Immune Network最新文献_第4页

Balancing Intrinsic and Extrinsic Factors in CD8⁺ T Cell Therapy. 平衡CD8+ T细胞治疗的内在和外在因素。

IF 5.9 4区医学

Immune Network Pub Date : 2026-02-12 eCollection Date: 2026-02-01 DOI: 10.4110/in.2026.26.e5

Dongwook Lee, Yoontae Lee

{"title":"Balancing Intrinsic and Extrinsic Factors in CD8+ T Cell Therapy.","authors":"Dongwook Lee, Yoontae Lee","doi":"10.4110/in.2026.26.e5","DOIUrl":"10.4110/in.2026.26.e5","url":null,"abstract":"Persistent Ag exposure in tumors, chronic infections, and autoimmune diseases progressively drive CD8+ T cell dysfunction-a process known as T cell exhaustion. During this process, progenitor exhausted CD8+ T (Tpex) cells represent an early subset with stem cell-like properties and serve as key mediators of immune checkpoint blockade responses. Despite their longevity and proliferative capacity, Tpex cells display limited cytotoxicity. Upon sustained TCR stimulation, they differentiate into exhausted CD8+ T (Tex) cells that express high levels of granzyme B and contribute critically to tumor elimination. Accumulating evidence indicates that Tex cells are functionally heterogeneous, as defined by diverse surface markers and transcriptional programs, and their states are further shaped by tissue- and context-specific cues within the tumor or inflammatory microenvironment. Such extrinsic signals can compromise CD8+ T cell function and limit the efficacy of anti-PD-1 therapy. A comprehensive understanding of this heterogeneity, integrating both intrinsic transcriptional regulation and extrinsic modulatory signals, is crucial for developing more effective immunotherapeutic strategies. Finally, T cell exhaustion should not be viewed solely as a pathological endpoint but also as an adaptive mechanism that restrains immunopathology, underscoring its context-dependent roles across cancer, infection, and autoimmunity.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 1","pages":"e5"},"PeriodicalIF":5.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative Roles of NK Receptors and γδ TCRs in γδ T Cell-Mediated Cancer Immunity. NK受体和γδ TCRs在γδ T细胞介导的肿瘤免疫中的综合作用

IF 5.9 4区医学

Immune Network Pub Date : 2026-02-10 eCollection Date: 2026-02-01 DOI: 10.4110/in.2026.26.e3

Won Joon Oh, Haryoung Cho, Tilanka Kalanapriya Dahanayake, Tae Jin Kim

引用次数: 0

Complement Anaphylatoxin C5a-Induced Mouse Lymphatic Functions Modulate Interactions Between Endothelial Cells and T Lymphocytes. 补体过敏毒素c5a诱导的小鼠淋巴功能调节内皮细胞和T淋巴细胞之间的相互作用。

IF 5.9 4区医学

Immune Network Pub Date : 2026-02-10 eCollection Date: 2026-04-01 DOI: 10.4110/in.2026.26.e4

Haydn E Rich, Yi-Dong Li, Kathryn D Hok, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, Anthony Shadid, Rajarajan A Thandavarayan, Hari Krishna Yalamanchili, Marie-Francoise Doursout, Tingting Weng-Mills, Faraz Bishehsari, Nirmal K Banda, Kristin L Eckel-Mahan, Marcos I Restrepo, Pooja Shivshankar

