Indian Journal of Orthopaedics最新文献

{"title":"Four-Year Treatment Effect of Custom-Made Foot Orthosis on Pediatric Symptomatic Accessory Navicular Bone Combined with Flexible Flatfoot","authors":"Wen Shu, Guoyong Jiang, Zimo Yang, Zhao Rong, Xiangrui Li, Bin Yu, Xin Tang","doi":"10.1007/s43465-024-01210-7","DOIUrl":"https://doi.org/10.1007/s43465-024-01210-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Congenital accessory navicular bone (ANB) is a common variant in the foot and is prone to cause several clinical symptoms. Wearing custom-made foot orthosis is considered a desirable option; however, there is limited evidence of its effectiveness. This study aims to report the mid-term effect of foot orthosis for symptomatic pediatric ANBs.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>School-age children with symptomatic ANBs combined with flexible flatfoot in the authors' institute were recruited and got custom-made foot orthosis treatment. They were followed up over 4 years. The general characteristics of these children were collected before treatment, including age, gender, and body mass index (BMI). The indicators of foot symptoms, including frequency and location of pain, visual analogue scale (VAS), arch index (AI), and hind foot valgus angle (HVA), were measured during pretreatment and at the last follow-up.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Twenty-seven children were recruited for this study. After 4 years of custom-made foot orthosis treatment, significant improvements showed in pain frequency, VAS, AI, and HVA (<i>P</i> &lt; 0.001). Type II ANBs showed a higher pain index pretreatment (<i>P</i> &lt; 0.001) and reduced after treatment (<i>P</i> &lt; 0.001).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Mid-term effect of custom-made foot orthosis is inspiring in clinical symptoms of pediatric congenital ANBs combined with flexible flatfoot and may be an optional nonoperative treatment.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Injuries in Multiligament Knee Injuries (MLKIs)","authors":"Surasak Srimongkolpitak, Bancha Chernchujit","doi":"10.1007/s43465-024-01220-5","DOIUrl":"https://doi.org/10.1007/s43465-024-01220-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Vascular injuries are rarely associated with severe knee injuries; nonetheless, it is imperative to efficiently detect this condition and plan for either immediate or definitive treatment at later stages. The diagnosis and management of multiligament knee injuries still present unresolved issues, particularly in the early detection of vascular issues and the sequential stabilisation of ligaments. High-energy trauma is a frequently encountered cause, however, even low-energy trauma in those who are morbidly obese might pose a significant risk. Advancements in detection and management methods have greatly decreased the occurrence of vascular complications and amputation rates over time. MLKIs after transient knee dislocations are frequently misdiagnosed for vascular injuries, underscoring the necessity for improved diagnostic techniques to avoid avoidable amputations.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This article is a new conceptual review of vascular injuries associated with MLKIs. It provides a full overview of these conditions and includes a review of the most recent literature. We have included pertinent citations from the literature, together with suggestions derived from the latest studies. This review article had additional evaluation by proficient specialists with commendable outcomes and more than a decade of expertise in surgical techniques.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This article offers a detailed overview of orthopaedic management, including new definitions and summaries of the causes, evaluation of patients, clinical assessment, identification of vascular injuries, and initial management in patients with vascular impairment following major limb and joint injuries (MLKIs).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>MLKIs (patients with lower limb ischaemia) who have vascular damage necessitate meticulous physical assessment and sophisticated treatments in order to decrease amputation rates. Prompt identification and timely treatment of vascular lesions, namely in the popliteal artery, can substantially reduce the occurrence of amputations. Emerging research suggests that there is a heightened risk in low-energy situations, particularly amongst individuals who are extremely obese. Progress in vascular intervention has led to a reduction in amputation rates, whilst the implementation of new guidelines has enhanced identification. Thorough patient assessment is essential, utilising physical examinations and imaging techniques such as Computed tomography angiography, magnetic resonance angiography (CTA or MRA) to guide treatment decisions. MRA, in particular, is capable of identifying both vascular and knee structural damage.</p><h3 data-test=\"abstract-sub-heading\">Level of Evidence</h3><p>Level IV, Literature reviews.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"24 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroneus Longus Graft Harvest Does Not Affect Ankle Biomechanics: A Narrative Review","authors":"Arora Manit, Rambani Rohit, Kini Abhishek, Tapish Shukla","doi":"10.1007/s43465-024-01219-y","DOIUrl":"https://doi.org/10.1007/s43465-024-01219-y","url":null,"abstract":"<p>The peroneus longus graft has gained much attention in recent years as a reliable autograft for primary ACL surgery. Critics have voiced concerns related to its impact on ankle biomechanics. The current review aims to synthesize the available literature on ankle biomechanics after peroneus harvest. The quantum of evidence available shows that PL harvest does not significantly impact ankle eversion or plantarflexion strength. Its impact on gait needs to be studied more deeply before any significant conclusions can be drawn.