Shalini Subramanian, Deepa Shetty, Gagan Dudeja, Priyanka Das
{"title":"Median effective dose of intranasal dexmedetomidine for satisfactory mask induction in children undergoing examination under anaesthesia for retinoblastoma - A prospective up and down sequential allocation study.","authors":"Shalini Subramanian, Deepa Shetty, Gagan Dudeja, Priyanka Das","doi":"10.4103/ija.ija_496_23","DOIUrl":"10.4103/ija.ija_496_23","url":null,"abstract":"<p><strong>Background and aims: </strong>Inhalational technique is used to induce anaesthesia in children without intravenous access. We aimed to determine the median effective dose (ED50) of intranasal dexmedetomidine to ensure satisfactory mask acceptance during inhalation induction in children with retinoblastoma undergoing examination under anaesthesia.</p><p><strong>Methods: </strong>A prospective sequential allocation study was conducted in children aged 1-60 months divided into Group A (1-18 months) and Group B (18-60 months). Children were administered dexmedetomidine intranasally as premedication. Sedation was assessed using the modified Observer Assessment of Alertness and Sedation Scale until induction. Successful mask acceptance was defined as a cooperative or asleep child during inhalational induction. The starting dose of dexmedetomidine was 1 µg/kg. The next dose varied by 0.2 µg/kg depending on the outcome of this case. According to the Dixon up-and-down method, the mean of midpoints of the failure-success sequence was calculated to obtain the ED50 values.</p><p><strong>Results: </strong>The ED50 of intranasal dexmedetomidine for satisfactory mask acceptance was 0.7 µg/kg (95% confidence interval [CI]: 0.54-0.86) in Group A (n = 23) and 0.96 µg/kg (95% CI: 0.83-1.08) in Group B (n = 25) (<i>P</i> = 0.020). The mean (standard deviation) duration of anaesthesia was 33.5 (14.9) minutes in group A versus 23.5 (8.48) minutes in Group B (<i>P</i> = 0.007).</p><p><strong>Conclusion: </strong>ED50 was lower in children younger than 18 months than in older children. There was no difference in the time to discharge from the post-anaesthesia care unit despite the procedure being longer in smaller children.</p>","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 2","pages":"165-169"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Message by the Past President and Academic Chairperson, Indian Society of Anaesthesiologists (ISA) National (2023).","authors":"K M Venkatagiri","doi":"10.4103/ija.ija_171_24","DOIUrl":"https://doi.org/10.4103/ija.ija_171_24","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 Suppl 1","pages":"S4"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac autonomic function in post-COVID-19 patients and its impact on haemodynamics during neurosurgery - A prospective observational study.","authors":"Sonia Bansal, Dhritiman Chakrabarti, Parthiban Giribabu, Kamath Sriganesh, Dhaval Shukla","doi":"10.4103/ija.ija_874_23","DOIUrl":"10.4103/ija.ija_874_23","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 2","pages":"200-204"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anju Gupta, Nitin Choudhary, Nishkarsh Gupta, Chitta R Mohanty
{"title":"Broken bougie: Prevention is better than cure!","authors":"Anju Gupta, Nitin Choudhary, Nishkarsh Gupta, Chitta R Mohanty","doi":"10.4103/ija.ija_965_23","DOIUrl":"10.4103/ija.ija_965_23","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 2","pages":"214"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to make your Abstract noticeable during submission for paper presentation in a Conference: Points to ponder!!!","authors":"Vanita Ahuja, Kaushic Theerth, Rakesh Garg","doi":"10.4103/ija.ija_165_24","DOIUrl":"10.4103/ija.ija_165_24","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 Suppl 1","pages":"S6-S7"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Message by the Honorary Secretary Indian Society of Anaesthesiologists (ISA) National.","authors":"Sukhminder Jit Singh Bajwa","doi":"10.4103/ija.ija_156_24","DOIUrl":"10.4103/ija.ija_156_24","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 Suppl 1","pages":"S2-S3"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aanchal Bharuka, Basanth K Rayani, Vibhavari Naik, Sushma Konduri
{"title":"An unusual complication during lung isolation with RUSCH EZ-blocker<sup>®</sup> - A case study.","authors":"Aanchal Bharuka, Basanth K Rayani, Vibhavari Naik, Sushma Konduri","doi":"10.4103/ija.ija_647_23","DOIUrl":"10.4103/ija.ija_647_23","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 2","pages":"205-206"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safe not to underestimate the danger of a bougie.","authors":"Walston R Martis","doi":"10.4103/ija.ija_907_23","DOIUrl":"10.4103/ija.ija_907_23","url":null,"abstract":"","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 2","pages":"213"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaissar Sassi, Elsa Tardif, Louis Lasry, Lola Manenc, Paul Guerby, Vincent Minville