{"title":"Complement Anaphylatoxin C5a-Induced Mouse Lymphatic Functions Modulate Interactions Between Endothelial Cells and T Lymphocytes.","authors":"Haydn E Rich, Yi-Dong Li, Kathryn D Hok, Stacey L Mueller-Ortiz, Aleksey Y Domozhirov, Anthony Shadid, Rajarajan A Thandavarayan, Hari Krishna Yalamanchili, Marie-Francoise Doursout, Tingting Weng-Mills, Faraz Bishehsari, Nirmal K Banda, Kristin L Eckel-Mahan, Marcos I Restrepo, Pooja Shivshankar","doi":"10.4110/in.2026.26.e4","DOIUrl":"10.4110/in.2026.26.e4","url":null,"abstract":"The lymphatic system is a highly branched endothelial tubular network that facilitates the migration of immune cells from the peripheral tissues to lymph nodes (LNs) and other lymphoid organs. Complement factors are essential for innate and adaptive immune functions. Complement anaphylatoxin C5a is crucial in vascular endothelial cell activation and lymphocyte polarization. Understanding the impact of C5a and its cognate receptor C5ar1 signaling on lymphatic function could provide new insights into the mechanisms of immune dysregulation observed in chronic inflammatory diseases. We demonstrate that acute C5a challenge in wildtype C57B6/J mice significantly reduced lymph propulsion compared to their C5ar1-deficient counterparts. C5ar1-dependent attenuation of lymph propulsion with LPS challenge corroborated with significantly increased endothelial-derived inducible nitric oxide synthase (iNOS) expression. C5ar1-iNOS axis modulated T helper cell polarization towards Cd4+/Ccr5+ Th1 subtypes, indicating that C5a-activated endothelial-iNOS may contribute to Th1 polarization in the peripheral LNs during homing. Finally, we observed C5a-mediated endothelial surface glycoprotein CD146 interaction with Th1 cell intermediate filament protein vimentin that may facilitate transmigration of activated Th1 cells into systemic circulation and tissue interstitium. Given the critical role of the C5a/C5ar1 axis in promoting lymphatic dysfunction, our study highlights the therapeutic potential of targeting C5ar1 in chronic inflammatory conditions.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 2","pages":"e4"},"PeriodicalIF":5.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining PI3K Signaling as a Key Regulator of Molecular Heterogeneity and Inflammation in Glomerular Lupus Nephritis. 确定PI3K信号作为肾小球狼疮肾炎分子异质性和炎症的关键调节因子。

IF 5.9 4区医学

Immune Network Pub Date : 2026-01-22 eCollection Date: 2026-04-01 DOI: 10.4110/in.2026.26.e2

Su-Jin Moon, Young Jae Park, Seung-Ki Kwok, Ha-Hee Son, Howook Jeon, Kyung-Su Park, Ki-Jo Kim

{"title":"Defining PI3K Signaling as a Key Regulator of Molecular Heterogeneity and Inflammation in Glomerular Lupus Nephritis.","authors":"Su-Jin Moon, Young Jae Park, Seung-Ki Kwok, Ha-Hee Son, Howook Jeon, Kyung-Su Park, Ki-Jo Kim","doi":"10.4110/in.2026.26.e2","DOIUrl":"10.4110/in.2026.26.e2","url":null,"abstract":"Lupus nephritis (LN) is a critical manifestation in systemic lupus erythematosus. However, there has been little progress in treatment outcomes, and the discovery of robust and clinically relevant molecular subtypes would be informative for guiding stratified therapy for LN. Glomerular transcriptomic datasets of LN were obtained from publicly repositories. We investigate the molecular heterogeneity of LN by analyzing renal glomerular transcriptomic data from 135 patients with LN using integrated optimal algorithms and propose a refined two-molecular subtype scheme for LN (designated GC1 and GC2). GC1 represents an active form of LN enriched by IFN signaling pathways, Fc receptor-mediated signals, and neutrophil activation-associated processes. In contrast, GC2 is a subset characterized by class A/1 (rhodopsin-like) and B cell (BC) receptor signaling pathways. The communication probability by receptor-ligand pairs is highly scored between BCs, CD4+ T cells and macrophages/monocytes. Proteinuria and renal insufficiency were more significant in GC1. We identified PIK3R2 as a hidden regulator in the disease module, and inhibition of PI3K subunits showed promising efficacy in counteracting altered molecular signatures in an active state of LN. The proposed two-molecular subtype scheme offers novel insights into the divergent mechanistic features of LN and represents a critical step toward precision medicine for LN.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 2","pages":"e2"},"PeriodicalIF":5.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Search of Adaptive-Like Features of NK Cells Co-Expressing NKG2C and NKG2A. NK细胞共表达NKG2C和NKG2A的适应性特征研究

