Chikeluba V Okafor, Dmitry Tumin, Sunny R Cai, Adrienne L Hutton
{"title":"Safe use of sugammadex and 5% dextrose in 0.45% saline in Leigh syndrome.","authors":"Chikeluba V Okafor, Dmitry Tumin, Sunny R Cai, Adrienne L Hutton","doi":"10.4103/ija.ija_1199_24","DOIUrl":"10.4103/ija.ija_1199_24","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 5","pages":"518-519"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bilateral intranasal transmucosal sphenopalatine ganglion block in children undergoing palatoplasty.","authors":"","doi":"10.4103/ija.ija_374_25","DOIUrl":"https://doi.org/10.4103/ija.ija_374_25","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 5","pages":"433"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longitudinal approach to common flexor plane block to block both median and ulnar nerves at the elbow.","authors":"Amarjeet Kumar, Chandni Sinha","doi":"10.4103/ija.ija_57_25","DOIUrl":"10.4103/ija.ija_57_25","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 5","pages":"513-514"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Na Yang, Lihua Peng, Ruixing Kuang, Rui Xu, Ling Zhou, Yinglong Wang
{"title":"Effect of perioperative intravenous ketamine on postoperative sleep disturbance in patients undergoing non-cardiac surgery: A systematic review and meta-analysis.","authors":"Na Yang, Lihua Peng, Ruixing Kuang, Rui Xu, Ling Zhou, Yinglong Wang","doi":"10.4103/ija.ija_75_25","DOIUrl":"10.4103/ija.ija_75_25","url":null,"abstract":"<p><strong>Background and aims: </strong>Postoperative sleep disturbance (PSD) is a common condition that may lead to pain, cognitive impairment, depression, and delayed recovery. This review evaluates the efficacy of perioperative intravenous ketamine in alleviating PSD and offers evidence-based recommendations for clinical practice.</p><p><strong>Methods: </strong>A systematic search was performed in PubMed, Embase, Cochrane Library, Wanfang Data, VIP Information Resource System, China National Knowledge Infrastructure and China Biology Medicine disc (SinoMed) up to 6<sup>th</sup> November 2024. This article included a meta-analysis of randomised controlled trials (RCTs) along with a Grading of Recommendations Assessment, Development and Evaluation analysis.</p><p><strong>Results: </strong>A total of 2355 patients from 21 RCTs were analysed. The pooled results indicated that ketamine improved sleep quality compared to placebo on the first postoperative day, as evidenced by a reduction in Pittsburgh Sleep Quality Index scores [mean difference (MD): -2.69; 95% confidence interval (CI): -3.95, -1.42; <i>P</i> < 0.0001, <i>I</i> <sup>2</sup> = 96%]. Ketamine also improved sleep quality on the second postoperative day (MD: -2.45; 95% CI: -3.99, -0.91; <i>P</i> = 0.002, <i>I</i> <sup>2</sup> = 96%) and during the first three postoperative days (MD: -2.90; 95% CI: -4.79, -1.00; <i>P</i> = 0.003, <i>I</i> <sup>2</sup> = 97%). In addition, ketamine reduced Visual Analogue Scale scores for pain (MD: -0.38; 95% CI: -0.55, -0.21; <i>P</i> < 0.00001, <i>I</i> <sup>2</sup> = 84%). These results suggest that ketamine reduces PSDs and pain without significantly increasing adverse reactions. However, given the high heterogeneity and limited quality of evidence in this review, the results should be interpreted with caution.</p><p><strong>Conclusion: </strong>This meta-analysis indicates that administering ketamine during the perioperative period can enhance postoperative sleep quality. However, the optimal dose, timing and method of administration remain undetermined, emphasising the need for further research to establish standardised guidelines.</p>","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 5","pages":"434-449"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yashika Pandey, Manisha Sapate, Harsha H Narkhede, Poonam Mane
{"title":"Quality of recovery (QoR-15) following opioid-free versus opioid anaesthesia for elective endoscopic nasal surgeries: A randomised, open-label comparative trial.","authors":"Yashika Pandey, Manisha Sapate, Harsha H Narkhede, Poonam Mane","doi":"10.4103/ija.ija_984_24","DOIUrl":"10.4103/ija.ija_984_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Newer modalities like opioid-free analgesia overcome the opioid-related side effect profile and are equally efficacious. This study aims to compare the clinical outcomes between opioid-free anaesthesia (OFA) and opioid-based anaesthesia (OA) in elective nasal endoscopic surgeries.</p><p><strong>Methods: </strong>A randomised, open-label trial was conducted to evaluate the quality of recovery (QoR). The study included 64 patients with American Society of Anesthesiologists physical status I and II, of either gender, aged between 18 and 60 years, scheduled for elective endoscopic nasal surgery at a tertiary care centre. The patients were randomised into two groups: Group OA (patients receiving opioid anaesthesia) and Group OFA (patients receiving opioid-free anaesthesia). The primary outcome was the effects of OFA versus OA on the QoR-15 in patients undergoing endoscopic nasal surgeries under general anaesthesia. Secondary outcomes included intraoperative haemodynamics, respiratory depression, nausea/vomiting, pruritus, postoperative analgesia, and length of stay in the post-anaesthesia care unit. An independent sample <i>t</i>-test and Chi-squared test were employed for between-group comparisons.