{"title":"Assessing feasibility and satisfaction in third-trimester pre-anaesthetic teleconsultations: A prospective observational study.","authors":"Kaissar Sassi, Elsa Tardif, Louis Lasry, Lola Manenc, Paul Guerby, Vincent Minville","doi":"10.4103/ija.ija_721_23","DOIUrl":"10.4103/ija.ija_721_23","url":null,"abstract":"<p><strong>Background and aims: </strong>Pregnancy presents risks, particularly for women with pre-existing health problems. Pre-anaesthetic consultations can help anticipate these risks and establish a medical management strategy on the delivery day. While teleconsultations gained popularity during the coronavirus disease 2019 (COVID-19) pandemic, research on pre-anaesthetic teleconsultations during pregnancy is limited. This study aimed to assess patient satisfaction and physician perception of teleconsultations for third-trimester pre-anaesthetic consultations.</p><p><strong>Methods: </strong>A prospective observational study included pregnant women who opted for teleconsultations for pre-anaesthetic consultations. Patient satisfaction was assessed using Likert scale questions and the System Use Scale. Anaesthetist satisfaction was evaluated using a Likert scale and by considering changes in anaesthetic techniques and missing clinical data in the pre-anaesthetic assessment. Data analysis utilised SPSS Statistics for Windows, Version 20.0. encompassing descriptive statistics, hypothesis testing and odds ratio calculations. This approach explored the correlation between patient and anaesthetist satisfaction and pertinent risk factors.</p><p><strong>Results: </strong>The study enroled 99 patients, with 85% expressing satisfaction and high satisfaction on the Likert scale and 88% finding the teleconsultation acceptable based on the System Use Scale (score ≥ 70). Anaesthetists reported being satisfied with the pre-anaesthetic consultations in 94% of cases.</p><p><strong>Conclusion: </strong>This study demonstrates the feasibility and effectiveness of telemedicine consultations in obstetric anaesthesia, showing high patient and anaesthetist satisfaction rates.</p>","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"68 2","pages":"183-188"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Saran, Swathy S. Iyengar, Nitesh Sinha, Kumar Abhishek, Amit Kumar, Jay Prakash
{"title":"Role of Mycobacterium indicus pranii in clinical outcomes in patients with sepsis: A systematic review and meta-analysis of randomised controlled trials","authors":"K. Saran, Swathy S. Iyengar, Nitesh Sinha, Kumar Abhishek, Amit Kumar, Jay Prakash","doi":"10.4103/ija.ija_726_23","DOIUrl":"https://doi.org/10.4103/ija.ija_726_23","url":null,"abstract":"\u0000 \u0000 Sepsis-induced immunosuppression appears to be reversible with immunomodulatory drugs. Mycobacterium indicus pranii (MIP) stimulates the Th1 type of immune response. This systematic review and meta-analysis of randomised controlled trials (RCTs) was aimed to find out if MIP is effective at improving clinical outcomes in sepsis patients.\u0000 \u0000 \u0000 \u0000 The databases (PubMed, Google Scholar, Web of Science, and Cochrane Library), along with preprint servers until June 2023, were searched. The methodology was evaluated using the ‘Cochrane Collaboration risk of bias-2 tool’ for RCT. The study included patients more than 18 years of age with sepsis within 48 h of first organ dysfunction. The primary outcome was 28-day mortality, and secondary outcomes were the length of stay in the intensive care unit (ICU), days on vasopressor support, ventilator-associated pneumonia (VAP), secondary infections, catheter-related bloodstream infections (CRBSI), and the delta sequential organ failure assessment (SOFA) score.\u0000 \u0000 \u0000 \u0000 The meta-analysis included two studies with 252 participants. In a pooled analysis, mortality in the MIP group was 43% lower than in the control (RR: 0.57, 95%CI: 0.33–1); however, this difference was statistically not significant. We observed the days on a vasopressor day (standardised mean difference [SMD]: 0.38; 95%CI: −1.20 to 0.44), length of ICU stay (SMD: 0.46; 95%CI: −1.44 to 0.51), secondary infection (RR: 0.75; 95%CI: 0.19–3.01), VAP (RR: 0.6; 95%CI: 0.28–1.56), CRBSI (RR: 0.97, 95%CI: 0.14–6.98), delta SOFA score (SMD: 0.88, 95%CI: −1.66 to − 0.10) between the two groups.\u0000 \u0000 \u0000 \u0000 Our findings observed preliminary evidence in the trends for a positive association of MIP with better outcomes in sepsis patients.\u0000","PeriodicalId":13339,"journal":{"name":"Indian Journal of Anaesthesia","volume":"266 ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}