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"68 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SPAIRE Approach for Hip Arthroplasty: Short-Term Functional Outcome in an Indian Scenario","authors":"Jayant Kumar, Akash Nagnath Mane, Nishant Kumar Niraj, Kumar Rahul, Ravi Teja Bobbili, Kanishk Shankar","doi":"10.1007/s43465-024-01215-2","DOIUrl":"https://doi.org/10.1007/s43465-024-01215-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction </h3><p>Hip arthroplasty, including hemiarthroplasty and total hip arthroplasty is a common surgical procedure for patients suffering from hip joint disorders with an aim of complication free early return to activities of daily living. Various minimally invasive surgical approaches have been described to achieve this aim including a relatively new SPAIRE approach. This case series shows our technique of hip arthroplasty using the SPAIRE technique with the help of conventional instruments in an Indian Scenario at a tertiary care center in Eastern India along with our short-term functional outcomes till a follow up period of 6 months.</p><h3 data-test=\"abstract-sub-heading\">Materials and method </h3><p>This was the prospective observational study done between May 2022 to Oct 2023 in Tata Main hospital, Jamshedpur. Total 35 patients were operated by this technique. Data including age, gender, time to return orthotic assisted mobility, Harris hip score at 2 months &amp; any complications till the follow up of 6 months were recorded for each patient who underwent Hemiarthroplasty or Total Hip arthroplasty using the SPAIRE technique with conventional instruments for hip arthroplasty (performed by single surgeon – the senior author) in our tertiary care center.</p><h3 data-test=\"abstract-sub-heading\">Results </h3><p>35 patients were operated during this span by using the SPAIRE technique. There were 30 cases of hip hemiarthroplasty and 5 cases of total hip arthroplasty (1 bilateral). 5 patients were lost to follow up during the period of 6 months. Harris hip score was measured for each patient at 2 months and mean Harris hip score was 83.16. Out of 35 patients, 9 patients had excellent outcome, 14 patients had good outcome and 7 patients had fair outcome. No patient had complications such as infection, delayed wound healing, periprosthetic fractures or sciatic nerve injury. One patient reported dislocation at 3 months following a fall. Mean time to return to orthotic assisted ambulation was 1.5 days for all 35 patients.</p><h3 data-test=\"abstract-sub-heading\">Conclusion </h3><p>SPAIRE technique is one of the safe surgical approaches for primary hip arthroplasties. This minimally invasive tendon sparing approach which preserves quadricep coxa provides excellent hip stability, early return to preinjury activities. It also reduces postoperative complications such as dislocation.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"14 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Study of Multimodality Imaging Features of Chondroblastoma","authors":"Aashna Karbhari, Antariksh Vijan, Amit Kumar Janu, Ashish Gulia, Suyash Kulkarni, Nitin Shetty, Kunal Gala, Poonam Panjwani","doi":"10.1007/s43465-024-01214-3","DOIUrl":"https://doi.org/10.1007/s43465-024-01214-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To evaluate the multimodality imaging features of chondroblastoma.</p><h3 data-test=\"abstract-sub-heading\">Materials and Methods</h3><p>Retrospective analysis of imaging features of 52 cases of histopathologically proven chondroblastoma from 2010 to 2022 was performed. Radiographs were evaluated for lesion site, location, morphology, margins, matrix mineralization, cortical breach, periosteal reaction, eccentricity, and subarticular extension. Appearance on T1, T2 weighted and post-contrast T1 was evaluated on MRI, with analysis of peritumoral edema and joint effusion.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Mean patient age was 18 years (10–57 years) with male preponderance (<i>M</i> = 39; <i>F</i> = 13). 75% (<i>n</i> = 39) cases involved an unfused skeleton and 25% (<i>n</i> = 13) affected a mature skeleton. Appendicular skeleton was involved in 88.5% (<i>n</i> = 46) cases and axial skeleton was involved in 11.5% (<i>n</i> = 6) cases with all cases involving epiphysis/epiphyseal equivalent. Radiographically, all cases were well-defined geographic osteolytic lesions with a narrow zone of transition, thin sclerotic rim and lobulated [56% (<i>n</i> = 29)] or smooth [44% (<i>n</i> = 23)] margins. Matrix calcification appreciable in 62% (<i>n</i> = 32) cases was ‘fluffy/smudgy’. Chondroblastoma appeared isointense (83%, <i>n</i> = 43) on T1 MRI with characteristically low signal and hyperintense foci within (67%, <i>n</i> = 35) on T2-weighted images and post-contrast enhancement [heterogeneous lobular (88%, <i>n</i> = 46) or septal pattern (12%, <i>n</i> = 6)] with all barring three lesions showing perilesional edema. None of the cases of chondroblastoma in our study developed metastasis till last follow-up (mean: 71 months).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Chondroblastoma has distinctive imaging appearance and is often unlike majority other cartilaginous benign lesions due to characteristic low T2 signal on MRI and associated exuberant perilesional edema.