) (FEV1/FVC<0.7 and FEV1-reversibility <200 ml and/or 12%), and 'unclassified' (neither asthma nor COPD) were determined on post-salbutamol changes. The performances of the two classes of bronchodilators were compared on FVC, FEV1/FVC, FEV1, and FEF-25-75 while the relative frequency of significant responsiveness for salbutamol (≥200 ml) and glycopyrronium (≥100 ml) were noted. Results Fifteen hundred and eighty study participants consisting of asthma (n=329; 21%), COPD (n=641; 40%), and 'unclassified' (n=610; 39%) were included. Both salbutamol and glycopyrronium had demonstrated improvement across the spirometric parameters. The salbutamol responsiveness was statistically significant in all but COPD in terms of absolute values of FEV1, FEV1/FVC, and FEF25-75 and the glycopyrronium responsiveness was significant in all plus COPD in FVC, FEV1, and FEF25-75 values. While all the asthmatics, 9.83 per cent of 'unclassified' study participants, and none of the COPD affected individuals had significant FEV1 responsiveness to salbutamol, the glycopyrronium responsiveness for the three conditions were 38.3, 40.25 and 24.26 per cent, respectively. The combined reversibility for asthma, COPD, and unclassified were 401.5±173.9, 119.5±109.3, and 158.7±136.3 ml, respectively. Interpretation & conclusions Spirometry with serial salbutamol and glycopyrronium responsiveness may prove helpful in identifying syndromic diagnosis and choosing the bronchodilator treatment of airway diseases.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"439-447"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in dengue virus positivity & serotyping in Rajasthan.","authors":"Pratibha Sharma, Bharti Malhotra, Himanshu Sharma, Neha Bhomia, Farah Deeba, Anjana Kuldeep, Khushbu Trivedi, Jitendra Tiwari, Harmanmeet Kaur, Neetu Vijay","doi":"10.25259/ijmr_1343_23","DOIUrl":"10.25259/ijmr_1343_23","url":null,"abstract":"<p><p>Background & objectives Dengue virus causes frequent outbreaks and epidemics with high morbidity and mortality. It is important to monitor the trends of the dengue virus and its serotypes. We carried out the present work to study the prevalence of the dengue virus and its serotypes in clinically suspected cases of dengue in Rajasthan. Methods A total of 1,47,777 individuals reporting as pyrexia of unknown origin or clinically suspected of dengue infection were included in this study. The presence of dengue NS1 antigen and dengue IgM was tested by ELISA. Nucleic acid extraction and PCR was done for detection of dengue virus RNA. Serotyping of representative dengue PCR-positive samples was done by real time PCR. Results Of the 1,47,777 dengue suspected cases, 28092 (19.01%) were positive for dengue by NS1antigen or IgM ELISA. Year-wise percentage positivity from 2015 to 2022 was 30.42, 16.49, 17.81, 20.15, 20.50, 9.25, 24.55 and 15.16 per cent, respectively. Males of age >15 yr were found to be more commonly affected. The number of dengue cases was significantly higher during the post-monsoon period throughout the eight-year study period. All four dengue serotypes circulated during the study period. DENV-2 and DENV-3 were the predominant serotypes during 2015 to 2017, while DENV-1 and DENV-2 were predominant during 2018 to 2022. Interpretation & conclusion The findings of this study suggest that the dengue positivity in Rajasthan was the highest in post-monsoon season among adult males. The serotype prevalent varied from time to time and was helpful in understanding the changing epidemiology of DENV.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"479-488"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 antibodies in breast milk of women given one & two doses of COVID-19 vaccine.","authors":"Sheetal Verma, Astha Yadav, Vimala Venkatesh, Amita Jain, Mala Kumar, Shalini Tripathi, Renu Singh","doi":"10.25259/ijmr_964_23","DOIUrl":"10.25259/ijmr_964_23","url":null,"abstract":"<p><p>Background & objectives The COVID-19 pandemic underscores the significance of vaccination in mitigating disease spread, with Covishield and Covaxin serving as pivotal vaccines in India. Breast milk, rich in vital antibodies like IgA and IgG, plays a crucial role in enhancing the immune defence of