</p><p><strong>Results: </strong>Patients undergoing OFA showed higher postoperative QoR-15 scores compared to the opioid group. Intraoperatively, the OFA group demonstrated a better haemodynamic profile at 15, 30, 60, 90, and 120 min, with lower mean arterial pressure values compared to the opioid group. Notably, the OFA group experienced reduced nausea/vomiting and pruritus. Postoperative analgesia requirements and length of stay in recovery were also lower in the OFA group.</p><p><strong>Conclusion: </strong>OFA in elective nasal endoscopic surgeries results in higher QoR-15 scores, better postoperative analgesia and fewer adverse effects associated with opioids.</p>","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 5","pages":"465-470"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of i-gel®, Ambu® AuraGain™, Baska Mask, LMA® Protector™ for airway management of obese surgical patients - A randomised comparative study.","authors":"Rajesh Raman, Apoorva Gupta, Rati Prabha, Shefali Gautam, Akshay Anand","doi":"10.4103/ija.ija_755_24","DOIUrl":"10.4103/ija.ija_755_24","url":null,"abstract":"<p><strong>Background and aims: </strong>A few trials have studied the use of supraglottic airway devices (SADs) for obese patients. This trial aimed to compare four SADs: I-gel, Ambu AuraGain, Baska mask, and Laryngeal Mask Airway (LMA) Protector for airway management of obese patients.</p><p><strong>Methods: </strong>This parallel-group, single-blind, comparative randomised study included 154 obese patients aged between 18 and 60 years who were planned for elective surgery. They were randomly allocated one of the above four SADs for airway management. Each group had 38 patients. The allocated SAD was inserted after induction of anaesthesia. oropharyngeal leak pressure (OLP) was the primary outcome. Data were analysed using analysis of variance, Kruskal-Wallis, or χ<sup>2</sup> test.</p><p><strong>Results: </strong>Baseline data of the patients were comparable. Mean OLP was highest with the Baska mask and lowest with the LMA Protector [32.97 (standard deviation (SD): 1.30) (95% confidence interval (CI): 32.54, 33.40] vs 30.08 (SD: 1.51) (95% CI: 29.58, 30.58) cm H<sub>2</sub>O). The mean leak fraction was highest with the Baska mask and lowest with Ambu AuraGain (6.88 (SD: 1.33) (95% CI: 6.44, 7.31) vs 6.08 (SD: 1.18) (95% CI: 5.69, 6.47)). The mean time taken to insert the SAD was shortest with I-gel and longest with Ambu AuraGain (18.58 (SD: 1.97) (95% CI: 17.93, 19.23) vs 29.11 (SD: 2.50) (95% CI: 28.28, 29.93) sec). Heart rate, SAD placement success rate, fibreoptic view of the glottis, blood pressure, and side effects were comparable amongst the devices.</p><p><strong>Conclusion: </strong>For obese patients undergoing elective surgery, the Baska mask has the highest OLP, but I-gel, Ambu AuraGain, and LMA Protector are also acceptable choices.</p>","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 3","pages":"289-295"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khaled Sarhan, Maha Gebreel, Ashgan Raouf, Islam Reda, Mohammed Ameen, Rana Walaa, Nazmy Seif
{"title":"Effect of different volumes of bupivacaine 0.25% caudal blocks on cardiac index measured by electrical cardiometry in children undergoing elective lower abdominal surgeries: A randomised controlled trial.","authors":"Khaled Sarhan, Maha Gebreel, Ashgan Raouf, Islam Reda, Mohammed Ameen, Rana Walaa, Nazmy Seif","doi":"10.4103/ija.ija_858_24","DOIUrl":"10.4103/ija.ija_858_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Studies assessing caudal block's effects on children's cardiac output are scarce. We aimed to estimate the effects of the caudal block using different volumes of plain bupivacaine 0.25% on the cardiac index assessed by electrical cardiometry.</p><p><strong>Methods: </strong>Children aged 1-8 years undergoing minor lower abdominal surgeries were randomly assigned to one of three equal groups: The 0.8 group received general anaesthesia (GA) along with caudal block with 0.8 mL/kg of bupivacaine 0.25%, the 1.2 group received GA along with caudal block with 1.2 mL/kg of bupivacaine 0.25%, and the control group received GA only. The primary outcome was the percentage of change in the cardiac index from the baseline 10 minutes after the caudal block. Continuous variables were analysed using the ANOVA test, while categorical data was analysed using a chi-squared test with the significance level set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>The mean percentage of change of cardiac index from baseline 10 minutes after caudal block was significantly lower in the 0.8 and 1.2 groups (-11.4 (standard deviation (SD): 12.5%) and -17.1 (SD: 15.5%), respectively) compared to the control group (-0.7 (SD: 11.5%), (<i>P</i> = 0.007 and <i>P</i> = 0.0001). Mean differences were -11 (0.8 vs control, 95% confidence interval (CI): -18.7, -3.3%, and -15.2 (1.2 vs control, 95% CI: -23, -7.5%).</p><p><strong>Conclusion: </strong>The cardiac index progressively decreased with the increase in the volume of the caudal block with plain bupivacaine at 0.25% compared to the baseline. However, this decrease was not clinically significant, suggesting that the cardiac index remained within an acceptable range after the caudal block. Nevertheless, caution is warranted due to the increased incidence of hypotension with increasing volumes of plain local anaesthetics in the caudal block.</p>","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"69 3","pages":"275-281"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}