IF 5.9 4区医学

Immune Network Pub Date : 2026-01-22 eCollection Date: 2026-04-01 DOI: 10.4110/in.2026.26.e1

Nadezhda A Alekseeva, Maria O Ustiuzhanina, Julia D Vavilova, Maria A Streltsova, Anna A Boyko, Alexander M Sapozhnikov, Elena I Kovalenko

{"title":"In Search of Adaptive-Like Features of NK Cells Co-Expressing NKG2C and NKG2A.","authors":"Nadezhda A Alekseeva, Maria O Ustiuzhanina, Julia D Vavilova, Maria A Streltsova, Anna A Boyko, Alexander M Sapozhnikov, Elena I Kovalenko","doi":"10.4110/in.2026.26.e1","DOIUrl":"10.4110/in.2026.26.e1","url":null,"abstract":"Adaptive-like functions of NK cells have been extensively studied in the context of human cytomegalovirus (HCMV) infection, particularly for NKG2C+ NK cells. The NKG2A inhibitory and the NKG2C activating receptors share a common ligand, the HLA-E molecule, and can be co-expressed in a unique NK cell subset. However, key characteristics and memory response capacity of this subset remain unclear. We analyzed the proliferative responses, functional attributes and transcriptional signatures of NKG2C+NKG2A+ subsets within CD57+ and CD57- fractions of peripheral blood CD56dimNK cells by comparing them with NKG2A- counterparts. Double-positive NK cells displayed a less mature phenotype, increased MHC-II and exhibited transcriptome profile indicating enhanced adhesion/migration capacities with no difference in adaptive state associated genes expression. These cells showed enhanced proliferation compared to NKG2A- cells, which was not reduced upon interaction with HLA-E presenting the HCMV (VMAPRTLFL, LFL) peptide. CD57+NKG2C+NKG2A+ subset showed enhanced antibody-dependent IFNγ production. Expanded upon LFL stimulation this subset again exhibited enhanced IFNγ production capacity along with peptide-specific mRNA expression profile, demonstrating an adaptive-like response. These results provide additional insight into the diversity of HCMV-specific NK cell subsets, highlighting NKG2A+NKG2C+ NK cells' immunotherapeutical potential.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"26 2","pages":"e1"},"PeriodicalIF":5.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VISTA: An Emerging Immune Checkpoint With Clinical Relevance Across Diverse Malignancies. VISTA：一种新兴的免疫检查点，在不同的恶性肿瘤中具有临床意义。

IF 4.1 4区医学

Immune Network Pub Date : 2025-12-24 eCollection Date: 2025-12-01 DOI: 10.4110/in.2025.25.e44

Hiba Laraki, Ibtissam Rezouki, Khalil Choukri, Abdallah Badou

{"title":"VISTA: An Emerging Immune Checkpoint With Clinical Relevance Across Diverse Malignancies.","authors":"Hiba Laraki, Ibtissam Rezouki, Khalil Choukri, Abdallah Badou","doi":"10.4110/in.2025.25.e44","DOIUrl":"10.4110/in.2025.25.e44","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) offer tremendous promise as therapeutic targets for a range of tumor types, and their development is advancing rapidly in cancer treatment. Nevertheless, the limited efficacy of anti-PD-1/PD-L1 immunotherapy in several cancers has driven researchers to explore other immune checkpoints as potential therapeutic targets. The inhibitory V-domain Ig suppressor of T-cell activation (VISTA) appears to be a captivating candidate. As a member of the B7 family, VISTA is expressed on hematopoietic cells and has the ability to significantly suppress T cell function and the anti-tumor immune response. In this review, our objective is to shed light on the multifaceted potential of VISTA as a therapeutic target. We will highlight the expressions and role of VISTA in various cancer types. Subsequently, we will go through distinct potential VISTA ligands, while underscoring the role of the pathway within the tumor microenvironments (TME). Finally, we will conclude with a comprehensive overview of the latest clinical trials, highlighting VISTA's emerging potential in cancer treatment.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 6","pages":"e44"},"PeriodicalIF":4.1,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine Engineering in CAR-T Cell Therapy: Next-Generation Strategies. 细胞因子工程在CAR-T细胞治疗：新一代策略。