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"9 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Outcomes of Lateral Versus Medial Approach in the Total Knee Arthroplasty for Valgus Deformity: A Systematic Review and Meta-analysis","authors":"Rajesh Kumar Rajnish, Amit Srivastava, Sandeep Kumar Yadav, Abhay Elhence, Nitesh Gahlot, Prasoon Kumar, Saurabh Gupta, Sameer Aggarwal","doi":"10.1007/s43465-024-01211-6","DOIUrl":"https://doi.org/10.1007/s43465-024-01211-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Valgus knee deformity poses great challenges in total knee arthroplasty (TKA) and requires precision in balancing of soft tissue and implant component positioning. The surgical approach used for TKA has a determinantal impact on intraoperative soft tissue balancing, postoperative knee function, and complications. We executed a systematic review and meta-analysis of current literature, which included a maximum number of studies with quantitative analysis of all possible outcomes to substantiate the current evidence of the advantage of lateral versus medial approach in TKA for valgus knee deformity.</p><h3 data-test=\"abstract-sub-heading\">Methodology</h3><p>We performed a meticulous primary electronic search across PubMed, Emabse, Scopus, and Cochrane Library databases, and looked for the comparative studies that evaluated the medial versus lateral approach in TKA for valgus knees. Statistical analyses were executed with RevMan-5.4.1.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>On the evaluation of four randomized controlled trials (RCTs), two prospective and five retrospective comparative studies, our analysis revealed a better functional outcome in terms of Knee Society Score [MD 2.24, 95% CI 0.42, 4.05; p = 0.02] with the medial approach. However, comparable results were observed for two approaches with regard to Knee Society Function [MD 0.69, 95% CI − 1.77, 3.15; p = 0.58], knee flexion range of motion (ROM) [MD 3.30, 95% CI − 1.34, 7.95; p = 0.16], overall complications [OR 0.60, 95% CI 0.27,1.34; p = 0.22], wound-related complications, infection, nerve injury, periprosthetic fracture, post-operative valgus, blood loss, duration of surgery, postoperative pain, and patellar tilt for TKA in valgus knee.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Evidence from the currently available published data suggests that the lateral approach, compared to the medial approach in TKA for the valgus knee, does not show clear superiority.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"44 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound as a Diagnostic Modality in Hand and Wrist Musculoskeletal Pathologies: A Narrative Review","authors":"J. Terrence Jose Jerome","doi":"10.1007/s43465-024-01206-3","DOIUrl":"https://doi.org/10.1007/s43465-024-01206-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Musculoskeletal ultrasonography of the hand and wrist is becoming the trend in assessing and diagnosing most hand and wrist injuries, soft-tissue mass, and occult fractures. Its advantages include ultra-high frequency probes, noninvasiveness, cost-effectiveness, lack of ionising radiation, and portability. The patients are comfortable doing this procedure in the outpatient department, and visualising the ultrasound images increases their confidence.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Ultrasound has a practical and dynamic real-time diagnostic capability compared to other modalities, playing an important role in hand and wrist pathologies. Apart from the diagnostic utility, it has also been beneficial in musculoskeletal intervention procedures, such as trigger finger, carpal tunnel syndrome, and various tenosynovitis. The learning curve and limited deeper penetrations are relative limitations to ultrasound usage. More dedicated training centres and modules for future generations and CT/MRI for deeper structures are always an alternative. This article reviews the role of ultrasound in hand and wrist pathologies.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"37 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141531080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Timed 360° Turn Test in Individuals with Ankle Sprain","authors":"Nazım Tolgahan Yıldız, Mehmet Canlı, Hikmet Kocaman, Şafak Kuzu, İrem Valamur, Hasan Yıldırım, Halil Alkan","doi":"10.1007/s43465-024-01213-4","DOIUrl":"https://doi.org/10.1007/s43465-024-01213-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>The Timed 360° turn test (T-360° TT) was developed to assess balance and turning ability. Although validity and reliability have been performed in different diseases, validity and reliability have not been performed in individuals with ankle sprain (AS).</p><h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The purpose of this study was to investigate the validity and reliability of the T-360° TT in individuals with AS.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The study included 54 individuals with AS. Participants were initially evaluated with T-360° TT, Timed Up and Go (TUG) test and Biodex Balance System (BBS). To assess test–retest reliability, the T-360° TT was performed again 5 days after the first measurement by the same assessor.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>At the end of the study, strong positive correlations were found between T-360° TT with TUG test and BBS (<i>p</i> &lt; 0.05). In addition, T-360° TT had excellent test–retest reliability (Intraclass correlation coefficient = 0.87).