breastfeeding infants. However, limited research exists on the antibody responses in breast milk among individuals receiving single versus double doses of the COVID-19 vaccine. This study aimed to bridge this gap by exploring IgA and IgG antibody levels in breast milk and assessing the correlation with COVID-19 vaccination status. Methods This hospital-based descriptive study aimed to assess the relationship between COVID-19 vaccination and the presence of anti-SARS-CoV-2 IgA/IgG antibodies in breast milk. Breast milk samples were collected using a sterile, closed-system electric breast pump and stored at -20°C. ELISA testing, utilizing commercially available kits, was utilized to assess anti-SARS-CoV-2 IgA and IgG antibodies. Results Among the 151 women participants, 76 (50.3%) received COVID-19 vaccination. Of these vaccinated women, 70 (92.1%) received Covishield, and 6 (7.9%) received Covaxin. Within the vaccinated cohort, 32 (42.1%) completed the recommended double-dose regimen, while 44 (57.9%) received a single dose. While no significant association was found between vaccination status and IgA positivity (P=0.491), a notable association emerged for IgG positivity (P<0.001). Notably, individuals who completed the recommended double-dose regimen exhibited higher IgA (63.6%) and IgG (65.4%) positivity compared to those receiving a single dose. Interpretation & conclusions This study underscores the significance of COVID-19 vaccination in impacting IgA and IgG antibody presence in breast milk. Completing the double-dose regimen correlated with higher IgA and IgG levels, emphasizing the benefits of complete vaccination. These findings contribute to understanding vaccination's impact on maternal-infant health.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"501-505"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of risk factors of non-communicable diseases among adults in urban slums of Burdwan municipality, West Bengal: A cross sectional study.","authors":"Utpal Dakua, Sulagna Das, Sutapa Mandal, Priya Shaw","doi":"10.25259/ijmr_2166_23","DOIUrl":"10.25259/ijmr_2166_23","url":null,"abstract":"<p><p>Background & objectives Non communicable diseases (NCD) have emerged as one of the leading causes of mortality and morbidity in India in the past few decades. This study was undertaken to determine the prevalence of NCD risk factors among adults residing in urban slums of West Bengal, India. Methods A community based cross-sectional study was conducted among adult population aged 15-69 yr in urban slums of Purba Burdwan district, West Bengal over a period of two months. A total of with 180 study participants selected by simple random sampling. Data were collected using a semi-structured schedule, adopted from the WHO STEPS questionnaire. Analysis was done using Chi-square test and logistic analysis. P<0.05 was considered to be significant. Results The prevalence of alcohol intake, smoking, inadequate vegetable and fruit intake, reduced physical activity and overweight and/or obesity was 27.8, 15.6 , 93.3 , 32.8 and 15.5 per cent, respectively among the study population. A significant association of smoking was found among males [Adjusted odds ratio (AOR) 2.54 Confidence interval (CI):1.76-6.99], those living in joint families (AOR 1.24 CI:1.17-1.34) and without any formal education (AOR 3.22 CI:1.50-13.87). The odds of alcohol consumption alcohol, were higher among those aged >44 yr (AOR 1.98 CI:1.34-7.22), males (AOR 2.65 CI:1.89-8.76), those who had no formal education (AOR 1.43 CI:1.23-2.77) and those who were employed (AOR 1.34 CI:1.02-4.09). Again respondents aged 45-69 yr (AOR 4.45 CI:1.79-10.99) and married (AOR 3.77 CI:1.76-7.44) were associated with overweight and or/obesity. Furthermore, age AOR 5.04 CI:1.34-17.98) and employment status (AOR 1.78 CI:1.67-3.09) were significantly associated with raised blood pressure in multivariate analysis. Interpretation & conclusions The high prevalence of risk factors of NCD in the study population is suggestive of a need for health promotion by creating awareness about the dangers of smoking and alcohol consumption as well as educating the people about the benefits of physical activity and eating a healthy diet.