IF 4.1 4区医学

Immune Network Pub Date : 2025-12-18 eCollection Date: 2025-12-01 DOI: 10.4110/in.2025.25.e43

Sunggu Kim, So Hyeon Heo, Hyojin Baek, Soo Seok Hwang

{"title":"Cytokine Engineering in CAR-T Cell Therapy: Next-Generation Strategies.","authors":"Sunggu Kim, So Hyeon Heo, Hyojin Baek, Soo Seok Hwang","doi":"10.4110/in.2025.25.e43","DOIUrl":"10.4110/in.2025.25.e43","url":null,"abstract":"Chimeric Ag receptor (CAR)-T cell therapy has demonstrated success primarily in B-cell malignancies, but efficacy in solid tumors remains limited by Ag heterogeneity, immunosuppressive tumor microenvironments, and restricted infiltration. Cytokine engineering has emerged as a promising strategy to overcome these barriers. Fourth-generation CAR-T cells, known as T cells redirected for universal cytokine-mediated killing, demonstrated the feasibility of localized immune modulation through activation-induced IL-12 release, and this concept has been extended to various cytokines. Receptor engineering strategies, including switch/inverted and orthogonal designs, restrict cytokine signaling to CAR-T cells, thereby enhancing both specificity and safety. Beyond CAR-T engineering, external cell-based 'cytokine factories' and immune-cytokines further underscore the versatility of localized cytokine delivery strategies. In addition, fifth-generation CAR-T cells, incorporating approaches that enhance or mimic cytokine-mediated JAK-STAT signaling pathways, highlight a new direction toward programmable intracellular signaling. These strategies remain in the early stages of clinical application due to substantial limitations related to safety and clinical translation, including risks of uncontrolled cytokine activation and complexities in manufacturing. Nevertheless, they offer significant potential to improve therapeutic outcomes not only in hematologic malignancies but also across a broad range of solid tumors.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 6","pages":"e43"},"PeriodicalIF":4.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis. 靶向IL-7和TGF-β通路的双细胞因子调节剂IL7-TBRII抑制肿瘤进展和转移

IF 4.1 4区医学

Immune Network Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.4110/in.2025.25.e42

Youngsik Oh, Sora Kim, Ji-Hae Kim, Kun-Joo Lee, Dain Moon, Chaerim Jeong, Hyun Gyung Kim, Seung-Min Chun, Mi-Sun Byun, Seung-Woo Lee