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The T-360° TT is a valid and reliable tool for the evaluation of balance and turning ability in individuals with AS. We also think that it can be used practically in clinical settings because it is a test that can be easily and quickly performed.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"16 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141516980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmentation of Autologous Platelet-Rich Plasma in Hip Salvage in Stages I and II of Avascular Necrosis: Randomized Blinded Trial Comparing 3 Surgical Techniques in 82 Patients","authors":"Nishit Palo, Binayak Ray, Mahima Lakhanpal, Naveen Jeyaraman, Abhishek Shukla, Abhishek Malik","doi":"10.1007/s43465-024-01204-5","DOIUrl":"https://doi.org/10.1007/s43465-024-01204-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Avascular necrosis of the femoral head is common in routine orthopedic clinics. The challenge arises in managing early stages (I and II) without obvious radiological evidence. Authors explore this naïve research area by comparing surgical procedures in early AVN patients.</p><h3 data-test=\"abstract-sub-heading\">Materials and Methods</h3><p>A prospective multicentric study was performed from November 2020 to February 2023 on 82 patients treated with surgical decompression and adjuvants, concerning the defined inclusion and exclusion criteria. Radiopacity and intraosseous edema resolution and THA conversion rates were assessed. Hip pain VAS, groin/thigh pain, difficulty in sitting cross-legged incidence, pain-free walking distance, Harris hip scores, 30-s chair test, and complications were noted.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Among 82 patients, the mean age was 28.46 years. Male:female ratio of 3.9:1. 8.5% had bilateral affection and 48.78% had a positive family history. 93.90% presented with groin pain and difficulty in sitting cross-legged, restricted hip movements in 85.3%, and thigh pain in 54.87%. Harris hip scored worst in Group 3 followed by Group 2 and Group 1. 63.41% and 36.58% of patients had Grades 1 and 2 AVN, respectively. At 1 week post-operatively, 96.3% and 93.9% of patients were relieved from groin and thigh pain, respectively (<i>p</i> &lt; 0.001); the trend being Group 3 &gt; Group 2 &gt; Group 1. Hip pain VAS followed a similar trend. At 4 weeks, Harris hip scores improved in Group 3 &gt; Group 2 &gt; Group 1. At 6 months, the trend was Group 2 &gt; Group 3 &gt; Group 1. Group 3 had better 30-s chair test results, pain-free walking distance, and longer cross-legged sitting time. Complication rate of 3.6%. 6.09% of patients underwent THA later. Sclerotic patch and marrow edema resolution early in Group 3, i.e., 46 and 31 days respectively, followed by Group 2 and Group 1.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>In Stages I and II AVN, biplanar core decompression (double) and intraosseous PRP injection is a promising salvage option; patients have better early hip scores (4 weeks), and early groin and thigh pain recovery. Patients treated early have better clinical and radiological recovery.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"20 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum IL-6 as a Surrogate Biomarker of Post-operative Complications in Invasive Orthopaedic Surgeries: A Prospective Observational Study","authors":"Kanchana Laishram, Bhaskar Borgohain, Aparna Laishram, Tashi G. Khonglah, Alice A. Ruram, Sachlang Debbarma","doi":"10.1007/s43465-024-01195-3","DOIUrl":"https://doi.org/10.1007/s43465-024-01195-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Interleukin-6 (IL-6) is a cytokine released in response to tissue injury. Elevated serum IL-6 levels in trauma patients have been linked with increased risk of complications such as inapparent hypoxia (SpO₂ &lt; 94%), acute respiratory distress syndrome, fat embolism syndrome (FES), systemic inflammatory response syndrome, multiple organ dysfunction syndrome and sepsis. This study aims to determine the role of serum IL-6 as surrogate biomarker of post-operative complications after invasive orthopaedic surgeries.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Thirty-seven adults between 18 and 65 years of age undergoing invasive orthopaedic surgeries were included in this hospital-based study. Serum IL-6 levels were estimated serially in the pre-operative period, after 24 h and 7 days post-operatively. Cases were monitored for post-operative complications.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Serum IL-6 levels showed maximum rise in the first 24 h post-operatively especially among older patients (&gt; 60 years). Older patients undergoing bipolar hemiarthroplasty for neck of femur fracture showed highest median post-operative IL-6 level of 258 pg/ml. Serum IL-6 level &gt; 130 pg/ml measured 24 h after surgery was predictive of post-operative complications (sensitivity of 75%). Among the cases with post-operative complications, inapparent hypoxia was the most common complication/event observed. Cases with sub-clinical FES had highest level of serum IL-6 in first 24 h following surgery with median IL-6 level of 300 pg/ml (range 155–444 pg/ml).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Monitoring serum IL-6 level may help in both anticipation and early detection of post-operative complications in patients undergoing invasive orthopaedic surgeries; potentially enhancing patient safety.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"28 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}