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"506-513"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy approaches for non-malignant diseases & non-haematological diseases in India: A systematic review.","authors":"Chandrashekhar Chavan, Suman Ray, Chandra Mohan Kumar","doi":"10.25259/ijmr_2141_23","DOIUrl":"10.25259/ijmr_2141_23","url":null,"abstract":"<p><p>Background & objectives Our study aims to provide the diversity of stem cell use for non-malignant, non-haematological diseases in India through the lens of clinical trials. Methods A PRISMA approach was used to evaluate the safety and efficacy of stem cell use for the period 2001-2021 in India. The outcomes were measured using each disease category, types of stem cells, the origin of stem cells, safety, and efficacy. Results Of the 9206 studies screened, 61 studies that were relevant to stem cell use for non-malignant diseases were included for analysis. Autologous stem cells (75%) were used predominantly compared to allogenic stem cells (18.33%), followed by mixed type (6.67%). Use of bone marrow-derived stem cells (51%) was dominant, followed by melanocytes (19%), adipose (7%), haematopoietic (12%), and (11%) other types of stem cells. The study revealed 37 randomized clinical trial studies conducted in the government research hospital compared to the non-government. Interpretation & conclusions Maintaining the gold standard for stem cell therapy requires randomized clinical trials with large sample sizes, control groups, failures, adverse effects, etc. It is important to have a monitoring and regulation system in stem cell clinical research activities with enough preclinical data and repeated exchanges between the bench and the bedside.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"411-427"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance for surgical site infections developed during hospital stay & after discharge: A multicentric study.","authors":"Sharad Srivastav, Surbhi Khurana, Chiranjay Mukhopadhyay, Sheila N Myatra, Sonal Katyal, Omika Katoch, Samarth Mittal, Vivek Trikha, Vijay Sharma, Kamran Farooque, Subodh Kumar, Sushma Sagar, Amit Gupta, Shyamasunder N Bhat, Prasad S S, Jigeeshu Vasishtha Divatia, Ajay Puri, Prakash Nayak, Ashish Gulia, Anuja Deshmukh, Shivakumar Thiagarajan, Sanjay Biswas, Kamini Walia, Rajesh Malhotra, Purva Mathur","doi":"10.25259/IJMR_369_2024","DOIUrl":"10.25259/IJMR_369_2024","url":null,"abstract":"<p><p>Background & objectives Surgical site infections (SSIs) are among the most prevalent healthcare-associated infections (HCAIs). They cause significant morbidity, leading to excess health expenditures and increased length of hospital stay. Despite a high population burden, data on post-discharge SSIs is lacking from low-and middle-income countries (LMICs). There is no existing surveillance system of SSIs in India that covers the post-discharge period. Therefore, we proposed a multicentric analysis to estimate the proportion and identify the risk factors associated with SSIs occurring during hospital stay and after discharge. Methods SSI Surveillance was conducted in three hospitals in different parts of India according to the Centers for Disease Control and Prevention (CDC) guidelines (30 days-6 months). An indigenous database was developed for data entry and analysis. Logistic regression analysis was performed to test for an association between SSI and potential risk factors. Results A total of 161 out of 3090 patients acquired SSI, resulting in a 5.2 per cent SSI incidence. Debridement surgery, which was carried out with either an amputation, open reduction internal fixation surgery (ORIF), or closed reduction internal fixation (CRIF) surgery, had the highest SSI rate (54.2%). Clean, polluted wound class and surgeries lasting longer than 120 minutes were substantially linked to an increased risk of SSI. Interpretation & conclusions Post-discharge surveillance helped with the detection of 66 per cent of SSI cases. Combination surgeries were seen to increase the risk of SSIs in patients.</p>","PeriodicalId":13349,"journal":{"name":"Indian Journal of Medical Research","volume":"160 5","pages":"428-437"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}