{"title":"IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis.","authors":"Youngsik Oh, Sora Kim, Ji-Hae Kim, Kun-Joo Lee, Dain Moon, Chaerim Jeong, Hyun Gyung Kim, Seung-Min Chun, Mi-Sun Byun, Seung-Woo Lee","doi":"10.4110/in.2025.25.e42","DOIUrl":"10.4110/in.2025.25.e42","url":null,"abstract":"Tumor-infiltrating CD8+ T cells are a key determinant of anti-tumor efficacy in immunotherapy. IL-7 has been explored as a cytokine therapy to expand CD8+ T cells, showing promising anti-tumor effects in preclinical models. However, clinical outcomes remain limited, likely due to the immunosuppressive tumor microenvironment. To enhance the efficacy of IL-7 therapy, we reanalyzed publicly available single-cell RNA-sequencing (scRNA-seq) data of tumors treated with IL-7, identifying elevated TGF-β signaling in CD8+ T cells following treatment. As TGF-β impairs CD8+ T cell function and antagonizes IL-7 signaling, we developed a bifunctional fusion protein, recombinant human IL-7 (rhIL-7)-hyFc-sTBRII (IL7-TBRII), by fusing a TGF-β trap (Fc-TBRII) to rhIL-7-hyFc (IL7-Fc). We evaluated the binding affinities and functionalities of each domain in vitro and in vivo, and assessed anti-tumor effects in the MC38 colon cancer model. IL7-TBRII demonstrated superior anti-tumor efficacy compared to IL7-Fc or Fc-TBRII alone, primarily through increased infiltration of cytotoxic CD8+ T cells into tumors. Also, IL7-TBRII expanded the number of activated CD44+ CD8+ T cells. Furthermore, IL7-TBRII reduced metastasis in the 4T1 breast cancer model by reshaping the immune cell composition, and demonstrated synergistic efficacy when combined with radiotherapy or anti-CTLA-4 therapy in the EMT6 breast tumor model. These findings suggest that dual modulation of the IL-7 and TGF-β pathways by IL7-TBRII effectively reprograms the immune microenvironment in both primary and metastatic tumors, particularly by promoting CD8+ T cell activation and infiltration, thus offering a promising strategy to improve clinical responses to immunotherapy.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 6","pages":"e42"},"PeriodicalIF":4.1,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria Derived From iPSCs Control by Reciprocal Regulation of Th17/Treg and Anti-Fibrosis. 通过Th17/Treg和抗纤维化的相互调节控制iPSCs产生的线粒体。

IF 4.1 4区医学

Immune Network Pub Date : 2025-12-08 eCollection Date: 2025-12-01 DOI: 10.4110/in.2025.25.e41

Jin Seok Woo, Hanbi Lee, JooYeon Jhun, SeungCheon Yang, Yeon Su Lee, Yoo-Jin Shin, Sun Woo Lim, Bo-In Lee, Chul Woo Yang, Byung Ha Chung, Mi-La Cho

{"title":"Mitochondria Derived From iPSCs Control by Reciprocal Regulation of Th17/Treg and Anti-Fibrosis.","authors":"Jin Seok Woo, Hanbi Lee, JooYeon Jhun, SeungCheon Yang, Yeon Su Lee, Yoo-Jin Shin, Sun Woo Lim, Bo-In Lee, Chul Woo Yang, Byung Ha Chung, Mi-La Cho","doi":"10.4110/in.2025.25.e41","DOIUrl":"10.4110/in.2025.25.e41","url":null,"abstract":"Several studies have reported the immunoregulatory effects of transplanting mitochondria from mesenchymal stem cells. However, whether similar effects can be achieved using mitochondria derived from human induced pluripotent stem cells (iPSCs; iMito) has not yet been investigated. Here, we examined the protective effects of iMito in a dextran sodium sulfate (DSS)-induced colitis mouse model. To address this, we investigated the effects both in vitro and in vivo. First, iMitos were transferred into mouse splenocytes, and the expression and secretion of IL-17 and FoxP3 were measured. Next, iMitos were transferred into mice with inflammatory bowel disease (IBD) induced by DSS. Intestinal tissues were assessed histologically, and immune cell infiltration was measured. In vitro, iMitos transfer increased mitochondrial function, evidenced by higher ATP synthesis. An immunomodulatory effect was observed, with decreased IL-17 and increased FoxP3 expression. In vivo, iMitos transplantation in IBD mice led to improvements in body weight and intestinal tissue damage; it decreased Th17 cells, increased Tregs, and reduced inflammatory cytokines and fibrosis markers. These data suggest the therapeutic potential of iMitos in treating human inflammatory diseases.","PeriodicalId":13307,"journal":{"name":"Immune Network","volume":"25 6","pages":"e41"},"PeriodicalIF":4.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits. 跨器官组织驻留ILC2s：异质性、生态位串扰和共享调节电路。

IF 4.1 4区医学

Immune Network Pub Date : 2025-12-01 DOI: 10.4110/in.2025.25.e40

Haksung Kim, Jangho Lim, Jongmin Baek, Steven J Van Dyken, Do-Hyun Kim

引用次数: 0